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The map label for this gene is trpC

Identifier: 120609286

GI number: 120609286

Start: 638974

End: 639774

Strand: Direct

Name: trpC

Synonym: Aave_0586

Alternate gene names: 120609286

Gene position: 638974-639774 (Clockwise)

Preceding gene: 120609285

Following gene: 120609287

Centisome position: 11.94

GC content: 67.67

Gene sequence:

>801_bases
ATGAGTGACATCCTGAACAAGATCGTGGCCGTCAAGCGCGAGGAAATCGCGGCGGCGCAGAAGAAGATCCCCCTGGCCGC
CATGCGCGCCGACGCCGAGAGCCGCGTGCTCACGCGCGATTTCGAGGGCGCCCTGCGCGCGAAGATCGCCGCGGGCCAGG
CGGCGGTGATCGCCGAGATCAAGAAGGCCAGCCCCAGCAAGGGCGTGATCCGCGAAAACTTCATCCCGGCCGACATCGCC
CAGAGCTATGCCGAAGGCAATGGCAAGGTCAGCGCGGCCTGTCTCTCGGTGCTGACCGACAGGCAGTTCTTCCAGGGCCA
GCCCGACTACCTCAAGCAGGCCCGCGCGAGCTGCGCGCTGCCGGTGCTGCGCAAGGACTTCATGGTCGATGCCTACCAGA
TCTACGAATCGCGCGCGATGGGTGCCGACGCCATCCTGCTGATCGCCGCCTGCCTGGAGGATGCGCAGATGGCGGAGTTC
GAGGCCATCGCCCACAGCCTGGGCATGGCCGCGCTGGTGGAGGTGCACGACGGCGCCGAACTGGACCGCGCCCTCAAGCT
GCGCACGCCGCTGGTGGGCATCAACAACCGCAACCTGCGCACCTTCGAGGTGTCGCTGGACACCACCGTCTCGCTGCGCA
AAGCGGTCCCGTCCGACCGGCTGCTGGTGGCGGAATCCGGCATCCTCACGCCACAGGACGTCAAGACCCTGCGCGATGCC
GACGTGCATGCCTTCCTCGTGGGTGAAGCCTTCATGCGGGCCCAGGAGCCCGGGGCCGCGCTGGCGAAGCTGTTCGCCTG
A

Upstream 100 bases:

>100_bases
TTCATCGTGGCGGGCATCGTGATGCACCGCGTCTTCATCCACATCCTGAAAAATGGCGCCCCCGAAGCGGAGGCGTCTCC
TTTGAAGAAAGCACCGGAAC

Downstream 100 bases:

>100_bases
TCCCGCCCACTCCGCCACCGCTGCCGGGCCCGCCCGGTATTTGCCCACCGACCATGACCCCATCCGCGCACGCCCCCTCC
GCCCCGCCTTCGCAGTTGCA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSDILNKIVAVKREEIAAAQKKIPLAAMRADAESRVLTRDFEGALRAKIAAGQAAVIAEIKKASPSKGVIRENFIPADIA
QSYAEGNGKVSAACLSVLTDRQFFQGQPDYLKQARASCALPVLRKDFMVDAYQIYESRAMGADAILLIAACLEDAQMAEF
EAIAHSLGMAALVEVHDGAELDRALKLRTPLVGINNRNLRTFEVSLDTTVSLRKAVPSDRLLVAESGILTPQDVKTLRDA
DVHAFLVGEAFMRAQEPGAALAKLFA

Sequences:

>Translated_266_residues
MSDILNKIVAVKREEIAAAQKKIPLAAMRADAESRVLTRDFEGALRAKIAAGQAAVIAEIKKASPSKGVIRENFIPADIA
QSYAEGNGKVSAACLSVLTDRQFFQGQPDYLKQARASCALPVLRKDFMVDAYQIYESRAMGADAILLIAACLEDAQMAEF
EAIAHSLGMAALVEVHDGAELDRALKLRTPLVGINNRNLRTFEVSLDTTVSLRKAVPSDRLLVAESGILTPQDVKTLRDA
DVHAFLVGEAFMRAQEPGAALAKLFA
>Mature_265_residues
SDILNKIVAVKREEIAAAQKKIPLAAMRADAESRVLTRDFEGALRAKIAAGQAAVIAEIKKASPSKGVIRENFIPADIAQ
SYAEGNGKVSAACLSVLTDRQFFQGQPDYLKQARASCALPVLRKDFMVDAYQIYESRAMGADAILLIAACLEDAQMAEFE
AIAHSLGMAALVEVHDGAELDRALKLRTPLVGINNRNLRTFEVSLDTTVSLRKAVPSDRLLVAESGILTPQDVKTLRDAD
VHAFLVGEAFMRAQEPGAALAKLFA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=265, Percent_Identity=39.2452830188679, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=269, Percent_Identity=37.1747211895911, Blast_Score=148, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_ACIAC (A1TJQ2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_968964.1
- ProteinModelPortal:   A1TJQ2
- SMR:   A1TJQ2
- STRING:   A1TJQ2
- GeneID:   4668141
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0586
- NMPDR:   fig|397945.5.peg.503
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- PhylomeDB:   A1TJQ2
- ProtClustDB:   PRK00278
- BioCyc:   AAVE397945:AAVE_0586-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28679; Mature: 28548

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILNKIVAVKREEIAAAQKKIPLAAMRADAESRVLTRDFEGALRAKIAAGQAAVIAEI
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
KKASPSKGVIRENFIPADIAQSYAEGNGKVSAACLSVLTDRQFFQGQPDYLKQARASCAL
HHCCCCCCCHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCH
PVLRKDFMVDAYQIYESRAMGADAILLIAACLEDAQMAEFEAIAHSLGMAALVEVHDGAE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEECCCHH
LDRALKLRTPLVGINNRNLRTFEVSLDTTVSLRKAVPSDRLLVAESGILTPQDVKTLRDA
HHHHHHHCCCEEECCCCCEEEEEEECCCHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHC
DVHAFLVGEAFMRAQEPGAALAKLFA
CHHHHHHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure 
SDILNKIVAVKREEIAAAQKKIPLAAMRADAESRVLTRDFEGALRAKIAAGQAAVIAEI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
KKASPSKGVIRENFIPADIAQSYAEGNGKVSAACLSVLTDRQFFQGQPDYLKQARASCAL
HHCCCCCCCHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCH
PVLRKDFMVDAYQIYESRAMGADAILLIAACLEDAQMAEFEAIAHSLGMAALVEVHDGAE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEECCCHH
LDRALKLRTPLVGINNRNLRTFEVSLDTTVSLRKAVPSDRLLVAESGILTPQDVKTLRDA
HHHHHHHCCCEEECCCCCEEEEEEECCCHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHC
DVHAFLVGEAFMRAQEPGAALAKLFA
CHHHHHHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA