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The map label for this gene is ilvD [H]

Identifier: 120610922

GI number: 120610922

Start: 2471530

End: 2473263

Strand: Reverse

Name: ilvD [H]

Synonym: Aave_2248

Alternate gene names: 120610922

Gene position: 2473263-2471530 (Counterclockwise)

Preceding gene: 120610923

Following gene: 120610921

Centisome position: 46.21

GC content: 69.26

Gene sequence:

>1734_bases
ATGACCACCCCTCCGCGCAAACTCCGCTCCACCGAATGGTTCGGCACGGCCGACAAGAACGGCTTCATGTACCGCAGCTG
GATGAAGAACCAGGGCATCCCCGACCATGAGTTCGACGGCCGCCCGATCATCGGCATCTGCAACACCTGGTCCGAACTCA
CGCCCTGCAACGCGCACTTCCGCAAGATCGCCGAGCACGTCAAGCGCGGCATCTACGAAGCGGGCGGCTTCCCGGTCGAA
TTCCCCGTGTTCTCCAACGGCGAATCCAACCTGCGCCCCACCGCCATGCTCACGCGCAACCTGGCCAGCATGGATGTGGA
AGAAGCCATCCGCGGCAACCCGATCGACGCCGTCGTGCTGCTCACGGGCTGCGACAAGACCACGCCCGCGCTGCTGATGG
GCGCGGCCAGCTGCGACGTGCCGGCCATCGTGGTCACGGGCGGGCCCATGCTCAACGGCAAGCTGGCCGGCAAGGACATC
GGCTCGGGCACGGCCGTGTGGCAGCTGCACGAATCCCTGAAGGCGGGCGAGATCGAGCTGCACCAGTTCCTCGCGGCCGA
AGGCGGCATGTCGCGCTCGGCCGGCACCTGCAACACCATGGGCACGGCCAGCACCATGGCCTGCATGGCCGAATCGCTGG
GCACCTCGCTGCCGCACAACGCCGCGATTCCCGCGGTGGACGCGCGCCGCTACGTGCTGGCGCACATGTCCGGCAAGCGC
ATCGTCGAGATGGCGCACGAAGGGCTCACGCTCTCGAAGATCCTGACGCGCGAAGCCTTCGAGAACGCCATCCGCACCAA
CGCCGCCATCGGCGGCTCGACCAATGCCGTCATCCACCTGAAGGCGATCGCCGGCCGCATCGGCGTGCAGCTCGACCTGG
AGGACTGGACCCGCATCGGGCGTGGCACGCCCACGCTGGTGGACCTGCAGCCCTCGGGCCGCTTCCTGATGGAGGAGTTC
TACTACGCGGGCGGCCTGCCCGCCGTGCTGCGCCGCCTGGGCGAGAACGGCCTGCTGCCCCACCCCGACGCGCTCACCGT
GAACGGCAGGAGCCTGTGGGACAACGTGCGCGACGCGCCCCAGTACAACGACGAGGTGATCCGCCCGCTGGACAACCCGC
TGATCGCGGATGGCGGCATCTGCATCCTGCGCGGCAACCTGGCGCCGCGCGGCGCGGTGCTCAAGCCTTCGGCCGCCACG
CCCGAGCTGCTCCGGCACCGGGGCCGCGCCGTGGTGTTCGAGAACCTGGAGCATTACAAGGAGCGCATCGTCGATGAGGA
CCTGGACATCGACGCCAGCTGCGTGATGGTCATGAAGAACTGCGGCCCCAAGGGCTACCCCGGCATGGCCGAGGTGGGCA
ACATGGGCCTGCCGCCCAAGCTGCTGCGGCAGGGCGTGAAGGACATGGTCCGCATCTCCGACGCGCGCATGAGCGGCACC
GCCTACGGCACCGTGGTGCTGCACGTGGCGCCCGAGGCCGCGGCCGGCGGGCCGCTGGCCGCCGTGCGCGACGGCGACTT
CATCGAGCTGGACTGCGAACAGGGGCGCCTGCACCTGGACATCAGCGACGAGGAACTGGCCGCGCGCCTGGCCGAACTGG
CCGCCACCGACCATGGCGGCCGCGGCGGGTACCAGCGCCTGTACGTCGATCACGTGCTGCAGGCCGACGAAGGCTGCGAC
TTCGATTTCCTGGTGGGGTGCCGTGGCGCGGCGGTTCCGCGCCACTCGCATTGA

Upstream 100 bases:

>100_bases
GCCTGCTGCAACGCCTGCTCACGCGCCGCTCCGGCCGGCGGCGCTGACCCGACCCCGCCCTTTTCGCTTTCCTTTCCCGC
ATCCCTCCCGAGCTCCCACG

Downstream 100 bases:

>100_bases
TTATGAACACCCCCCTGAGGCGCTGCGCGCCTTCCCCCCGCTCTCGCCTTGCTGCGCAATGCGGGCAGGGGGACGCAGCC
CTCGCTGCGGGGCGGCCCTT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MTTPPRKLRSTEWFGTADKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHFRKIAEHVKRGIYEAGGFPVE
FPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPIDAVVLLTGCDKTTPALLMGAASCDVPAIVVTGGPMLNGKLAGKDI
GSGTAVWQLHESLKAGEIELHQFLAAEGGMSRSAGTCNTMGTASTMACMAESLGTSLPHNAAIPAVDARRYVLAHMSGKR
IVEMAHEGLTLSKILTREAFENAIRTNAAIGGSTNAVIHLKAIAGRIGVQLDLEDWTRIGRGTPTLVDLQPSGRFLMEEF
YYAGGLPAVLRRLGENGLLPHPDALTVNGRSLWDNVRDAPQYNDEVIRPLDNPLIADGGICILRGNLAPRGAVLKPSAAT
PELLRHRGRAVVFENLEHYKERIVDEDLDIDASCVMVMKNCGPKGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
AYGTVVLHVAPEAAAGGPLAAVRDGDFIELDCEQGRLHLDISDEELAARLAELAATDHGGRGGYQRLYVDHVLQADEGCD
FDFLVGCRGAAVPRHSH

Sequences:

>Translated_577_residues
MTTPPRKLRSTEWFGTADKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHFRKIAEHVKRGIYEAGGFPVE
FPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPIDAVVLLTGCDKTTPALLMGAASCDVPAIVVTGGPMLNGKLAGKDI
GSGTAVWQLHESLKAGEIELHQFLAAEGGMSRSAGTCNTMGTASTMACMAESLGTSLPHNAAIPAVDARRYVLAHMSGKR
IVEMAHEGLTLSKILTREAFENAIRTNAAIGGSTNAVIHLKAIAGRIGVQLDLEDWTRIGRGTPTLVDLQPSGRFLMEEF
YYAGGLPAVLRRLGENGLLPHPDALTVNGRSLWDNVRDAPQYNDEVIRPLDNPLIADGGICILRGNLAPRGAVLKPSAAT
PELLRHRGRAVVFENLEHYKERIVDEDLDIDASCVMVMKNCGPKGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
AYGTVVLHVAPEAAAGGPLAAVRDGDFIELDCEQGRLHLDISDEELAARLAELAATDHGGRGGYQRLYVDHVLQADEGCD
FDFLVGCRGAAVPRHSH
>Mature_576_residues
TTPPRKLRSTEWFGTADKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHFRKIAEHVKRGIYEAGGFPVEF
PVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPIDAVVLLTGCDKTTPALLMGAASCDVPAIVVTGGPMLNGKLAGKDIG
SGTAVWQLHESLKAGEIELHQFLAAEGGMSRSAGTCNTMGTASTMACMAESLGTSLPHNAAIPAVDARRYVLAHMSGKRI
VEMAHEGLTLSKILTREAFENAIRTNAAIGGSTNAVIHLKAIAGRIGVQLDLEDWTRIGRGTPTLVDLQPSGRFLMEEFY
YAGGLPAVLRRLGENGLLPHPDALTVNGRSLWDNVRDAPQYNDEVIRPLDNPLIADGGICILRGNLAPRGAVLKPSAATP
ELLRHRGRAVVFENLEHYKERIVDEDLDIDASCVMVMKNCGPKGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGTA
YGTVVLHVAPEAAAGGPLAAVRDGDFIELDCEQGRLHLDISDEELAARLAELAATDHGGRGGYQRLYVDHVLQADEGCDF
DFLVGCRGAAVPRHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=562, Percent_Identity=31.1387900355872, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI2367371, Length=499, Percent_Identity=33.8677354709419, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1786464, Length=449, Percent_Identity=34.075723830735, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1788157, Length=516, Percent_Identity=30.0387596899225, Blast_Score=183, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=575, Percent_Identity=32.1739130434783, Blast_Score=265, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62152; Mature: 62021

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPPRKLRSTEWFGTADKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHF
CCCCCCHHCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHH
RKIAEHVKRGIYEAGGFPVEFPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPIDAVVL
HHHHHHHHHHHHHCCCCCEECCEECCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCEEEEE
LTGCDKTTPALLMGAASCDVPAIVVTGGPMLNGKLAGKDIGSGTAVWQLHESLKAGEIEL
EECCCCCCHHHEEECCCCCCCEEEEECCCEECCEECCCCCCCCHHHHHHHHHHCCCCHHH
HQFLAAEGGMSRSAGTCNTMGTASTMACMAESLGTSLPHNAAIPAVDARRYVLAHMSGKR
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEECCCCHH
IVEMAHEGLTLSKILTREAFENAIRTNAAIGGSTNAVIHLKAIAGRIGVQLDLEDWTRIG
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEHHHHHHHC
RGTPTLVDLQPSGRFLMEEFYYAGGLPAVLRRLGENGLLPHPDALTVNGRSLWDNVRDAP
CCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHCCC
QYNDEVIRPLDNPLIADGGICILRGNLAPRGAVLKPSAATPELLRHRGRAVVFENLEHYK
CCCCHHHCCCCCCEEECCCEEEEECCCCCCCCEECCCCCCHHHHHHCCCEEEHHHHHHHH
ERIVDEDLDIDASCVMVMKNCGPKGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
HHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
AYGTVVLHVAPEAAAGGPLAAVRDGDFIELDCEQGRLHLDISDEELAARLAELAATDHGG
EEEEEEEEECCCCCCCCCEEEECCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCC
RGGYQRLYVDHVLQADEGCDFDFLVGCRGAAVPRHSH
CCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TTPPRKLRSTEWFGTADKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHF
CCCCCHHCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHH
RKIAEHVKRGIYEAGGFPVEFPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPIDAVVL
HHHHHHHHHHHHHCCCCCEECCEECCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCEEEEE
LTGCDKTTPALLMGAASCDVPAIVVTGGPMLNGKLAGKDIGSGTAVWQLHESLKAGEIEL
EECCCCCCHHHEEECCCCCCCEEEEECCCEECCEECCCCCCCCHHHHHHHHHHCCCCHHH
HQFLAAEGGMSRSAGTCNTMGTASTMACMAESLGTSLPHNAAIPAVDARRYVLAHMSGKR
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEECCCCHH
IVEMAHEGLTLSKILTREAFENAIRTNAAIGGSTNAVIHLKAIAGRIGVQLDLEDWTRIG
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEHHHHHHHC
RGTPTLVDLQPSGRFLMEEFYYAGGLPAVLRRLGENGLLPHPDALTVNGRSLWDNVRDAP
CCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHCCC
QYNDEVIRPLDNPLIADGGICILRGNLAPRGAVLKPSAATPELLRHRGRAVVFENLEHYK
CCCCHHHCCCCCCEEECCCEEEEECCCCCCCCEECCCCCCHHHHHHCCCEEEHHHHHHHH
ERIVDEDLDIDASCVMVMKNCGPKGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
HHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
AYGTVVLHVAPEAAAGGPLAAVRDGDFIELDCEQGRLHLDISDEELAARLAELAATDHGG
EEEEEEEEECCCCCCCCCEEEECCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCC
RGGYQRLYVDHVLQADEGCDFDFLVGCRGAAVPRHSH
CCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA