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The map label for this gene is gltC [H]

Identifier: 120609006

GI number: 120609006

Start: 335581

End: 336504

Strand: Direct

Name: gltC [H]

Synonym: Aave_0303

Alternate gene names: 120609006

Gene position: 335581-336504 (Clockwise)

Preceding gene: 120609000

Following gene: 120609009

Centisome position: 6.27

GC content: 74.13

Gene sequence:

>924_bases
ATGGACATGAACCGCCTGCGCGCCCTGCGCGAGCTGGCCCGCTGCGGCACGATGGCCGCGGCCGCCGAGGCGCTGGCCCT
CACGCCCTCGGCGGTGTCGCAGCAGATCGCGCAGCTGGAGGCGGAAGCGGGCATCGCGCTCACCGAGCGCCAGGGGCGCG
GCGTGCGGCTCACGCCTGGGGGTGAAGCTTTGGTGCGGCATGCGGAACGCCTGATGGCGGTGCTGGACGAGGCCAAGTCC
GAGCTGGCGCTGCTGCGCCGGGAACTCGCGGGCGAGCTGCGCGTGGCGGCCTTCCCGTCGATCGCCTCGGCCCTGCTGCC
CGAGACCATCCAGGCGCTGCGGGCCGCCTATCCGCGCCTGCGCCTGGCCGTGGAGGAAATGGAGCCGGCGGACGGCCTGG
CGGCGCTCGGCTCCTGGCGCGCCGATATCGCGCTCATCGACCACCTCGCGCTGCGCCGTGACCGCCGGCAGGACGGATAC
GGCTTCGTGGCGCTGGCCCGGGATTCGCTGCACGTGCTGCTGCCCGCCACCCATCCCCTGGCGGCTCGTCCGTGGCTGGG
CGTGGCCGACCTGCGGGACGAGCCCTGGGCCATGGACGCCGCCTCCAGCAGCTTCGGCGAGTTCGTGCGCAACCTGTGCC
TTGCGGAAGGTTTCGAGCCGCGCATGGATGTGCGCGCCCTCGGCTTCGAGGTGGTGTCCGCCATGGTGGGCGCCGGCTGC
GCCGTGACCGTGGTGCCCGGGCTGCGCCTGCTGCGCCTGCTGCCGGGCACCCGCGCCGTGCCCCTGCGCCCGGCCGTCGC
CCGGGAAATATCCGTCGCCTTCCGGCGCGGCGAGCGCGACCACCCGGCCGTGAAGGTATTCATCGGCGAAATCGTGCGAG
CGGCGGAGCGCCTGTCCCGCCCGGCAGGCGATGTCACCTCATGA

Upstream 100 bases:

>100_bases
ATGGGCGCACAGCGTAGGCAACAAGTTTCGTCAGGTCCATTGATCTTTCATAAAGGAATACATTAGCAGTCTTGTCGAAT
TGCGAAAGGCCGGGGGACCC

Downstream 100 bases:

>100_bases
AGCCGTCATAGCCCGTCTTGAGGATCAGCGCCCCCACGACGAGGATGAAAATGCCGCGCACGAAGCCCGTGCCGTGCTTC
ATCGCCATGTGCGTGCCCAG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MDMNRLRALRELARCGTMAAAAEALALTPSAVSQQIAQLEAEAGIALTERQGRGVRLTPGGEALVRHAERLMAVLDEAKS
ELALLRRELAGELRVAAFPSIASALLPETIQALRAAYPRLRLAVEEMEPADGLAALGSWRADIALIDHLALRRDRRQDGY
GFVALARDSLHVLLPATHPLAARPWLGVADLRDEPWAMDAASSSFGEFVRNLCLAEGFEPRMDVRALGFEVVSAMVGAGC
AVTVVPGLRLLRLLPGTRAVPLRPAVAREISVAFRRGERDHPAVKVFIGEIVRAAERLSRPAGDVTS

Sequences:

>Translated_307_residues
MDMNRLRALRELARCGTMAAAAEALALTPSAVSQQIAQLEAEAGIALTERQGRGVRLTPGGEALVRHAERLMAVLDEAKS
ELALLRRELAGELRVAAFPSIASALLPETIQALRAAYPRLRLAVEEMEPADGLAALGSWRADIALIDHLALRRDRRQDGY
GFVALARDSLHVLLPATHPLAARPWLGVADLRDEPWAMDAASSSFGEFVRNLCLAEGFEPRMDVRALGFEVVSAMVGAGC
AVTVVPGLRLLRLLPGTRAVPLRPAVAREISVAFRRGERDHPAVKVFIGEIVRAAERLSRPAGDVTS
>Mature_307_residues
MDMNRLRALRELARCGTMAAAAEALALTPSAVSQQIAQLEAEAGIALTERQGRGVRLTPGGEALVRHAERLMAVLDEAKS
ELALLRRELAGELRVAAFPSIASALLPETIQALRAAYPRLRLAVEEMEPADGLAALGSWRADIALIDHLALRRDRRQDGY
GFVALARDSLHVLLPATHPLAARPWLGVADLRDEPWAMDAASSSFGEFVRNLCLAEGFEPRMDVRALGFEVVSAMVGAGC
AVTVVPGLRLLRLLPGTRAVPLRPAVAREISVAFRRGERDHPAVKVFIGEIVRAAERLSRPAGDVTS

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=283, Percent_Identity=27.9151943462898, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI157672245, Length=275, Percent_Identity=26.1818181818182, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787601, Length=247, Percent_Identity=22.2672064777328, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787806, Length=296, Percent_Identity=22.972972972973, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=292, Percent_Identity=24.6575342465753, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789204, Length=253, Percent_Identity=26.4822134387352, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788887, Length=299, Percent_Identity=26.4214046822742, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082132, Length=146, Percent_Identity=30.8219178082192, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788481, Length=226, Percent_Identity=27.8761061946903, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790262, Length=323, Percent_Identity=24.4582043343653, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787530, Length=258, Percent_Identity=24.8062015503876, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI48994962, Length=110, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788296, Length=185, Percent_Identity=29.7297297297297, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788297, Length=147, Percent_Identity=29.2517006802721, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1788626, Length=148, Percent_Identity=34.4594594594595, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33076; Mature: 33076

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMNRLRALRELARCGTMAAAAEALALTPSAVSQQIAQLEAEAGIALTERQGRGVRLTPG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCEEECCC
GEALVRHAERLMAVLDEAKSELALLRRELAGELRVAAFPSIASALLPETIQALRAAYPRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAVEEMEPADGLAALGSWRADIALIDHLALRRDRRQDGYGFVALARDSLHVLLPATHPL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCC
AARPWLGVADLRDEPWAMDAASSSFGEFVRNLCLAEGFEPRMDVRALGFEVVSAMVGAGC
CCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
AVTVVPGLRLLRLLPGTRAVPLRPAVAREISVAFRRGERDHPAVKVFIGEIVRAAERLSR
CEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
PAGDVTS
CCCCCCC
>Mature Secondary Structure
MDMNRLRALRELARCGTMAAAAEALALTPSAVSQQIAQLEAEAGIALTERQGRGVRLTPG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCEEECCC
GEALVRHAERLMAVLDEAKSELALLRRELAGELRVAAFPSIASALLPETIQALRAAYPRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAVEEMEPADGLAALGSWRADIALIDHLALRRDRRQDGYGFVALARDSLHVLLPATHPL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCC
AARPWLGVADLRDEPWAMDAASSSFGEFVRNLCLAEGFEPRMDVRALGFEVVSAMVGAGC
CCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
AVTVVPGLRLLRLLPGTRAVPLRPAVAREISVAFRRGERDHPAVKVFIGEIVRAAERLSR
CEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
PAGDVTS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]