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The map label for this gene is ilvE [H]

Identifier: 120608967

GI number: 120608967

Start: 293988

End: 294926

Strand: Direct

Name: ilvE [H]

Synonym: Aave_0264

Alternate gene names: 120608967

Gene position: 293988-294926 (Clockwise)

Preceding gene: 120608966

Following gene: 120608968

Centisome position: 5.49

GC content: 66.13

Gene sequence:

>939_bases
ATGAGCCCCGTAGTTCCCTCGATGGCCGACCGTGACGGCAAGATCTGGATGGACGGCCAGATGGTGGATTGGCGCGATGC
CAAGATCCACGTGCTCACCCACACGCTGCACTACGGCTGCGGCGCGTTCGAGGGCGTGCGGGCCTACCAGACGCCGCAGG
GCACGGCCATCTTCCGCCTGCAGGAACACACCGAGCGGCTCTTCAACAGCGCCAAGATCCTGCGCATGCAGATTCCCTTC
ACGCGGGACGAGGTGAACGAGGCCCAGCGCGCCGTGGTGCGCGAGAACCGGCTCGCTTCCTGCTACCTGCGGCCGCTCAC
CTGGATCGGTTCGCAGAAGCTGGGCGTGTCGCCCAAGGGCAACCAGATCCACCTGATGGTCGCGGCCTGGGCCTGGGGCG
CCTACCTCGGCGAAGAGGGCATGCAGCGCGGCATCCGCGTGAAGACCAGCAGCTACACGCGCCACCACGTCAACATCACC
ATGACGCAGGCCAAGGCGGTGAGCAACTACACCAACTCCATCCTGGCCAACATGGAGGCCACGGAGGACGGCTACGACGA
GGCCCTGCTGCTCGATTCCGCCGGCTTCGTGTCCGAGGGCGCGGGCGAGAACATCTTCGTGATCAAGGACGGTGTGGTCT
ATACGCCCGACCTGTCGGCCGGCGCGCTCAACGGCATCACGCGCAACACCATCCTGCACATCTGCCGCGACCTCGGCATC
GAGCTCGTGCAAAAGCGCATCACGCGCGACGAGGTGTATATCGCCGACGAGGCGTTCTTCACCGGCACGGCCGCCGAGGT
GACGCCGATCCGCGAGCTCGACCGCATCGCCATCGGCGCGGGCGCCCGCGGCCCCGTGACCGAGAAGATCCAGAGCGCGT
TCTTCGACATCGTGAACGGCCGCAATCCGAAATACGCCCACTGGCTCACGCTGGTCTGA

Upstream 100 bases:

>100_bases
CGGCGGCCGGCGCTTCCGATGCGCCAGCGCCCTCCGTGGGGCCGTCCGCGCCGTAAAATCGCCGGTTTTGCGACAGCATG
CCCCCGGAAAAAGGATTCCC

Downstream 100 bases:

>100_bases
CTTCCTCCGCCTTTCCTGCCCTCACAGCGCGAACCCCACCATGACGCAAGCCATCATCGAACTGCTCGCCAAAGACCTGA
ACCCGCAGGGCGGCGTCTTC

Product: branched-chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSPVVPSMADRDGKIWMDGQMVDWRDAKIHVLTHTLHYGCGAFEGVRAYQTPQGTAIFRLQEHTERLFNSAKILRMQIPF
TRDEVNEAQRAVVRENRLASCYLRPLTWIGSQKLGVSPKGNQIHLMVAAWAWGAYLGEEGMQRGIRVKTSSYTRHHVNIT
MTQAKAVSNYTNSILANMEATEDGYDEALLLDSAGFVSEGAGENIFVIKDGVVYTPDLSAGALNGITRNTILHICRDLGI
ELVQKRITRDEVYIADEAFFTGTAAEVTPIRELDRIAIGAGARGPVTEKIQSAFFDIVNGRNPKYAHWLTLV

Sequences:

