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The map label for this gene is dapA2 [H]

Identifier: 120609930

GI number: 120609930

Start: 1367478

End: 1368434

Strand: Reverse

Name: dapA2 [H]

Synonym: Aave_1243

Alternate gene names: 120609930

Gene position: 1368434-1367478 (Counterclockwise)

Preceding gene: 120609931

Following gene: 120609923

Centisome position: 25.56

GC content: 71.89

Gene sequence:

>957_bases
ATGCCTCTCGACCCAGCGCTGTCTCCTCCCTCGATGCCGCGGCCGCAGCGCGCCCGCGGCGATTTCTCCGGCCTGTGGGT
CCCCCTGGTGACGCCCTTCAGCCCGTCCGGCGACGCGGTGGACCATGCCGGGCTGGACGCCATGGTCCGCCGGCTCGCGG
GCGAAGGCATCGCGGGCTTCGTGGCCTGCGGATCCACCGGCGAAGCCGCAGCGCTGGATGGAAAAGAGCAGGACGCGGTA
CTGGCCACCATCCTGGAAGCAGCCGATGGCCTTCCGGTGGTAATGGGCCTGTCGGGCCACCACCTCGAACACGCGGTGCA
GCGCGCCCGCCACCTCGGCGCATTGCAGCTCGCCGGACTGCTCGTGCCCGCGCCGCACTACATCCGGCCGTCCCAGCCAG
GGCTGCTGCAGTGGTTCCACGCGATCGCCGACGCGAGCGCCGTGCCACTCATCGTGTACGACATTCCCTACCGCACGGGC
GCCATGCTGGAACTGGGCACGCTGCGCACGCTGGCGGCCCATCCCAATATCCGGGCCCTCAAGGACTGCGGCGGCAACGT
CTCCAAGACACAGGCGCTGATCGCCGACGGAGCACTGCAGGTGCTGGCAGGCGAGGACGCCAACATCTTCACCACGGCCG
CGCTCGGCGGGGCCGGGGCCATCGCGGCCAGCGCCCACTGGCAGCCCGCGCGGCTGGTGCAATGCCTGGAAGCCATCGAG
CGCGGCGACCTCGGCCGGGCACGTGAGCTCTGGCGTGTCCTCCTGCCGCTGATCGAGGCCTTCTTCGCGGAGCCCAACCC
GGCACCGCTCAAGGCGCTCCTCGCCGCGGAGGGATGGATGGACGGCGCCCTGCGCGCGCCCATGGCGCCGGCTTCCGCGG
CACTCGCCCTGCGCCTGCAGGAGGCGGCGCGCGCCCAGGCCCACCAATTGCAAGCTTTGGACCAGGCAGCGGCCTGA

Upstream 100 bases:

>100_bases
GCCCTCTTCGCGAGGGCCGCTCGCCCGGCGGGCGCACTTTGAAACGCGCCACGGCACTTATTGACAGCGCTTTTACGGCA
CCGCCGATACACTGCGGCGC

Downstream 100 bases:

>100_bases
TCCGGCGGGTTCAGCCGCCCGTCACGGGAGGAAAGAACGCGATCTCCGCGCCTTCCGAGAGTGCGGCTTCCTCGCGGCAC
AGCACCTGGTCCAGCGCCGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MPLDPALSPPSMPRPQRARGDFSGLWVPLVTPFSPSGDAVDHAGLDAMVRRLAGEGIAGFVACGSTGEAAALDGKEQDAV
LATILEAADGLPVVMGLSGHHLEHAVQRARHLGALQLAGLLVPAPHYIRPSQPGLLQWFHAIADASAVPLIVYDIPYRTG
AMLELGTLRTLAAHPNIRALKDCGGNVSKTQALIADGALQVLAGEDANIFTTAALGGAGAIAASAHWQPARLVQCLEAIE
RGDLGRARELWRVLLPLIEAFFAEPNPAPLKALLAAEGWMDGALRAPMAPASAALALRLQEAARAQAHQLQALDQAAA

Sequences:

>Translated_318_residues
MPLDPALSPPSMPRPQRARGDFSGLWVPLVTPFSPSGDAVDHAGLDAMVRRLAGEGIAGFVACGSTGEAAALDGKEQDAV
LATILEAADGLPVVMGLSGHHLEHAVQRARHLGALQLAGLLVPAPHYIRPSQPGLLQWFHAIADASAVPLIVYDIPYRTG
AMLELGTLRTLAAHPNIRALKDCGGNVSKTQALIADGALQVLAGEDANIFTTAALGGAGAIAASAHWQPARLVQCLEAIE
RGDLGRARELWRVLLPLIEAFFAEPNPAPLKALLAAEGWMDGALRAPMAPASAALALRLQEAARAQAHQLQALDQAAA
>Mature_317_residues
PLDPALSPPSMPRPQRARGDFSGLWVPLVTPFSPSGDAVDHAGLDAMVRRLAGEGIAGFVACGSTGEAAALDGKEQDAVL
ATILEAADGLPVVMGLSGHHLEHAVQRARHLGALQLAGLLVPAPHYIRPSQPGLLQWFHAIADASAVPLIVYDIPYRTGA
MLELGTLRTLAAHPNIRALKDCGGNVSKTQALIADGALQVLAGEDANIFTTAALGGAGAIAASAHWQPARLVQCLEAIER
GDLGRARELWRVLLPLIEAFFAEPNPAPLKALLAAEGWMDGALRAPMAPASAALALRLQEAARAQAHQLQALDQAAA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=288, Percent_Identity=28.125, Blast_Score=98, Evalue=8e-21,
Organism=Escherichia coli, GI1788823, Length=276, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786463, Length=247, Percent_Identity=29.9595141700405, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082415, Length=243, Percent_Identity=28.8065843621399, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789620, Length=281, Percent_Identity=26.6903914590747, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 33101; Mature: 32970

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDPALSPPSMPRPQRARGDFSGLWVPLVTPFSPSGDAVDHAGLDAMVRRLAGEGIAGF
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHCCHHHHHHHHHCCCCEEE
VACGSTGEAAALDGKEQDAVLATILEAADGLPVVMGLSGHHLEHAVQRARHLGALQLAGL
EEECCCCCCEECCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LVPAPHYIRPSQPGLLQWFHAIADASAVPLIVYDIPYRTGAMLELGTLRTLAAHPNIRAL
HCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHCCCCCHHH
KDCGGNVSKTQALIADGALQVLAGEDANIFTTAALGGAGAIAASAHWQPARLVQCLEAIE
HHCCCCHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHH
RGDLGRARELWRVLLPLIEAFFAEPNPAPLKALLAAEGWMDGALRAPMAPASAALALRLQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHH
EAARAQAHQLQALDQAAA
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLDPALSPPSMPRPQRARGDFSGLWVPLVTPFSPSGDAVDHAGLDAMVRRLAGEGIAGF
CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHCCHHHHHHHHHCCCCEEE
VACGSTGEAAALDGKEQDAVLATILEAADGLPVVMGLSGHHLEHAVQRARHLGALQLAGL
EEECCCCCCEECCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LVPAPHYIRPSQPGLLQWFHAIADASAVPLIVYDIPYRTGAMLELGTLRTLAAHPNIRAL
HCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHCCCCCHHH
KDCGGNVSKTQALIADGALQVLAGEDANIFTTAALGGAGAIAASAHWQPARLVQCLEAIE
HHCCCCHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHH
RGDLGRARELWRVLLPLIEAFFAEPNPAPLKALLAAEGWMDGALRAPMAPASAALALRLQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHH
EAARAQAHQLQALDQAAA
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]