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The map label for this gene is phbA [H]

Identifier: 120611149

GI number: 120611149

Start: 2709601

End: 2710782

Strand: Direct

Name: phbA [H]

Synonym: Aave_2478

Alternate gene names: 120611149

Gene position: 2709601-2710782 (Clockwise)

Preceding gene: 120611148

Following gene: 120611150

Centisome position: 50.62

GC content: 70.22

Gene sequence:

>1182_bases
ATGGAAGACATCGTCATCGTTTCGGCCGTCCGCACGGCCGTGGGCAAGTTCGGCGGCGCGCTCGCCAGGACCCCGGCCAC
CGAGCTGGGCGCCATCGTGATCAAGGAGGCGCTGGCCCGTGCCAACGTGCCGCTGGACCAGGTGGGTGAAGTGATCATGG
GGCAGGTGCTGACCGCGGGCGTGGGCCAGAATCCCGCGCGCCAGGCCATGATGAAGGCCGGCGTGGCCAGGGAAACGCCG
GCGCTGACCATCAACGCCGTCTGCGGTTCCGGCCTGAAGGCCGTGATGCTTGCGGCCCAGGCAGTGGCCACGGGCGACAG
CGAGATCGTGGTCGCGGGCGGCCAGGAGAACATGAGCCTCGCGCCCCACGTGCTCAACGGCTCGCGCGAGGGCCAGCGCA
TGGGCGACTGGAAGATGACCGACTCGATGATCGTGGACGGCCTGTGGGACGTGTACAACCAGTACCACATGGGCATCACC
GCCGAGAACGTCGCCAGGCAGGAGGGCATCTCCCGCGAGCAGCAGGACGCGCTCGCCCTGGGCAGCCAGCAGAAGGCCGC
CGCGGCGCAGGATGCGGGCCGCTTCAAGGACGAGATCGTCGGCGTGAGCCTGCCCCAGAAGAAGGGCGATCCCATCGTCT
TCGATGCCGACGAGTACCTCAACCGCAAGACCAATGCCGAGGCACTGGCAGGGCTGCGCCCGGCCTTCGACAAGGCCGGC
ACCGTGACGGCCGGCAACGCGTCCGGCCTCAACGACGGCGCGGCCGCCGTGGTGGTGATGAGCGCGAAGAAGGCCGCGGC
CCTGGGACTGAAGCCGCTAGCGCGCATCGCCGCCTACGCCACGAGCGGCCTCGATCCGGCCACCATGGGCCTGGGGCCCG
TGCCCGCGACGCGCAAGGTGCTGCAGCGTGCCGGCTGGACAGCGGCCGACGTGGATCTTTTCGAGCTGAACGAAGCCTTC
GCCGCGCAGGCCTGCGCCGTCAACCAGCAACTGGGCATCGATCCTGCCAAGGTGAACGTGAACGGCGGCGCGATCGCCAT
CGGCCACCCCATCGGCGCCTCGGGCTGCCGCGTGCTGGTGACCCTGCTGCACGAACTGCAGCGCCGTGGCGCCCGCAAGG
GCGTGGCTGCGCTCTGCATCGGCGGGGGCATGGGCGTCTCGCTCGCGGTGGAGCGGGTCTGA

Upstream 100 bases:

>100_bases
GCGGTTCCAGGCCATCGAGCCGGCACCGGGACGCTATGTGCGCGAGCGGGCCTGAGGCGCCGCGCCACCCCTTTTCCCAT
CATTACCTTTGAGGATCGAC

Downstream 100 bases:

>100_bases
GTTGTCCGGACGGCCCGCCGTACTGCAGCCGCACGTGGTGCGGCTTTTTTGCAGGCTTCGGCGGCGGGCGCCATCCGGCG
GCCACGCCCGTCCAGGAGCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MEDIVIVSAVRTAVGKFGGALARTPATELGAIVIKEALARANVPLDQVGEVIMGQVLTAGVGQNPARQAMMKAGVARETP
ALTINAVCGSGLKAVMLAAQAVATGDSEIVVAGGQENMSLAPHVLNGSREGQRMGDWKMTDSMIVDGLWDVYNQYHMGIT
AENVARQEGISREQQDALALGSQQKAAAAQDAGRFKDEIVGVSLPQKKGDPIVFDADEYLNRKTNAEALAGLRPAFDKAG
TVTAGNASGLNDGAAAVVVMSAKKAAALGLKPLARIAAYATSGLDPATMGLGPVPATRKVLQRAGWTAADVDLFELNEAF
AAQACAVNQQLGIDPAKVNVNGGAIAIGHPIGASGCRVLVTLLHELQRRGARKGVAALCIGGGMGVSLAVERV

Sequences:

>Translated_393_residues
MEDIVIVSAVRTAVGKFGGALARTPATELGAIVIKEALARANVPLDQVGEVIMGQVLTAGVGQNPARQAMMKAGVARETP
ALTINAVCGSGLKAVMLAAQAVATGDSEIVVAGGQENMSLAPHVLNGSREGQRMGDWKMTDSMIVDGLWDVYNQYHMGIT
AENVARQEGISREQQDALALGSQQKAAAAQDAGRFKDEIVGVSLPQKKGDPIVFDADEYLNRKTNAEALAGLRPAFDKAG
TVTAGNASGLNDGAAAVVVMSAKKAAALGLKPLARIAAYATSGLDPATMGLGPVPATRKVLQRAGWTAADVDLFELNEAF
AAQACAVNQQLGIDPAKVNVNGGAIAIGHPIGASGCRVLVTLLHELQRRGARKGVAALCIGGGMGVSLAVERV
>Mature_393_residues
MEDIVIVSAVRTAVGKFGGALARTPATELGAIVIKEALARANVPLDQVGEVIMGQVLTAGVGQNPARQAMMKAGVARETP
ALTINAVCGSGLKAVMLAAQAVATGDSEIVVAGGQENMSLAPHVLNGSREGQRMGDWKMTDSMIVDGLWDVYNQYHMGIT
AENVARQEGISREQQDALALGSQQKAAAAQDAGRFKDEIVGVSLPQKKGDPIVFDADEYLNRKTNAEALAGLRPAFDKAG
TVTAGNASGLNDGAAAVVVMSAKKAAALGLKPLARIAAYATSGLDPATMGLGPVPATRKVLQRAGWTAADVDLFELNEAF
AAQACAVNQQLGIDPAKVNVNGGAIAIGHPIGASGCRVLVTLLHELQRRGARKGVAALCIGGGMGVSLAVERV

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=53.9440203562341, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=44.2748091603053, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=43.0379746835443, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=42.7848101265823, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=32.7102803738318, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=34.0153452685422, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=60.4591836734694, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=59.3908629441624, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1787663, Length=407, Percent_Identity=45.7002457002457, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI48994986, Length=403, Percent_Identity=41.9354838709677, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1788683, Length=404, Percent_Identity=36.8811881188119, Blast_Score=217, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=46.8030690537084, Blast_Score=340, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=41.9023136246787, Blast_Score=291, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=38.5786802030457, Blast_Score=263, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=32.741116751269, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.8638497652582, Blast_Score=177, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=42.964824120603, Blast_Score=296, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=39.746835443038, Blast_Score=233, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=57.5063613231552, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=46.1734693877551, Blast_Score=324, Evalue=5e-89,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=43.5114503816794, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI17137578, Length=432, Percent_Identity=32.6388888888889, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40331; Mature: 40331

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDIVIVSAVRTAVGKFGGALARTPATELGAIVIKEALARANVPLDQVGEVIMGQVLTAG
CCCEEEHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
VGQNPARQAMMKAGVARETPALTINAVCGSGLKAVMLAAQAVATGDSEIVVAGGQENMSL
CCCCHHHHHHHHHCCCCCCCCEEEECHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLNGSREGQRMGDWKMTDSMIVDGLWDVYNQYHMGITAENVARQEGISREQQDALAL
CCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHC
GSQQKAAAAQDAGRFKDEIVGVSLPQKKGDPIVFDADEYLNRKTNAEALAGLRPAFDKAG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHCCCCCHHHHHCCCHHHCCCC
TVTAGNASGLNDGAAAVVVMSAKKAAALGLKPLARIAAYATSGLDPATMGLGPVPATRKV
CEECCCCCCCCCCCEEEEEEECHHHHHHCHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHH
LQRAGWTAADVDLFELNEAFAAQACAVNQQLGIDPAKVNVNGGAIAIGHPIGASGCRVLV
HHHCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCEEEEECCCEEEECCCCCCHHHHHHH
TLLHELQRRGARKGVAALCIGGGMGVSLAVERV
HHHHHHHHCCHHCCEEEEEECCCCCEEEEEECC
>Mature Secondary Structure
MEDIVIVSAVRTAVGKFGGALARTPATELGAIVIKEALARANVPLDQVGEVIMGQVLTAG
CCCEEEHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
VGQNPARQAMMKAGVARETPALTINAVCGSGLKAVMLAAQAVATGDSEIVVAGGQENMSL
CCCCHHHHHHHHHCCCCCCCCEEEECHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLNGSREGQRMGDWKMTDSMIVDGLWDVYNQYHMGITAENVARQEGISREQQDALAL
CCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHC
GSQQKAAAAQDAGRFKDEIVGVSLPQKKGDPIVFDADEYLNRKTNAEALAGLRPAFDKAG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHCCCCCHHHHHCCCHHHCCCC
TVTAGNASGLNDGAAAVVVMSAKKAAALGLKPLARIAAYATSGLDPATMGLGPVPATRKV
CEECCCCCCCCCCCEEEEEEECHHHHHHCHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHH
LQRAGWTAADVDLFELNEAFAAQACAVNQQLGIDPAKVNVNGGAIAIGHPIGASGCRVLV
HHHCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCEEEEECCCEEEECCCCCCHHHHHHH
TLLHELQRRGARKGVAALCIGGGMGVSLAVERV
HHHHHHHHCCHHCCEEEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]