>Translated_312_residues
MSPVVPSMADRDGKIWMDGQMVDWRDAKIHVLTHTLHYGCGAFEGVRAYQTPQGTAIFRLQEHTERLFNSAKILRMQIPF
TRDEVNEAQRAVVRENRLASCYLRPLTWIGSQKLGVSPKGNQIHLMVAAWAWGAYLGEEGMQRGIRVKTSSYTRHHVNIT
MTQAKAVSNYTNSILANMEATEDGYDEALLLDSAGFVSEGAGENIFVIKDGVVYTPDLSAGALNGITRNTILHICRDLGI
ELVQKRITRDEVYIADEAFFTGTAAEVTPIRELDRIAIGAGARGPVTEKIQSAFFDIVNGRNPKYAHWLTLV
>Mature_311_residues
SPVVPSMADRDGKIWMDGQMVDWRDAKIHVLTHTLHYGCGAFEGVRAYQTPQGTAIFRLQEHTERLFNSAKILRMQIPFT
RDEVNEAQRAVVRENRLASCYLRPLTWIGSQKLGVSPKGNQIHLMVAAWAWGAYLGEEGMQRGIRVKTSSYTRHHVNITM
TQAKAVSNYTNSILANMEATEDGYDEALLLDSAGFVSEGAGENIFVIKDGVVYTPDLSAGALNGITRNTILHICRDLGIE
LVQKRITRDEVYIADEAFFTGTAAEVTPIRELDRIAIGAGARGPVTEKIQSAFFDIVNGRNPKYAHWLTLV

Specific function: Acts on leucine, isoleucine and valine [H]

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI48994963, Length=299, Percent_Identity=46.4882943143813, Blast_Score=297, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17565728, Length=284, Percent_Identity=26.056338028169, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322002, Length=311, Percent_Identity=28.2958199356913, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005785 [H]

Pfam domain/function: PF01063 Aminotran_4 [H]

EC number: =2.6.1.42 [H]

Molecular weight: Translated: 34712; Mature: 34581

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00770 AA_TRANSFER_CLASS_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPVVPSMADRDGKIWMDGQMVDWRDAKIHVLTHTLHYGCGAFEGVRAYQTPQGTAIFRL
CCCCCCCCCCCCCEEEECCEEECCCCCEEEEEEEEHHHCCCCCCCCCEEECCCCCEEEEE
QEHTERLFNSAKILRMQIPFTRDEVNEAQRAVVRENRLASCYLRPLTWIGSQKLGVSPKG
HHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHCCHHHHCCCCCCCCCCCC
NQIHLMVAAWAWGAYLGEEGMQRGIRVKTSSYTRHHVNITMTQAKAVSNYTNSILANMEA
CEEEEEEEEEHHHHHHCHHHHHCCEEEEECCCEEEEEEEEEEHHHHHHHHHHHHHCCCCC
TEDGYDEALLLDSAGFVSEGAGENIFVIKDGVVYTPDLSAGALNGITRNTILHICRDLGI
CCCCCCCEEEEECCCCCCCCCCCEEEEEECCEEECCCCCCCHHCCCHHHHHHHHHHHHHH
ELVQKRITRDEVYIADEAFFTGTAAEVTPIRELDRIAIGAGARGPVTEKIQSAFFDIVNG
HHHHHHCCCCEEEEECCCEECCCCCCCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCC
RNPKYAHWLTLV
CCCCEEEEEEEC
>Mature Secondary Structure 
SPVVPSMADRDGKIWMDGQMVDWRDAKIHVLTHTLHYGCGAFEGVRAYQTPQGTAIFRL
CCCCCCCCCCCCEEEECCEEECCCCCEEEEEEEEHHHCCCCCCCCCEEECCCCCEEEEE
QEHTERLFNSAKILRMQIPFTRDEVNEAQRAVVRENRLASCYLRPLTWIGSQKLGVSPKG
HHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHCCHHHHCCCCCCCCCCCC
NQIHLMVAAWAWGAYLGEEGMQRGIRVKTSSYTRHHVNITMTQAKAVSNYTNSILANMEA
CEEEEEEEEEHHHHHHCHHHHHCCEEEEECCCEEEEEEEEEEHHHHHHHHHHHHHCCCCC
TEDGYDEALLLDSAGFVSEGAGENIFVIKDGVVYTPDLSAGALNGITRNTILHICRDLGI
CCCCCCCEEEEECCCCCCCCCCCEEEEEECCEEECCCCCCCHHCCCHHHHHHHHHHHHHH
ELVQKRITRDEVYIADEAFFTGTAAEVTPIRELDRIAIGAGARGPVTEKIQSAFFDIVNG
HHHHHHCCCCEEEEECCCEECCCCCCCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCC
RNPKYAHWLTLV
CCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]