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The map label for this gene is iclR [H]

Identifier: 120608961

GI number: 120608961

Start: 288444

End: 289223

Strand: Direct

Name: iclR [H]

Synonym: Aave_0258

Alternate gene names: 120608961

Gene position: 288444-289223 (Clockwise)

Preceding gene: 120608958

Following gene: 120608965

Centisome position: 5.39

GC content: 74.87

Gene sequence:

>780_bases
ATGACCACCGTGGTGCTCGACCGCGTCCTGCGCATCCTCGACCAGCTCTCGCGCTACGACGCGGGAGGACTCTCGCTGTC
GGACATCGCCCGCCAGTCGGGCATACCGCATCCGACCGTGCACCGCCTGCTGCGCGACCTCGCGCAGGCGCGCCTCGTGA
CGCTGCTGCCCGACGGGCGCGGCTACGTGCTGGGCCGGCTTGCTTTCGAGGTGGGGCTGGCCGCCCGCGCGCGGCACGAC
GTGGCGCCGCTCTTCGCGGCCCACCTGCGCCGCCTGGCCGAGGCCACGGGCTACGCCGCCTACTTGTTCGTGCGCAGCGG
CCTCGAAGCCGTCTGCCATGACCACACCCATGCGCAACGGCTCGATCCGCCGCTGTCCGTCACCGTGGGCGGCCGCCGGC
CGCTGGGCGTGGGCGCCGCGGGCCTGGCCCTGCTGGCCGCGCAGGACGATGCCCGGGTGGAGGCGTCGCTCGCGGCCCAT
GCGGGAGTGCTCGGGCGCTACGGAGGGCTCGACGTGCCGTCGCTGCGCACGCTCATCGCGCAAACGCGGGCCCTGGGCTA
TGCCCGCAGCGGTGGCTGCCTGAACACCAACACCGCCGCCGTGGGCCACGCCGTGCGCGATCCGGGCGGCTGCGCATTCG
CTGCCGTGAGCCTGTCCACCACCGTCGCGCGCCTCACGCAGCGCGAGGCCGCCCGCCTGGCGTCGCTGCTGCGCGCGGAG
ATCGCGCAGATCGAGCCGCGCGTGCACTTCGCGTGGAGCGACGAAGCCGCGCTGCGGTGA

Upstream 100 bases:

>100_bases
TGCCGCGATTGTTGCCAGCCTTCCCGGCCGCGCCAGCGGTTTGTCCACGGTGTGGACAAGAAGCGGCGGGATTCCATTCC
CCTCCGGGTATGCTGGCGCC

Downstream 100 bases:

>100_bases
TGCCCATGACGCGGCGCATCCCCCCGTATGCACCTCGTGCCACCACGTTCCATGGAAGCCCGCACGGCGCCACCCCTCCG
ATGGCCGCGGAGCAGGCCAT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTTVVLDRVLRILDQLSRYDAGGLSLSDIARQSGIPHPTVHRLLRDLAQARLVTLLPDGRGYVLGRLAFEVGLAARARHD
VAPLFAAHLRRLAEATGYAAYLFVRSGLEAVCHDHTHAQRLDPPLSVTVGGRRPLGVGAAGLALLAAQDDARVEASLAAH
AGVLGRYGGLDVPSLRTLIAQTRALGYARSGGCLNTNTAAVGHAVRDPGGCAFAAVSLSTTVARLTQREAARLASLLRAE
IAQIEPRVHFAWSDEAALR

Sequences:

>Translated_259_residues
MTTVVLDRVLRILDQLSRYDAGGLSLSDIARQSGIPHPTVHRLLRDLAQARLVTLLPDGRGYVLGRLAFEVGLAARARHD
VAPLFAAHLRRLAEATGYAAYLFVRSGLEAVCHDHTHAQRLDPPLSVTVGGRRPLGVGAAGLALLAAQDDARVEASLAAH
AGVLGRYGGLDVPSLRTLIAQTRALGYARSGGCLNTNTAAVGHAVRDPGGCAFAAVSLSTTVARLTQREAARLASLLRAE
IAQIEPRVHFAWSDEAALR
>Mature_258_residues
TTVVLDRVLRILDQLSRYDAGGLSLSDIARQSGIPHPTVHRLLRDLAQARLVTLLPDGRGYVLGRLAFEVGLAARARHDV
APLFAAHLRRLAEATGYAAYLFVRSGLEAVCHDHTHAQRLDPPLSVTVGGRRPLGVGAAGLALLAAQDDARVEASLAAHA
GVLGRYGGLDVPSLRTLIAQTRALGYARSGGCLNTNTAAVGHAVRDPGGCAFAAVSLSTTVARLTQREAARLASLLRAEI
AQIEPRVHFAWSDEAALR

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=247, Percent_Identity=27.9352226720648, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786715, Length=239, Percent_Identity=28.8702928870293, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 27419; Mature: 27288

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVVLDRVLRILDQLSRYDAGGLSLSDIARQSGIPHPTVHRLLRDLAQARLVTLLPDGR
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEECCCC
GYVLGRLAFEVGLAARARHDVAPLFAAHLRRLAEATGYAAYLFVRSGLEAVCHDHTHAQR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
LDPPLSVTVGGRRPLGVGAAGLALLAAQDDARVEASLAAHAGVLGRYGGLDVPSLRTLIA
CCCCCEEEECCCCCCCCCHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
QTRALGYARSGGCLNTNTAAVGHAVRDPGGCAFAAVSLSTTVARLTQREAARLASLLRAE
HHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAQIEPRVHFAWSDEAALR
HHHCCCCEEEEECCCCCCC
>Mature Secondary Structure 
TTVVLDRVLRILDQLSRYDAGGLSLSDIARQSGIPHPTVHRLLRDLAQARLVTLLPDGR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEECCCC
GYVLGRLAFEVGLAARARHDVAPLFAAHLRRLAEATGYAAYLFVRSGLEAVCHDHTHAQR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
LDPPLSVTVGGRRPLGVGAAGLALLAAQDDARVEASLAAHAGVLGRYGGLDVPSLRTLIA
CCCCCEEEECCCCCCCCCHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
QTRALGYARSGGCLNTNTAAVGHAVRDPGGCAFAAVSLSTTVARLTQREAARLASLLRAE
HHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAQIEPRVHFAWSDEAALR
HHHCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]