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The map label for this gene is sdhA [H]

Identifier: 120610876

GI number: 120610876

Start: 2421878

End: 2423686

Strand: Reverse

Name: sdhA [H]

Synonym: Aave_2202

Alternate gene names: 120610876

Gene position: 2423686-2421878 (Counterclockwise)

Preceding gene: 120610877

Following gene: 120610875

Centisome position: 45.28

GC content: 66.72

Gene sequence:

>1809_bases
ATGAGCTACACCAAAGCGAACATCACCACGCGCAAGTTCGACGTCGTCATCGTCGGCGCGGGCGGCTCCGGCATGCGTGC
CGCACTGGAACTCTCCCGCGCGGGCCTGAACGTGGCCTCGCTCTCCAAGGTCTTCCCCACCCGTTCGCACACCGTGGCGG
CGCAGGGCGGCGTGTCGGCCTCGCTCGGCAACATGAGCGAGGACAACTGGCACTACCACTTCTACGACACCATCAAGGGC
TCCGACTGGCTGGGCGACCAGGATGCCATCGAGTTCATGTGCCGCGAAGCCCCCAAGGTGGTGTATGAGCTGGAACACTT
CGGCATGCCCTTCGACCGCAACCCGGACGGCACGATCTACCAGCGCCCCTTCGGCGGCCACACGGCCAACTACGGCGAGA
AGCCCGTGCAGCGCGCCTGCGCCGCGGCCGACCGCACCGGCCACGCGATGCTGCACACGCTCTACCAGCAGAACGTGAAG
GCCAAGACGAACTTCTTCGTCGAGTGGATGGCCCTGGACCTGATCCGCGACGCCTCCGGCGACGTGGTCGGCGTGACGGC
CCTCGAACTGGAAACCGGCGAGCTCTACCAGCTCCAGGCCAAGGCCGTTCTGCTGGCCACCGGTGGCGCCGGCCGCATCT
TCGCGGCATCGACCAACGCCTTCATCAACACCGGCGACGGCCTGGGCATGGCGGCGCGCGCCGGCATCCCGCTGCAGGAC
ATGGAGTTCTGGCAGTTCCACCCCACCGGCGTGGCCGGCGCGGGCGTGCTGCTGACCGAGGGCTGCCGCGGCGAGGGCGC
CATCCTGCTCAACAGCAACGGCGAACGCTTCATGGAGCGCTACGCGCCCACCCTGAAGGACCTGGCGCCGCGCGACTTCG
TCTCGCGCTCGATGGACCAGGAGATCAAGGAAGGCCGCGGCTGCGGTCCCAACAAGGACTACGTGCTGCTCAAGCTCGAC
CACCTGGGCGCGGACACCATCCACAAGCGCCTGCCCTCGGTGTACGAGATCGGCGTCAACTTCGCCAACGTGGACATCAC
GAAGGAACCGATCCCGGTCGTGCCCACCATCCACTACCAGATGGGCGGCATCCCGACCAACATCAACGGCCAGGTCGTGA
TCCAGAACGGCGACGTGCACAACCAGGTGGTGAACGGCCTCTACGCCGTGGGCGAATGCTCCTGCGTGTCCGTGCACGGC
GCCAACCGCCTGGGCACGAACTCGCTGCTCGACCTGCTGGTGTTCGGCAAGTCCGCCGGCCGCCACATCGTCGAGATGGT
CAAGAACAGCGGCGAGCACAAGCCGCTGCCGGCCGACGGCGCAGACCGCACGCTGGCCCGCCTCAACCAGCTGCAGGAAT
CCAGCCAGGGCATCTATGCCCAGGACATCGCCAACGACATCCGCGCATCGATGCAGCAGCACGCCGGCGTGTTCCGCACG
CAGGAAGGCATGGACGAAGGCGTGGTGAAAATCAACGCGATCCGCGAGCGCGTGGGCGCGATCACGCTGAAGGACAAGTC
CAAGGTGTGGAACACGGCCCGCATGGAAGCGCTGGAAGTGGACAACCTGATCGAGGTCGCCCAGGCGACGATGGTCTCGG
CCGCAGCCCGCAAGGAATGCCGCGGCGCGCACACGGTGTACGACTACGAGCACCCCGCCGACCACCCCGACTTCCCGCTG
GGCCGCAACGACAAGGAATGGATGAAGCACACGCTGTGGCACAGCGAGAGCAACAGCCTCACCTACAAGCCCGTGAACCT
CCAGCCCCTGACCGTGGACAGCGTGCCGCCCAAGGTCCGCACGTTCTGA

Upstream 100 bases:

>100_bases
GCGGTCACGATCTTCTGGCTCGTCGGCTGCGCCGGCTGGGGCATCCAGATCCTCTGGCGCCTCTGATCCGATTACCCCGC
GACTGAAAGAGCACACAACA

Downstream 100 bases:

>100_bases
CACGCCCACGAGAACCCACGAGACACCACCATGAAGCGCACCTTTCAAATCTACCGCTACGATCCGGACAAGGACGCCAA
GCCCTACATGCAGACCGTCG

Product: succinate dehydrogenase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MSYTKANITTRKFDVVIVGAGGSGMRAALELSRAGLNVASLSKVFPTRSHTVAAQGGVSASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNPDGTIYQRPFGGHTANYGEKPVQRACAAADRTGHAMLHTLYQQNVK
AKTNFFVEWMALDLIRDASGDVVGVTALELETGELYQLQAKAVLLATGGAGRIFAASTNAFINTGDGLGMAARAGIPLQD
MEFWQFHPTGVAGAGVLLTEGCRGEGAILLNSNGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNKDYVLLKLD
HLGADTIHKRLPSVYEIGVNFANVDITKEPIPVVPTIHYQMGGIPTNINGQVVIQNGDVHNQVVNGLYAVGECSCVSVHG
ANRLGTNSLLDLLVFGKSAGRHIVEMVKNSGEHKPLPADGADRTLARLNQLQESSQGIYAQDIANDIRASMQQHAGVFRT
QEGMDEGVVKINAIRERVGAITLKDKSKVWNTARMEALEVDNLIEVAQATMVSAAARKECRGAHTVYDYEHPADHPDFPL
GRNDKEWMKHTLWHSESNSLTYKPVNLQPLTVDSVPPKVRTF

Sequences:

>Translated_602_residues
MSYTKANITTRKFDVVIVGAGGSGMRAALELSRAGLNVASLSKVFPTRSHTVAAQGGVSASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNPDGTIYQRPFGGHTANYGEKPVQRACAAADRTGHAMLHTLYQQNVK
AKTNFFVEWMALDLIRDASGDVVGVTALELETGELYQLQAKAVLLATGGAGRIFAASTNAFINTGDGLGMAARAGIPLQD
MEFWQFHPTGVAGAGVLLTEGCRGEGAILLNSNGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNKDYVLLKLD
HLGADTIHKRLPSVYEIGVNFANVDITKEPIPVVPTIHYQMGGIPTNINGQVVIQNGDVHNQVVNGLYAVGECSCVSVHG
ANRLGTNSLLDLLVFGKSAGRHIVEMVKNSGEHKPLPADGADRTLARLNQLQESSQGIYAQDIANDIRASMQQHAGVFRT
QEGMDEGVVKINAIRERVGAITLKDKSKVWNTARMEALEVDNLIEVAQATMVSAAARKECRGAHTVYDYEHPADHPDFPL
GRNDKEWMKHTLWHSESNSLTYKPVNLQPLTVDSVPPKVRTF
>Mature_601_residues
SYTKANITTRKFDVVIVGAGGSGMRAALELSRAGLNVASLSKVFPTRSHTVAAQGGVSASLGNMSEDNWHYHFYDTIKGS
DWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNPDGTIYQRPFGGHTANYGEKPVQRACAAADRTGHAMLHTLYQQNVKA
KTNFFVEWMALDLIRDASGDVVGVTALELETGELYQLQAKAVLLATGGAGRIFAASTNAFINTGDGLGMAARAGIPLQDM
EFWQFHPTGVAGAGVLLTEGCRGEGAILLNSNGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNKDYVLLKLDH
LGADTIHKRLPSVYEIGVNFANVDITKEPIPVVPTIHYQMGGIPTNINGQVVIQNGDVHNQVVNGLYAVGECSCVSVHGA
NRLGTNSLLDLLVFGKSAGRHIVEMVKNSGEHKPLPADGADRTLARLNQLQESSQGIYAQDIANDIRASMQQHAGVFRTQ
EGMDEGVVKINAIRERVGAITLKDKSKVWNTARMEALEVDNLIEVAQATMVSAAARKECRGAHTVYDYEHPADHPDFPLG
RNDKEWMKHTLWHSESNSLTYKPVNLQPLTVDSVPPKVRTF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=587, Percent_Identity=49.9148211243612, Blast_Score=590, Evalue=1e-168,
Organism=Escherichia coli, GI1786942, Length=597, Percent_Identity=54.9413735343384, Blast_Score=633, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=580, Percent_Identity=39.1379310344828, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=550, Percent_Identity=32.3636363636364, Blast_Score=236, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17505833, Length=615, Percent_Identity=50.0813008130081, Blast_Score=582, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17550100, Length=590, Percent_Identity=50, Blast_Score=572, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6322701, Length=607, Percent_Identity=49.9176276771005, Blast_Score=600, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6322416, Length=607, Percent_Identity=49.9176276771005, Blast_Score=585, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6320788, Length=489, Percent_Identity=26.5848670756646, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322511, Length=498, Percent_Identity=24.0963855421687, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17137288, Length=609, Percent_Identity=50.7389162561576, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24655642, Length=609, Percent_Identity=50.7389162561576, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24655647, Length=609, Percent_Identity=50.7389162561576, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=47.1451876019576, Blast_Score=547, Evalue=1e-156,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65760; Mature: 65629

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTKANITTRKFDVVIVGAGGSGMRAALELSRAGLNVASLSKVFPTRSHTVAAQGGVSA
CCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNPDGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHAMLHTLYQQNVKAKTNFFVEWMALDLIRDASG
ECCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
DVVGVTALELETGELYQLQAKAVLLATGGAGRIFAASTNAFINTGDGLGMAARAGIPLQD
CEEEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEEECCCEEECCCCCCCHHHCCCCCCC
MEFWQFHPTGVAGAGVLLTEGCRGEGAILLNSNGERFMERYAPTLKDLAPRDFVSRSMDQ
CCCEEECCCCCCCCCEEEECCCCCCCEEEECCCCHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGCGPNKDYVLLKLDHLGADTIHKRLPSVYEIGVNFANVDITKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEECCCCHHHHHHHCCCHHHHCCEEEEEEECCCCCCCCEEEEEE
MGGIPTNINGQVVIQNGDVHNQVVNGLYAVGECSCVSVHGANRLGTNSLLDLLVFGKSAG
ECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCC
RHIVEMVKNSGEHKPLPADGADRTLARLNQLQESSQGIYAQDIANDIRASMQQHAGVFRT
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCCHHH
QEGMDEGVVKINAIRERVGAITLKDKSKVWNTARMEALEVDNLIEVAQATMVSAAARKEC
HCCCCCCCEEHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGAHTVYDYEHPADHPDFPLGRNDKEWMKHTLWHSESNSLTYKPVNLQPLTVDSVPPKVR
CCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCCCC
TF
CC
>Mature Secondary Structure 
SYTKANITTRKFDVVIVGAGGSGMRAALELSRAGLNVASLSKVFPTRSHTVAAQGGVSA
CCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNPDGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHAMLHTLYQQNVKAKTNFFVEWMALDLIRDASG
ECCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
DVVGVTALELETGELYQLQAKAVLLATGGAGRIFAASTNAFINTGDGLGMAARAGIPLQD
CEEEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEEECCCEEECCCCCCCHHHCCCCCCC
MEFWQFHPTGVAGAGVLLTEGCRGEGAILLNSNGERFMERYAPTLKDLAPRDFVSRSMDQ
CCCEEECCCCCCCCCEEEECCCCCCCEEEECCCCHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGCGPNKDYVLLKLDHLGADTIHKRLPSVYEIGVNFANVDITKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEECCCCHHHHHHHCCCHHHHCCEEEEEEECCCCCCCCEEEEEE
MGGIPTNINGQVVIQNGDVHNQVVNGLYAVGECSCVSVHGANRLGTNSLLDLLVFGKSAG
ECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCC
RHIVEMVKNSGEHKPLPADGADRTLARLNQLQESSQGIYAQDIANDIRASMQQHAGVFRT
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCCHHH
QEGMDEGVVKINAIRERVGAITLKDKSKVWNTARMEALEVDNLIEVAQATMVSAAARKEC
HCCCCCCCEEHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGAHTVYDYEHPADHPDFPLGRNDKEWMKHTLWHSESNSLTYKPVNLQPLTVDSVPPKVR
CCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCCCC
TF
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA