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The map label for this gene is yeiA [H]

Identifier: 120609661

GI number: 120609661

Start: 1060702

End: 1062030

Strand: Direct

Name: yeiA [H]

Synonym: Aave_0967

Alternate gene names: 120609661

Gene position: 1060702-1062030 (Clockwise)

Preceding gene: 120609660

Following gene: 120609662

Centisome position: 19.82

GC content: 67.57

Gene sequence:

>1329_bases
ATGGCAGACATCCGCAGCGATTTCCTCGGCATCCGCAGCCCGAACCCCTTCTGGCTGGCCTCCGCGCCGCCGACGGACAA
GGAGGTGAACGTCACCCGCGCCTTCGAGGCGGGCTGGGGCGGCGTGGTCTGGAAGACCTTGGGCGAGGACCCGCACGTGG
TCAACGTGAACGGCCCGCGCTATTCCACCCTCATGTCGCAGGACCGGCGCGTGATCGGGCTCAACAACATCGAGCTGATC
ACCGACCGGCCGCTGGCCGTGAACCTGGAGGAGATCCGCCGCGTGAAGCGCACCTGGCCGGACCGCGCGATGATCGTCTC
GATCATGGTGCCTTGCGTGGAAGAGAGCTGGAAGCGCATCCTGCCGATGGTGGAGGACACGGGCGCGGACGGCATCGAGC
TGAACTTCGGCTGCCCGCACGGCATGAGCGAGCGCGGCATGGGCGCGGCCGTGGGCCAGGTGCCCGAATACATCCAGATG
GTCACGCAATGGTGCAAGCACTACACGCACCTGCCGGTGATCGTGAAGCTCACGCCCAACATCACCGACGTGCGGCAGCC
GGCCCGTGCGGCGCGGGCCGGCGGAGCGGACGCGGTGTCGCTCATCAACACCATCAATTCCATCATGGGCGTGGACCTGG
ACCGCATGGCGATGAGCCCGAACACCGGTGGGCAGGGGTCGCACGGCGGCTACTGCGGGCCGGCCGTCAAGCCCATCGCG
CTCAACATGGTGGCCGAGATCGCGCGCGACGAGCAGACGGCGGGCCTGCCCATCAGCGGCATCGGTGGCGTGAGCACCTG
GCGAGACGCGGCCGAGTTCATCGCCCTGGGCTGCGGCACCGTGCAGGTCTGCACGGCCGCGATGGTCTATGGCTTCAAGA
TCGTGCAGGACATGTGCGGCGGGCTGTCCAATTTCATGGATGCGCACGGCTACCGGACGATCGAGGACTTCCGCGGCGGC
GCCGTGCCCACGGTGAAGGACTGGAAGCAGCTCGACCTCAACCACATCGACAAGGCCGTGATCAACCAGGATGCGTGTAT
CCAGTGCGGCCGCTGCCACGTGGTGTGCGAGGACACTTCGCACCAGGCGATCACCTTCACCCGGGAGGGCGGGGTGCGCA
GGTTCGAGGTGGACGAATCCGAGTGCGTGGGCTGCAACCTGTGCGTCTCGATCTGCCCGGTGCCCGAGTGCATCACCCTG
CGCAGTCTGCAGCCGGGCGAGGTCGATGCACGCACGGGCAAGGTGGTCAGCGGCGAGTATGCCAACTGGACCACGCATCC
CAACAACCCGCAGCGCGTCGCTACGGCCACGGCCACGGTCGCCGCCTGA

Upstream 100 bases:

>100_bases
CACGGCAAGGTGGCCGCGGTGTCCATCCACGAAGCGCTGCTGGCGGCCTGAAAGCCGCCGCCGACCCCACGACCCCCGGA
GCAAGACAACGGAGAAACAC

Downstream 100 bases:

>100_bases
CGTCATCCATCCAGCCCCTCATTCAGGAGTGACGACATGATGAACAGTCCAGGCGGCGCGGCACCGATGGCAACCGCAAC
CACCACCTTTCCGGGCGGGC

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MADIRSDFLGIRSPNPFWLASAPPTDKEVNVTRAFEAGWGGVVWKTLGEDPHVVNVNGPRYSTLMSQDRRVIGLNNIELI
TDRPLAVNLEEIRRVKRTWPDRAMIVSIMVPCVEESWKRILPMVEDTGADGIELNFGCPHGMSERGMGAAVGQVPEYIQM
VTQWCKHYTHLPVIVKLTPNITDVRQPARAARAGGADAVSLINTINSIMGVDLDRMAMSPNTGGQGSHGGYCGPAVKPIA
LNMVAEIARDEQTAGLPISGIGGVSTWRDAAEFIALGCGTVQVCTAAMVYGFKIVQDMCGGLSNFMDAHGYRTIEDFRGG
AVPTVKDWKQLDLNHIDKAVINQDACIQCGRCHVVCEDTSHQAITFTREGGVRRFEVDESECVGCNLCVSICPVPECITL
RSLQPGEVDARTGKVVSGEYANWTTHPNNPQRVATATATVAA

Sequences:

>Translated_442_residues
MADIRSDFLGIRSPNPFWLASAPPTDKEVNVTRAFEAGWGGVVWKTLGEDPHVVNVNGPRYSTLMSQDRRVIGLNNIELI
TDRPLAVNLEEIRRVKRTWPDRAMIVSIMVPCVEESWKRILPMVEDTGADGIELNFGCPHGMSERGMGAAVGQVPEYIQM
VTQWCKHYTHLPVIVKLTPNITDVRQPARAARAGGADAVSLINTINSIMGVDLDRMAMSPNTGGQGSHGGYCGPAVKPIA
LNMVAEIARDEQTAGLPISGIGGVSTWRDAAEFIALGCGTVQVCTAAMVYGFKIVQDMCGGLSNFMDAHGYRTIEDFRGG
AVPTVKDWKQLDLNHIDKAVINQDACIQCGRCHVVCEDTSHQAITFTREGGVRRFEVDESECVGCNLCVSICPVPECITL
RSLQPGEVDARTGKVVSGEYANWTTHPNNPQRVATATATVAA
>Mature_441_residues
ADIRSDFLGIRSPNPFWLASAPPTDKEVNVTRAFEAGWGGVVWKTLGEDPHVVNVNGPRYSTLMSQDRRVIGLNNIELIT
DRPLAVNLEEIRRVKRTWPDRAMIVSIMVPCVEESWKRILPMVEDTGADGIELNFGCPHGMSERGMGAAVGQVPEYIQMV
TQWCKHYTHLPVIVKLTPNITDVRQPARAARAGGADAVSLINTINSIMGVDLDRMAMSPNTGGQGSHGGYCGPAVKPIAL
NMVAEIARDEQTAGLPISGIGGVSTWRDAAEFIALGCGTVQVCTAAMVYGFKIVQDMCGGLSNFMDAHGYRTIEDFRGGA
VPTVKDWKQLDLNHIDKAVINQDACIQCGRCHVVCEDTSHQAITFTREGGVRRFEVDESECVGCNLCVSICPVPECITLR
SLQPGEVDARTGKVVSGEYANWTTHPNNPQRVATATATVAA

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=341, Percent_Identity=35.4838709677419, Blast_Score=215, Evalue=8e-56,
Organism=Escherichia coli, GI87082059, Length=412, Percent_Identity=40.0485436893204, Blast_Score=315, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI71984108, Length=334, Percent_Identity=38.3233532934132, Blast_Score=217, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6322633, Length=239, Percent_Identity=27.1966527196653, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640763, Length=310, Percent_Identity=40, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI18858217, Length=310, Percent_Identity=40, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 47905; Mature: 47774

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIRSDFLGIRSPNPFWLASAPPTDKEVNVTRAFEAGWGGVVWKTLGEDPHVVNVNGPR
CCCCCCHHCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEHHCCCCCCCEEECCCCC
YSTLMSQDRRVIGLNNIELITDRPLAVNLEEIRRVKRTWPDRAMIVSIMVPCVEESWKRI
HHHHHHCCCEEEECCCEEEEECCCCEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LPMVEDTGADGIELNFGCPHGMSERGMGAAVGQVPEYIQMVTQWCKHYTHLPVIVKLTPN
CCHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
ITDVRQPARAARAGGADAVSLINTINSIMGVDLDRMAMSPNTGGQGSHGGYCGPAVKPIA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCCCCCCCCCCCHHH
LNMVAEIARDEQTAGLPISGIGGVSTWRDAAEFIALGCGTVQVCTAAMVYGFKIVQDMCG
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GLSNFMDAHGYRTIEDFRGGAVPTVKDWKQLDLNHIDKAVINQDACIQCGRCHVVCEDTS
HHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHCHHHHHHHHHCCCHHEECCCEEEEEECCC
HQAITFTREGGVRRFEVDESECVGCNLCVSICPVPECITLRSLQPGEVDARTGKVVSGEY
CCEEEEEECCCCEEEECCCCCCCCCHHHHHHCCCCCHHEECCCCCCCCCCCCCCEEECCC
ANWTTHPNNPQRVATATATVAA
CCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
ADIRSDFLGIRSPNPFWLASAPPTDKEVNVTRAFEAGWGGVVWKTLGEDPHVVNVNGPR
CCCCCHHCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEHHCCCCCCCEEECCCCC
YSTLMSQDRRVIGLNNIELITDRPLAVNLEEIRRVKRTWPDRAMIVSIMVPCVEESWKRI
HHHHHHCCCEEEECCCEEEEECCCCEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LPMVEDTGADGIELNFGCPHGMSERGMGAAVGQVPEYIQMVTQWCKHYTHLPVIVKLTPN
CCHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
ITDVRQPARAARAGGADAVSLINTINSIMGVDLDRMAMSPNTGGQGSHGGYCGPAVKPIA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCCCCCCCCCCCHHH
LNMVAEIARDEQTAGLPISGIGGVSTWRDAAEFIALGCGTVQVCTAAMVYGFKIVQDMCG
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GLSNFMDAHGYRTIEDFRGGAVPTVKDWKQLDLNHIDKAVINQDACIQCGRCHVVCEDTS
HHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHCHHHHHHHHHCCCHHEECCCEEEEEECCC
HQAITFTREGGVRRFEVDESECVGCNLCVSICPVPECITLRSLQPGEVDARTGKVVSGEY
CCEEEEEECCCCEEEECCCCCCCCCHHHHHHCCCCCHHEECCCCCCCCCCCCCCEEECCC
ANWTTHPNNPQRVATATATVAA
CCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]