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The map label for this gene is degP [H]

Identifier: 120609880

GI number: 120609880

Start: 1311493

End: 1312974

Strand: Direct

Name: degP [H]

Synonym: Aave_1192

Alternate gene names: 120609880

Gene position: 1311493-1312974 (Clockwise)

Preceding gene: 120609879

Following gene: 120609881

Centisome position: 24.5

GC content: 67.68

Gene sequence:

>1482_bases
ATGTTTTCCATGCCGTGTGACCCATCGCGTTTCCGGACACTCGTCCGCTCCCTCGCTGCCGCTGGAGCCGTCGCCCTGTT
CCCCGCCGGTGCGCTGCATGCGCAGGCTGCCACGGCCAGCCCGCCGCCGCTGGTGCAGGGCCTGCCCGACTTCACCGACC
TGGTGGACCAGGTCGGCCCGGCGGTGGTGAACATCCGGACCATCGAGAAGGCGCCCGACCGCTCCTCCACCAGCGGCATG
GACGAGGAAATGCTGGAGTTCTTCAAGCGCTTCGGCCTGCCCATGCCGGGCGTTCCGCGCCAGCAGCGTCCCCAGCGCCC
CGACGAAGAGCAGCCACGCGGCGTGGGTTCCGGCTTCATCGTGACCTCCGACGGCTACGTGATGACGAATGCCCACGTGG
TGGAGGGCGCGCAGGAAGTGCTCGTCACCCTCACCGACAAGCGTGAATTCAAGGCCAAGATCGTGGGTTCGGACAAGCGC
ACGGATGTGGCGGTGGTGAAGATCGACGCCACGGGGCTTCCCGCGGTGAAGGTCGGCGACATGAACCGGCTGCGCGTCGG
TGAATGGGTGATGGCCATCGGCTCGCCGTTCGGCCTCGAGAACACGGTCACCGCCGGCATCGTGAGTGCCAAGCAGCGCG
ACACGGGCGACTACCTGCCGTTCATCCAGACGGACGTGGCCATCAATCCCGGCAATTCGGGCGGCCCGCTCATCAACATG
CGCGGCGAAGTGGTGGGCATCAACAGCCAGATCTACTCGCGTTCCGGCGGATTCATGGGCATCTCCTTCGCCATCCCGAT
CGACGAGGCCATCCGTGTGAGCGACCAGCTGCGCGCCACGGGGCGCGTGACCCGCGGGCGCATCGGCGTGCAGATCGGCC
AGGTCACCAAGGACGTTGCGGAGTCTATCGGCCTGGGCAAGACCCAGGGTGCGCTGGTGACGGGCGTGGAGACCGGCTCG
CCGGCGGACAAGGCCGGCGTGGAGGCGGGCGACATCATCACCCGCTTCGACGGCAAGAGCATCGACAAGATTTCCGACCT
GCCGCGCCTCGTGGGCAACACCAAGCCCGGCAACAAGAGCACGGTGACGGTGTTCCGGCGCGGGGCCACGAAGGATCTGC
CCATCACGGTGGCGGAGGTGGAACCCGACGACAGGCCGACGGCCGCAGCCGGCGACCGAGGCGCGAAGCCCAAGGCATCG
CCTGCCGCGCTGCAGCTCGGCCTGGCGGCGGTCGATCTGACGGATGCCCAGAAGAAGGAGCTCAAGCTCAAGGGCGGGGT
GCGCGTGACGGGCGTGACCGATGCCGCGGCCCGTGCAGGGCTGCGGGAGGGCGACGTCATCCTGGGCGTCGCCAATACCG
AGATCTCCGGCATGAAGGACTTCGAAGCCGTGCTGGCCAAGGCCGACAAATCCAAGCCCATCAATGTGCTGTTCCGCAGG
GGCGACTGGACCCAATATGCCGTGATCCGTCCGAGCCGCTGA

Upstream 100 bases:

>100_bases
CCGCGGCGCAGGGAACCAAACACGGCCTTGTCCTTCACACCTTCGCATGCGTTTTTGCACAACATCGGCGATTTGCCCCG
AAAAGAAAGAAAGGTCTTCC

Downstream 100 bases:

>100_bases
TGTCCGGCGGCTGTCCGGGGCAGAGTCCCCATCCCGGAGTGGGAATTGGGGCCTTCCGCGCAGGATGAGTCCCCCCTGGA
GGGGGCGCCTGCGCCCCCGG

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MFSMPCDPSRFRTLVRSLAAAGAVALFPAGALHAQAATASPPPLVQGLPDFTDLVDQVGPAVVNIRTIEKAPDRSSTSGM
DEEMLEFFKRFGLPMPGVPRQQRPQRPDEEQPRGVGSGFIVTSDGYVMTNAHVVEGAQEVLVTLTDKREFKAKIVGSDKR
TDVAVVKIDATGLPAVKVGDMNRLRVGEWVMAIGSPFGLENTVTAGIVSAKQRDTGDYLPFIQTDVAINPGNSGGPLINM
RGEVVGINSQIYSRSGGFMGISFAIPIDEAIRVSDQLRATGRVTRGRIGVQIGQVTKDVAESIGLGKTQGALVTGVETGS
PADKAGVEAGDIITRFDGKSIDKISDLPRLVGNTKPGNKSTVTVFRRGATKDLPITVAEVEPDDRPTAAAGDRGAKPKAS
PAALQLGLAAVDLTDAQKKELKLKGGVRVTGVTDAAARAGLREGDVILGVANTEISGMKDFEAVLAKADKSKPINVLFRR
GDWTQYAVIRPSR

Sequences:

>Translated_493_residues
MFSMPCDPSRFRTLVRSLAAAGAVALFPAGALHAQAATASPPPLVQGLPDFTDLVDQVGPAVVNIRTIEKAPDRSSTSGM
DEEMLEFFKRFGLPMPGVPRQQRPQRPDEEQPRGVGSGFIVTSDGYVMTNAHVVEGAQEVLVTLTDKREFKAKIVGSDKR
TDVAVVKIDATGLPAVKVGDMNRLRVGEWVMAIGSPFGLENTVTAGIVSAKQRDTGDYLPFIQTDVAINPGNSGGPLINM
RGEVVGINSQIYSRSGGFMGISFAIPIDEAIRVSDQLRATGRVTRGRIGVQIGQVTKDVAESIGLGKTQGALVTGVETGS
PADKAGVEAGDIITRFDGKSIDKISDLPRLVGNTKPGNKSTVTVFRRGATKDLPITVAEVEPDDRPTAAAGDRGAKPKAS
PAALQLGLAAVDLTDAQKKELKLKGGVRVTGVTDAAARAGLREGDVILGVANTEISGMKDFEAVLAKADKSKPINVLFRR
GDWTQYAVIRPSR
>Mature_493_residues
MFSMPCDPSRFRTLVRSLAAAGAVALFPAGALHAQAATASPPPLVQGLPDFTDLVDQVGPAVVNIRTIEKAPDRSSTSGM
DEEMLEFFKRFGLPMPGVPRQQRPQRPDEEQPRGVGSGFIVTSDGYVMTNAHVVEGAQEVLVTLTDKREFKAKIVGSDKR
TDVAVVKIDATGLPAVKVGDMNRLRVGEWVMAIGSPFGLENTVTAGIVSAKQRDTGDYLPFIQTDVAINPGNSGGPLINM
RGEVVGINSQIYSRSGGFMGISFAIPIDEAIRVSDQLRATGRVTRGRIGVQIGQVTKDVAESIGLGKTQGALVTGVETGS
PADKAGVEAGDIITRFDGKSIDKISDLPRLVGNTKPGNKSTVTVFRRGATKDLPITVAEVEPDDRPTAAAGDRGAKPKAS
PAALQLGLAAVDLTDAQKKELKLKGGVRVTGVTDAAARAGLREGDVILGVANTEISGMKDFEAVLAKADKSKPINVLFRR
GDWTQYAVIRPSR

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=352, Percent_Identity=34.6590909090909, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=36.8, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI22129776, Length=347, Percent_Identity=32.5648414985591, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI7019477, Length=314, Percent_Identity=33.1210191082803, Blast_Score=137, Evalue=3e-32,
Organism=Escherichia coli, GI1789629, Length=452, Percent_Identity=36.5044247787611, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1786356, Length=479, Percent_Identity=33.1941544885177, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1789630, Length=282, Percent_Identity=39.0070921985816, Blast_Score=169, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24646839, Length=291, Percent_Identity=35.0515463917526, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 52059; Mature: 52059

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSMPCDPSRFRTLVRSLAAAGAVALFPAGALHAQAATASPPPLVQGLPDFTDLVDQVGP
CCCCCCCHHHHHHHHHHHHHCCEEEECCCCHHHCCCCCCCCCHHHCCCCCHHHHHHHCCC
AVVNIRTIEKAPDRSSTSGMDEEMLEFFKRFGLPMPGVPRQQRPQRPDEEQPRGVGSGFI
EEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VTSDGYVMTNAHVVEGAQEVLVTLTDKREFKAKIVGSDKRTDVAVVKIDATGLPAVKVGD
EECCCEEEECCHHHCCCCEEEEEEECCCCEEEEEECCCCCCEEEEEEEECCCCCEEEECC
MNRLRVGEWVMAIGSPFGLENTVTAGIVSAKQRDTGDYLPFIQTDVAINPGNSGGPLINM
CCCEEHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEE
RGEVVGINSQIYSRSGGFMGISFAIPIDEAIRVSDQLRATGRVTRGRIGVQIGQVTKDVA
CCCEEEECHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHCCCEECCEEEEEHHHHHHHHH
ESIGLGKTQGALVTGVETGSPADKAGVEAGDIITRFDGKSIDKISDLPRLVGNTKPGNKS
HHCCCCCCCCCEEEEECCCCCCHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCC
TVTVFRRGATKDLPITVAEVEPDDRPTAAAGDRGAKPKASPAALQLGLAAVDLTDAQKKE
EEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHEECEEEEECCCCHHHH
LKLKGGVRVTGVTDAAARAGLREGDVILGVANTEISGMKDFEAVLAKADKSKPINVLFRR
EEECCCEEEEECCHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEC
GDWTQYAVIRPSR
CCCEEEEEEECCC
>Mature Secondary Structure
MFSMPCDPSRFRTLVRSLAAAGAVALFPAGALHAQAATASPPPLVQGLPDFTDLVDQVGP
CCCCCCCHHHHHHHHHHHHHCCEEEECCCCHHHCCCCCCCCCHHHCCCCCHHHHHHHCCC
AVVNIRTIEKAPDRSSTSGMDEEMLEFFKRFGLPMPGVPRQQRPQRPDEEQPRGVGSGFI
EEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VTSDGYVMTNAHVVEGAQEVLVTLTDKREFKAKIVGSDKRTDVAVVKIDATGLPAVKVGD
EECCCEEEECCHHHCCCCEEEEEEECCCCEEEEEECCCCCCEEEEEEEECCCCCEEEECC
MNRLRVGEWVMAIGSPFGLENTVTAGIVSAKQRDTGDYLPFIQTDVAINPGNSGGPLINM
CCCEEHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEE
RGEVVGINSQIYSRSGGFMGISFAIPIDEAIRVSDQLRATGRVTRGRIGVQIGQVTKDVA
CCCEEEECHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHCCCEECCEEEEEHHHHHHHHH
ESIGLGKTQGALVTGVETGSPADKAGVEAGDIITRFDGKSIDKISDLPRLVGNTKPGNKS
HHCCCCCCCCCEEEEECCCCCCHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCC
TVTVFRRGATKDLPITVAEVEPDDRPTAAAGDRGAKPKASPAALQLGLAAVDLTDAQKKE
EEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHEECEEEEECCCCHHHH
LKLKGGVRVTGVTDAAARAGLREGDVILGVANTEISGMKDFEAVLAKADKSKPINVLFRR
EEECCCEEEEECCHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEC
GDWTQYAVIRPSR
CCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]