Click here to switch to the map view.

The map label for this gene is intA [H]

Identifier: 120609187

GI number: 120609187

Start: 523213

End: 524478

Strand: Direct

Name: intA [H]

Synonym: Aave_0484

Alternate gene names: 120609187

Gene position: 523213-524478 (Clockwise)

Preceding gene: 120609186

Following gene: 120609199

Centisome position: 9.77

GC content: 60.98

Gene sequence:

>1266_bases
ATGGCAGTCAACCTGCTTTCCGCGCGTAGGGTCGAGACCGCCCAGCCCCGTGAAAAGAGCTACATGCTCAAGGACGGGGG
AAGCCTGTTCCTATACATCACACCGCACGGTGCCAAGCTCTTCCGGTACCGCTATCGCATCGGTGGGAAGCCGCAGATCT
ACTCCATAGGCGCCTACCCGGAGGTCTCACTTGAGGCTGCCCGAAAGGAGCGAGACCAGGCTCGCGAACTGGTGAAGAAG
GGCATCCACCCGCTGACGAACAAGAAGATCAAGCTGGTGGAGCAGATCGCGAGCAATGACAACACGTACGAGGCGGTGGC
TCGCCGATGGATGCAAGACAACAGCCACTGGAGCAGTGGGTACGCCGGTCAGGTCAAGCACTATCTGACCCAGGACGTTT
TTCCCCTGATCGGTCGGTTGCCGCTGGTATCCATCAAGCCGTCGCACCTCCGTCCGGTGATCGAGGCCGTGTCTGCTCGT
GGGGCGAAAAGCATCGCGGTGCTCATTCGGCAGTGGAGTGGTCAGATCTTTGCGTACGGCGCGACCCGAGGGCTCTGTGA
GGACGATCCTGCGGCCCTGTTGAAGGGATTGGTCAAGCGTCCACCCGTGCGTCACAACCCGCCTCTGAGCTGGTCCGAGT
TGCCGGGCTACCTTCGTAGAGTGGATGCGGAAGGCGGGTATCGGACCACGGTGATCGCACTGCGGTTGATGGCGCTGCTC
TTCGTCCGCACGGCCGAACTGCGCAAAGCATGGTGGGAAGAGTTCGATTTCGAGGCCGCTTTGTGGATCATTCCCGCCGG
GCGCATGAAGATGCGGCGGCCGCACATCGTGCCGCTGTCGAAACAGGCGATTGCGCTCTTGCTTGAGCTGCGGCAACTCA
CCGGCGGCGGCAAGGTGCTCTTTCCCAGCTATCGCAAGCCTGGCCAAGTGATGTCCGCAAGCACGCTGAACCAGGCACTG
AAGCGCATGGGATACGGCGGCCGATTCTCGGCACATGGGTTCCGTTCAACGGCGATGACGATGCTGAGCTTGCTGTCTTA
TCCGGAGAAGCGGGTGGACCTCCAGTTGGCCCACAGCGAGGAAGACTCTTCTCGCGCCCCATACGACCACACCAAGTTCA
TGGAGTCGCGCAAGATCATCATGCAGGACTGGGCAGACATCCTGGACGAATGCGCGGGCGGTGCATCCGTAGCGGACATC
ACAGCGAAGTTCGGTCCCATGTCCGAGCGCCGGAAAGCACTTTTGAGTGTCATCGAGCGCGAGTGA

Upstream 100 bases:

>100_bases
CGGCAACTTATGGCGGTTTAGTGTCTGCTGACGGCTGGGGAAATCTGCCGCGAATGTGTATATTTGGGTGTGTATCAGGT
CCTTCGGAAGGGATATACAC

Downstream 100 bases:

>100_bases
CCGTAAAAGAGACAAGGCCGGGCTGAGGCCTCAATTCTTGTAGCCCTGTTTTTGTGGCCCGGGGAGAAGTCGTAGAGAAA
TGTCGTCGGCCACCCCGTCT

Product: phage integrase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MAVNLLSARRVETAQPREKSYMLKDGGSLFLYITPHGAKLFRYRYRIGGKPQIYSIGAYPEVSLEAARKERDQARELVKK
GIHPLTNKKIKLVEQIASNDNTYEAVARRWMQDNSHWSSGYAGQVKHYLTQDVFPLIGRLPLVSIKPSHLRPVIEAVSAR
GAKSIAVLIRQWSGQIFAYGATRGLCEDDPAALLKGLVKRPPVRHNPPLSWSELPGYLRRVDAEGGYRTTVIALRLMALL
FVRTAELRKAWWEEFDFEAALWIIPAGRMKMRRPHIVPLSKQAIALLLELRQLTGGGKVLFPSYRKPGQVMSASTLNQAL
KRMGYGGRFSAHGFRSTAMTMLSLLSYPEKRVDLQLAHSEEDSSRAPYDHTKFMESRKIIMQDWADILDECAGGASVADI
TAKFGPMSERRKALLSVIERE

Sequences:

>Translated_421_residues
MAVNLLSARRVETAQPREKSYMLKDGGSLFLYITPHGAKLFRYRYRIGGKPQIYSIGAYPEVSLEAARKERDQARELVKK
GIHPLTNKKIKLVEQIASNDNTYEAVARRWMQDNSHWSSGYAGQVKHYLTQDVFPLIGRLPLVSIKPSHLRPVIEAVSAR
GAKSIAVLIRQWSGQIFAYGATRGLCEDDPAALLKGLVKRPPVRHNPPLSWSELPGYLRRVDAEGGYRTTVIALRLMALL
FVRTAELRKAWWEEFDFEAALWIIPAGRMKMRRPHIVPLSKQAIALLLELRQLTGGGKVLFPSYRKPGQVMSASTLNQAL
KRMGYGGRFSAHGFRSTAMTMLSLLSYPEKRVDLQLAHSEEDSSRAPYDHTKFMESRKIIMQDWADILDECAGGASVADI
TAKFGPMSERRKALLSVIERE
>Mature_420_residues
AVNLLSARRVETAQPREKSYMLKDGGSLFLYITPHGAKLFRYRYRIGGKPQIYSIGAYPEVSLEAARKERDQARELVKKG
IHPLTNKKIKLVEQIASNDNTYEAVARRWMQDNSHWSSGYAGQVKHYLTQDVFPLIGRLPLVSIKPSHLRPVIEAVSARG
AKSIAVLIRQWSGQIFAYGATRGLCEDDPAALLKGLVKRPPVRHNPPLSWSELPGYLRRVDAEGGYRTTVIALRLMALLF
VRTAELRKAWWEEFDFEAALWIIPAGRMKMRRPHIVPLSKQAIALLLELRQLTGGGKVLFPSYRKPGQVMSASTLNQALK
RMGYGGRFSAHGFRSTAMTMLSLLSYPEKRVDLQLAHSEEDSSRAPYDHTKFMESRKIIMQDWADILDECAGGASVADIT
AKFGPMSERRKALLSVIERE

Specific function: Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome [H]

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1788974, Length=395, Percent_Identity=33.4177215189873, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1788690, Length=388, Percent_Identity=32.2164948453608, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI145693166, Length=398, Percent_Identity=32.1608040201005, Blast_Score=204, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR023109 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 47461; Mature: 47330

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: PS00024 HEMOPEXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNLLSARRVETAQPREKSYMLKDGGSLFLYITPHGAKLFRYRYRIGGKPQIYSIGAYP
CCCCCCHHHHCCCCCCHHHCEEEECCCEEEEEECCCCHHHHHHHHHCCCCCCEEEECCCC
EVSLEAARKERDQARELVKKGIHPLTNKKIKLVEQIASNDNTYEAVARRWMQDNSHWSSG
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
YAGQVKHYLTQDVFPLIGRLPLVSIKPSHLRPVIEAVSARGAKSIAVLIRQWSGQIFAYG
CHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEE
ATRGLCEDDPAALLKGLVKRPPVRHNPPLSWSELPGYLRRVDAEGGYRTTVIALRLMALL
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHCCCCCHHHHHHHHHHHHHH
FVRTAELRKAWWEEFDFEAALWIIPAGRMKMRRPHIVPLSKQAIALLLELRQLTGGGKVL
HHHHHHHHHHHHHHCCCCEEEEEEECCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
FPSYRKPGQVMSASTLNQALKRMGYGGRFSAHGFRSTAMTMLSLLSYPEKRVDLQLAHSE
ECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHCEEEEECCC
EDSSRAPYDHTKFMESRKIIMQDWADILDECAGGASVADITAKFGPMSERRKALLSVIER
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHC
E
C
>Mature Secondary Structure 
AVNLLSARRVETAQPREKSYMLKDGGSLFLYITPHGAKLFRYRYRIGGKPQIYSIGAYP
CCCCCHHHHCCCCCCHHHCEEEECCCEEEEEECCCCHHHHHHHHHCCCCCCEEEECCCC
EVSLEAARKERDQARELVKKGIHPLTNKKIKLVEQIASNDNTYEAVARRWMQDNSHWSSG
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
YAGQVKHYLTQDVFPLIGRLPLVSIKPSHLRPVIEAVSARGAKSIAVLIRQWSGQIFAYG
CHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEE
ATRGLCEDDPAALLKGLVKRPPVRHNPPLSWSELPGYLRRVDAEGGYRTTVIALRLMALL
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHCCCCCHHHHHHHHHHHHHH
FVRTAELRKAWWEEFDFEAALWIIPAGRMKMRRPHIVPLSKQAIALLLELRQLTGGGKVL
HHHHHHHHHHHHHHCCCCEEEEEEECCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
FPSYRKPGQVMSASTLNQALKRMGYGGRFSAHGFRSTAMTMLSLLSYPEKRVDLQLAHSE
ECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHCEEEEECCC
EDSSRAPYDHTKFMESRKIIMQDWADILDECAGGASVADITAKFGPMSERRKALLSVIER
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7511583; 9278503; 9205837; 7524073 [H]