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The map label for this gene is glnS [H]

Identifier: 120610973

GI number: 120610973

Start: 2527928

End: 2529742

Strand: Reverse

Name: glnS [H]

Synonym: Aave_2300

Alternate gene names: 120610973

Gene position: 2529742-2527928 (Counterclockwise)

Preceding gene: 120610982

Following gene: 120610970

Centisome position: 47.26

GC content: 68.6

Gene sequence:

>1815_bases
ATGAGTTCGCACGCCCCCTCCCCCGCGACGGCCGAGTCCGCCAAACCGAGCAATTTCCTGCGCCAGATCATCGAATCCGA
CCTTGCCCAGGGCACCTACGCCCAGGCCCGCTGGGCCGGCACGCCGGGCGACGCCGCCCACCACGCCTGCGGCCAGCCCG
ACCCCGCGAAGATCCGCACCCGCTTCCCGCCCGAGCCCAACGGCTACCTGCACGTGGGCCACGCCAAGAGCATCTGCCTG
AACTTCGGGCTGGCGCGCGACTATGGCGGAGTGTGCCACCTGCGCTTCGACGACACCAACCCCGAGAAGGAAGACCAGGA
ATACGTCGATGGCATCATCGACGCCGTGCACTGGCTGGGCTTCGACTGGGCGCAGATCGGCCAGGCCCCCGGCACCGCCG
CGCCCTACCAGGCCAGCGACTATTTCGACTTCATGTACCGCGCGGCCGAGTACCTGATCGAGACCGGCCACGCCTACGTG
GACGAGCAGAGCCCGGAGGAGATGCGCGCCAACCGCGGCGACTTCGGCAAACCCGGCGTGGACAGCCCCTTCCGCGCCCG
CACGCCCGCCGAGAACCTCGCACGCTTCCGGGAAATGCGCGACGGCAAGCTGCCCGACGGCGCCGCCGTGCTGCGCGCGA
AGATCGACATGGCCTCGCCCAACATCAACCTGCGCGATCCGGCCATCTACCGCATCAAGCACGCCGAGCACCACCACACT
GGCAACAAGTGGTGCATCTACCCGATGTACACCTTCGCGCACCCCATCGAGGACGCGCTGGAGCGCATCACCCACAGCAT
CTGCACGCTGGAGTTCGAAGACCAGCGGCCCTTCTACGACTGGCTGCTGGACCGCCTGGCCGAAGGCGGCCTGATCGCCA
CGCCCCAGCCGCGCCAGTACGAGTTCGCGCGCCTGAACCTCACCTACGTGGTGACCAGCAAGCGCAAGCTCAAGCATCTT
GTGGACAACGGCATCGTGAGCGGCTGGGACGACCCCCGCATGCCCACCATCGTCGGCCTCCGGCGCCGCGGCTACACGCC
CGAGGCCCTGCAGCTGTTCTGCGAGCGCATCGGCGTGACCAGGGACTATTCCTGGATCGACTACGCCACGCTGGAAGGCT
GCCTGCGCGAGGACCTGGAGAACCAGGCCCACCGCGGCATGGCCGTGCTGGACCCGGTGAGGCTCGAACTCACCAACTGG
GACGAGCTCTTCGGCGCCGGTCACCTCGAGCCCTGCCAGTTGCCCGCCCTGCCCCATCCGCCCGAAGGCACGGAAGCGCC
CGTGCGCCACTTCACGCTCGGCAGGGACGTCTGGATCGAGCGCGAGGACTTCGAGGAAACCCCGCCCAAGGGCTACAAGC
GCCTCTTCCCGGGCAACAGGGTCCGGCTGAAGGGCGGCTACGTCATCGAATGCACGGGCTGCGAGAAGGATGCCGAAGGC
AAAGTGACCAAGGTGCTCGCGACCGTGGTGCCCGACACCAAAAGCGGCACGCCCGGGGCCGACAGCGTGAAGGTGAAGGC
CGCCATCACCTGGGTGGGCGTGGCCGACGGCGTGCCCGCCGAGGTGCGCCTGTACGACCGCCTGTTCACCGACGCCCAGC
CCGACGCGGGCGGCAAGGACTTCCTGGCGCTGCTCAACCCGGACAGCCTGAAGGTGGTGACCGCCTATGTCGAGCCCTCG
CTGGCCGGGGCGCAGCCGGACGACAAGTTCCAGTTCGAGCGGTTCGGGTACTTCGTGGCGGACCGGGAGGACCATGCGCC
GGGCAAGCCGGTGTTCAACCGGGCGACCGGCCTGAAGGACAGCTGGGGCAAGTAG

Upstream 100 bases:

>100_bases
GCCCCGCAGGATGGCACAAATGCCGAACAATCTTGTTTCCGGACGTAGCGGCGTTTGTTGCAGGGGGTTACCGGCAGGGG
CAGCGCCCTAGAATGCGTCC

Downstream 100 bases:

>100_bases
CCCCGGCGATACCCGCGGAACGCAGGCGCCCCGCCATGCTGCCCGACCTCACGCACTTCCTGCTCCACCGGGCCATCACG
GCGTTCGCGCTGTGGGTGGC

Product: glutaminyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamine--tRNA ligase; GlnRS [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MSSHAPSPATAESAKPSNFLRQIIESDLAQGTYAQARWAGTPGDAAHHACGQPDPAKIRTRFPPEPNGYLHVGHAKSICL
NFGLARDYGGVCHLRFDDTNPEKEDQEYVDGIIDAVHWLGFDWAQIGQAPGTAAPYQASDYFDFMYRAAEYLIETGHAYV
DEQSPEEMRANRGDFGKPGVDSPFRARTPAENLARFREMRDGKLPDGAAVLRAKIDMASPNINLRDPAIYRIKHAEHHHT
GNKWCIYPMYTFAHPIEDALERITHSICTLEFEDQRPFYDWLLDRLAEGGLIATPQPRQYEFARLNLTYVVTSKRKLKHL
VDNGIVSGWDDPRMPTIVGLRRRGYTPEALQLFCERIGVTRDYSWIDYATLEGCLREDLENQAHRGMAVLDPVRLELTNW
DELFGAGHLEPCQLPALPHPPEGTEAPVRHFTLGRDVWIEREDFEETPPKGYKRLFPGNRVRLKGGYVIECTGCEKDAEG
KVTKVLATVVPDTKSGTPGADSVKVKAAITWVGVADGVPAEVRLYDRLFTDAQPDAGGKDFLALLNPDSLKVVTAYVEPS
LAGAQPDDKFQFERFGYFVADREDHAPGKPVFNRATGLKDSWGK

Sequences:

>Translated_604_residues
MSSHAPSPATAESAKPSNFLRQIIESDLAQGTYAQARWAGTPGDAAHHACGQPDPAKIRTRFPPEPNGYLHVGHAKSICL
NFGLARDYGGVCHLRFDDTNPEKEDQEYVDGIIDAVHWLGFDWAQIGQAPGTAAPYQASDYFDFMYRAAEYLIETGHAYV
DEQSPEEMRANRGDFGKPGVDSPFRARTPAENLARFREMRDGKLPDGAAVLRAKIDMASPNINLRDPAIYRIKHAEHHHT
GNKWCIYPMYTFAHPIEDALERITHSICTLEFEDQRPFYDWLLDRLAEGGLIATPQPRQYEFARLNLTYVVTSKRKLKHL
VDNGIVSGWDDPRMPTIVGLRRRGYTPEALQLFCERIGVTRDYSWIDYATLEGCLREDLENQAHRGMAVLDPVRLELTNW
DELFGAGHLEPCQLPALPHPPEGTEAPVRHFTLGRDVWIEREDFEETPPKGYKRLFPGNRVRLKGGYVIECTGCEKDAEG
KVTKVLATVVPDTKSGTPGADSVKVKAAITWVGVADGVPAEVRLYDRLFTDAQPDAGGKDFLALLNPDSLKVVTAYVEPS
LAGAQPDDKFQFERFGYFVADREDHAPGKPVFNRATGLKDSWGK
>Mature_603_residues
SSHAPSPATAESAKPSNFLRQIIESDLAQGTYAQARWAGTPGDAAHHACGQPDPAKIRTRFPPEPNGYLHVGHAKSICLN
FGLARDYGGVCHLRFDDTNPEKEDQEYVDGIIDAVHWLGFDWAQIGQAPGTAAPYQASDYFDFMYRAAEYLIETGHAYVD
EQSPEEMRANRGDFGKPGVDSPFRARTPAENLARFREMRDGKLPDGAAVLRAKIDMASPNINLRDPAIYRIKHAEHHHTG
NKWCIYPMYTFAHPIEDALERITHSICTLEFEDQRPFYDWLLDRLAEGGLIATPQPRQYEFARLNLTYVVTSKRKLKHLV
DNGIVSGWDDPRMPTIVGLRRRGYTPEALQLFCERIGVTRDYSWIDYATLEGCLREDLENQAHRGMAVLDPVRLELTNWD
ELFGAGHLEPCQLPALPHPPEGTEAPVRHFTLGRDVWIEREDFEETPPKGYKRLFPGNRVRLKGGYVIECTGCEKDAEGK
VTKVLATVVPDTKSGTPGADSVKVKAAITWVGVADGVPAEVRLYDRLFTDAQPDAGGKDFLALLNPDSLKVVTAYVEPSL
AGAQPDDKFQFERFGYFVADREDHAPGKPVFNRATGLKDSWGK

Specific function: Unknown

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI4826960, Length=558, Percent_Identity=43.5483870967742, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI62241042, Length=539, Percent_Identity=32.2820037105751, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI134288884, Length=111, Percent_Identity=32.4324324324324, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1786895, Length=592, Percent_Identity=51.6891891891892, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1788743, Length=311, Percent_Identity=26.6881028938907, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17543332, Length=552, Percent_Identity=41.6666666666667, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17511007, Length=539, Percent_Identity=30.0556586270872, Blast_Score=230, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324742, Length=587, Percent_Identity=37.9897785349233, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6321192, Length=543, Percent_Identity=33.5174953959484, Blast_Score=256, Evalue=8e-69,
Organism=Drosophila melanogaster, GI17864488, Length=555, Percent_Identity=40.5405405405405, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24649466, Length=529, Percent_Identity=31.758034026465, Blast_Score=238, Evalue=9e-63,

Paralogues:

None

Copy number: 520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR004514
- InterPro:   IPR022861
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR020059
- InterPro:   IPR020056
- InterPro:   IPR011035
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c; PF03950 tRNA-synt_1c_C [H]

EC number: =6.1.1.18 [H]

Molecular weight: Translated: 67519; Mature: 67388

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHAPSPATAESAKPSNFLRQIIESDLAQGTYAQARWAGTPGDAAHHACGQPDPAKIRT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHEEECCCCCCHHHHCCCCCCCCCEEE
RFPPEPNGYLHVGHAKSICLNFGLARDYGGVCHLRFDDTNPEKEDQEYVDGIIDAVHWLG
CCCCCCCCEEEECCHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
FDWAQIGQAPGTAAPYQASDYFDFMYRAAEYLIETGHAYVDEQSPEEMRANRGDFGKPGV
CCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCC
DSPFRARTPAENLARFREMRDGKLPDGAAVLRAKIDMASPNINLRDPAIYRIKHAEHHHT
CCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEECCHHCCC
GNKWCIYPMYTFAHPIEDALERITHSICTLEFEDQRPFYDWLLDRLAEGGLIATPQPRQY
CCEEEEEEHHHHHCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCE
EFARLNLTYVVTSKRKLKHLVDNGIVSGWDDPRMPTIVGLRRRGYTPEALQLFCERIGVT
EEEEEEEEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCC
RDYSWIDYATLEGCLREDLENQAHRGMAVLDPVRLELTNWDELFGAGHLEPCQLPALPHP
CCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCHHHHHCCCCCCCCCCCCCCCC
PEGTEAPVRHFTLGRDVWIEREDFEETPPKGYKRLFPGNRVRLKGGYVIECTGCEKDAEG
CCCCCCCHHHEECCCCEEEECCCCCCCCCHHHHHCCCCCEEEECCCEEEEEECCCCCCCC
KVTKVLATVVPDTKSGTPGADSVKVKAAITWVGVADGVPAEVRLYDRLFTDAQPDAGGKD
HHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
FLALLNPDSLKVVTAYVEPSLAGAQPDDKFQFERFGYFVADREDHAPGKPVFNRATGLKD
EEEEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHCEEEECCCCCCCCCCHHHHHCCCCC
SWGK
CCCC
>Mature Secondary Structure 
SSHAPSPATAESAKPSNFLRQIIESDLAQGTYAQARWAGTPGDAAHHACGQPDPAKIRT
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHEEECCCCCCHHHHCCCCCCCCCEEE
RFPPEPNGYLHVGHAKSICLNFGLARDYGGVCHLRFDDTNPEKEDQEYVDGIIDAVHWLG
CCCCCCCCEEEECCHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
FDWAQIGQAPGTAAPYQASDYFDFMYRAAEYLIETGHAYVDEQSPEEMRANRGDFGKPGV
CCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCC
DSPFRARTPAENLARFREMRDGKLPDGAAVLRAKIDMASPNINLRDPAIYRIKHAEHHHT
CCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEECCHHCCC
GNKWCIYPMYTFAHPIEDALERITHSICTLEFEDQRPFYDWLLDRLAEGGLIATPQPRQY
CCEEEEEEHHHHHCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCE
EFARLNLTYVVTSKRKLKHLVDNGIVSGWDDPRMPTIVGLRRRGYTPEALQLFCERIGVT
EEEEEEEEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCC
RDYSWIDYATLEGCLREDLENQAHRGMAVLDPVRLELTNWDELFGAGHLEPCQLPALPHP
CCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCHHHHHCCCCCCCCCCCCCCCC
PEGTEAPVRHFTLGRDVWIEREDFEETPPKGYKRLFPGNRVRLKGGYVIECTGCEKDAEG
CCCCCCCHHHEECCCCEEEECCCCCCCCCHHHHHCCCCCEEEECCCEEEEEECCCCCCCC
KVTKVLATVVPDTKSGTPGADSVKVKAAITWVGVADGVPAEVRLYDRLFTDAQPDAGGKD
HHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
FLALLNPDSLKVVTAYVEPSLAGAQPDDKFQFERFGYFVADREDHAPGKPVFNRATGLKD
EEEEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHCEEEECCCCCCCCCCHHHHHCCCCC
SWGK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]