Click here to switch to the map view.

The map label for this gene is trpE [H]

Identifier: 120609145

GI number: 120609145

Start: 479180

End: 480679

Strand: Direct

Name: trpE [H]

Synonym: Aave_0442

Alternate gene names: 120609145

Gene position: 479180-480679 (Clockwise)

Preceding gene: 120609143

Following gene: 120609146

Centisome position: 8.95

GC content: 67.73

Gene sequence:

>1500_bases
GTGATCACCGAACTCGAATTCAAAAGCTTGGCCGGCGAAGGCTACAACCGCATTCCGCTCATCGCGGAGGCCTTCGCGGA
CCTGGAAACCCCCCTGTCCCTCTACCTCAAGCTGGCCCATGCCCGCGACGGCGGCCGCTACAGCTTCCTGCTGGAATCCG
TGGTGGGCGGCGAGCGCTTCGGGCGCTACAGCTTCATCGGCCTGCCGGCACGCACGCTGCTGCGCGCCAGCGGCTTCGGC
GCCCAGGCGCGCACGGAAGTGGTGACCGACGGGCAGGTGGTGGAAACCGGCCACGGCAATCCCCTGGATTTCATCGCCGA
CTACCAGAAGCGCTTCAAGGTGGCGCTGCGACCCGGCCTGCCGCGCTTCTGCGGCGGCCTGGCGGGCTATTTCGGCTACG
ACGCGGTGCGCTACATCGAGAAGAAGCTGGAAGCGAGCTGCCCGCCCGACACGCTGGGCATGCCGGACATCCTGCTGCTG
CAGTGCGAGGAGGTGGCCGTCATCGACAACCTCTCTGGCAAGCTCTACCTGATCGTCTATGCGGATCCGGCGCAGCCCGA
GGCCTATGCCCGCGGCAAGAAGCGCCTGCGCGAACTGAAGGAGCAGCTCAAGTACTCGGTGGCCGCCCCCGTGGTCAAGC
CGACGGAGAGCCACCCGCCGCAGCGCGATTTCGCCAAGGCCGACTACCTGGCGGCCGTGGAGCGGGCCAAGGAACTCATC
GCCGCGGGCGACTTCATGCAGGTGCAGGTGGGCCAGCGCATCCACAAGCGCTACACCGAGTCGCCGCTGTCGCTCTACCG
CGCGCTGCGCTCGCTCAATCCTTCGCCCTACATGTACTACTACCACTTCGGCGACTGCCACGTGGTGGGGGCGAGCCCGG
AGATCCTGGTGCGCCAGGAGCGCACGGACGAGGGCCAGAAGATCACCATCCGCCCGCTGGCCGGCACGCGCCCGCGCGGC
GCCACGCCCGAGAAGGACAAGGCGGCCGAAAACGAGCTGGTGAACGACCCCAAGGAGCGTGCCGAGCACGTGATGCTCAT
CGACCTGGCGCGCAACGACATCGGGCGCATCGCCCGCACCGGCACGGTGAAGGTGACGGAGGCCTTCGCGGTGGAGCGCT
ACAGCCACGTGATGCACATCGTGAGCAATGTGGAAGGCCTGCTGAACGAAGGCATGACGAGCATGGACGTGCTCAAGGCG
ACCTTCCCCGCCGGCACGCTCACCGGCGCGCCCAAGGTGCATGCGATGGAGCTCATCGACCGGCTCGAGCCCACCAAGCG
GGGGCTGTACGGCGGCGCCTGCGGCTACCTCAGCTACGCAGGCGACATGGACGTGGCCATCGCCATCCGCACCGGGATCG
TGAAGGACGGGACGCTCTACGTGCAGGCCGCGGCCGGCGTGGTGGCGGACTCGGTCCCCGAGCTGGAATGGAAGGAAACG
GAGCACAAGGCCCGCGCCCTGCTGCGCGCGGCCGAACTCGTCGAAGAAGGACTGGAATGA

Upstream 100 bases:

>100_bases
CCGTGGCCCCTGCGGGGCCGAACGCAATGAACCTGGCGCGGCACCGGCCGCGGGCGCAACGACTGCCTGCGGCGGGCCGG
CCGATCTGGAGCGATCTCCC

Downstream 100 bases:

>100_bases
CCCGCGCCATCGAAAAGACCCGCAGTTGCAGCAGCATGGCGGAGGTGCGCGAGCGCATCGATGCGCTCGACGACATCCTC
GTGCCGTTGCTGGTGGAGCG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MITELEFKSLAGEGYNRIPLIAEAFADLETPLSLYLKLAHARDGGRYSFLLESVVGGERFGRYSFIGLPARTLLRASGFG
AQARTEVVTDGQVVETGHGNPLDFIADYQKRFKVALRPGLPRFCGGLAGYFGYDAVRYIEKKLEASCPPDTLGMPDILLL
QCEEVAVIDNLSGKLYLIVYADPAQPEAYARGKKRLRELKEQLKYSVAAPVVKPTESHPPQRDFAKADYLAAVERAKELI
AAGDFMQVQVGQRIHKRYTESPLSLYRALRSLNPSPYMYYYHFGDCHVVGASPEILVRQERTDEGQKITIRPLAGTRPRG
ATPEKDKAAENELVNDPKERAEHVMLIDLARNDIGRIARTGTVKVTEAFAVERYSHVMHIVSNVEGLLNEGMTSMDVLKA
TFPAGTLTGAPKVHAMELIDRLEPTKRGLYGGACGYLSYAGDMDVAIAIRTGIVKDGTLYVQAAAGVVADSVPELEWKET
EHKARALLRAAELVEEGLE

Sequences:

>Translated_499_residues
MITELEFKSLAGEGYNRIPLIAEAFADLETPLSLYLKLAHARDGGRYSFLLESVVGGERFGRYSFIGLPARTLLRASGFG
AQARTEVVTDGQVVETGHGNPLDFIADYQKRFKVALRPGLPRFCGGLAGYFGYDAVRYIEKKLEASCPPDTLGMPDILLL
QCEEVAVIDNLSGKLYLIVYADPAQPEAYARGKKRLRELKEQLKYSVAAPVVKPTESHPPQRDFAKADYLAAVERAKELI
AAGDFMQVQVGQRIHKRYTESPLSLYRALRSLNPSPYMYYYHFGDCHVVGASPEILVRQERTDEGQKITIRPLAGTRPRG
ATPEKDKAAENELVNDPKERAEHVMLIDLARNDIGRIARTGTVKVTEAFAVERYSHVMHIVSNVEGLLNEGMTSMDVLKA
TFPAGTLTGAPKVHAMELIDRLEPTKRGLYGGACGYLSYAGDMDVAIAIRTGIVKDGTLYVQAAAGVVADSVPELEWKET
EHKARALLRAAELVEEGLE
>Mature_499_residues
MITELEFKSLAGEGYNRIPLIAEAFADLETPLSLYLKLAHARDGGRYSFLLESVVGGERFGRYSFIGLPARTLLRASGFG
AQARTEVVTDGQVVETGHGNPLDFIADYQKRFKVALRPGLPRFCGGLAGYFGYDAVRYIEKKLEASCPPDTLGMPDILLL
QCEEVAVIDNLSGKLYLIVYADPAQPEAYARGKKRLRELKEQLKYSVAAPVVKPTESHPPQRDFAKADYLAAVERAKELI
AAGDFMQVQVGQRIHKRYTESPLSLYRALRSLNPSPYMYYYHFGDCHVVGASPEILVRQERTDEGQKITIRPLAGTRPRG
ATPEKDKAAENELVNDPKERAEHVMLIDLARNDIGRIARTGTVKVTEAFAVERYSHVMHIVSNVEGLLNEGMTSMDVLKA
TFPAGTLTGAPKVHAMELIDRLEPTKRGLYGGACGYLSYAGDMDVAIAIRTGIVKDGTLYVQAAAGVVADSVPELEWKET
EHKARALLRAAELVEEGLE

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=377, Percent_Identity=39.7877984084881, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788114, Length=450, Percent_Identity=30.8888888888889, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1786809, Length=225, Percent_Identity=29.3333333333333, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87082077, Length=278, Percent_Identity=28.4172661870504, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320935, Length=481, Percent_Identity=37.8378378378378, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6324361, Length=481, Percent_Identity=26.4033264033264, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54992; Mature: 54992

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITELEFKSLAGEGYNRIPLIAEAFADLETPLSLYLKLAHARDGGRYSFLLESVVGGERF
CCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCHHC
GRYSFIGLPARTLLRASGFGAQARTEVVTDGQVVETGHGNPLDFIADYQKRFKVALRPGL
CCEEEECCCHHHHHHHCCCCCCCCCEEECCCEEEECCCCCCHHHHHHHHHHHHHHCCCCC
PRFCGGLAGYFGYDAVRYIEKKLEASCPPDTLGMPDILLLQCEEVAVIDNLSGKLYLIVY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEECCCCCEEEEEE
ADPAQPEAYARGKKRLRELKEQLKYSVAAPVVKPTESHPPQRDFAKADYLAAVERAKELI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AAGDFMQVQVGQRIHKRYTESPLSLYRALRSLNPSPYMYYYHFGDCHVVGASPEILVRQE
HCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCEEEEEC
RTDEGQKITIRPLAGTRPRGATPEKDKAAENELVNDPKERAEHVMLIDLARNDIGRIART
CCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHCCEEEEEEEHHHHHHHHHCC
GTVKVTEAFAVERYSHVMHIVSNVEGLLNEGMTSMDVLKATFPAGTLTGAPKVHAMELID
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
RLEPTKRGLYGGACGYLSYAGDMDVAIAIRTGIVKDGTLYVQAAAGVVADSVPELEWKET
HCCHHHCCCCCCCHHHHEECCCCCEEEEEEECEEECCEEEEEECCCHHHCCCCCCCHHHH
EHKARALLRAAELVEEGLE
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITELEFKSLAGEGYNRIPLIAEAFADLETPLSLYLKLAHARDGGRYSFLLESVVGGERF
CCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCHHC
GRYSFIGLPARTLLRASGFGAQARTEVVTDGQVVETGHGNPLDFIADYQKRFKVALRPGL
CCEEEECCCHHHHHHHCCCCCCCCCEEECCCEEEECCCCCCHHHHHHHHHHHHHHCCCCC
PRFCGGLAGYFGYDAVRYIEKKLEASCPPDTLGMPDILLLQCEEVAVIDNLSGKLYLIVY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEECCCCCEEEEEE
ADPAQPEAYARGKKRLRELKEQLKYSVAAPVVKPTESHPPQRDFAKADYLAAVERAKELI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AAGDFMQVQVGQRIHKRYTESPLSLYRALRSLNPSPYMYYYHFGDCHVVGASPEILVRQE
HCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCEEEEEC
RTDEGQKITIRPLAGTRPRGATPEKDKAAENELVNDPKERAEHVMLIDLARNDIGRIART
CCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHCCEEEEEEEHHHHHHHHHCC
GTVKVTEAFAVERYSHVMHIVSNVEGLLNEGMTSMDVLKATFPAGTLTGAPKVHAMELID
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
RLEPTKRGLYGGACGYLSYAGDMDVAIAIRTGIVKDGTLYVQAAAGVVADSVPELEWKET
HCCHHHCCCCCCCHHHHEECCCCCEEEEEEECEEECCEEEEEECCCHHHCCCCCCCHHHH
EHKARALLRAAELVEEGLE
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]