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The map label for this gene is zraS [C]

Identifier: 120611204

GI number: 120611204

Start: 2783027

End: 2785093

Strand: Direct

Name: zraS [C]

Synonym: Aave_2535

Alternate gene names: 120611204

Gene position: 2783027-2785093 (Clockwise)

Preceding gene: 120611203

Following gene: 120611205

Centisome position: 51.99

GC content: 70.15

Gene sequence:

>2067_bases
ATGAGTGTTCCTTCCCCCACGCATTCCGACTTCCTGCGGACCGCCGGCGAGATGAGCGAGCGCGTGCGCCGGCACGACTG
GTCCTCCACGCCGCTCGGCCCCATGGAGTCCTGGCCCGAGGCGTTGCGGGTGGCGGTGCAGATGGTGCTGGCGTCGCGCT
TCCCCAAGTGCCTGGCCTGGGGGCCGGAAATGGTCTCCATCTACAACGATGCCTTCCGTGTCATCCTGGGGGCCAAGCCC
GAAGCGCTGGGCCGGTCTTTCTACGATGTCTGGGCCGAAGCGTGGGAGACAATCGGCCCGCTGGCCGAGCGCGCGCTCGC
CGGGGATTCCGTGTTCCTGGAAGACTTCCCGCTGGTGGTGCGCCGCCAGGGCTACGACGAGCAGGCCTACTTCACCTTCT
GCTACAGCCCGGTCTGCGATGGCTCCGGCACCGTGGTGGGCTTCATGGACACGGTGGTCGAGACCACCGGCAAGTTCCTG
GCCCAGCAGCGGCTGCAGGACCTGGCCGCCACGCTGGATCAGCAGGTGGCCGACCGCACGGCCGACCGCAACCGGCTCTG
GCTGCTGTCGGACGCCATGCTGGTCGTCACGCGGCTCGACGGCACCATCGCCGCCGTCAATCCCGCGTGGCAGGCCACGC
TGGGCTATTCCGAGGACGAGACCATCGGCCGGCGCATCCTCTCCTTCATCCATGACGACGAGGCGGTGCGCGTGCCGGAC
GACGTGCAGCGCCTGGCCGAGGCCGTGCGCCACCAGGCCACGCTGCGCTTTCGCCACCGCAGCGGCGCCGACCGCTGGAT
CGACTGGACCGCGGTGCCCGGCGACGGCTTCGTGCAGGCCGTGGGCCGCGACGTGACCGACGAGCGCGCCCGCACCGAAG
CCCTGCTGCAGTCCCAGGAGCGCGTGCGCCACAGCCAGAAGATGGAGGCGATCGGGCAGCTCACGGGCGGCATCGCGCAC
GACTTCAACAACATGCTGCAGGGCGTGGTGCTGCCCCTGCAGTTGATCGGCCAGCGCCATGCGCGCGGCCACATGGACGA
CATTCCCCGCTACGTGGAGGCCGGCCTGTCGTCGGCCCGGCGCGCCGCCGCGCTCACGCAGCGGCTGCTGGCCTTCTCGC
GGCGCCAGCCGCTGGACGTGCGCCCGGTGGATGCCGCCGCGTCCATCCGCAACCTGGAGCCCATGCTGCGCAACACCTGC
GGGGAAAACACTCGCCTGGACATCGAGATTCCCGAGGATCTCTGGCCGGTGCTCACCGATGTCCACCAGCTCGAGAGCGC
GGTGCTCAACCTGGCCATCAATGCCCGCGACGCCATGCCCGAAGGCGGGCGCCTGCGCATCGCCGGGGACAACCTGGGTG
GAGCGCAGGCGCTGCCTCCCCAGGTACGCGAGGCGCTCGGGCTGCCGCCGGGCGACCTGGTGCGCCTGCAGGTGAGCGAT
ACCGGCCACGGCATGTCCAAGGAAGTGCTGGACCTGGCCTTCGATCCGTTCTTCACCACCAAGCCGATCGGGCAGGGAAC
GGGGCTGGGCCTGTCGATGATCTACGGCTACATGCGCCAGTCGGGCGGCGCCGTGGCGCTGGAAAGCGAAGAGGGGCGCG
GCACCTGCGTGTCGCTCTACTTTCCGCGCTCGTCCGAGGAGGTCAGCGACGAGGCGCCTGCCGGCCTGGACAGTGCCGAG
GCGGGCAAGCGGCCGGATTCGGTGCTGGTGGTGGAGGACGACGCCACGGTGCGCGAGTTCGTGTGCGAACTGCTGCGCGA
CCTCGGCTTCCAGGTGCTGTCGGCCAGCTCAGGCGCCGGGGGCATGGCGATGCTGTCGGGCGCCATCCACTTCGACCTGC
TGGTGTCCGACGTGGGGCTGCCGGGGCCCAATGGCCGGCAGGTGGCGGATTTCGCGCGCGAGCGTCTTCCCGGCATCCTG
GTGCTGCTCATGACGGGCTACGCCGAGCAGGCGGCCATGGATCCCGGCTTCCTGGCCGCCCACCACATGGAGCTCATCGT
CAAGCCGTTCGATGCCCAGGCGCTGGTGCGGAAGGTGCTGGACATGGTGGGCACGCCCGGCCACTGA

Upstream 100 bases:

>100_bases
CGGCCGTGTTCCGGTCGGCGGAACAGCCCCTCGTGCCCCTGCGGGCGCAATGGCGGTTGGTGCGGAGGGGCGCTTTGGCC
ATGTCATCATCGCCCCCGAC

Downstream 100 bases:

>100_bases
GCGGCTCGGGCCGGCGAAACCCCGGAAAGCCCGCGAAACCCCGCTGCGACCGCAGGACGGGCCGGGTGTTGCACAATCCC
CTCCCTCATAACCGCGGCGT

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MSVPSPTHSDFLRTAGEMSERVRRHDWSSTPLGPMESWPEALRVAVQMVLASRFPKCLAWGPEMVSIYNDAFRVILGAKP
EALGRSFYDVWAEAWETIGPLAERALAGDSVFLEDFPLVVRRQGYDEQAYFTFCYSPVCDGSGTVVGFMDTVVETTGKFL
AQQRLQDLAATLDQQVADRTADRNRLWLLSDAMLVVTRLDGTIAAVNPAWQATLGYSEDETIGRRILSFIHDDEAVRVPD
DVQRLAEAVRHQATLRFRHRSGADRWIDWTAVPGDGFVQAVGRDVTDERARTEALLQSQERVRHSQKMEAIGQLTGGIAH
DFNNMLQGVVLPLQLIGQRHARGHMDDIPRYVEAGLSSARRAAALTQRLLAFSRRQPLDVRPVDAAASIRNLEPMLRNTC
GENTRLDIEIPEDLWPVLTDVHQLESAVLNLAINARDAMPEGGRLRIAGDNLGGAQALPPQVREALGLPPGDLVRLQVSD
TGHGMSKEVLDLAFDPFFTTKPIGQGTGLGLSMIYGYMRQSGGAVALESEEGRGTCVSLYFPRSSEEVSDEAPAGLDSAE
AGKRPDSVLVVEDDATVREFVCELLRDLGFQVLSASSGAGGMAMLSGAIHFDLLVSDVGLPGPNGRQVADFARERLPGIL
VLLMTGYAEQAAMDPGFLAAHHMELIVKPFDAQALVRKVLDMVGTPGH

Sequences:

>Translated_688_residues
MSVPSPTHSDFLRTAGEMSERVRRHDWSSTPLGPMESWPEALRVAVQMVLASRFPKCLAWGPEMVSIYNDAFRVILGAKP
EALGRSFYDVWAEAWETIGPLAERALAGDSVFLEDFPLVVRRQGYDEQAYFTFCYSPVCDGSGTVVGFMDTVVETTGKFL
AQQRLQDLAATLDQQVADRTADRNRLWLLSDAMLVVTRLDGTIAAVNPAWQATLGYSEDETIGRRILSFIHDDEAVRVPD
DVQRLAEAVRHQATLRFRHRSGADRWIDWTAVPGDGFVQAVGRDVTDERARTEALLQSQERVRHSQKMEAIGQLTGGIAH
DFNNMLQGVVLPLQLIGQRHARGHMDDIPRYVEAGLSSARRAAALTQRLLAFSRRQPLDVRPVDAAASIRNLEPMLRNTC
GENTRLDIEIPEDLWPVLTDVHQLESAVLNLAINARDAMPEGGRLRIAGDNLGGAQALPPQVREALGLPPGDLVRLQVSD
TGHGMSKEVLDLAFDPFFTTKPIGQGTGLGLSMIYGYMRQSGGAVALESEEGRGTCVSLYFPRSSEEVSDEAPAGLDSAE
AGKRPDSVLVVEDDATVREFVCELLRDLGFQVLSASSGAGGMAMLSGAIHFDLLVSDVGLPGPNGRQVADFARERLPGIL
VLLMTGYAEQAAMDPGFLAAHHMELIVKPFDAQALVRKVLDMVGTPGH
>Mature_687_residues
SVPSPTHSDFLRTAGEMSERVRRHDWSSTPLGPMESWPEALRVAVQMVLASRFPKCLAWGPEMVSIYNDAFRVILGAKPE
ALGRSFYDVWAEAWETIGPLAERALAGDSVFLEDFPLVVRRQGYDEQAYFTFCYSPVCDGSGTVVGFMDTVVETTGKFLA
QQRLQDLAATLDQQVADRTADRNRLWLLSDAMLVVTRLDGTIAAVNPAWQATLGYSEDETIGRRILSFIHDDEAVRVPDD
VQRLAEAVRHQATLRFRHRSGADRWIDWTAVPGDGFVQAVGRDVTDERARTEALLQSQERVRHSQKMEAIGQLTGGIAHD
FNNMLQGVVLPLQLIGQRHARGHMDDIPRYVEAGLSSARRAAALTQRLLAFSRRQPLDVRPVDAAASIRNLEPMLRNTCG
ENTRLDIEIPEDLWPVLTDVHQLESAVLNLAINARDAMPEGGRLRIAGDNLGGAQALPPQVREALGLPPGDLVRLQVSDT
GHGMSKEVLDLAFDPFFTTKPIGQGTGLGLSMIYGYMRQSGGAVALESEEGRGTCVSLYFPRSSEEVSDEAPAGLDSAEA
GKRPDSVLVVEDDATVREFVCELLRDLGFQVLSASSGAGGMAMLSGAIHFDLLVSDVGLPGPNGRQVADFARERLPGILV
LLMTGYAEQAAMDPGFLAAHHMELIVKPFDAQALVRKVLDMVGTPGH

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=253, Percent_Identity=25.296442687747, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788549, Length=363, Percent_Identity=25.3443526170799, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI48994928, Length=513, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 75197; Mature: 75066

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPSPTHSDFLRTAGEMSERVRRHDWSSTPLGPMESWPEALRVAVQMVLASRFPKCLAW
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHC
GPEMVSIYNDAFRVILGAKPEALGRSFYDVWAEAWETIGPLAERALAGDSVFLEDFPLVV
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCHHH
RRQGYDEQAYFTFCYSPVCDGSGTVVGFMDTVVETTGKFLAQQRLQDLAATLDQQVADRT
HCCCCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADRNRLWLLSDAMLVVTRLDGTIAAVNPAWQATLGYSEDETIGRRILSFIHDDEAVRVPD
CCCCEEEEEECCEEEEEECCCCEEECCCCHHHHCCCCCCHHHHHHHHHHHCCCCCEECCH
DVQRLAEAVRHQATLRFRHRSGADRWIDWTAVPGDGFVQAVGRDVTDERARTEALLQSQE
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHH
RVRHSQKMEAIGQLTGGIAHDFNNMLQGVVLPLQLIGQRHARGHMDDIPRYVEAGLSSAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHH
RAAALTQRLLAFSRRQPLDVRPVDAAASIRNLEPMLRNTCGENTRLDIEIPEDLWPVLTD
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHH
VHQLESAVLNLAINARDAMPEGGRLRIAGDNLGGAQALPPQVREALGLPPGDLVRLQVSD
HHHHHHHHHHHHEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCEEEEEECC
TGHGMSKEVLDLAFDPFFTTKPIGQGTGLGLSMIYGYMRQSGGAVALESEEGRGTCVSLY
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEE
FPRSSEEVSDEAPAGLDSAEAGKRPDSVLVVEDDATVREFVCELLRDLGFQVLSASSGAG
ECCCCCCCCCCCCCCCCCHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCHHEEECCCCCC
GMAMLSGAIHFDLLVSDVGLPGPNGRQVADFARERLPGILVLLMTGYAEQAAMDPGFLAA
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEHHHHCCHHHHCCCCCHHHH
HHMELIVKPFDAQALVRKVLDMVGTPGH
HHHHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVPSPTHSDFLRTAGEMSERVRRHDWSSTPLGPMESWPEALRVAVQMVLASRFPKCLAW
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHC
GPEMVSIYNDAFRVILGAKPEALGRSFYDVWAEAWETIGPLAERALAGDSVFLEDFPLVV
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCHHH
RRQGYDEQAYFTFCYSPVCDGSGTVVGFMDTVVETTGKFLAQQRLQDLAATLDQQVADRT
HCCCCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADRNRLWLLSDAMLVVTRLDGTIAAVNPAWQATLGYSEDETIGRRILSFIHDDEAVRVPD
CCCCEEEEEECCEEEEEECCCCEEECCCCHHHHCCCCCCHHHHHHHHHHHCCCCCEECCH
DVQRLAEAVRHQATLRFRHRSGADRWIDWTAVPGDGFVQAVGRDVTDERARTEALLQSQE
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHH
RVRHSQKMEAIGQLTGGIAHDFNNMLQGVVLPLQLIGQRHARGHMDDIPRYVEAGLSSAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHH
RAAALTQRLLAFSRRQPLDVRPVDAAASIRNLEPMLRNTCGENTRLDIEIPEDLWPVLTD
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHH
VHQLESAVLNLAINARDAMPEGGRLRIAGDNLGGAQALPPQVREALGLPPGDLVRLQVSD
HHHHHHHHHHHHEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCEEEEEECC
TGHGMSKEVLDLAFDPFFTTKPIGQGTGLGLSMIYGYMRQSGGAVALESEEGRGTCVSLY
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEE
FPRSSEEVSDEAPAGLDSAEAGKRPDSVLVVEDDATVREFVCELLRDLGFQVLSASSGAG
ECCCCCCCCCCCCCCCCCHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCHHEEECCCCCC
GMAMLSGAIHFDLLVSDVGLPGPNGRQVADFARERLPGILVLLMTGYAEQAAMDPGFLAA
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEHHHHCCHHHHCCCCCHHHH
HHMELIVKPFDAQALVRKVLDMVGTPGH
HHHHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA