Click here to switch to the map view.

The map label for this gene is degP [C]

Identifier: 120609757

GI number: 120609757

Start: 1167498

End: 1168463

Strand: Reverse

Name: degP [C]

Synonym: Aave_1064

Alternate gene names: 120609757

Gene position: 1168463-1167498 (Counterclockwise)

Preceding gene: 120609764

Following gene: 120609756

Centisome position: 21.83

GC content: 74.64

Gene sequence:

>966_bases
ATGCCCAGGCCCGCCCGCTACAGCAGCTCCCGCCGCGCGCCGGCCGCGGCCTCCCCGCCATATCCTTTCCCGGACGGGTC
CGCGGACCCGCCGCCGGCCGGTCCTGCGGCCGCGGCTCCCGGCAGCGCCGGACCTGCAGGCGCTGCCGGCCCATCCCGTG
CCCGTCCCTCGCGGCGCTGGCTCGGCGGCGCGCCGGCGGCCGTGCTGGCGACCGTGTTGTTGGCCGGCTTCGGCTGGCTG
GCCTGGCGCATGCCGCCGCCGGCGCCGCGCATCACCCAGCAGGACATCGACGCGGCCGTGCTGCACACCCTCTCCACCCA
GCCCCTGCCCTCGGCCGCCGCACGCGCCGCCGAGGCCGTGGCCCCGTCGGTGGTGCGCGTCGCCGGCTTCGCCCGGACGA
AGAAAGGCAAGGGCAAGGTCCAGGAGGAAGAGCGCGGCGTGGGCACCGGCATCGTGATCGTGGACAAGGGCGTGATCCTC
ACCAACCTGCATGTGGTGCGGGGCGCGGCGCGCATCCAGGTCACCTTCGCCGACGGCTCCGAAAGCGACGCCTCCCTGAC
CGGCGCCCAGCCCGCGAACGACCTCGCCGTGCTGCAGGCACGCCGCGTGCCGGACGACCTGCAGGCCGCGCCGCTGCGCT
CCACGCAGGGCCTCAAGCCCGGCGACGGCGTGGTCGCCATCGGCTTTCCCTTCGGCATCGGGCCCTCGGTCTCGGCCGGC
GTGATCTCGGGCCTGCAGCGCGAATTCGATTCGCCCCAGGGCAAACAGGAGATGCGCAACCTCATCCAGTTCGACGCCGC
CGCCAACCCCGGCAATTCCGGCGGCCCGCTCGTCACGCTCGACGGCGAGGTCGTGGGCATCGTCACCGCCATCCTCAACC
CCACGCCCGCGCGCACCTTCATCGGCATCGGCTTCGCCGTACCCATCGAGAACGCCGCCGAGGCCGCGGGCTCGCCACCG
TTCTGA

Upstream 100 bases:

>100_bases
GCGGACACATGCGCGGCGGGCGGTTCCGTGCTACCGTCGCCGGGAACCGCCTGCCCGGCGCACGACGCCGCGCGCGGGCC
CCCTGACCCGAGGTGACCGC

Downstream 100 bases:

>100_bases
CCTTTCGCAAGGAGCCTCCATGGACATCACCCCGCCCCCGACGGCCGCCGCCACCGCCACGCTGATGGAGCAGATCCTCT
ACGAGGTCAAGCGCGTGGTG

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MPRPARYSSSRRAPAAASPPYPFPDGSADPPPAGPAAAAPGSAGPAGAAGPSRARPSRRWLGGAPAAVLATVLLAGFGWL
AWRMPPPAPRITQQDIDAAVLHTLSTQPLPSAAARAAEAVAPSVVRVAGFARTKKGKGKVQEEERGVGTGIVIVDKGVIL
TNLHVVRGAARIQVTFADGSESDASLTGAQPANDLAVLQARRVPDDLQAAPLRSTQGLKPGDGVVAIGFPFGIGPSVSAG
VISGLQREFDSPQGKQEMRNLIQFDAAANPGNSGGPLVTLDGEVVGIVTAILNPTPARTFIGIGFAVPIENAAEAAGSPP
F

Sequences:

>Translated_321_residues
MPRPARYSSSRRAPAAASPPYPFPDGSADPPPAGPAAAAPGSAGPAGAAGPSRARPSRRWLGGAPAAVLATVLLAGFGWL
AWRMPPPAPRITQQDIDAAVLHTLSTQPLPSAAARAAEAVAPSVVRVAGFARTKKGKGKVQEEERGVGTGIVIVDKGVIL
TNLHVVRGAARIQVTFADGSESDASLTGAQPANDLAVLQARRVPDDLQAAPLRSTQGLKPGDGVVAIGFPFGIGPSVSAG
VISGLQREFDSPQGKQEMRNLIQFDAAANPGNSGGPLVTLDGEVVGIVTAILNPTPARTFIGIGFAVPIENAAEAAGSPP
F
>Mature_320_residues
PRPARYSSSRRAPAAASPPYPFPDGSADPPPAGPAAAAPGSAGPAGAAGPSRARPSRRWLGGAPAAVLATVLLAGFGWLA
WRMPPPAPRITQQDIDAAVLHTLSTQPLPSAAARAAEAVAPSVVRVAGFARTKKGKGKVQEEERGVGTGIVIVDKGVILT
NLHVVRGAARIQVTFADGSESDASLTGAQPANDLAVLQARRVPDDLQAAPLRSTQGLKPGDGVVAIGFPFGIGPSVSAGV
ISGLQREFDSPQGKQEMRNLIQFDAAANPGNSGGPLVTLDGEVVGIVTAILNPTPARTFIGIGFAVPIENAAEAAGSPPF

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=195, Percent_Identity=35.3846153846154, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4506141, Length=195, Percent_Identity=34.3589743589744, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI22129776, Length=325, Percent_Identity=29.2307692307692, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI7019477, Length=170, Percent_Identity=36.4705882352941, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1786356, Length=163, Percent_Identity=45.398773006135, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789629, Length=218, Percent_Identity=38.5321100917431, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789630, Length=211, Percent_Identity=36.0189573459716, Blast_Score=106, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646839, Length=165, Percent_Identity=36.969696969697, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 32470; Mature: 32339

Theoretical pI: Translated: 10.51; Mature: 10.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPARYSSSRRAPAAASPPYPFPDGSADPPPAGPAAAAPGSAGPAGAAGPSRARPSRRW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
LGGAPAAVLATVLLAGFGWLAWRMPPPAPRITQQDIDAAVLHTLSTQPLPSAAARAAEAV
CCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
APSVVRVAGFARTKKGKGKVQEEERGVGTGIVIVDKGVILTNLHVVRGAARIQVTFADGS
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCEEEEHHHHHCCCEEEEEEECCCC
ESDASLTGAQPANDLAVLQARRVPDDLQAAPLRSTQGLKPGDGVVAIGFPFGIGPSVSAG
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHH
VISGLQREFDSPQGKQEMRNLIQFDAAANPGNSGGPLVTLDGEVVGIVTAILNPTPARTF
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCHHEEHHHHHHCCCCCCEE
IGIGFAVPIENAAEAAGSPPF
EECEEEECCCHHHHCCCCCCC
>Mature Secondary Structure 
PRPARYSSSRRAPAAASPPYPFPDGSADPPPAGPAAAAPGSAGPAGAAGPSRARPSRRW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
LGGAPAAVLATVLLAGFGWLAWRMPPPAPRITQQDIDAAVLHTLSTQPLPSAAARAAEAV
CCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
APSVVRVAGFARTKKGKGKVQEEERGVGTGIVIVDKGVILTNLHVVRGAARIQVTFADGS
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCEEEEHHHHHCCCEEEEEEECCCC
ESDASLTGAQPANDLAVLQARRVPDDLQAAPLRSTQGLKPGDGVVAIGFPFGIGPSVSAG
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHH
VISGLQREFDSPQGKQEMRNLIQFDAAANPGNSGGPLVTLDGEVVGIVTAILNPTPARTF
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCHHEEHHHHHHCCCCCCEE
IGIGFAVPIENAAEAAGSPPF
EECEEEECCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]