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The map label for this gene is ung [H]

Identifier: 120609287

GI number: 120609287

Start: 639828

End: 640553

Strand: Direct

Name: ung [H]

Synonym: Aave_0587

Alternate gene names: 120609287

Gene position: 639828-640553 (Clockwise)

Preceding gene: 120609286

Following gene: 120609288

Centisome position: 11.95

GC content: 72.04

Gene sequence:

>726_bases
ATGACCCCATCCGCGCACGCCCCCTCCGCCCCGCCTTCGCAGTTGCAGAGCGCCGATCCCGCCGACTGGCCGGTGGCGTC
CGGCTGGCAGCCGCTGGTCGATGATTTCTTCGCGAGCGCGCGCGGGCAGGCGCTGCTGGGCTTCCTGCGCCAGCGGCTGG
ATGCGGGTGCGGTGATCTTTCCGCCTCGGCCGCTGCGCGCGCTGGAGCTCACGCCGCCGGAGTCGGTGCGCGTGGTCATC
CTGGGACAGGACCCCTACCACGGGCGCGGCCAGGCCGAAGGGCTGGCCTTCTCGGTCGCCCCCGGCGTGGCCCTGCCGCC
CTCGCTGCGCAACATCTTCAAGGAATTGCAGCGCGACCTGGGCACACCGTTCCCCGCCTGGCCCGAGCCGGGCGGCAGCC
TCGTCAAGTGGGCGAAGAACGGCGTGCTGCTGCTCAACACCTGCCTCACCGTCGAAGAGTCCCAGCCCGCAAGCCACGCG
GGCAAGGGCTGGGAGCAGCTCACCGACGCCGTGATCCGCAAGGTGGGCGAGGGCGACCGGCCCGCGGTCTTCATGCTATG
GGGATCGCACGCGCAGTCCAAGCGGCCGCTCATCGACGCCAGCCGCCACCTCGTGCTGACCGCCAACCATCCATCGCCCC
TGTCCGCACTGAGGCCGCCCGTGCCCTTCATCGGCTGCGGGCATTTCGGCCGGGCGCGGGAGTTCCGCGAGCAGCAGAGC
GGCTGA

Upstream 100 bases:

>100_bases
TGCGGGCCCAGGAGCCCGGGGCCGCGCTGGCGAAGCTGTTCGCCTGATCCCGCCCACTCCGCCACCGCTGCCGGGCCCGC
CCGGTATTTGCCCACCGACC

Downstream 100 bases:

>100_bases
CGCGTTGCGGCGAAGCGTTTCCGGCGGAGCGCCCCACGGACTCGCGTGCAGTACGTGCATGACAGTAAGCGGGAGGAAGA
CACCATGAGGGCCGTGTGAG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTPSAHAPSAPPSQLQSADPADWPVASGWQPLVDDFFASARGQALLGFLRQRLDAGAVIFPPRPLRALELTPPESVRVVI
LGQDPYHGRGQAEGLAFSVAPGVALPPSLRNIFKELQRDLGTPFPAWPEPGGSLVKWAKNGVLLLNTCLTVEESQPASHA
GKGWEQLTDAVIRKVGEGDRPAVFMLWGSHAQSKRPLIDASRHLVLTANHPSPLSALRPPVPFIGCGHFGRAREFREQQS
G

Sequences:

>Translated_241_residues
MTPSAHAPSAPPSQLQSADPADWPVASGWQPLVDDFFASARGQALLGFLRQRLDAGAVIFPPRPLRALELTPPESVRVVI
LGQDPYHGRGQAEGLAFSVAPGVALPPSLRNIFKELQRDLGTPFPAWPEPGGSLVKWAKNGVLLLNTCLTVEESQPASHA
GKGWEQLTDAVIRKVGEGDRPAVFMLWGSHAQSKRPLIDASRHLVLTANHPSPLSALRPPVPFIGCGHFGRAREFREQQS
G
>Mature_240_residues
TPSAHAPSAPPSQLQSADPADWPVASGWQPLVDDFFASARGQALLGFLRQRLDAGAVIFPPRPLRALELTPPESVRVVIL
GQDPYHGRGQAEGLAFSVAPGVALPPSLRNIFKELQRDLGTPFPAWPEPGGSLVKWAKNGVLLLNTCLTVEESQPASHAG
KGWEQLTDAVIRKVGEGDRPAVFMLWGSHAQSKRPLIDASRHLVLTANHPSPLSALRPPVPFIGCGHFGRAREFREQQSG

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=222, Percent_Identity=44.5945945945946, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI6224979, Length=222, Percent_Identity=44.5945945945946, Blast_Score=158, Evalue=4e-39,
Organism=Escherichia coli, GI1788934, Length=188, Percent_Identity=52.1276595744681, Blast_Score=179, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17556304, Length=229, Percent_Identity=37.9912663755458, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323620, Length=241, Percent_Identity=37.7593360995851, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25953; Mature: 25822

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSAHAPSAPPSQLQSADPADWPVASGWQPLVDDFFASARGQALLGFLRQRLDAGAVIF
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEE
PPRPLRALELTPPESVRVVILGQDPYHGRGQAEGLAFSVAPGVALPPSLRNIFKELQRDL
CCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
GTPFPAWPEPGGSLVKWAKNGVLLLNTCLTVEESQPASHAGKGWEQLTDAVIRKVGEGDR
CCCCCCCCCCCCHHHHHHCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCC
PAVFMLWGSHAQSKRPLIDASRHLVLTANHPSPLSALRPPVPFIGCGHFGRAREFREQQS
CEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCCEEECCCCHHHHHHHHHCC
G
C
>Mature Secondary Structure 
TPSAHAPSAPPSQLQSADPADWPVASGWQPLVDDFFASARGQALLGFLRQRLDAGAVIF
CCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEE
PPRPLRALELTPPESVRVVILGQDPYHGRGQAEGLAFSVAPGVALPPSLRNIFKELQRDL
CCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
GTPFPAWPEPGGSLVKWAKNGVLLLNTCLTVEESQPASHAGKGWEQLTDAVIRKVGEGDR
CCCCCCCCCCCCHHHHHHCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCC
PAVFMLWGSHAQSKRPLIDASRHLVLTANHPSPLSALRPPVPFIGCGHFGRAREFREQQS
CEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCCEEECCCCHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA