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The map label for this gene is mrdA [H]

Identifier: 120609000

GI number: 120609000

Start: 328568

End: 330514

Strand: Direct

Name: mrdA [H]

Synonym: Aave_0297

Alternate gene names: 120609000

Gene position: 328568-330514 (Clockwise)

Preceding gene: 120608999

Following gene: 120609006

Centisome position: 6.14

GC content: 68.46

Gene sequence:

>1947_bases
ATGACCGAGCTGCGCAATACCGAGGCCGATCTCTCGCGGTTCCGCCTGCGCGTCCTGGTCGTGGGCTTCGTGGTGCTGCT
CGCCATGTGCCTGATCGTGGCGCGCCTGCTCGTGCTGCAGGTGGTTCGCCACGAAGACCTCGCCGACCAGGCCGAGAGCA
ACCGCACAGCGGTCGTGCCCATCGTACCCAACCGCGGGCTCATCCTGGACCGCAACGGCGTGGTGCTGGCCACCAACTAC
TCGGCCTATACGCTGGAGATCACGCCCTCGAAGGTGGACGGCCTGGAAGAGACCATCGACGCGCTTTCCAACATCGTGGA
GATCCACGCGCGCGACCGGCGCCGGTTCAAGAGGCTCATGGAGGAGTCGCGCAGCTTCGAATCCCTGCCGATCCGCACGC
GGTTGTCGGACCAGGAGGTCGCCCGCTTCACCGCCCAGCGCTACCGCTTCCCGGGCGTGGACATCAAGGCGCGGCTTTTC
CGCAACTACCCCCTGGGCGAAACCGCCAGCCATGCCATCGGCTACATCGGCCGCATCAACCAGCGCGAGAAGGAGCGCAT
CGAGGATTCCGAGGACGCGGCCAACTACCGCGGCACCGACCACATCGGCAAGCTCGGCATCGAGCAGAGCCAGGAGACCA
CGCTGCACGGCCAGACCGGCGTGGAGCGCATGGAGACCTCGGCCGGCGGCCATGCCGTGCGGCGGCTCGCGAGCCATCCG
GCCACGCCGGGCAACACCGTGATGCTGTCGCTCGACATCAAGCTGCAGAAGCTCGTGGAGGACATGTTCGGCGACCGCCG
CGGCGCGCTGGTGGCGATCGACCCGCGCAACGGCGAAGTGCTCGCGCTGGTGTCCAAGCCCACGTTCGATCCCAACCTGT
TCGTGGAAGGCATCGACTCGGAGAACTGGCAGGCGCTCAACGAATCGATCGACAAGCCGCTGCTCAACCGCGCCCTGCGC
GGCACCTACCCGCCCGGCTCCACCTACAAGCCCTTCATGGCGCTGGCCGCGCTGCAGCTGAACAAGCGCTCTCCCACGCA
GGTGTACAACGATCCGGGCTTCTACACCTACGGCGGCCACACCTTCCGCAGCCACGAGGGCGGGCTGGGCGGCGTGGACA
TGGTGCGCGCCATCCAGTTTTCCAGCAATACCTACTTCTATTCGCTGGCCGTGGACATGGGGGTGGACACCATCCACGAC
TTCATGAAGCCGCTGGGCTTCGGCCAGCTCACCGGCATCGACCTCAACGGCGAGGTGCGCGGCGTGCTGCCCAGCACCGA
ATGGAAGCGCAACGCCTACAAGCGCCCGGAGATGAAGCGCTGGTATTCGGGCGAGACCGTGTCCCTCGGCATCGGCCAGG
GCTACAACAGCTTCACCATGCTGCAACTGGCCTCGGCCGAGGCCACGCTGGCCAACGGCGGGATCCGCTACCGCCCCCAC
CTCGTGAAGGCCGTGCGCGACACCGTCACCGGCGTGGTCACGGAAGTGGCGCAGCCGCCCGGCGAGAACCTGGGCTATTC
GCCCCGCAACCTGGAGATCGTGCGCAATGGCCTCGTCGCGGTGATCAAGGCCGGCACGGGAACGCGCGTGTTCGCGGGCG
CGCCCTACACCGCGGCCGGCAAGACCGGCACCGCGCAGGCCGTGAGCCTCGGGCAGAACGTGAAGTACAACGCCAAGCTG
CTCGAAGAGCACCAGCGCGACCACTCGCTGTTCGCCGCCTTCGCGCCTGCGGAGAACCCGCGCATCGCCGTGGCGGTGAT
CGTCGAGAACGCGGGCTTCGGCGCGGCCGCCGCGGCGCCCATCGTGCGCCGCGTGTTCGACTACTGGCTGCAGGGGGACT
ACCCCAACGAGCAGGATCTGGCGGCCGTCGCCAAGGGCCAGGCCGGCGCGCCCATGGGCACGCCGCGGCGCGCGGCCGAC
GTGCCGGTCATGGCGCCCGCGCCCTGA

Upstream 100 bases:

>100_bases
CTCGCCAGTTGGGTGCTGCTCGCGCCGCAGCGCCTGCCGCCCGACCGCGACGAGAACCGGCCGCTCTGATCCGGCATCCG
TTTCCTTCCGCCCCGCCGAC

Downstream 100 bases:

>100_bases
CACCGGGCTGCCGGGCCGCCGCTCTTCAGCCGGTGGCCTGCGGCGAGCGCGGCGGCTGCAGCTGGCTGGCGATCAGCGCG
CCGACGATGAGCGCCGCCCC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MTELRNTEADLSRFRLRVLVVGFVVLLAMCLIVARLLVLQVVRHEDLADQAESNRTAVVPIVPNRGLILDRNGVVLATNY
SAYTLEITPSKVDGLEETIDALSNIVEIHARDRRRFKRLMEESRSFESLPIRTRLSDQEVARFTAQRYRFPGVDIKARLF
RNYPLGETASHAIGYIGRINQREKERIEDSEDAANYRGTDHIGKLGIEQSQETTLHGQTGVERMETSAGGHAVRRLASHP
ATPGNTVMLSLDIKLQKLVEDMFGDRRGALVAIDPRNGEVLALVSKPTFDPNLFVEGIDSENWQALNESIDKPLLNRALR
GTYPPGSTYKPFMALAALQLNKRSPTQVYNDPGFYTYGGHTFRSHEGGLGGVDMVRAIQFSSNTYFYSLAVDMGVDTIHD
FMKPLGFGQLTGIDLNGEVRGVLPSTEWKRNAYKRPEMKRWYSGETVSLGIGQGYNSFTMLQLASAEATLANGGIRYRPH
LVKAVRDTVTGVVTEVAQPPGENLGYSPRNLEIVRNGLVAVIKAGTGTRVFAGAPYTAAGKTGTAQAVSLGQNVKYNAKL
LEEHQRDHSLFAAFAPAENPRIAVAVIVENAGFGAAAAAPIVRRVFDYWLQGDYPNEQDLAAVAKGQAGAPMGTPRRAAD
VPVMAPAP

Sequences:

>Translated_648_residues
MTELRNTEADLSRFRLRVLVVGFVVLLAMCLIVARLLVLQVVRHEDLADQAESNRTAVVPIVPNRGLILDRNGVVLATNY
SAYTLEITPSKVDGLEETIDALSNIVEIHARDRRRFKRLMEESRSFESLPIRTRLSDQEVARFTAQRYRFPGVDIKARLF
RNYPLGETASHAIGYIGRINQREKERIEDSEDAANYRGTDHIGKLGIEQSQETTLHGQTGVERMETSAGGHAVRRLASHP
ATPGNTVMLSLDIKLQKLVEDMFGDRRGALVAIDPRNGEVLALVSKPTFDPNLFVEGIDSENWQALNESIDKPLLNRALR
GTYPPGSTYKPFMALAALQLNKRSPTQVYNDPGFYTYGGHTFRSHEGGLGGVDMVRAIQFSSNTYFYSLAVDMGVDTIHD
FMKPLGFGQLTGIDLNGEVRGVLPSTEWKRNAYKRPEMKRWYSGETVSLGIGQGYNSFTMLQLASAEATLANGGIRYRPH
LVKAVRDTVTGVVTEVAQPPGENLGYSPRNLEIVRNGLVAVIKAGTGTRVFAGAPYTAAGKTGTAQAVSLGQNVKYNAKL
LEEHQRDHSLFAAFAPAENPRIAVAVIVENAGFGAAAAAPIVRRVFDYWLQGDYPNEQDLAAVAKGQAGAPMGTPRRAAD
VPVMAPAP
>Mature_647_residues
TELRNTEADLSRFRLRVLVVGFVVLLAMCLIVARLLVLQVVRHEDLADQAESNRTAVVPIVPNRGLILDRNGVVLATNYS
AYTLEITPSKVDGLEETIDALSNIVEIHARDRRRFKRLMEESRSFESLPIRTRLSDQEVARFTAQRYRFPGVDIKARLFR
NYPLGETASHAIGYIGRINQREKERIEDSEDAANYRGTDHIGKLGIEQSQETTLHGQTGVERMETSAGGHAVRRLASHPA
TPGNTVMLSLDIKLQKLVEDMFGDRRGALVAIDPRNGEVLALVSKPTFDPNLFVEGIDSENWQALNESIDKPLLNRALRG
TYPPGSTYKPFMALAALQLNKRSPTQVYNDPGFYTYGGHTFRSHEGGLGGVDMVRAIQFSSNTYFYSLAVDMGVDTIHDF
MKPLGFGQLTGIDLNGEVRGVLPSTEWKRNAYKRPEMKRWYSGETVSLGIGQGYNSFTMLQLASAEATLANGGIRYRPHL
VKAVRDTVTGVVTEVAQPPGENLGYSPRNLEIVRNGLVAVIKAGTGTRVFAGAPYTAAGKTGTAQAVSLGQNVKYNAKLL
EEHQRDHSLFAAFAPAENPRIAVAVIVENAGFGAAAAAPIVRRVFDYWLQGDYPNEQDLAAVAKGQAGAPMGTPRRAADV
PVMAPAP

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=627, Percent_Identity=40.3508771929825, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI1786272, Length=617, Percent_Identity=26.0940032414911, Blast_Score=136, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71075; Mature: 70944

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELRNTEADLSRFRLRVLVVGFVVLLAMCLIVARLLVLQVVRHEDLADQAESNRTAVVP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
IVPNRGLILDRNGVVLATNYSAYTLEITPSKVDGLEETIDALSNIVEIHARDRRRFKRLM
EECCCCEEEECCCEEEEECCCEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EESRSFESLPIRTRLSDQEVARFTAQRYRFPGVDIKARLFRNYPLGETASHAIGYIGRIN
HHCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCC
QREKERIEDSEDAANYRGTDHIGKLGIEQSQETTLHGQTGVERMETSAGGHAVRRLASHP
HHHHHHCCCCHHHHCCCCCCHHHHCCCCCCCCCEECCCCCHHHHHHCCCHHHHHHHHHCC
ATPGNTVMLSLDIKLQKLVEDMFGDRRGALVAIDPRNGEVLALVSKPTFDPNLFVEGIDS
CCCCCEEEEEECHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEECCCC
ENWQALNESIDKPLLNRALRGTYPPGSTYKPFMALAALQLNKRSPTQVYNDPGFYTYGGH
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCEECCCCEEEECCC
TFRSHEGGLGGVDMVRAIQFSSNTYFYSLAVDMGVDTIHDFMKPLGFGQLTGIDLNGEVR
EEECCCCCCCHHHHHHHEEECCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCEE
GVLPSTEWKRNAYKRPEMKRWYSGETVSLGIGQGYNSFTMLQLASAEATLANGGIRYRPH
ECCCCCHHHHHCCCCCCHHHHCCCCEEEEECCCCCCCEEEEEEECCCHHHHCCCEEECHH
LVKAVRDTVTGVVTEVAQPPGENLGYSPRNLEIVRNGLVAVIKAGTGTRVFAGAPYTAAG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCEEEECCCCCCCC
KTGTAQAVSLGQNVKYNAKLLEEHQRDHSLFAAFAPAENPRIAVAVIVENAGFGAAAAAP
CCCCHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHH
IVRRVFDYWLQGDYPNEQDLAAVAKGQAGAPMGTPRRAADVPVMAPAP
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TELRNTEADLSRFRLRVLVVGFVVLLAMCLIVARLLVLQVVRHEDLADQAESNRTAVVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
IVPNRGLILDRNGVVLATNYSAYTLEITPSKVDGLEETIDALSNIVEIHARDRRRFKRLM
EECCCCEEEECCCEEEEECCCEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EESRSFESLPIRTRLSDQEVARFTAQRYRFPGVDIKARLFRNYPLGETASHAIGYIGRIN
HHCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCC
QREKERIEDSEDAANYRGTDHIGKLGIEQSQETTLHGQTGVERMETSAGGHAVRRLASHP
HHHHHHCCCCHHHHCCCCCCHHHHCCCCCCCCCEECCCCCHHHHHHCCCHHHHHHHHHCC
ATPGNTVMLSLDIKLQKLVEDMFGDRRGALVAIDPRNGEVLALVSKPTFDPNLFVEGIDS
CCCCCEEEEEECHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEECCCC
ENWQALNESIDKPLLNRALRGTYPPGSTYKPFMALAALQLNKRSPTQVYNDPGFYTYGGH
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCEECCCCEEEECCC
TFRSHEGGLGGVDMVRAIQFSSNTYFYSLAVDMGVDTIHDFMKPLGFGQLTGIDLNGEVR
EEECCCCCCCHHHHHHHEEECCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCEE
GVLPSTEWKRNAYKRPEMKRWYSGETVSLGIGQGYNSFTMLQLASAEATLANGGIRYRPH
ECCCCCHHHHHCCCCCCHHHHCCCCEEEEECCCCCCCEEEEEEECCCHHHHCCCEEECHH
LVKAVRDTVTGVVTEVAQPPGENLGYSPRNLEIVRNGLVAVIKAGTGTRVFAGAPYTAAG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCEEEECCCCCCCC
KTGTAQAVSLGQNVKYNAKLLEEHQRDHSLFAAFAPAENPRIAVAVIVENAGFGAAAAAP
CCCCHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHH
IVRRVFDYWLQGDYPNEQDLAAVAKGQAGAPMGTPRRAADVPVMAPAP
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]