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The map label for this gene is fabH

Identifier: 120609871

GI number: 120609871

Start: 1303918

End: 1304895

Strand: Direct

Name: fabH

Synonym: Aave_1183

Alternate gene names: 120609871

Gene position: 1303918-1304895 (Clockwise)

Preceding gene: 120609870

Following gene: 120609872

Centisome position: 24.36

GC content: 68.61

Gene sequence:

>978_bases
ATGAGCCGTTATTCCCGTATCACAGGCACCGGCAGCAGCCTGCCCCCGCGCCGTCTGACCAATGCCGACCTCGTGGCCGA
ACTGGCCGGGCGGGGCGTTGAGACCTCGGACCAGTGGATCGTGGAGCGCACGGGCATCCGCGCCCGGCATTTCGCCGAGC
GGGACGTGTGCAGCAGCGATCTGGGACTGGAGGCGGCGCGGCAGGCGCTCGATGCTGCGGGCGTGCAGCCTGCGGACATC
GACCTCATCATCGTCGCCACGTCCACGCCGGACATGGTCTTCCCTTCCACTGCGTGCATCCTTCAGAACAAGCTGGGCGC
CAATGGCTGCCCCGCATTCGACGTGCAGGCGGTGTGCAGCGGCTTCATCTATGCGCTGACGGTGGCGGATTCCATGATCC
GCTCCGGCGCGGCCCGCCGCGCCCTCGTCGTGGGCTCCGAAGTGTTCAGCCGCCTGCTCGATTTCAACGACCGCACCACC
TGCGTGCTGTTCGGCGACGGTGCGGGTGCGGTGGTCCTGGAGGCCTCCGAGACGCCGGGCATCCTCGCCAGCGACCTGCA
CGCCGACGGCAGGCACGTCGGCATCCTGTGCGTACCGGGCAACGTGTACGGCGGCCAGATCCTCGGCGATCCGCTGCTCA
AGATGGATGGCCAGGCCGTTTTCAAACTGGCCGTGGGGGTGCTCGACAAGGCGGCCCGCGCCGTGCTGGACAAGGCCGGC
CTGAAGGAGTCGGACGTGGACTGGCTGATTCCCCACCAGGCCAACATCCGCATCATGCAGGGCACGGCCAAGAAGCTGGG
CCTGCCGATGGACAGGGTGGTGGTCACGGTGGACCAGCACGGCAACACGTCGGCCGCATCCATTCCCCTGGCGCTCGACC
ATGCCGTGCGCTCCGGCCAGGCCCGTCCCGGCCAGAACCTGCTGCTCGAAGGCGTGGGTGGGGGCTTCACCTGGGGCGCC
GTGCTGCTCACGCTCTGA

Upstream 100 bases:

>100_bases
TGCTCGATCGAGTCCGTTCGCGGGTTGCGCATGCCGCTCCCCTGCTGGGGCCCGCCGCCGCGCAGCCGTCGCCCTGACTG
ACCGTTTCGGGCCCCAATGA

Downstream 100 bases:

>100_bases
GTGCTGCCGCGGCCTGCGCCGAAGCACGGCCCCGGTGACTCGTATGACCTGAATTTCCCTCATGACCACGAAGAACTTCG
CATTCGTTTTTCCCGGACAA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSRYSRITGTGSSLPPRRLTNADLVAELAGRGVETSDQWIVERTGIRARHFAERDVCSSDLGLEAARQALDAAGVQPADI
DLIIVATSTPDMVFPSTACILQNKLGANGCPAFDVQAVCSGFIYALTVADSMIRSGAARRALVVGSEVFSRLLDFNDRTT
CVLFGDGAGAVVLEASETPGILASDLHADGRHVGILCVPGNVYGGQILGDPLLKMDGQAVFKLAVGVLDKAARAVLDKAG
LKESDVDWLIPHQANIRIMQGTAKKLGLPMDRVVVTVDQHGNTSAASIPLALDHAVRSGQARPGQNLLLEGVGGGFTWGA
VLLTL

Sequences:

>Translated_325_residues
MSRYSRITGTGSSLPPRRLTNADLVAELAGRGVETSDQWIVERTGIRARHFAERDVCSSDLGLEAARQALDAAGVQPADI
DLIIVATSTPDMVFPSTACILQNKLGANGCPAFDVQAVCSGFIYALTVADSMIRSGAARRALVVGSEVFSRLLDFNDRTT
CVLFGDGAGAVVLEASETPGILASDLHADGRHVGILCVPGNVYGGQILGDPLLKMDGQAVFKLAVGVLDKAARAVLDKAG
LKESDVDWLIPHQANIRIMQGTAKKLGLPMDRVVVTVDQHGNTSAASIPLALDHAVRSGQARPGQNLLLEGVGGGFTWGA
VLLTL
>Mature_324_residues
SRYSRITGTGSSLPPRRLTNADLVAELAGRGVETSDQWIVERTGIRARHFAERDVCSSDLGLEAARQALDAAGVQPADID
LIIVATSTPDMVFPSTACILQNKLGANGCPAFDVQAVCSGFIYALTVADSMIRSGAARRALVVGSEVFSRLLDFNDRTTC
VLFGDGAGAVVLEASETPGILASDLHADGRHVGILCVPGNVYGGQILGDPLLKMDGQAVFKLAVGVLDKAARAVLDKAGL
KESDVDWLIPHQANIRIMQGTAKKLGLPMDRVVVTVDQHGNTSAASIPLALDHAVRSGQARPGQNLLLEGVGGGFTWGAV
LLTL

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=320, Percent_Identity=53.125, Blast_Score=328, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_ACIAC (A1TLD7)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969549.1
- ProteinModelPortal:   A1TLD7
- SMR:   A1TLD7
- STRING:   A1TLD7
- GeneID:   4667457
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1183
- NMPDR:   fig|397945.5.peg.1033
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- PhylomeDB:   A1TLD7
- ProtClustDB:   PRK09352
- BioCyc:   AAVE397945:AAVE_1183-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34062; Mature: 33931

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: ACT_SITE 119-119 ACT_SITE 252-252 ACT_SITE 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYSRITGTGSSLPPRRLTNADLVAELAGRGVETSDQWIVERTGIRARHFAERDVCSSD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHCCCC
LGLEAARQALDAAGVQPADIDLIIVATSTPDMVFPSTACILQNKLGANGCPAFDVQAVCS
CCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHH
GFIYALTVADSMIRSGAARRALVVGSEVFSRLLDFNDRTTCVLFGDGAGAVVLEASETPG
HHHHHHHHHHHHHHCCCHHEEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCC
ILASDLHADGRHVGILCVPGNVYGGQILGDPLLKMDGQAVFKLAVGVLDKAARAVLDKAG
CEEECCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
LKESDVDWLIPHQANIRIMQGTAKKLGLPMDRVVVTVDQHGNTSAASIPLALDHAVRSGQ
CCCCCCCEECCCCCCEEEEECCHHHHCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHCCC
ARPGQNLLLEGVGGGFTWGAVLLTL
CCCCCCEEEEECCCCCEEHHHEEEC
>Mature Secondary Structure 
SRYSRITGTGSSLPPRRLTNADLVAELAGRGVETSDQWIVERTGIRARHFAERDVCSSD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHCCCC
LGLEAARQALDAAGVQPADIDLIIVATSTPDMVFPSTACILQNKLGANGCPAFDVQAVCS
CCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHH
GFIYALTVADSMIRSGAARRALVVGSEVFSRLLDFNDRTTCVLFGDGAGAVVLEASETPG
HHHHHHHHHHHHHHCCCHHEEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCC
ILASDLHADGRHVGILCVPGNVYGGQILGDPLLKMDGQAVFKLAVGVLDKAARAVLDKAG
CEEECCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
LKESDVDWLIPHQANIRIMQGTAKKLGLPMDRVVVTVDQHGNTSAASIPLALDHAVRSGQ
CCCCCCCEECCCCCCEEEEECCHHHHCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHCCC
ARPGQNLLLEGVGGGFTWGAVLLTL
CCCCCCEEEEECCCCCEEHHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA