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The map label for this gene is truC [H]

Identifier: 120610952

GI number: 120610952

Start: 2507174

End: 2508007

Strand: Reverse

Name: truC [H]

Synonym: Aave_2278

Alternate gene names: 120610952

Gene position: 2508007-2507174 (Counterclockwise)

Preceding gene: 120610953

Following gene: 120610951

Centisome position: 46.85

GC content: 76.26

Gene sequence:

>834_bases
ATGCCGCTTCCGAACGCCCCCCGCCATCCGCCCCTGGCCATCCTCCGGCAGGACGACGACCTCGTCGCCGTGTACAAGCC
CGCCGGCTGGCTCGTGCACCGCACGGGCCTGGACGCGGGCGAGACCCGCTTCGTGATGCAGGCGCTGCGCGACCAGCTCG
GCCGCCGGGTGTACCCGGTGCACCGGCTCGACAAGGGCACCTGCGGAGTGCTGGTGATGGGGCTGCACGCGGAGGCAGCC
CGCGCGCTGTCGCAGGCCTTCGAGCAGCACCGGGTGGACAAGCGCTACCTGGCCCTGGTGCGCGGCCATGCACCGGACCG
GGTGCAGGTGGACCATGCCCTGCGCCCGGACGATGCGCCGCCCGATGCCGCCGTGCAGCCGGCCCGCACGGCGCTGCGCT
GCCTGGCGCGGCTGGAGCTGCCCGAGGCCAGCGATGCGCGCTTCGCCACCACGCGGGCCTCGCTGGTGGAAGCCCTGCCG
GAAACCGGCCGCCGCCACCAGATCCGCCGGCACCTCAAGCACATCGCCCATCCGATCCTGGGCGACGCCACCCATGGCAA
GGGCCCGCTGAACCGCTGGTGGGCGCAGCGGCTGGGTCTGCAGCGGCTCTGGCTGCACGCCTGGCGGCTGGCGCTGCCGC
ATCCGGCGACGGGCGAGACGGTGGTGGTGGACAGCGGCCTGCGGGGCGGGCCGCTGCCCGGCACGACGGCTGCGCCGGGC
GGGGCGGGCCCGGCGGAGATGCCGGCGGCCGCGCCCGACCTGCACGACTGGCAGGCGCGCGTCCTCAGCCTCGACTGGGT
CCCCCGCGGCGATGCAGCCGCCCCGGGACGCTGA

Upstream 100 bases:

>100_bases
GGCGACGCGCTGGCGATCCGCTGCGAGTTCGGCAACTGCCGCGTGCTGCGCTGAGCGGCCGGGCCGCGGTGGACGCGCCC
CGGGGTATGCTGCGCGCCCG

Downstream 100 bases:

>100_bases
CGCCGCAGTCCGTCGGGGAACGCGCATGTCGAGCCCGGCAGGAAGACCTTGCCGCGCCCGGGTAGGCGCCGTCCTACCCG
CTGTCGCGACGGGTGCTGCC

Product: tRNA pseudouridine synthase C

Products: NA

Alternate protein names: tRNA pseudouridylate synthase C; tRNA-uridine isomerase C [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MPLPNAPRHPPLAILRQDDDLVAVYKPAGWLVHRTGLDAGETRFVMQALRDQLGRRVYPVHRLDKGTCGVLVMGLHAEAA
RALSQAFEQHRVDKRYLALVRGHAPDRVQVDHALRPDDAPPDAAVQPARTALRCLARLELPEASDARFATTRASLVEALP
ETGRRHQIRRHLKHIAHPILGDATHGKGPLNRWWAQRLGLQRLWLHAWRLALPHPATGETVVVDSGLRGGPLPGTTAAPG
GAGPAEMPAAAPDLHDWQARVLSLDWVPRGDAAAPGR

Sequences:

>Translated_277_residues
MPLPNAPRHPPLAILRQDDDLVAVYKPAGWLVHRTGLDAGETRFVMQALRDQLGRRVYPVHRLDKGTCGVLVMGLHAEAA
RALSQAFEQHRVDKRYLALVRGHAPDRVQVDHALRPDDAPPDAAVQPARTALRCLARLELPEASDARFATTRASLVEALP
ETGRRHQIRRHLKHIAHPILGDATHGKGPLNRWWAQRLGLQRLWLHAWRLALPHPATGETVVVDSGLRGGPLPGTTAAPG
GAGPAEMPAAAPDLHDWQARVLSLDWVPRGDAAAPGR
>Mature_276_residues
PLPNAPRHPPLAILRQDDDLVAVYKPAGWLVHRTGLDAGETRFVMQALRDQLGRRVYPVHRLDKGTCGVLVMGLHAEAAR
ALSQAFEQHRVDKRYLALVRGHAPDRVQVDHALRPDDAPPDAAVQPARTALRCLARLELPEASDARFATTRASLVEALPE
TGRRHQIRRHLKHIAHPILGDATHGKGPLNRWWAQRLGLQRLWLHAWRLALPHPATGETVVVDSGLRGGPLPGTTAAPGG
AGPAEMPAAAPDLHDWQARVLSLDWVPRGDAAAPGR

Specific function: Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs [H]

COG id: COG0564

COG function: function code J; Pseudouridylate synthases, 23S RNA-specific

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudouridine synthase rluA family [H]

Homologues:

Organism=Homo sapiens, GI17158025, Length=217, Percent_Identity=29.4930875576037, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789155, Length=223, Percent_Identity=51.1210762331839, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1787327, Length=224, Percent_Identity=34.8214285714286, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786244, Length=235, Percent_Identity=33.1914893617021, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788946, Length=233, Percent_Identity=29.1845493562232, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17534965, Length=186, Percent_Identity=31.1827956989247, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320168, Length=196, Percent_Identity=29.5918367346939, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324506, Length=196, Percent_Identity=30.6122448979592, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR006224
- InterPro:   IPR006145 [H]

Pfam domain/function: PF00849 PseudoU_synth_2 [H]

EC number: NA

Molecular weight: Translated: 30278; Mature: 30147

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: PS01129 PSI_RLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPNAPRHPPLAILRQDDDLVAVYKPAGWLVHRTGLDAGETRFVMQALRDQLGRRVYPV
CCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCEECCH
HRLDKGTCGVLVMGLHAEAARALSQAFEQHRVDKRYLALVRGHAPDRVQVDHALRPDDAP
HHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCC
PDAAVQPARTALRCLARLELPEASDARFATTRASLVEALPETGRRHQIRRHLKHIAHPIL
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
GDATHGKGPLNRWWAQRLGLQRLWLHAWRLALPHPATGETVVVDSGLRGGPLPGTTAAPG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCC
GAGPAEMPAAAPDLHDWQARVLSLDWVPRGDAAAPGR
CCCCCCCCCCCCCCHHHHHHHEEEECCCCCCCCCCCC
>Mature Secondary Structure 
PLPNAPRHPPLAILRQDDDLVAVYKPAGWLVHRTGLDAGETRFVMQALRDQLGRRVYPV
CCCCCCCCCCEEEEECCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCEECCH
HRLDKGTCGVLVMGLHAEAARALSQAFEQHRVDKRYLALVRGHAPDRVQVDHALRPDDAP
HHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCC
PDAAVQPARTALRCLARLELPEASDARFATTRASLVEALPETGRRHQIRRHLKHIAHPIL
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
GDATHGKGPLNRWWAQRLGLQRLWLHAWRLALPHPATGETVVVDSGLRGGPLPGTTAAPG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCC
GAGPAEMPAAAPDLHDWQARVLSLDWVPRGDAAAPGR
CCCCCCCCCCCCCCHHHHHHHEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]