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The map label for this gene is sdhB [H]

Identifier: 120610875

GI number: 120610875

Start: 2421146

End: 2421847

Strand: Reverse

Name: sdhB [H]

Synonym: Aave_2201

Alternate gene names: 120610875

Gene position: 2421847-2421146 (Counterclockwise)

Preceding gene: 120610876

Following gene: 120610874

Centisome position: 45.24

GC content: 63.82

Gene sequence:

>702_bases
ATGAAGCGCACCTTTCAAATCTACCGCTACGATCCGGACAAGGACGCCAAGCCCTACATGCAGACCGTCGAGATCGAACT
CGACGGCCATGAGCGCATGCTGCTCGACGCGCTCATCAAGCTGAAGGCGCAGGACCCGTCCATCTCGTTCCGCCGCTCCT
GCCGCGAAGGCGTCTGCGGCTCCGACGCGATGAACATCAACGGCAAGAACGGCCTGGCGTGCCTCACGAACATGAACACG
CTCAAGGGCACGATCGTGCTCAAGCCGCTGCCGGGCCTGCCCGTGATCCGCGACCTGATCGTGGACATGACGCAGTTCTT
CAAGCAGTACCACTCGATCAAGCCCTACCTCATCACGGAAGGCATCGCGCCCGAGCGCGAGCGCCTGCAGTCCCCCGAGG
AGCGCGACGAGCTCAACGGCCTGTACGAGTGCATCCTGTGCGCGAGCTGCTCGACCAGCTGCCCCAGCTTCTGGTGGAAC
CCCGACAAGTTCGTGGGCCCCGCCGGCCTGCTGCAGGCCTACCGCTTCATCGCCGACAGCCGCGACGAAGCCACGGGCGC
GCGCCTGGACAACCTGGAAGATCCGTACCGGCTCTTCCGCTGCCACACCATCATGAACTGCGTGGACGTGTGCCCGAAGG
GACTCAATCCGACGAAGGCCATCGGTAAGATCAAGGAACTGATGGTGCGCCGCGCCGTCTGA

Upstream 100 bases:

>100_bases
CACCTACAAGCCCGTGAACCTCCAGCCCCTGACCGTGGACAGCGTGCCGCCCAAGGTCCGCACGTTCTGACACGCCCACG
AGAACCCACGAGACACCACC

Downstream 100 bases:

>100_bases
CTTTGCACATGGCCGAAGACGTGCTCGACGACCGCGAAGTCGCCAAGCTCCGGTGGCGCTGCCGCCGGGGCCTGGTGGAG
AACGACCTCTTCATCGAGCA

Product: succinate dehydrogenase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKRTFQIYRYDPDKDAKPYMQTVEIELDGHERMLLDALIKLKAQDPSISFRRSCREGVCGSDAMNINGKNGLACLTNMNT
LKGTIVLKPLPGLPVIRDLIVDMTQFFKQYHSIKPYLITEGIAPERERLQSPEERDELNGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDEATGARLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV

Sequences:

>Translated_233_residues
MKRTFQIYRYDPDKDAKPYMQTVEIELDGHERMLLDALIKLKAQDPSISFRRSCREGVCGSDAMNINGKNGLACLTNMNT
LKGTIVLKPLPGLPVIRDLIVDMTQFFKQYHSIKPYLITEGIAPERERLQSPEERDELNGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDEATGARLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
>Mature_233_residues
MKRTFQIYRYDPDKDAKPYMQTVEIELDGHERMLLDALIKLKAQDPSISFRRSCREGVCGSDAMNINGKNGLACLTNMNT
LKGTIVLKPLPGLPVIRDLIVDMTQFFKQYHSIKPYLITEGIAPERERLQSPEERDELNGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDEATGARLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=232, Percent_Identity=56.8965517241379, Blast_Score=271, Evalue=3e-73,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=65.6779661016949, Blast_Score=328, Evalue=2e-91,
Organism=Escherichia coli, GI1790596, Length=226, Percent_Identity=34.5132743362832, Blast_Score=141, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17533915, Length=236, Percent_Identity=52.9661016949153, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6322987, Length=228, Percent_Identity=51.3157894736842, Blast_Score=249, Evalue=3e-67,
Organism=Drosophila melanogaster, GI17137106, Length=234, Percent_Identity=55.1282051282051, Blast_Score=269, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24643156, Length=232, Percent_Identity=53.8793103448276, Blast_Score=261, Evalue=2e-70,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26469; Mature: 26469

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTFQIYRYDPDKDAKPYMQTVEIELDGHERMLLDALIKLKAQDPSISFRRSCREGVCG
CCCEEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
SDAMNINGKNGLACLTNMNTLKGTIVLKPLPGLPVIRDLIVDMTQFFKQYHSIKPYLITE
CCCCEECCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
GIAPERERLQSPEERDELNGLYECILCASCSTSCPSFWWNPDKFVGPAGLLQAYRFIADS
CCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
RDEATGARLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRTFQIYRYDPDKDAKPYMQTVEIELDGHERMLLDALIKLKAQDPSISFRRSCREGVCG
CCCEEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
SDAMNINGKNGLACLTNMNTLKGTIVLKPLPGLPVIRDLIVDMTQFFKQYHSIKPYLITE
CCCCEECCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
GIAPERERLQSPEERDELNGLYECILCASCSTSCPSFWWNPDKFVGPAGLLQAYRFIADS
CCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
RDEATGARLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]