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The map label for this gene is mcl1 [H]

Identifier: 120610882

GI number: 120610882

Start: 2427516

End: 2428541

Strand: Direct

Name: mcl1 [H]

Synonym: Aave_2208

Alternate gene names: 120610882

Gene position: 2427516-2428541 (Clockwise)

Preceding gene: 120610881

Following gene: 120610883

Centisome position: 45.35

GC content: 73.1

Gene sequence:

>1026_bases
ATGAACTCCGCCGTGGCTGCTCCTTCCAGGCTCCATCCCGCCGAGGTGCTGCTCGGCGCCCAGGCCGCGGCCGCGCGGCT
GCCGGTGTGCGACCACTACAGCGGCGTCGAGGTGCGCATGCGCAAGAGCCTGCAGCTGCAGGCCGAGATGGCGGCCGAGT
TCGGCCGCTGCGTGTTCGACGTCACGCTCGACTGCGAGGACGGCGCTCCCGCGGGCCAGGAGCGCGCCCATGCCGAGCTG
GTCGCCGCGCTGGCGCGCGACGCGCAGCCCGGGGCCCGCGTGGCGGCCCGGGTGCACACGGTGGACCATCCCGCCTTCGC
GCACGACGTCGCCACCATCGCCGGGGAGGCCAGCCACCGGCTCTCCCACCTCATGGTGCCGAAGGTCGAATCCGTGGACG
ACGTGCTGCGCGCCGAGCGGGCCGTGAACGCCGCGGGCGCCACCGCGCTGCCGCTGCACGTGCTCATCGAATCGCCCGCG
GCCGTGCACCATGCCTTCGAGATCGCGGCCCACCCGCGCGTGGAGTCGATCAGCTTCGGTCTCATGGACTTCGTGTCCGC
GCACGGCGGTGCGATCCCCGCGCGGGCGATGGGCGTGCAGGGCCAGTTCGAGCATCCGCTCGTGGTGCGCGCCAAGCTCG
AGATCGCGTCCGCCTGCCATGCGCACGGCAAGGTGCCATCGCACTGCGTGGTGACCGAGTTCAGCGACGCCGCGGCCCTG
GGTGCCGCAGCCGGGCGCGCCGCGCGCGAGTTCGGCTACACCCGCATGTGGAGCATCCACCCGGCCCAGATCCGTCCCAT
CCTGGAGGCCTTCGCGCCCGCCCGGGACGAGATCGTCCAGGCCGCCGCCATCCTTTCCGCCGCCGAGCACGCCGCATGGG
CTCCCATCAGCGTGGACGGCGTTCTGCACGACCGCGCCAGCTACCGCTATTTCTGGCAGGTGCTGGAGCGTGCACACCAG
ACCGGCCGTGTGCTGCCTTCCGAGGCGCGCGGCTGGTTCGATTCCGCCGCGGCAGCGGTCGCCTGA

Upstream 100 bases:

>100_bases
CCGCGTACGAGCGCGGCATCGACGCCGCCTATCCCGTGCGGGCCGACGGGCAGCGCCTGCTCGCCTTCCCGCGCATGTTC
ATCGTGGCGCGGCGCTCCGC

Downstream 100 bases:

>100_bases
CGTACCGGCTGCCCTTCACGACCCCGTTCCCACGACCCCTCTCCCTTGCTGGAGCTTCCATGAAACAACTCGTCGCTTCC
GCCCTGATGCTGCTGAGCCC

Product: HpcH/HpaI aldolase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MNSAVAAPSRLHPAEVLLGAQAAAARLPVCDHYSGVEVRMRKSLQLQAEMAAEFGRCVFDVTLDCEDGAPAGQERAHAEL
VAALARDAQPGARVAARVHTVDHPAFAHDVATIAGEASHRLSHLMVPKVESVDDVLRAERAVNAAGATALPLHVLIESPA
AVHHAFEIAAHPRVESISFGLMDFVSAHGGAIPARAMGVQGQFEHPLVVRAKLEIASACHAHGKVPSHCVVTEFSDAAAL
GAAAGRAAREFGYTRMWSIHPAQIRPILEAFAPARDEIVQAAAILSAAEHAAWAPISVDGVLHDRASYRYFWQVLERAHQ
TGRVLPSEARGWFDSAAAAVA

Sequences:

>Translated_341_residues
MNSAVAAPSRLHPAEVLLGAQAAAARLPVCDHYSGVEVRMRKSLQLQAEMAAEFGRCVFDVTLDCEDGAPAGQERAHAEL
VAALARDAQPGARVAARVHTVDHPAFAHDVATIAGEASHRLSHLMVPKVESVDDVLRAERAVNAAGATALPLHVLIESPA
AVHHAFEIAAHPRVESISFGLMDFVSAHGGAIPARAMGVQGQFEHPLVVRAKLEIASACHAHGKVPSHCVVTEFSDAAAL
GAAAGRAAREFGYTRMWSIHPAQIRPILEAFAPARDEIVQAAAILSAAEHAAWAPISVDGVLHDRASYRYFWQVLERAHQ
TGRVLPSEARGWFDSAAAAVA
>Mature_341_residues
MNSAVAAPSRLHPAEVLLGAQAAAARLPVCDHYSGVEVRMRKSLQLQAEMAAEFGRCVFDVTLDCEDGAPAGQERAHAEL
VAALARDAQPGARVAARVHTVDHPAFAHDVATIAGEASHRLSHLMVPKVESVDDVLRAERAVNAAGATALPLHVLIESPA
AVHHAFEIAAHPRVESISFGLMDFVSAHGGAIPARAMGVQGQFEHPLVVRAKLEIASACHAHGKVPSHCVVTEFSDAAAL
GAAAGRAAREFGYTRMWSIHPAQIRPILEAFAPARDEIVQAAAILSAAEHAAWAPISVDGVLHDRASYRYFWQVLERAHQ
TGRVLPSEARGWFDSAAAAVA

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 36132; Mature: 36132

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAVAAPSRLHPAEVLLGAQAAAARLPVCDHYSGVEVRMRKSLQLQAEMAAEFGRCVFD
CCCCCCCCCCCCHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEE
VTLDCEDGAPAGQERAHAELVAALARDAQPGARVAARVHTVDHPAFAHDVATIAGEASHR
EEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCHHHHHHHHHHHHHHHH
LSHLMVPKVESVDDVLRAERAVNAAGATALPLHVLIESPAAVHHAFEIAAHPRVESISFG
HHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCHHHHHHHHHHCCCCHHHHHHH
LMDFVSAHGGAIPARAMGVQGQFEHPLVVRAKLEIASACHAHGKVPSHCVVTEFSDAAAL
HHHHHHHCCCCCCHHHCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCEEEEECCCHHHH
GAAAGRAAREFGYTRMWSIHPAQIRPILEAFAPARDEIVQAAAILSAAEHAAWAPISVDG
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECC
VLHDRASYRYFWQVLERAHQTGRVLPSEARGWFDSAAAAVA
CHHCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHCC
>Mature Secondary Structure
MNSAVAAPSRLHPAEVLLGAQAAAARLPVCDHYSGVEVRMRKSLQLQAEMAAEFGRCVFD
CCCCCCCCCCCCHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEE
VTLDCEDGAPAGQERAHAELVAALARDAQPGARVAARVHTVDHPAFAHDVATIAGEASHR
EEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCHHHHHHHHHHHHHHHH
LSHLMVPKVESVDDVLRAERAVNAAGATALPLHVLIESPAAVHHAFEIAAHPRVESISFG
HHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCHHHHHHHHHHCCCCHHHHHHH
LMDFVSAHGGAIPARAMGVQGQFEHPLVVRAKLEIASACHAHGKVPSHCVVTEFSDAAAL
HHHHHHHCCCCCCHHHCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCEEEEECCCHHHH
GAAAGRAAREFGYTRMWSIHPAQIRPILEAFAPARDEIVQAAAILSAAEHAAWAPISVDG
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECC
VLHDRASYRYFWQVLERAHQTGRVLPSEARGWFDSAAAAVA
CHHCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA