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The map label for this gene is ilvA [H]

Identifier: 120609623

GI number: 120609623

Start: 1009793

End: 1011376

Strand: Reverse

Name: ilvA [H]

Synonym: Aave_0929

Alternate gene names: 120609623

Gene position: 1011376-1009793 (Counterclockwise)

Preceding gene: 120609625

Following gene: 120609622

Centisome position: 18.89

GC content: 68.88

Gene sequence:

>1584_bases
ATGACGAAGACCTCCCCCCCTGCCCTGACACCCGCCGACTACCTCAAGAAGATCCTGACGGCGCGCGTGTACGACGTGGC
CGTCGAGTCGGCACTGGAGCCCGCGCGCGCGCTGGGCCGCCGGCTGCACAACACGGTGCTGCTCAAGCGCGAGGACCAGC
AGCCCGTGTTCAGCTTCAAGCTGCGGGGTGCCTACAACAAGATGGCGCACCTGTCTGCCGAGCAGTTGCAGCGCGGCGTG
ATCTGCGCCTCGGCCGGCAACCATGCGCAGGGCGTGGCCATGAGCGCCAAGCGCCTGGGCACGCGTGCGGTGGTGGTGAT
GCCCACGACCACGCCGCAGCTCAAGGTGGACGCCGTGAAGACGCTGGGCGGCGAGGTCGTGCTGCACGGGGACAGCTACT
CCGACGCCTACGAGCACGCCGCGCGCCTGCAGCAGGAGCAGGGCCTGACCTTCGTGCATCCGTTCGACGATCCGGACGTG
ATCGCCGGACAGGGCACCATCGCCATGGAAATCCTGCGCCAGCTGCAGAGCCTGGGCAGCAATCGGCTGGACGCGGTGTT
CGTGGCGATCGGCGGCGGCGGCCTGGTGAGCGGGGTGGCCAACTACATCAAGGCCGTGCGGCCGGAGATCCGCATCGTCG
GCGTGCAGATGAACGATTCCGACGCCATGGCACGCTCGGTCGCGTCCGGCAGCCGCGTGGCGCTCCCCGACGTGGGGCTG
TTTTCGGACGGCACGGCCGTGAAGCTGGTGGGCGAGGAGACCTTCCGCGTCGCGAGCGGGCTGGTGGACGAGTTCATCAC
GGTGGACACCGACGCCGTCTGCGCGGCGATCAAGGACATCTTCGTGGACACGCGCAGCATCGTGGAGCCCGCCGGGGCCC
TGGCGGTGGCGGCCATCAAGCAGTACGTGGCCCAACACAAGACCCGCGGGGAAACGTACGCCGCCATCCTGTGCGGCGCC
AACATGAATTTCGACCGCCTGCGCTTCGTCGCGGAGCGTGCCGAAGTGGGCGAAGAGCGCGAGGCGCTGCTGGCGGTGAC
GATCCCCGAGGAGCGCGGGAGCTTCCGGCGCTTCTGCGAGGTGGTCGGCCAGTTGCCCGGCGGCCCCCGCAACGTGACGG
AGTTCAACTACCGCATCAGCGATGCGTCGCGAGCCCACGTCTTCGTCGGGCTGACCACGCATGGCAAGGGCGAGTCGGAG
AAGATCGCGCGCAACTTCCAGCGCCATGGGTTCGAGGCGCTGGACCTCACGCACGACGAACTGACCAAGGAGCACCTGCG
GCACCTCGTGGGCGGCCGCTCCGGGCTCGCCCAGGACGAGCGGCTGCTGCGCATCATCTTCCCGGAGCGCCCGGGCGCGC
TCTTCAAGTTCCTGAGCATGATGCAGCCAAGCTGGAACATCAGCCTCTTCCACTACCGCAACCAGGGGGCGGACTACGGC
CGCATCCTCGTGGGCATGCAGGTGCCGGCGGGCGACGCACAGGCCTTCGAGGCCTTCCTGCAGACGCTGGGCTACCCCTA
CGTGGAAGAAACGCAGAACCCCGCGTACCGGCTGTTCCTGCAGGCGCCCGCGGGCCGGGGCTGA

Upstream 100 bases:

>100_bases
ATCTCACGATCCGGGGCCGTTTTTTTTTGCCCCGCCCGGCTGGGGCGGGCCGGCTGGGGCAAAGGCCTATGATGTCGGCC
CTGCCGCAGCCCACGCATCC

Downstream 100 bases:

>100_bases
CGCCTTCCGATCGCCAACGAGAAGCGACCGCCCCGCTGCCCCATGCAGGCCCTTCGCCACTTCCTGCTGGCCGTGCAGTT
CTTCACGCGCATCCCCGTGA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MTKTSPPALTPADYLKKILTARVYDVAVESALEPARALGRRLHNTVLLKREDQQPVFSFKLRGAYNKMAHLSAEQLQRGV
ICASAGNHAQGVAMSAKRLGTRAVVVMPTTTPQLKVDAVKTLGGEVVLHGDSYSDAYEHAARLQQEQGLTFVHPFDDPDV
IAGQGTIAMEILRQLQSLGSNRLDAVFVAIGGGGLVSGVANYIKAVRPEIRIVGVQMNDSDAMARSVASGSRVALPDVGL
FSDGTAVKLVGEETFRVASGLVDEFITVDTDAVCAAIKDIFVDTRSIVEPAGALAVAAIKQYVAQHKTRGETYAAILCGA
NMNFDRLRFVAERAEVGEEREALLAVTIPEERGSFRRFCEVVGQLPGGPRNVTEFNYRISDASRAHVFVGLTTHGKGESE
KIARNFQRHGFEALDLTHDELTKEHLRHLVGGRSGLAQDERLLRIIFPERPGALFKFLSMMQPSWNISLFHYRNQGADYG
RILVGMQVPAGDAQAFEAFLQTLGYPYVEETQNPAYRLFLQAPAGRG

Sequences:

>Translated_527_residues
MTKTSPPALTPADYLKKILTARVYDVAVESALEPARALGRRLHNTVLLKREDQQPVFSFKLRGAYNKMAHLSAEQLQRGV
ICASAGNHAQGVAMSAKRLGTRAVVVMPTTTPQLKVDAVKTLGGEVVLHGDSYSDAYEHAARLQQEQGLTFVHPFDDPDV
IAGQGTIAMEILRQLQSLGSNRLDAVFVAIGGGGLVSGVANYIKAVRPEIRIVGVQMNDSDAMARSVASGSRVALPDVGL
FSDGTAVKLVGEETFRVASGLVDEFITVDTDAVCAAIKDIFVDTRSIVEPAGALAVAAIKQYVAQHKTRGETYAAILCGA
NMNFDRLRFVAERAEVGEEREALLAVTIPEERGSFRRFCEVVGQLPGGPRNVTEFNYRISDASRAHVFVGLTTHGKGESE
KIARNFQRHGFEALDLTHDELTKEHLRHLVGGRSGLAQDERLLRIIFPERPGALFKFLSMMQPSWNISLFHYRNQGADYG
RILVGMQVPAGDAQAFEAFLQTLGYPYVEETQNPAYRLFLQAPAGRG
>Mature_526_residues
TKTSPPALTPADYLKKILTARVYDVAVESALEPARALGRRLHNTVLLKREDQQPVFSFKLRGAYNKMAHLSAEQLQRGVI
CASAGNHAQGVAMSAKRLGTRAVVVMPTTTPQLKVDAVKTLGGEVVLHGDSYSDAYEHAARLQQEQGLTFVHPFDDPDVI
AGQGTIAMEILRQLQSLGSNRLDAVFVAIGGGGLVSGVANYIKAVRPEIRIVGVQMNDSDAMARSVASGSRVALPDVGLF
SDGTAVKLVGEETFRVASGLVDEFITVDTDAVCAAIKDIFVDTRSIVEPAGALAVAAIKQYVAQHKTRGETYAAILCGAN
MNFDRLRFVAERAEVGEEREALLAVTIPEERGSFRRFCEVVGQLPGGPRNVTEFNYRISDASRAHVFVGLTTHGKGESEK
IARNFQRHGFEALDLTHDELTKEHLRHLVGGRSGLAQDERLLRIIFPERPGALFKFLSMMQPSWNISLFHYRNQGADYGR
ILVGMQVPAGDAQAFEAFLQTLGYPYVEETQNPAYRLFLQAPAGRG

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=304, Percent_Identity=30.2631578947368, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI33469958, Length=321, Percent_Identity=28.6604361370716, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI19923959, Length=307, Percent_Identity=26.7100977198697, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790207, Length=524, Percent_Identity=51.1450381679389, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1789505, Length=332, Percent_Identity=35.8433734939759, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17537387, Length=387, Percent_Identity=31.266149870801, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71991565, Length=373, Percent_Identity=30.0268096514745, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17508781, Length=281, Percent_Identity=29.1814946619217, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320930, Length=525, Percent_Identity=48, Blast_Score=480, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322631, Length=307, Percent_Identity=33.5504885993485, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6319788, Length=228, Percent_Identity=27.6315789473684, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355833, Length=312, Percent_Identity=30.7692307692308, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24645328, Length=253, Percent_Identity=28.0632411067194, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 57417; Mature: 57286

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00583 PFKB_KINASES_1 ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTSPPALTPADYLKKILTARVYDVAVESALEPARALGRRLHNTVLLKREDQQPVFSFK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEE
LRGAYNKMAHLSAEQLQRGVICASAGNHAQGVAMSAKRLGTRAVVVMPTTTPQLKVDAVK
ECCHHHHHHHCCHHHHHCCEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCEEHHHHH
TLGGEVVLHGDSYSDAYEHAARLQQEQGLTFVHPFDDPDVIAGQGTIAMEILRQLQSLGS
HCCCEEEEECCCCCHHHHHHHHHHHHCCCEEECCCCCCCEEECCCHHHHHHHHHHHHCCC
NRLDAVFVAIGGGGLVSGVANYIKAVRPEIRIVGVQMNDSDAMARSVASGSRVALPDVGL
CCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHCCCCEEECCCCCC
FSDGTAVKLVGEETFRVASGLVDEFITVDTDAVCAAIKDIFVDTRSIVEPAGALAVAAIK
CCCCCEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
QYVAQHKTRGETYAAILCGANMNFDRLRFVAERAEVGEEREALLAVTIPEERGSFRRFCE
HHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCHHHHHHH
VVGQLPGGPRNVTEFNYRISDASRAHVFVGLTTHGKGESEKIARNFQRHGFEALDLTHDE
HHHCCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEECCCHHH
LTKEHLRHLVGGRSGLAQDERLLRIIFPERPGALFKFLSMMQPSWNISLFHYRNQGADYG
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCC
RILVGMQVPAGDAQAFEAFLQTLGYPYVEETQNPAYRLFLQAPAGRG
EEEEEEECCCCCHHHHHHHHHHHCCCCHHCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
TKTSPPALTPADYLKKILTARVYDVAVESALEPARALGRRLHNTVLLKREDQQPVFSFK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEE
LRGAYNKMAHLSAEQLQRGVICASAGNHAQGVAMSAKRLGTRAVVVMPTTTPQLKVDAVK
ECCHHHHHHHCCHHHHHCCEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCEEHHHHH
TLGGEVVLHGDSYSDAYEHAARLQQEQGLTFVHPFDDPDVIAGQGTIAMEILRQLQSLGS
HCCCEEEEECCCCCHHHHHHHHHHHHCCCEEECCCCCCCEEECCCHHHHHHHHHHHHCCC
NRLDAVFVAIGGGGLVSGVANYIKAVRPEIRIVGVQMNDSDAMARSVASGSRVALPDVGL
CCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHCCCCEEECCCCCC
FSDGTAVKLVGEETFRVASGLVDEFITVDTDAVCAAIKDIFVDTRSIVEPAGALAVAAIK
CCCCCEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
QYVAQHKTRGETYAAILCGANMNFDRLRFVAERAEVGEEREALLAVTIPEERGSFRRFCE
HHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCHHHHHHH
VVGQLPGGPRNVTEFNYRISDASRAHVFVGLTTHGKGESEKIARNFQRHGFEALDLTHDE
HHHCCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEECCCHHH
LTKEHLRHLVGGRSGLAQDERLLRIIFPERPGALFKFLSMMQPSWNISLFHYRNQGADYG
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCC
RILVGMQVPAGDAQAFEAFLQTLGYPYVEETQNPAYRLFLQAPAGRG
EEEEEEECCCCCHHHHHHHHHHHCCCCHHCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA