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The map label for this gene is proX [H]

Identifier: 120610181

GI number: 120610181

Start: 1658820

End: 1659863

Strand: Reverse

Name: proX [H]

Synonym: Aave_1495

Alternate gene names: 120610181

Gene position: 1659863-1658820 (Counterclockwise)

Preceding gene: 120610182

Following gene: 120610180

Centisome position: 31.01

GC content: 67.05

Gene sequence:

>1044_bases
ATGCACATCACTTTCCAACGCTCTTTTCCCGTTCCGGCGGGCGTGCCGGCCTTCGCCCGCGCTGCCGCCTGCGCCGTCGC
CCTCGCCCTGGCCGCGCTGCCCGCCGGCGCCCAGTCCCTGCCCGGCAAGGGCATTTCCGTGCAGCCGCTGCAAAGCTCCA
ATGCCGAGGAAACCTTCCAGACGCTGCTGGTGTCCCGTGCACTGCAAAAGCTCGGCTACGAGGTGCAGCCCATCAAGGAA
ATCGAGTACGCCACGGCCCATCTCGCGGTCGCCAACGGCGACGCCACCTTCATCGCCGACCACTGGGATCCGCTACATGC
CGACTTCTACAAGAACGCCGGCGGCGACGCGAAGCTCTGGCGCAAGGGGGCGTATTCGCCCAACGCGGTGCAGGGCTACC
TGATCGACCGCAAGACCGCGGAGCAGTACCAGATCACCCACATCGACCAGCTCAAGGACCCGAAGCTCGCGAAGCTGTTC
GACGCCAACGGCGACGGGCGCGCCGACCTCACGGGCTGCAATCCGGGCTGGGGCTGCGAGGCGGTCATCGAGCACCAGCT
CAAGGACTTCGGCCTGTCGCGCACGGTCACGCACGTGCAGGGCAGCTACGCGGCGCTGATGGCAGACACCATCGCGCGCT
ACAAGCAGGGCAAGCCCATCCTCTACTACACCTGGACGCCCTACTGGGTGAGCGGCGTGCTGCGCCCGGGCCGGGACGTG
GTATGGCTGCAGGTGCCCCGCTCCTCTCTTCCGGGCGAGCAGGCCGGCATCGACACGAAGCTGCCGGACGGCAAGAACTA
CGGCTTCGTGCCGAACGTGCAGAAGATCGTGGCGAACAAGGCCTTCACCGAGAAGAACCCGGCAGCGGCGAAGCTGTTCG
AAGTGATGCAGTTGCCGGTGGCCGACATCAACGCGCAGAACCTCGCCATGCAGAAGGGGCAGAACCGGCAGGCCGACATC
GAGCGCCACGTGGACGGCTGGATCCGGGCGCACCAGAAGACCTTCGACGGCTGGATCGCGCAGGCGACGGCGGCCGACCA
CTGA

Upstream 100 bases:

>100_bases
CCGCCGCCGCGGAACCCGCCCCCGCCCTGTCCGCCGCGGAAGAGCCCACGCTGGCGGGAGCCGCCCGCTGACGCCCCCCA
TCCAGGAACCACTTCTCCCT

Downstream 100 bases:

>100_bases
GGCGGGGGGCGGCGGAGAGCCGGCGTCCACTTTTTCTCCTGATTCGGTGGGCACAGTCGAACCCATCCATACTCGAGGAA
CACGGACGCCCGGCCGGCCC

Product: glycine betaine transporter periplasmic subunit

Products: ADP; phosphate; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MHITFQRSFPVPAGVPAFARAAACAVALALAALPAGAQSLPGKGISVQPLQSSNAEETFQTLLVSRALQKLGYEVQPIKE
IEYATAHLAVANGDATFIADHWDPLHADFYKNAGGDAKLWRKGAYSPNAVQGYLIDRKTAEQYQITHIDQLKDPKLAKLF
DANGDGRADLTGCNPGWGCEAVIEHQLKDFGLSRTVTHVQGSYAALMADTIARYKQGKPILYYTWTPYWVSGVLRPGRDV
VWLQVPRSSLPGEQAGIDTKLPDGKNYGFVPNVQKIVANKAFTEKNPAAAKLFEVMQLPVADINAQNLAMQKGQNRQADI
ERHVDGWIRAHQKTFDGWIAQATAADH

Sequences:

>Translated_347_residues
MHITFQRSFPVPAGVPAFARAAACAVALALAALPAGAQSLPGKGISVQPLQSSNAEETFQTLLVSRALQKLGYEVQPIKE
IEYATAHLAVANGDATFIADHWDPLHADFYKNAGGDAKLWRKGAYSPNAVQGYLIDRKTAEQYQITHIDQLKDPKLAKLF
DANGDGRADLTGCNPGWGCEAVIEHQLKDFGLSRTVTHVQGSYAALMADTIARYKQGKPILYYTWTPYWVSGVLRPGRDV
VWLQVPRSSLPGEQAGIDTKLPDGKNYGFVPNVQKIVANKAFTEKNPAAAKLFEVMQLPVADINAQNLAMQKGQNRQADI
ERHVDGWIRAHQKTFDGWIAQATAADH
>Mature_347_residues
MHITFQRSFPVPAGVPAFARAAACAVALALAALPAGAQSLPGKGISVQPLQSSNAEETFQTLLVSRALQKLGYEVQPIKE
IEYATAHLAVANGDATFIADHWDPLHADFYKNAGGDAKLWRKGAYSPNAVQGYLIDRKTAEQYQITHIDQLKDPKLAKLF
DANGDGRADLTGCNPGWGCEAVIEHQLKDFGLSRTVTHVQGSYAALMADTIARYKQGKPILYYTWTPYWVSGVLRPGRDV
VWLQVPRSSLPGEQAGIDTKLPDGKNYGFVPNVQKIVANKAFTEKNPAAAKLFEVMQLPVADINAQNLAMQKGQNRQADI
ERHVDGWIRAHQKTFDGWIAQATAADH

Specific function: Member of a multicomponent binding-protein-dependent transport system (the proU transporter) which serves as the glycine betaine/L-proline transporter [H]

COG id: COG2113

COG function: function code E; ABC-type proline/glycine betaine transport systems, periplasmic components

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789034, Length=309, Percent_Identity=65.0485436893204, Blast_Score=432, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007210 [H]

Pfam domain/function: PF04069 OpuAC [H]

EC number: NA

Molecular weight: Translated: 37914; Mature: 37914

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHITFQRSFPVPAGVPAFARAAACAVALALAALPAGAQSLPGKGISVQPLQSSNAEETFQ
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCHHHHHH
TLLVSRALQKLGYEVQPIKEIEYATAHLAVANGDATFIADHWDPLHADFYKNAGGDAKLW
HHHHHHHHHHCCCCCCCHHHHHHHEEEEEEECCCEEEEECCCCCHHHHHHHCCCCCHHHH
RKGAYSPNAVQGYLIDRKTAEQYQITHIDQLKDPKLAKLFDANGDGRADLTGCNPGWGCE
HCCCCCCCCEEEEEECCCCCCCEEEEEHHHCCCCCHHHHCCCCCCCCEEECCCCCCCCHH
AVIEHQLKDFGLSRTVTHVQGSYAALMADTIARYKQGKPILYYTWTPYWVSGVLRPGRDV
HHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCE
VWLQVPRSSLPGEQAGIDTKLPDGKNYGFVPNVQKIVANKAFTEKNPAAAKLFEVMQLPV
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCC
ADINAQNLAMQKGQNRQADIERHVDGWIRAHQKTFDGWIAQATAADH
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHITFQRSFPVPAGVPAFARAAACAVALALAALPAGAQSLPGKGISVQPLQSSNAEETFQ
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCHHHHHH
TLLVSRALQKLGYEVQPIKEIEYATAHLAVANGDATFIADHWDPLHADFYKNAGGDAKLW
HHHHHHHHHHCCCCCCCHHHHHHHEEEEEEECCCEEEEECCCCCHHHHHHHCCCCCHHHH
RKGAYSPNAVQGYLIDRKTAEQYQITHIDQLKDPKLAKLFDANGDGRADLTGCNPGWGCE
HCCCCCCCCEEEEEECCCCCCCEEEEEHHHCCCCCHHHHCCCCCCCCEEECCCCCCCCHH
AVIEHQLKDFGLSRTVTHVQGSYAALMADTIARYKQGKPILYYTWTPYWVSGVLRPGRDV
HHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCE
VWLQVPRSSLPGEQAGIDTKLPDGKNYGFVPNVQKIVANKAFTEKNPAAAKLFEVMQLPV
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCC
ADINAQNLAMQKGQNRQADIERHVDGWIRAHQKTFDGWIAQATAADH
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-proline [Periplasm]; H2O [C]

Specific reaction: ATP + L-proline [Periplasm] + H2O = ADP + phosphate + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]