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The map label for this gene is tig

Identifier: 120610147

GI number: 120610147

Start: 1609386

End: 1610696

Strand: Reverse

Name: tig

Synonym: Aave_1460

Alternate gene names: 120610147

Gene position: 1610696-1609386 (Counterclockwise)

Preceding gene: 120610148

Following gene: 120610146

Centisome position: 30.09

GC content: 66.06

Gene sequence:

>1311_bases
ATGGCCGTTACTGTTGAAACCCTTGAAAAGCTCGAGCGCAAGATCACGCTGAGCCTGCCCCTGACCGCCATCCAGTCGGA
AGTGGACTCGCGCCTCAAGCGCCTGGCCCGCACGGTGAAGATGGACGGCTTCCGTCCCGGCAAGGTGCCGATGAACGTCG
TGGCCCAGCGCTACGGTTACTCCGTGCAGTACGAAGTGCTGAACGACAAGGTCGGCGAGGCCTTCGCCCAGGCCGCCAAT
GAGGCCAACCTGCGCGTCGCCGGCCAGCCCCGCATCACCGAGAAGGAAGGCGCTCCCGAAGGCCAGGTGACCTTCGACGC
CGTGTTCGAGGTGTTCCCCGAAGTGAAGATCGGCGATCTGTCCACGGCCGACGTCGAGAAGATCTCCGCCGACGTCACCG
ACGCCGCCATCGACAAGACCATCGACATCCTGCGCAAGCAGCGCCGCACCTTCGCCCAGCGCGCCCAGGGCACGCCTGCC
GAAGACGGCGACCGCGTGACCGTGGACTTCGAAGGCAAGATCGACGGCGAGACATTCTCCGGCGGCAAGGCCGAAGACTT
CCAGTTCCTGGTGGGCGAAGGCCAGATGCTCAAGGAATTCGAGGACGCCGTGCGCGGCATGAAGGCCGGTGAAAGCAAGA
CCTTCCCCCTCGCCTTCCCCGAGGACTACCATGGCAAGGACGTGGCCGGCAAGACCGCCGATTTCCTGGTCACCGTGAAG
AAGATCGAGGCAGCCCACCTGCCCGAAGTCAATGAGCAGCTGGCGAAGTCCCTGGGCATCGCCGACGGCACCGTGGAAGG
CCTGCGCGCCGACATCAAGAAGAACCTCGAGCGCGAGGTCAAGTTCCGCCTGCTGGCCCGCAACAAGCAGGCCGTGATGG
AAGCCCTGGTGTCCAAGGCCGAGCTGGACCTGCCCAACGCCAGCGTGCAGGCCGAGATCGCCCGCCTGCTGGAAGGCGCC
CGCGCCGACCTCAAGCAGCGCGGCATCAAGGACGCCGACAAGGCCGAGATCCCCGAGGACGTGTTCCGCCCGCAGGCCGA
GCGCCGCGTGCGCCTGGGCCTGGTCGTGGCCGAACTCGTGCGCGCCAACAACCTGCACGCCACCCCCGAGCAGTTGAAGG
CGCACGTGGACGAGCTCGCCGCCAGCTACGAGAAGCCCGAGGACGTGGTCCGCTGGTACTTCGGCGACCGCCAGCGCCTG
GCCGAGGTCGAGGCCGTGGTCATCGAGAACAACGTCACGGCGTTCGTGCTGGACAAGGCCAAGGTCACGGAAAAGGCCAT
TTCCTTCGACGAACTGATGGGCCAGGGCTGA

Upstream 100 bases:

>100_bases
GTGTGGGGGTTCGAGTCCCCCCCCGCGCACCACGAACAACACGGTGAGGCGGTCCCGGCACGGGACGGCCGTCACGGTCC
CATTACCTAGAGGAAGAGCC

Downstream 100 bases:

>100_bases
AGCCGCGGCGCCGGCGCATGCATCCGCAGCGCGCCGGCTCCTGCCCGCCATCCGGGGCTTGTGCTGGCGAGCACAGGCCC
CAATTCATTTCTCGGTACAG

Product: trigger factor

Products: peptidylproline (w =0) [C]

Alternate protein names: TF

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MAVTVETLEKLERKITLSLPLTAIQSEVDSRLKRLARTVKMDGFRPGKVPMNVVAQRYGYSVQYEVLNDKVGEAFAQAAN
EANLRVAGQPRITEKEGAPEGQVTFDAVFEVFPEVKIGDLSTADVEKISADVTDAAIDKTIDILRKQRRTFAQRAQGTPA
EDGDRVTVDFEGKIDGETFSGGKAEDFQFLVGEGQMLKEFEDAVRGMKAGESKTFPLAFPEDYHGKDVAGKTADFLVTVK
KIEAAHLPEVNEQLAKSLGIADGTVEGLRADIKKNLEREVKFRLLARNKQAVMEALVSKAELDLPNASVQAEIARLLEGA
RADLKQRGIKDADKAEIPEDVFRPQAERRVRLGLVVAELVRANNLHATPEQLKAHVDELAASYEKPEDVVRWYFGDRQRL
AEVEAVVIENNVTAFVLDKAKVTEKAISFDELMGQG

Sequences:

>Translated_436_residues
MAVTVETLEKLERKITLSLPLTAIQSEVDSRLKRLARTVKMDGFRPGKVPMNVVAQRYGYSVQYEVLNDKVGEAFAQAAN
EANLRVAGQPRITEKEGAPEGQVTFDAVFEVFPEVKIGDLSTADVEKISADVTDAAIDKTIDILRKQRRTFAQRAQGTPA
EDGDRVTVDFEGKIDGETFSGGKAEDFQFLVGEGQMLKEFEDAVRGMKAGESKTFPLAFPEDYHGKDVAGKTADFLVTVK
KIEAAHLPEVNEQLAKSLGIADGTVEGLRADIKKNLEREVKFRLLARNKQAVMEALVSKAELDLPNASVQAEIARLLEGA
RADLKQRGIKDADKAEIPEDVFRPQAERRVRLGLVVAELVRANNLHATPEQLKAHVDELAASYEKPEDVVRWYFGDRQRL
AEVEAVVIENNVTAFVLDKAKVTEKAISFDELMGQG
>Mature_435_residues
AVTVETLEKLERKITLSLPLTAIQSEVDSRLKRLARTVKMDGFRPGKVPMNVVAQRYGYSVQYEVLNDKVGEAFAQAANE
ANLRVAGQPRITEKEGAPEGQVTFDAVFEVFPEVKIGDLSTADVEKISADVTDAAIDKTIDILRKQRRTFAQRAQGTPAE
DGDRVTVDFEGKIDGETFSGGKAEDFQFLVGEGQMLKEFEDAVRGMKAGESKTFPLAFPEDYHGKDVAGKTADFLVTVKK
IEAAHLPEVNEQLAKSLGIADGTVEGLRADIKKNLEREVKFRLLARNKQAVMEALVSKAELDLPNASVQAEIARLLEGAR
ADLKQRGIKDADKAEIPEDVFRPQAERRVRLGLVVAELVRANNLHATPEQLKAHVDELAASYEKPEDVVRWYFGDRQRLA
EVEAVVIENNVTAFVLDKAKVTEKAISFDELMGQG

Specific function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation

COG id: COG0544

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Escherichia coli, GI1786640, Length=436, Percent_Identity=41.2844036697248, Blast_Score=335, Evalue=2e-93,

Paralogues:

None

Copy number: 1070 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 500 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 340 Molecules/Cell In: Growth-Phase, Mini

Swissprot (AC and ID): TIG_ACIAC (A1TM63)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969825.1
- ProteinModelPortal:   A1TM63
- STRING:   A1TM63
- GeneID:   4666302
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1460
- NMPDR:   fig|397945.5.peg.1282
- eggNOG:   COG0544
- HOGENOM:   HBG635105
- OMA:   RFIPGFE
- PhylomeDB:   A1TM63
- ProtClustDB:   PRK01490
- BioCyc:   AAVE397945:AAVE_1460-MONOMER
- HAMAP:   MF_00303
- InterPro:   IPR001179
- InterPro:   IPR005215
- InterPro:   IPR008880
- InterPro:   IPR008881
- Gene3D:   G3DSA:1.10.3120.10
- Gene3D:   G3DSA:3.30.70.1050
- PANTHER:   PTHR10516
- PIRSF:   PIRSF003095
- TIGRFAMs:   TIGR00115

Pfam domain/function: PF00254 FKBP_C; PF05698 Trigger_C; PF05697 Trigger_N; SSF109998 Trigger_fac_C_bac; SSF102735 Trigger_fac_ribosome-bd_bac

EC number: NA

Molecular weight: Translated: 48122; Mature: 47991

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTVETLEKLERKITLSLPLTAIQSEVDSRLKRLARTVKMDGFRPGKVPMNVVAQRYGY
CEEEHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
SVQYEVLNDKVGEAFAQAANEANLRVAGQPRITEKEGAPEGQVTFDAVFEVFPEVKIGDL
EEEEEHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEECCC
STADVEKISADVTDAAIDKTIDILRKQRRTFAQRAQGTPAEDGDRVTVDFEGKIDGETFS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCC
GGKAEDFQFLVGEGQMLKEFEDAVRGMKAGESKTFPLAFPEDYHGKDVAGKTADFLVTVK
CCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCHHHHEEHH
KIEAAHLPEVNEQLAKSLGIADGTVEGLRADIKKNLEREVKFRLLARNKQAVMEALVSKA
HHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ELDLPNASVQAEIARLLEGARADLKQRGIKDADKAEIPEDVFRPQAERRVRLGLVVAELV
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHCCCHHHHHHHHHHHHHHH
RANNLHATPEQLKAHVDELAASYEKPEDVVRWYFGDRQRLAEVEAVVIENNVTAFVLDKA
HHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHEEEEECCCEEEEECHH
KVTEKAISFDELMGQG
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVTVETLEKLERKITLSLPLTAIQSEVDSRLKRLARTVKMDGFRPGKVPMNVVAQRYGY
EEEHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
SVQYEVLNDKVGEAFAQAANEANLRVAGQPRITEKEGAPEGQVTFDAVFEVFPEVKIGDL
EEEEEHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEECCC
STADVEKISADVTDAAIDKTIDILRKQRRTFAQRAQGTPAEDGDRVTVDFEGKIDGETFS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCC
GGKAEDFQFLVGEGQMLKEFEDAVRGMKAGESKTFPLAFPEDYHGKDVAGKTADFLVTVK
CCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCHHHHEEHH
KIEAAHLPEVNEQLAKSLGIADGTVEGLRADIKKNLEREVKFRLLARNKQAVMEALVSKA
HHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ELDLPNASVQAEIARLLEGARADLKQRGIKDADKAEIPEDVFRPQAERRVRLGLVVAELV
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHCCCHHHHHHHHHHHHHHH
RANNLHATPEQLKAHVDELAASYEKPEDVVRWYFGDRQRLAEVEAVVIENNVTAFVLDKA
HHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHEEEEECCCEEEEECHH
KVTEKAISFDELMGQG
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: peptidylproline (w =180) [C]

Specific reaction: peptidylproline (w =180) = peptidylproline (w =0) [C]

General reaction: Isomerases; cis-trans-Isomerases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA