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The map label for this gene is lysS [H]

Identifier: 120609891

GI number: 120609891

Start: 1326082

End: 1327638

Strand: Reverse

Name: lysS [H]

Synonym: Aave_1204

Alternate gene names: 120609891

Gene position: 1327638-1326082 (Counterclockwise)

Preceding gene: 120609892

Following gene: 120609890

Centisome position: 24.8

GC content: 66.6

Gene sequence:

>1557_bases
ATGCTCCCCCCCCAGAATCCTTCCGCGCCCACCGCCGCCCCCTCCGACGACAACCAGCTCATCGCCGAGCGCCGCGACAA
GCTCAAGTCCCTCCGGGAGGCCCAGGCACAAGGCAAGGGCGTGGCCTTCCCCAATGACTTCAAGCCCGCGCACCATGCGG
CCGACCTGCAGGCGCAGTACGCGGAGACCGAGGCAGAGACGCTCGAAGCCAACCCCGTGCCGGTGAGCGTGGCCGGCCGC
ATGATGCTCAAGCGCGTCATGGGCAAGGCCAGCTTCGCCACCGTGCAGGACGGCTCGCTCGGCGCGACCCATGGCCGTAT
CCAGCTGTACGTGACGCGCGATGCGATCGGCGAAGAAGCCTATGCCGCCTTCAAGCACTGGGACCTGGGCGACATCGTCG
GTGCCGAGGGCACCCTCATGAAGACCAAGACCGGCGAGCTCTCGGTCAAGGTGACGAACCTGCGCCTGCTCACCAAGAGC
CTGCGCCCCATGCCCGACAAGTTCCATGGCGTGGCCGACCAGGAAGTGAAGTACCGCCAGCGCTACGTGGACCTGATGAC
CGACGAGGCGGCTCGCAGGCGCTTCATCGCGCGCAGCAAGGCCGTGAGCGGCATCCGCGAGTTCATGGTGCAGCACGGCT
TCCTGGAGGTGGAGACACCCATGCTCCACCCCATTCCCGGCGGCGCCAATGCCAAGCCGTTCGTGACCCACCACAACGCG
CTGGAGCAGGAGATGTACCTGCGCATCGCGCCCGAGCTCTACCTCAAGCGTCTGGTGGTCGGCGGCTTCGAGCGCGTGTT
CGAGATCAACCGCAACTTCCGCAACGAAGGCATCTCGGTGCGCCACAACCCCGAGTTCACGATGATGGAGTTCTACGCGG
CCTACTGGAATTACCGCGACCTGATGGACTTCACCGAACAGCTCGTGCGCGACGCGGCCACGAAGGCGGCGGGCAGCCTG
CAGCTCACCTACCAGGGCCGCGCGGTGGACCTGTCGCAGCCTTTCGAGCGCCTGACGATCCGCGAGGCCATCCTGCGCCA
CACCGACGCCGGCGACGGCGTGGACGATGCCGCCTGGCTGGTCGCCGCGCTGCGCAAGCTCGGCCTCTCCGAGGAGAAGG
ACCGCCTGTCCACGCGCTCGCTGGCAGGCCTGCAGGTGCTCTACTTCGAGGAGACGGTGGAGGACAAGCTCTGGCAGCCC
ACCTTCATCATGGAACACCCGACCGAGATCAGCCCGCTGGCGCGCGCCAACGACACGCGTCCGGAGGTGACGGAGCGCTT
CGAGCTCTACATCACGGGCCGCGAATTCGGCAATGGTTTCTCCGAGCTCAACGATGCGGAGGACCAGGCCGCCCGCTTCC
AGTCGCAGGTGGAAGCCAAGGACAGCGGGGACGACGAAGCCATGTATTTCGACCACGATTTCGTCCGCGCCCTCGAGTAC
GGCATGCCTCCCACCGGTGGCTGCGGCATCGGCATCGACCGGCTTATGATGCTGCTGACCGACAGCCCCAGTATCCGCGA
CGTGATCCTGTTCCCCGCCCTGCGCCGGGAGCATTGA

Upstream 100 bases:

>100_bases
CCGTCCTGCTGGCCATGGTGCGCTGGATGACGGGCAAAAAACTAAAATAGCGGGTTCAGCCAGTCCACCAGCCGCTACCA
CGGCGCATACGCTCGTTTCT

Downstream 100 bases:

>100_bases
AGCCGCTGCGGCCATGCACCCACCGCCCGGTCCGTAGAGAGGAAGGCCGATGACCGCCATGCCCCCCACTTCTCCCGCCG
CCCCAGGGCGGCATGGCGAT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MLPPQNPSAPTAAPSDDNQLIAERRDKLKSLREAQAQGKGVAFPNDFKPAHHAADLQAQYAETEAETLEANPVPVSVAGR
MMLKRVMGKASFATVQDGSLGATHGRIQLYVTRDAIGEEAYAAFKHWDLGDIVGAEGTLMKTKTGELSVKVTNLRLLTKS
LRPMPDKFHGVADQEVKYRQRYVDLMTDEAARRRFIARSKAVSGIREFMVQHGFLEVETPMLHPIPGGANAKPFVTHHNA
LEQEMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMEFYAAYWNYRDLMDFTEQLVRDAATKAAGSL
QLTYQGRAVDLSQPFERLTIREAILRHTDAGDGVDDAAWLVAALRKLGLSEEKDRLSTRSLAGLQVLYFEETVEDKLWQP
TFIMEHPTEISPLARANDTRPEVTERFELYITGREFGNGFSELNDAEDQAARFQSQVEAKDSGDDEAMYFDHDFVRALEY
GMPPTGGCGIGIDRLMMLLTDSPSIRDVILFPALRREH

Sequences:

>Translated_518_residues
MLPPQNPSAPTAAPSDDNQLIAERRDKLKSLREAQAQGKGVAFPNDFKPAHHAADLQAQYAETEAETLEANPVPVSVAGR
MMLKRVMGKASFATVQDGSLGATHGRIQLYVTRDAIGEEAYAAFKHWDLGDIVGAEGTLMKTKTGELSVKVTNLRLLTKS
LRPMPDKFHGVADQEVKYRQRYVDLMTDEAARRRFIARSKAVSGIREFMVQHGFLEVETPMLHPIPGGANAKPFVTHHNA
LEQEMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMEFYAAYWNYRDLMDFTEQLVRDAATKAAGSL
QLTYQGRAVDLSQPFERLTIREAILRHTDAGDGVDDAAWLVAALRKLGLSEEKDRLSTRSLAGLQVLYFEETVEDKLWQP
TFIMEHPTEISPLARANDTRPEVTERFELYITGREFGNGFSELNDAEDQAARFQSQVEAKDSGDDEAMYFDHDFVRALEY
GMPPTGGCGIGIDRLMMLLTDSPSIRDVILFPALRREH
>Mature_518_residues
MLPPQNPSAPTAAPSDDNQLIAERRDKLKSLREAQAQGKGVAFPNDFKPAHHAADLQAQYAETEAETLEANPVPVSVAGR
MMLKRVMGKASFATVQDGSLGATHGRIQLYVTRDAIGEEAYAAFKHWDLGDIVGAEGTLMKTKTGELSVKVTNLRLLTKS
LRPMPDKFHGVADQEVKYRQRYVDLMTDEAARRRFIARSKAVSGIREFMVQHGFLEVETPMLHPIPGGANAKPFVTHHNA
LEQEMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMEFYAAYWNYRDLMDFTEQLVRDAATKAAGSL
QLTYQGRAVDLSQPFERLTIREAILRHTDAGDGVDDAAWLVAALRKLGLSEEKDRLSTRSLAGLQVLYFEETVEDKLWQP
TFIMEHPTEISPLARANDTRPEVTERFELYITGREFGNGFSELNDAEDQAARFQSQVEAKDSGDDEAMYFDHDFVRALEY
GMPPTGGCGIGIDRLMMLLTDSPSIRDVILFPALRREH

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=531, Percent_Identity=38.6064030131827, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI194272210, Length=531, Percent_Identity=38.6064030131827, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI45439306, Length=348, Percent_Identity=24.4252873563218, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI40789249, Length=291, Percent_Identity=24.0549828178694, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790571, Length=505, Percent_Identity=58.6138613861386, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1789256, Length=507, Percent_Identity=58.974358974359, Blast_Score=593, Evalue=1e-171,
Organism=Escherichia coli, GI87082379, Length=327, Percent_Identity=30.8868501529052, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1788173, Length=206, Percent_Identity=30.0970873786408, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535925, Length=519, Percent_Identity=38.3429672447013, Blast_Score=338, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17535927, Length=519, Percent_Identity=38.3429672447013, Blast_Score=338, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI71994340, Length=498, Percent_Identity=38.9558232931727, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI32566633, Length=185, Percent_Identity=28.6486486486486, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=523, Percent_Identity=41.1089866156788, Blast_Score=357, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6324256, Length=484, Percent_Identity=30.5785123966942, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6323011, Length=359, Percent_Identity=27.0194986072423, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640849, Length=490, Percent_Identity=41.8367346938776, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24640851, Length=490, Percent_Identity=41.8367346938776, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI24584738, Length=258, Percent_Identity=26.7441860465116, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 58285; Mature: 58285

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPPQNPSAPTAAPSDDNQLIAERRDKLKSLREAQAQGKGVAFPNDFKPAHHAADLQAQY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
AETEAETLEANPVPVSVAGRMMLKRVMGKASFATVQDGSLGATHGRIQLYVTRDAIGEEA
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEHHHHCHHH
YAAFKHWDLGDIVGAEGTLMKTKTGELSVKVTNLRLLTKSLRPMPDKFHGVADQEVKYRQ
HHHHHCCCCHHHCCCCCCEEEECCCCEEEEEEHHHHHHHHCCCCCHHHCCCCHHHHHHHH
RYVDLMTDEAARRRFIARSKAVSGIREFMVQHGFLEVETPMLHPIPGGANAKPFVTHHNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEECCCCCCCCCCCEEECHHH
LEQEMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMEFYAAYWNYRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCHHH
LMDFTEQLVRDAATKAAGSLQLTYQGRAVDLSQPFERLTIREAILRHTDAGDGVDDAAWL
HHHHHHHHHHHHHHHCCCCEEEEECCCEECHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VAALRKLGLSEEKDRLSTRSLAGLQVLYFEETVEDKLWQPTFIMEHPTEISPLARANDTR
HHHHHHCCCCCHHHHHHHHHHCCEEEEEEHHHHHHHHCCCEEEECCCCCCCCHHCCCCCC
PEVTERFELYITGREFGNGFSELNDAEDQAARFQSQVEAKDSGDDEAMYFDHDFVRALEY
CCHHCEEEEEEECHHHCCCHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHH
GMPPTGGCGIGIDRLMMLLTDSPSIRDVILFPALRREH
CCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECHHHCCC
>Mature Secondary Structure
MLPPQNPSAPTAAPSDDNQLIAERRDKLKSLREAQAQGKGVAFPNDFKPAHHAADLQAQY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
AETEAETLEANPVPVSVAGRMMLKRVMGKASFATVQDGSLGATHGRIQLYVTRDAIGEEA
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEHHHHCHHH
YAAFKHWDLGDIVGAEGTLMKTKTGELSVKVTNLRLLTKSLRPMPDKFHGVADQEVKYRQ
HHHHHCCCCHHHCCCCCCEEEECCCCEEEEEEHHHHHHHHCCCCCHHHCCCCHHHHHHHH
RYVDLMTDEAARRRFIARSKAVSGIREFMVQHGFLEVETPMLHPIPGGANAKPFVTHHNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEECCCCCCCCCCCEEECHHH
LEQEMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMEFYAAYWNYRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCHHH
LMDFTEQLVRDAATKAAGSLQLTYQGRAVDLSQPFERLTIREAILRHTDAGDGVDDAAWL
HHHHHHHHHHHHHHHCCCCEEEEECCCEECHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VAALRKLGLSEEKDRLSTRSLAGLQVLYFEETVEDKLWQPTFIMEHPTEISPLARANDTR
HHHHHHCCCCCHHHHHHHHHHCCEEEEEEHHHHHHHHCCCEEEECCCCCCCCHHCCCCCC
PEVTERFELYITGREFGNGFSELNDAEDQAARFQSQVEAKDSGDDEAMYFDHDFVRALEY
CCHHCEEEEEEECHHHCCCHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHH
GMPPTGGCGIGIDRLMMLLTDSPSIRDVILFPALRREH
CCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA