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The map label for this gene is pgi [H]

Identifier: 120609638

GI number: 120609638

Start: 1028649

End: 1030247

Strand: Direct

Name: pgi [H]

Synonym: Aave_0944

Alternate gene names: 120609638

Gene position: 1028649-1030247 (Clockwise)

Preceding gene: 120609637

Following gene: 120609641

Centisome position: 19.22

GC content: 70.61

Gene sequence:

>1599_bases
ATGACGATGCCCGTTCCCGCCCGCGTGCGCTGCGACCGCACCGCCGCCTGGGCCGCACTGCAGGCGCACTACGAGGCCGC
CGGCCGCACCTTCGATATGCGTGAGGCGTTTGCGGCCGATCCGCAGCGCTTCGGCCGTTTCAGCCAGGAAGCGCCCCACG
TCTTCGCCGATCTGTCCAAGAACCGCATCGACGCGGGCACGGAAGCCCTGCTGCTGCAACTGGCGCGCGACTGCGGGCTG
GAGGGCTGGCGCGACGCGATGTTCGCGGGAGAGGCCATCAACCATACCGAGCAGCGCGCCGTCATGCACTGGCTGCTGCG
CGAGCCCGCCGCGGCGCGTGGGGCTTCGGGCCCCGGCGCGCCGGCACTGGTCACCGACGGCCTGCGCGACGTGCACGCCA
CGCTGCAGGCGATGCTGGACTTCGCCGAACGCGTGCGGGCCGACGGCACCATCACCGACATCGTCAACATCGGCATCGGC
GGCTCGGACCTCGGGCCTTCGATGGTGACCAAGGCGCTGGACGACCTGCGCCATCCGGGCAAGCGCCTGCACTTCGTCTC
CAACGTCGACGGGGCCGAGCTGGGCAGCGTGCTGCCCGAGCTGCGGCCGCAGAACACGCTGTTCCTGATCGCCTCCAAGA
CCTTCACCACGGCGGAGACGATGACCAACGCGCACGCCGCGCGCGCGTGGTTCCTGCAGCAGGGCGGCGGCGAAGCAGCG
GTGGGACGGCATTTCGCCGCGCTCACCACGAACATCGAGGCGGCGTCCGCCTTCGGCATCGACACCACCTTCGGCTTCTG
GGACTGGGTGGGCGGGCGCTATTCGCTCTGGTCGGCCATCGGCCTGCCGATCGCGATCGCCATCGGCGCCGAGGGCTTCC
GTAGCCTGCTGGCCGGCGCGCATGCGATGGACGAGCACTTCCGAACCGCGCCGCTGGAGCGCAACCTGCCGGTGCGCCTG
GGGCTGCTGGACGTCTGGTACCGCAACTTCCACGGTTTCGCGACGCGCAGCGTGGCCCCCTACAGCCATGCGCTGCGCCG
GCTGCCGGCCTACCTGCAGCAGCTGGAGATGGAGAGCAACGGCAAGGGCGTGGATGCGCAAGGGGACACGCTGCCCTTCG
CCACCTCGCCGGTGGTCTGGGGTGAGCCCGGCACCAATGGCCAGCATGCCTTCTTCCAGATGATCCACCAGGGTCCGGAC
ATCGTGCCGGTGGAGTTCATCGTGATGCGCGAGCCCGGGCGCGGCCTGCCGGAACAGCACCCCCGCCTCGTGGCGAATGC
GCTCGCGCAGGCCAAGGCGCTGATGCACGGCAAGCAGAGCGACGACGGCCACCGCCGCTTCACGGGCAACCGGCCCAGCA
CCTTCCTGGTGCTCGACCGGCTCGACCCCGCATCGCTGGGTGCGCTGATCGCGCTCTACGAGCACCGCGTCTTCGTGAGC
GGCGCGCTCTGGGGCATCAACAGCTTCGACCAGTGGGGCGTGGAGCTGGGCAAGGTGCTGGCCAAGGACCTGGAGCCGCG
CCTGTCTTCGGGCGATACGGCAGGGTTGGACGGCTCCACCGCCGGGTTGATGGCGCGGCTCGCCCAGGGCCGTCGCTGA

Upstream 100 bases:

>100_bases
CCATGGCCACCGAGAAGCTGGCCGAGGGCATCCGCGCCTTCGCGGCCGACGCGGCCAAGCTGGAACAGATGGTGCTGGCG
GCATGACGGGGATGACCGCC

Downstream 100 bases:

>100_bases
ACGATACCCCCAAAAGGAAAAGCCCGCAGGCCGTGAAGCCTGCGGGCTTTTTTGCTTTCCGCCCTGGGGCGGAGCAGCTG
GCGGCGTCGGGGGCGGAAAT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MTMPVPARVRCDRTAAWAALQAHYEAAGRTFDMREAFAADPQRFGRFSQEAPHVFADLSKNRIDAGTEALLLQLARDCGL
EGWRDAMFAGEAINHTEQRAVMHWLLREPAAARGASGPGAPALVTDGLRDVHATLQAMLDFAERVRADGTITDIVNIGIG
GSDLGPSMVTKALDDLRHPGKRLHFVSNVDGAELGSVLPELRPQNTLFLIASKTFTTAETMTNAHAARAWFLQQGGGEAA
VGRHFAALTTNIEAASAFGIDTTFGFWDWVGGRYSLWSAIGLPIAIAIGAEGFRSLLAGAHAMDEHFRTAPLERNLPVRL
GLLDVWYRNFHGFATRSVAPYSHALRRLPAYLQQLEMESNGKGVDAQGDTLPFATSPVVWGEPGTNGQHAFFQMIHQGPD
IVPVEFIVMREPGRGLPEQHPRLVANALAQAKALMHGKQSDDGHRRFTGNRPSTFLVLDRLDPASLGALIALYEHRVFVS
GALWGINSFDQWGVELGKVLAKDLEPRLSSGDTAGLDGSTAGLMARLAQGRR

Sequences:

>Translated_532_residues
MTMPVPARVRCDRTAAWAALQAHYEAAGRTFDMREAFAADPQRFGRFSQEAPHVFADLSKNRIDAGTEALLLQLARDCGL
EGWRDAMFAGEAINHTEQRAVMHWLLREPAAARGASGPGAPALVTDGLRDVHATLQAMLDFAERVRADGTITDIVNIGIG
GSDLGPSMVTKALDDLRHPGKRLHFVSNVDGAELGSVLPELRPQNTLFLIASKTFTTAETMTNAHAARAWFLQQGGGEAA
VGRHFAALTTNIEAASAFGIDTTFGFWDWVGGRYSLWSAIGLPIAIAIGAEGFRSLLAGAHAMDEHFRTAPLERNLPVRL
GLLDVWYRNFHGFATRSVAPYSHALRRLPAYLQQLEMESNGKGVDAQGDTLPFATSPVVWGEPGTNGQHAFFQMIHQGPD
IVPVEFIVMREPGRGLPEQHPRLVANALAQAKALMHGKQSDDGHRRFTGNRPSTFLVLDRLDPASLGALIALYEHRVFVS
GALWGINSFDQWGVELGKVLAKDLEPRLSSGDTAGLDGSTAGLMARLAQGRR
>Mature_531_residues
TMPVPARVRCDRTAAWAALQAHYEAAGRTFDMREAFAADPQRFGRFSQEAPHVFADLSKNRIDAGTEALLLQLARDCGLE
GWRDAMFAGEAINHTEQRAVMHWLLREPAAARGASGPGAPALVTDGLRDVHATLQAMLDFAERVRADGTITDIVNIGIGG
SDLGPSMVTKALDDLRHPGKRLHFVSNVDGAELGSVLPELRPQNTLFLIASKTFTTAETMTNAHAARAWFLQQGGGEAAV
GRHFAALTTNIEAASAFGIDTTFGFWDWVGGRYSLWSAIGLPIAIAIGAEGFRSLLAGAHAMDEHFRTAPLERNLPVRLG
LLDVWYRNFHGFATRSVAPYSHALRRLPAYLQQLEMESNGKGVDAQGDTLPFATSPVVWGEPGTNGQHAFFQMIHQGPDI
VPVEFIVMREPGRGLPEQHPRLVANALAQAKALMHGKQSDDGHRRFTGNRPSTFLVLDRLDPASLGALIALYEHRVFVSG
ALWGINSFDQWGVELGKVLAKDLEPRLSSGDTAGLDGSTAGLMARLAQGRR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=558, Percent_Identity=46.0573476702509, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI296080693, Length=558, Percent_Identity=43.5483870967742, Blast_Score=442, Evalue=1e-124,
Organism=Escherichia coli, GI1790457, Length=556, Percent_Identity=47.3021582733813, Blast_Score=490, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71996703, Length=550, Percent_Identity=46.5454545454545, Blast_Score=466, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71996708, Length=550, Percent_Identity=46.5454545454545, Blast_Score=465, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319673, Length=548, Percent_Identity=45.8029197080292, Blast_Score=465, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24651916, Length=564, Percent_Identity=46.8085106382979, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24651914, Length=564, Percent_Identity=46.8085106382979, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17737445, Length=564, Percent_Identity=46.8085106382979, Blast_Score=484, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 57700; Mature: 57569

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPVPARVRCDRTAAWAALQAHYEAAGRTFDMREAFAADPQRFGRFSQEAPHVFADLSK
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHCCCCCCCCHHHHHHHH
NRIDAGTEALLLQLARDCGLEGWRDAMFAGEAINHTEQRAVMHWLLREPAAARGASGPGA
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCC
PALVTDGLRDVHATLQAMLDFAERVRADGTITDIVNIGIGGSDLGPSMVTKALDDLRHPG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHEEECCCCCCCCHHHHHHHHHHHHCCC
KRLHFVSNVDGAELGSVLPELRPQNTLFLIASKTFTTAETMTNAHAARAWFLQQGGGEAA
HHEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHH
VGRHFAALTTNIEAASAFGIDTTFGFWDWVGGRYSLWSAIGLPIAIAIGAEGFRSLLAGA
HHHHHHHHHCCCHHHHHCCCCCCCCHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHHHH
HAMDEHFRTAPLERNLPVRLGLLDVWYRNFHGFATRSVAPYSHALRRLPAYLQQLEMESN
HHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
GKGVDAQGDTLPFATSPVVWGEPGTNGQHAFFQMIHQGPDIVPVEFIVMREPGRGLPEQH
CCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCH
PRLVANALAQAKALMHGKQSDDGHRRFTGNRPSTFLVLDRLDPASLGALIALYEHRVFVS
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEE
GALWGINSFDQWGVELGKVLAKDLEPRLSSGDTAGLDGSTAGLMARLAQGRR
EHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TMPVPARVRCDRTAAWAALQAHYEAAGRTFDMREAFAADPQRFGRFSQEAPHVFADLSK
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHCCCCCCCCHHHHHHHH
NRIDAGTEALLLQLARDCGLEGWRDAMFAGEAINHTEQRAVMHWLLREPAAARGASGPGA
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCC
PALVTDGLRDVHATLQAMLDFAERVRADGTITDIVNIGIGGSDLGPSMVTKALDDLRHPG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHEEECCCCCCCCHHHHHHHHHHHHCCC
KRLHFVSNVDGAELGSVLPELRPQNTLFLIASKTFTTAETMTNAHAARAWFLQQGGGEAA
HHEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHH
VGRHFAALTTNIEAASAFGIDTTFGFWDWVGGRYSLWSAIGLPIAIAIGAEGFRSLLAGA
HHHHHHHHHCCCHHHHHCCCCCCCCHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHHHH
HAMDEHFRTAPLERNLPVRLGLLDVWYRNFHGFATRSVAPYSHALRRLPAYLQQLEMESN
HHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
GKGVDAQGDTLPFATSPVVWGEPGTNGQHAFFQMIHQGPDIVPVEFIVMREPGRGLPEQH
CCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCH
PRLVANALAQAKALMHGKQSDDGHRRFTGNRPSTFLVLDRLDPASLGALIALYEHRVFVS
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEE
GALWGINSFDQWGVELGKVLAKDLEPRLSSGDTAGLDGSTAGLMARLAQGRR
EHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA