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The map label for this gene is czcC [H]

Identifier: 120611173

GI number: 120611173

Start: 2740441

End: 2741751

Strand: Direct

Name: czcC [H]

Synonym: Aave_2504

Alternate gene names: 120611173

Gene position: 2740441-2741751 (Clockwise)

Preceding gene: 120611172

Following gene: 120611174

Centisome position: 51.2

GC content: 70.4

Gene sequence:

>1311_bases
GTGTCCCATACCAGACCATTCATCGCAACGGCCTGCGCTGTCCTGTTGGCCGGCGTGCCCGTTGTCCCTGCGCTTGTCCA
TGCGCAATCCCTGAGCGCCCCTTCCGGGGCCGCGTTCCATGAGCCGACGGCCGCGACCCTGACTTTGGCGGAAGCCATTG
CGCTGGCGCTCGCCAGGCACCCCGCCGTCGCCGTGGCGCAGCGGGAGTTCGACGCGACGCGCGGCGCCGTCCTGCAGGCC
GGCCCGCGCCCGAACCCCGAGCTGTCCGTGCAGCAGGAGGATTTCAAGCAGGGGCGACGAACGTCCACCGTCCAGATCAC
GCAATCGCTGGAGCTCGGCGGCAAGCGGGCCAGCCGGACAGCTGTCGCCGAGCGGATCAGCGCGCAAGCGGCTGCCGACA
TCGAGCAGGCCCGTGCGGACGTGCGTTCCCAGGCCGTCGTCGCCTTTCATGAAGTGCTGGTCGGCCAGGAACGCCTGCGG
CTGGCCCAATCCTCGCTGCAACTGGCCAGCGGCGATGCGGAAGCGACCGGCAAACGGGTGCAGGCGGGCAAGATCGCCCC
GCTGGAGGAGACGCGGGCCAAGGTAGCGCGTGCCGCGGCGGCCGCAGAATTGGCGCAGGCGGAAGGCGCCCTGCGGGCCA
GCCGCCAGAGACTGTTCTCCTTATGGGGCGACATGGGCCGCAGCGGGACGGCGTTGATCGGCCACCTGGACCTGCCGGCC
GAAGGCCTGGCCGACGAGGCGGTGTTCGCGCGGATGGCCGCATCGCCCGCACTGCAGCGCGCCCGGCTCGAGCTGGAGCG
GGCGCAGGCCGCCGTGGCGCTCGAACGCTCGCGCCAGGTCGTGGATGTCGCGGTGTCCGTCGGTGTCAAGCGCAGCCAGG
AGAACGGGGTGACGGCTGCCGTCGTGGGCCTGACCGTGCCCCTGCCGGTGTTCGACCGGAACCAGGGCAACCTCGCCGAA
GCGCTGGCACGCGAGGAAAAGGCCCGCGAAGAGCTGAATGCGGTCGAGCTGAAGCTCGCGTCCGATATCGCCCAGGCCCG
GGAGCAGTTGCGGTCTGCCCGTGCCGAGGCGCAGACATTGCAGCAGGACGCGATTCCCGGTGCGCGCGAAGCCTACGAGG
CCGCATCGCGGGGATTCCAGCTGGGCAAGTTCAGCTACCTGGAAACGCTGGATGCCCAGCGCACCCTGGTCGGCGCCCAG
TCCCAGTTCCTTCGCGCGCTGCTCGATACCTACCGCGCCGCAGCCGAACTGGAGCGCCTGCTCCACGTCACGGACGCGTC
TTCCACCCTCCTGAATCCTTCCAGGCCCTGA

Upstream 100 bases:

>100_bases
GCCTTTCCTCGCTCCATCGACGGTGGACGGCGGGAGAACGATCGCCTGATTGACTGCGACCCTGCGGTCCACCGAAGTTT
TGTTCACTTCGGAGACCCAG

Downstream 100 bases:

>100_bases
ACGCCATGCAAAAAAATACCGATACTTCCACGGGCAAGGTCCAGGCCAGCCATGTGGTTCTCGTCATCGTCCTGGTCGTC
CTGACCGCCGTCGCCGGGTT

Product: outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSHTRPFIATACAVLLAGVPVVPALVHAQSLSAPSGAAFHEPTAATLTLAEAIALALARHPAVAVAQREFDATRGAVLQA
GPRPNPELSVQQEDFKQGRRTSTVQITQSLELGGKRASRTAVAERISAQAAADIEQARADVRSQAVVAFHEVLVGQERLR
LAQSSLQLASGDAEATGKRVQAGKIAPLEETRAKVARAAAAAELAQAEGALRASRQRLFSLWGDMGRSGTALIGHLDLPA
EGLADEAVFARMAASPALQRARLELERAQAAVALERSRQVVDVAVSVGVKRSQENGVTAAVVGLTVPLPVFDRNQGNLAE
ALAREEKAREELNAVELKLASDIAQAREQLRSARAEAQTLQQDAIPGAREAYEAASRGFQLGKFSYLETLDAQRTLVGAQ
SQFLRALLDTYRAAAELERLLHVTDASSTLLNPSRP

Sequences:

>Translated_436_residues
MSHTRPFIATACAVLLAGVPVVPALVHAQSLSAPSGAAFHEPTAATLTLAEAIALALARHPAVAVAQREFDATRGAVLQA
GPRPNPELSVQQEDFKQGRRTSTVQITQSLELGGKRASRTAVAERISAQAAADIEQARADVRSQAVVAFHEVLVGQERLR
LAQSSLQLASGDAEATGKRVQAGKIAPLEETRAKVARAAAAAELAQAEGALRASRQRLFSLWGDMGRSGTALIGHLDLPA
EGLADEAVFARMAASPALQRARLELERAQAAVALERSRQVVDVAVSVGVKRSQENGVTAAVVGLTVPLPVFDRNQGNLAE
ALAREEKAREELNAVELKLASDIAQAREQLRSARAEAQTLQQDAIPGAREAYEAASRGFQLGKFSYLETLDAQRTLVGAQ
SQFLRALLDTYRAAAELERLLHVTDASSTLLNPSRP
>Mature_435_residues
SHTRPFIATACAVLLAGVPVVPALVHAQSLSAPSGAAFHEPTAATLTLAEAIALALARHPAVAVAQREFDATRGAVLQAG
PRPNPELSVQQEDFKQGRRTSTVQITQSLELGGKRASRTAVAERISAQAAADIEQARADVRSQAVVAFHEVLVGQERLRL
AQSSLQLASGDAEATGKRVQAGKIAPLEETRAKVARAAAAAELAQAEGALRASRQRLFSLWGDMGRSGTALIGHLDLPAE
GLADEAVFARMAASPALQRARLELERAQAAVALERSRQVVDVAVSVGVKRSQENGVTAAVVGLTVPLPVFDRNQGNLAEA
LAREEKAREELNAVELKLASDIAQAREQLRSARAEAQTLQQDAIPGAREAYEAASRGFQLGKFSYLETLDAQRTLVGAQS
QFLRALLDTYRAAAELERLLHVTDASSTLLNPSRP

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 46225; Mature: 46094

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHTRPFIATACAVLLAGVPVVPALVHAQSLSAPSGAAFHEPTAATLTLAEAIALALARH
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
PAVAVAQREFDATRGAVLQAGPRPNPELSVQQEDFKQGRRTSTVQITQSLELGGKRASRT
CHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHCCCCCCCEEEHHHHHHCCCHHHHH
AVAERISAQAAADIEQARADVRSQAVVAFHEVLVGQERLRLAQSSLQLASGDAEATGKRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCC
QAGKIAPLEETRAKVARAAAAAELAQAEGALRASRQRLFSLWGDMGRSGTALIGHLDLPA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
EGLADEAVFARMAASPALQRARLELERAQAAVALERSRQVVDVAVSVGVKRSQENGVTAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
VVGLTVPLPVFDRNQGNLAEALAREEKAREELNAVELKLASDIAQAREQLRSARAEAQTL
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQDAIPGAREAYEAASRGFQLGKFSYLETLDAQRTLVGAQSQFLRALLDTYRAAAELERL
HHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHVTDASSTLLNPSRP
HHHCCCCHHCCCCCCC
>Mature Secondary Structure 
SHTRPFIATACAVLLAGVPVVPALVHAQSLSAPSGAAFHEPTAATLTLAEAIALALARH
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
PAVAVAQREFDATRGAVLQAGPRPNPELSVQQEDFKQGRRTSTVQITQSLELGGKRASRT
CHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHCCCCCCCEEEHHHHHHCCCHHHHH
AVAERISAQAAADIEQARADVRSQAVVAFHEVLVGQERLRLAQSSLQLASGDAEATGKRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCC
QAGKIAPLEETRAKVARAAAAAELAQAEGALRASRQRLFSLWGDMGRSGTALIGHLDLPA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
EGLADEAVFARMAASPALQRARLELERAQAAVALERSRQVVDVAVSVGVKRSQENGVTAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
VVGLTVPLPVFDRNQGNLAEALAREEKAREELNAVELKLASDIAQAREQLRSARAEAQTL
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQDAIPGAREAYEAASRGFQLGKFSYLETLDAQRTLVGAQSQFLRALLDTYRAAAELERL
HHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHVTDASSTLLNPSRP
HHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]