Click here to switch to the map view.

The map label for this gene is prlC [H]

Identifier: 120611129

GI number: 120611129

Start: 2680148

End: 2682187

Strand: Reverse

Name: prlC [H]

Synonym: Aave_2458

Alternate gene names: 120611129

Gene position: 2682187-2680148 (Counterclockwise)

Preceding gene: 120611130

Following gene: 120611128

Centisome position: 50.11

GC content: 68.33

Gene sequence:

>2040_bases
ATGAGCAATCCCCTCCTCGACTTCCAAGACCTCCCGCTGTTCGACCGCATCGCGCCCGCCGACGTGGCTCCTGCGATGGA
CGCCCTGCTCTCGCGCGCGAACACTGCTCTGGACACCGTCACGGCCCCGGACTTCCCCGCCACCTGGGAAGCCATCTCGC
GCGTGCTGGACGTGGCGATCGAGGAGCTGGGCCGAGCGTGGGGCGACGTCAGCCACCTGAACAGCGTTGCCGACACGCCC
GAGCTGCGCGCGGCCTACAACGAGGTCCTGCCGCGGGTGACCGAGTTCTGGACGCGCCTGGGGGCCGACGAGCGCCTCTA
CGCGAAGTACAAGGCCATCGACCCGGCCACGCTCAATCCGGAACAGCGCCAGGCCTGGAAGAACGCCGTGCGCAATTTCG
TGCTCTCCGGCGCCGAACTGCAGGGTGAAGCCAAGGAGCGCTTCGCCCAGATCCAGGAGCGGCAGGCCGAGCTGTCGCAG
AAGTTCAGCGAGAACGCACTCGACGCCACCGACGCCTTCGCCTACTACGCCCGCGAGGACGAACTGGCCGGGTTGCCGGA
CGACGTGCGCCAGGCGGCGCTCGCTGCAGCCCAGGCGGATGGCAAGGAAGGCTACAAGCTCACCCTCAAGATGCCCTGCT
ATCTGCCGGTGATGCAGTTCGCCGAGAGCAGCGCCCTGCGCGAAACGCTGTACCGCGCCTACGTCACCCGGGCCTCGGAC
CAGGCCGAGGGCGATGCGCGCCGCTTCGACAACTCCGCGCTGATCCGCGAAATCCTCGCCCTGCGCCAGGAAGAGGCCCG
ACTGCTGGGCTACGCGAATTTCGGCGAGGTGTCGGTCGTCGCCAAGATGGCGGACTCCCCCCGCGAAGTCATCGACTTCC
TGCGCGACCTCGCCCGGCGCGCGCGGCCCTATGCGGAAAAGGACGTCGCCGACCTGCGCGATTTCGCCGCGAAGCATCTG
GGCATCGCCGATCCGCAGTCCTGGGACTGGCCCTACATTTCCGAGAAACTCAAGGAAGCGCGCTACGCCTTCAGCGAGCA
GGAGGTGAAGCAGTACTTCACCGCGCCGAAGGTGCTGGCCGGCCTCTTCAAGATCGTCGAGACGCTCTTCGACGTGGCCA
TCCGGCGCGACACCGCCCCGGTCTGGAATCCGGCTGTGGAGTTCTACCGCATCGAGCGCGGGACCGAGCTCGTCGGCCAG
TTCTACCTGGACCAGCCGGCCCGCACCGGCAAGCGCGGCGGCGCCTGGATGGACGGCGTGCGCACGCGCTGGCTGCGCCC
CGACACCGGCCGGCTGCAGACGCCCGTCGCCCACCTGGTCTGCAACTTCGCTGCGGGCGTGGAAGGCAAGCCGCCGCTGC
TCACGCACGACGACGTGATCACCCTGTTCCACGAATTCGGCCACGGGCTGCACCACATGCTCACGCAGGTGAACGAGCGC
GATGTGTCCGGCATCAGCGGCGTCGAGTGGGACGCGGTGGAGCTGCCCAGCCAGTTCATGGAGAACTTCTGCTGGGAATG
GGACGTGCTGCGGCACATGACCGCCCACGTGGACACCGGCGCCCCCCTGCCCCGCGAGCTCTTCGACAAGATGCTGGCCG
CCAAGAACTTCCAGAGCGGCATGGCCACTCTGCGGCAGATCGAGTTCGCGCTGTTCGACATGCTGCTGCACACCGAGCAC
GATCCCTCGGAGGATTTCATGCCCCTGCTCGACCGGGTGCGCGAGGAAGTCGCCGTGCTGCAGCCGCCGGCCTTCAGCCG
CAGTGCGCACACTTTCAGCCATATCTTCGCGGGCGGCTACGCGGCCGGCTACTACAGCTACAAGTGGGCGGAAGTGCTGA
GCGCCGACGCCTATGCCGCTTTCGAGGAAACCGCCGGCGCCGACGGCCTGCCGAGCACGGAAACCGGCAGGCGCTATCGC
CAGGCCATCCTCGAAGCCGGCGGCAGCCGTCCGGCCATGGAGTCCTTCAAGGCCTTCCGCGGCCGGGCGCCGTCCCTGGA
CGCCCTGCTGCGCCACCAGGGCATGGCCCAGCCCGCCTGA

Upstream 100 bases:

>100_bases
GCCGAGCGCGCAGCCGGCTGACCGATACCATCGAGCCAGGCTATCGAAGAGATTGCGCAAGCCGCTTGAACCCATCGTCC
CCGCCGCCATCTGAACGCGC

Downstream 100 bases:

>100_bases
CGACCACCGCCTGACACCCCGCTGAAACGTCCCACGCCCGAGGAGACACGCCCCCATGCCATCCCTGCCCCCCGCAGTCC
GCCTGGCTGCGCTGTGCCTG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MSNPLLDFQDLPLFDRIAPADVAPAMDALLSRANTALDTVTAPDFPATWEAISRVLDVAIEELGRAWGDVSHLNSVADTP
ELRAAYNEVLPRVTEFWTRLGADERLYAKYKAIDPATLNPEQRQAWKNAVRNFVLSGAELQGEAKERFAQIQERQAELSQ
KFSENALDATDAFAYYAREDELAGLPDDVRQAALAAAQADGKEGYKLTLKMPCYLPVMQFAESSALRETLYRAYVTRASD
QAEGDARRFDNSALIREILALRQEEARLLGYANFGEVSVVAKMADSPREVIDFLRDLARRARPYAEKDVADLRDFAAKHL
GIADPQSWDWPYISEKLKEARYAFSEQEVKQYFTAPKVLAGLFKIVETLFDVAIRRDTAPVWNPAVEFYRIERGTELVGQ
FYLDQPARTGKRGGAWMDGVRTRWLRPDTGRLQTPVAHLVCNFAAGVEGKPPLLTHDDVITLFHEFGHGLHHMLTQVNER
DVSGISGVEWDAVELPSQFMENFCWEWDVLRHMTAHVDTGAPLPRELFDKMLAAKNFQSGMATLRQIEFALFDMLLHTEH
DPSEDFMPLLDRVREEVAVLQPPAFSRSAHTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEETAGADGLPSTETGRRYR
QAILEAGGSRPAMESFKAFRGRAPSLDALLRHQGMAQPA

Sequences:

>Translated_679_residues
MSNPLLDFQDLPLFDRIAPADVAPAMDALLSRANTALDTVTAPDFPATWEAISRVLDVAIEELGRAWGDVSHLNSVADTP
ELRAAYNEVLPRVTEFWTRLGADERLYAKYKAIDPATLNPEQRQAWKNAVRNFVLSGAELQGEAKERFAQIQERQAELSQ
KFSENALDATDAFAYYAREDELAGLPDDVRQAALAAAQADGKEGYKLTLKMPCYLPVMQFAESSALRETLYRAYVTRASD
QAEGDARRFDNSALIREILALRQEEARLLGYANFGEVSVVAKMADSPREVIDFLRDLARRARPYAEKDVADLRDFAAKHL
GIADPQSWDWPYISEKLKEARYAFSEQEVKQYFTAPKVLAGLFKIVETLFDVAIRRDTAPVWNPAVEFYRIERGTELVGQ
FYLDQPARTGKRGGAWMDGVRTRWLRPDTGRLQTPVAHLVCNFAAGVEGKPPLLTHDDVITLFHEFGHGLHHMLTQVNER
DVSGISGVEWDAVELPSQFMENFCWEWDVLRHMTAHVDTGAPLPRELFDKMLAAKNFQSGMATLRQIEFALFDMLLHTEH
DPSEDFMPLLDRVREEVAVLQPPAFSRSAHTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEETAGADGLPSTETGRRYR
QAILEAGGSRPAMESFKAFRGRAPSLDALLRHQGMAQPA
>Mature_678_residues
SNPLLDFQDLPLFDRIAPADVAPAMDALLSRANTALDTVTAPDFPATWEAISRVLDVAIEELGRAWGDVSHLNSVADTPE
LRAAYNEVLPRVTEFWTRLGADERLYAKYKAIDPATLNPEQRQAWKNAVRNFVLSGAELQGEAKERFAQIQERQAELSQK
FSENALDATDAFAYYAREDELAGLPDDVRQAALAAAQADGKEGYKLTLKMPCYLPVMQFAESSALRETLYRAYVTRASDQ
AEGDARRFDNSALIREILALRQEEARLLGYANFGEVSVVAKMADSPREVIDFLRDLARRARPYAEKDVADLRDFAAKHLG
IADPQSWDWPYISEKLKEARYAFSEQEVKQYFTAPKVLAGLFKIVETLFDVAIRRDTAPVWNPAVEFYRIERGTELVGQF
YLDQPARTGKRGGAWMDGVRTRWLRPDTGRLQTPVAHLVCNFAAGVEGKPPLLTHDDVITLFHEFGHGLHHMLTQVNERD
VSGISGVEWDAVELPSQFMENFCWEWDVLRHMTAHVDTGAPLPRELFDKMLAAKNFQSGMATLRQIEFALFDMLLHTEHD
PSEDFMPLLDRVREEVAVLQPPAFSRSAHTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEETAGADGLPSTETGRRYRQ
AILEAGGSRPAMESFKAFRGRAPSLDALLRHQGMAQPA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=615, Percent_Identity=31.3821138211382, Blast_Score=280, Evalue=5e-75,
Organism=Homo sapiens, GI14149738, Length=619, Percent_Identity=31.5024232633279, Blast_Score=276, Evalue=5e-74,
Organism=Homo sapiens, GI156105687, Length=575, Percent_Identity=25.3913043478261, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1789913, Length=684, Percent_Identity=48.8304093567251, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI1787819, Length=695, Percent_Identity=29.6402877697842, Blast_Score=229, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI71999758, Length=473, Percent_Identity=25.369978858351, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI32565901, Length=622, Percent_Identity=20.9003215434084, Blast_Score=90, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319793, Length=684, Percent_Identity=27.7777777777778, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6322715, Length=606, Percent_Identity=24.0924092409241, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21356111, Length=488, Percent_Identity=32.3770491803279, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI20129717, Length=465, Percent_Identity=26.2365591397849, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76169; Mature: 76038

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLDFQDLPLFDRIAPADVAPAMDALLSRANTALDTVTAPDFPATWEAISRVLDVAI
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
EELGRAWGDVSHLNSVADTPELRAAYNEVLPRVTEFWTRLGADERLYAKYKAIDPATLNP
HHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCH
EQRQAWKNAVRNFVLSGAELQGEAKERFAQIQERQAELSQKFSENALDATDAFAYYARED
HHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
ELAGLPDDVRQAALAAAQADGKEGYKLTLKMPCYLPVMQFAESSALRETLYRAYVTRASD
CCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QAEGDARRFDNSALIREILALRQEEARLLGYANFGEVSVVAKMADSPREVIDFLRDLARR
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
ARPYAEKDVADLRDFAAKHLGIADPQSWDWPYISEKLKEARYAFSEQEVKQYFTAPKVLA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFKIVETLFDVAIRRDTAPVWNPAVEFYRIERGTELVGQFYLDQPARTGKRGGAWMDGV
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHH
RTRWLRPDTGRLQTPVAHLVCNFAAGVEGKPPLLTHDDVITLFHEFGHGLHHMLTQVNER
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DVSGISGVEWDAVELPSQFMENFCWEWDVLRHMTAHVDTGAPLPRELFDKMLAAKNFQSG
CCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
MATLRQIEFALFDMLLHTEHDPSEDFMPLLDRVREEVAVLQPPAFSRSAHTFSHIFAGGY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCH
AAGYYSYKWAEVLSADAYAAFEETAGADGLPSTETGRRYRQAILEAGGSRPAMESFKAFR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
GRAPSLDALLRHQGMAQPA
CCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SNPLLDFQDLPLFDRIAPADVAPAMDALLSRANTALDTVTAPDFPATWEAISRVLDVAI
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
EELGRAWGDVSHLNSVADTPELRAAYNEVLPRVTEFWTRLGADERLYAKYKAIDPATLNP
HHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCH
EQRQAWKNAVRNFVLSGAELQGEAKERFAQIQERQAELSQKFSENALDATDAFAYYARED
HHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
ELAGLPDDVRQAALAAAQADGKEGYKLTLKMPCYLPVMQFAESSALRETLYRAYVTRASD
CCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QAEGDARRFDNSALIREILALRQEEARLLGYANFGEVSVVAKMADSPREVIDFLRDLARR
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
ARPYAEKDVADLRDFAAKHLGIADPQSWDWPYISEKLKEARYAFSEQEVKQYFTAPKVLA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFKIVETLFDVAIRRDTAPVWNPAVEFYRIERGTELVGQFYLDQPARTGKRGGAWMDGV
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHH
RTRWLRPDTGRLQTPVAHLVCNFAAGVEGKPPLLTHDDVITLFHEFGHGLHHMLTQVNER
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DVSGISGVEWDAVELPSQFMENFCWEWDVLRHMTAHVDTGAPLPRELFDKMLAAKNFQSG
CCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
MATLRQIEFALFDMLLHTEHDPSEDFMPLLDRVREEVAVLQPPAFSRSAHTFSHIFAGGY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCH
AAGYYSYKWAEVLSADAYAAFEETAGADGLPSTETGRRYRQAILEAGGSRPAMESFKAFR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
GRAPSLDALLRHQGMAQPA
CCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]