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The map label for this gene is hisS [H]

Identifier: 120610112

GI number: 120610112

Start: 1565660

End: 1567045

Strand: Direct

Name: hisS [H]

Synonym: Aave_1425

Alternate gene names: 120610112

Gene position: 1565660-1567045 (Clockwise)

Preceding gene: 120610111

Following gene: 120610113

Centisome position: 29.25

GC content: 69.26

Gene sequence:

>1386_bases
ATGCCCGCACCCGGGGCCCATGCCCCCACCTTCCGACGTATGTCCGCAAGCAATCCCCCCAGCCCGTCCCCGGCACCTGC
CTCCAGGCCCGCCAAACTCGCCGCCGTCAAAGGCATGAACGACATCCTGCCGCCCGAGTCGTCCCGCTGGGAATGGCTGG
AGGGCAAGGTGCGCGGCCTCATGGGACAGTTCGCCTACCGCAACGTCCGCACGCCCATCCTGGAGCACACCGCGCTGTTC
GTCCGCGGCATCGGCGAAGTCACCGACATCGTCGAGAAGGAGATGTACTCCTTCCACGACCGTTCCGACAAATACGGCGA
CAACGACCACCTCAGCCTGCGGCCCGAGAACACCGCCGGCGTGGTGCGCGCGGCCATCGAGCACAACATGCTCTACGACG
GTCCCAAGCGCCTCTGGTACACCGGCCCCATGTTCCGCCGCGAGAAGCCGCAGCGCGGACGTTTCCGGCAGTTCCACCAG
ATCGGCGCCGAGGCACTGGGCTTCGCAGGGCCGGACGTCGATGCGGAACTGATCCTGCTGGCGGATGCGCTCTGGAAGTC
CATCGGGCTCACCGATGTGCGGCTCGAACTCAACAGCCTCGGCCAGCCCGCGGAGCGCGCGCGCCACCGCGAGCAGCTCA
TCGCCCACTTCGAGCGGCACGCGGACCTGCTCGACGAGGACGGCAAGCGCCGCCTGCATACCAACCCGCTGCGCATCCTG
GACACCAAGAACCCCGCGATGAAGCCCGTGGTGGATTCGGCGCCCCGGCTCATGGATTTCCTCGGCGAGGAGTCGCTCGC
CCACTTCGATGGCCTGCGCGCCATCCTGGACGCCAACGGCATCGCCTACACCATCAACCCGCGCCTGGTGCGCGGCCTGG
ACTACTACAACCTCACGGTGTTCGAGTTCATCACCGACCGCCTCGGCTCCCAGGGTACGGTCTGTGCCGGGGGGCGCTAC
GACGATCTCATCGTCCAGGTGGGCGGCAAGCCGGCCCCGGCCGTCGGCTGGGCGATCGGCGTCGAGCGCGTGCTGGAACT
GCTCCGGGAGCAGGGCGCCGCCATTCCCGAGCCCCGGCCCGACGTCTATGCCGTCGTGCCCGACGCGTCCGCCGCCCCGG
TCGTGCTGCGCACCCTGCGTCAATTGCGCGAGGCGGGGCTCAGCGTGCAGATGCACGCCGCCAGCGCCGAAGGGCAGGGC
AGCTTCAAATCCCAGTTCAAGCGCGCTGACGCGAGCGGTGCGGCATTCGCCCTGGTGTTCGGCGCGGACGAACTGGCCCG
GGGCGCGGTCACCGTCAAGCCGCTGCGGGAGCAGGGCGCAGAGCAGGTCGAGCGGCGCCTCGACGAAATCCCCGCCTGGG
CCGCCACCCTACAATCCTCCCGCTAA

Upstream 100 bases:

>100_bases
CAGGTGGTCGAGGACTATATTTCCCGCCGCTTCGGCAGCACCGCCGAGGTTCTCTGATCCGCTCCGGGCAGGAGCGCCGC
ATCCCTTCGTGATGCCGGCC

Downstream 100 bases:

>100_bases
TCCTGTCGCGAACCCTTATTCATGGCAAAACACCTCGACCTCGAAGAACAAGAACAGCTCGACCAGCTCAAGCATTTCTG
GAATGCCTGGGGCACCCTCA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MPAPGAHAPTFRRMSASNPPSPSPAPASRPAKLAAVKGMNDILPPESSRWEWLEGKVRGLMGQFAYRNVRTPILEHTALF
VRGIGEVTDIVEKEMYSFHDRSDKYGDNDHLSLRPENTAGVVRAAIEHNMLYDGPKRLWYTGPMFRREKPQRGRFRQFHQ
IGAEALGFAGPDVDAELILLADALWKSIGLTDVRLELNSLGQPAERARHREQLIAHFERHADLLDEDGKRRLHTNPLRIL
DTKNPAMKPVVDSAPRLMDFLGEESLAHFDGLRAILDANGIAYTINPRLVRGLDYYNLTVFEFITDRLGSQGTVCAGGRY
DDLIVQVGGKPAPAVGWAIGVERVLELLREQGAAIPEPRPDVYAVVPDASAAPVVLRTLRQLREAGLSVQMHAASAEGQG
SFKSQFKRADASGAAFALVFGADELARGAVTVKPLREQGAEQVERRLDEIPAWAATLQSSR

Sequences:

>Translated_461_residues
MPAPGAHAPTFRRMSASNPPSPSPAPASRPAKLAAVKGMNDILPPESSRWEWLEGKVRGLMGQFAYRNVRTPILEHTALF
VRGIGEVTDIVEKEMYSFHDRSDKYGDNDHLSLRPENTAGVVRAAIEHNMLYDGPKRLWYTGPMFRREKPQRGRFRQFHQ
IGAEALGFAGPDVDAELILLADALWKSIGLTDVRLELNSLGQPAERARHREQLIAHFERHADLLDEDGKRRLHTNPLRIL
DTKNPAMKPVVDSAPRLMDFLGEESLAHFDGLRAILDANGIAYTINPRLVRGLDYYNLTVFEFITDRLGSQGTVCAGGRY
DDLIVQVGGKPAPAVGWAIGVERVLELLREQGAAIPEPRPDVYAVVPDASAAPVVLRTLRQLREAGLSVQMHAASAEGQG
SFKSQFKRADASGAAFALVFGADELARGAVTVKPLREQGAEQVERRLDEIPAWAATLQSSR
>Mature_460_residues
PAPGAHAPTFRRMSASNPPSPSPAPASRPAKLAAVKGMNDILPPESSRWEWLEGKVRGLMGQFAYRNVRTPILEHTALFV
RGIGEVTDIVEKEMYSFHDRSDKYGDNDHLSLRPENTAGVVRAAIEHNMLYDGPKRLWYTGPMFRREKPQRGRFRQFHQI
GAEALGFAGPDVDAELILLADALWKSIGLTDVRLELNSLGQPAERARHREQLIAHFERHADLLDEDGKRRLHTNPLRILD
TKNPAMKPVVDSAPRLMDFLGEESLAHFDGLRAILDANGIAYTINPRLVRGLDYYNLTVFEFITDRLGSQGTVCAGGRYD
DLIVQVGGKPAPAVGWAIGVERVLELLREQGAAIPEPRPDVYAVVPDASAAPVVLRTLRQLREAGLSVQMHAASAEGQGS
FKSQFKRADASGAAFALVFGADELARGAVTVKPLREQGAEQVERRLDEIPAWAATLQSSR

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI15029520, Length=465, Percent_Identity=21.0752688172043, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1788861, Length=431, Percent_Identity=50.1160092807425, Blast_Score=431, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 50819; Mature: 50688

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPGAHAPTFRRMSASNPPSPSPAPASRPAKLAAVKGMNDILPPESSRWEWLEGKVRGL
CCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCCCCCCHHHHHHHHHH
MGQFAYRNVRTPILEHTALFVRGIGEVTDIVEKEMYSFHDRSDKYGDNDHLSLRPENTAG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHH
VVRAAIEHNMLYDGPKRLWYTGPMFRREKPQRGRFRQFHQIGAEALGFAGPDVDAELILL
HHHHHHHHCCEECCCCCEEECCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ADALWKSIGLTDVRLELNSLGQPAERARHREQLIAHFERHADLLDEDGKRRLHTNPLRIL
HHHHHHHCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
DTKNPAMKPVVDSAPRLMDFLGEESLAHFDGLRAILDANGIAYTINPRLVRGLDYYNLTV
ECCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCHHHHH
FEFITDRLGSQGTVCAGGRYDDLIVQVGGKPAPAVGWAIGVERVLELLREQGAAIPEPRP
HHHHHHHCCCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
DVYAVVPDASAAPVVLRTLRQLREAGLSVQMHAASAEGQGSFKSQFKRADASGAAFALVF
CEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEE
GADELARGAVTVKPLREQGAEQVERRLDEIPAWAATLQSSR
CCHHHHCCCEEEHHHHHCCHHHHHHHHHHCCHHHHHHCCCC
>Mature Secondary Structure 
PAPGAHAPTFRRMSASNPPSPSPAPASRPAKLAAVKGMNDILPPESSRWEWLEGKVRGL
CCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCCCCCCHHHHHHHHHH
MGQFAYRNVRTPILEHTALFVRGIGEVTDIVEKEMYSFHDRSDKYGDNDHLSLRPENTAG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHH
VVRAAIEHNMLYDGPKRLWYTGPMFRREKPQRGRFRQFHQIGAEALGFAGPDVDAELILL
HHHHHHHHCCEECCCCCEEECCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
ADALWKSIGLTDVRLELNSLGQPAERARHREQLIAHFERHADLLDEDGKRRLHTNPLRIL
HHHHHHHCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
DTKNPAMKPVVDSAPRLMDFLGEESLAHFDGLRAILDANGIAYTINPRLVRGLDYYNLTV
ECCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCHHHHH
FEFITDRLGSQGTVCAGGRYDDLIVQVGGKPAPAVGWAIGVERVLELLREQGAAIPEPRP
HHHHHHHCCCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
DVYAVVPDASAAPVVLRTLRQLREAGLSVQMHAASAEGQGSFKSQFKRADASGAAFALVF
CEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEE
GADELARGAVTVKPLREQGAEQVERRLDEIPAWAATLQSSR
CCHHHHCCCEEEHHHHHCCHHHHHHHHHHCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA