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The map label for this gene is iciA [H]

Identifier: 120608840

GI number: 120608840

Start: 142960

End: 143877

Strand: Direct

Name: iciA [H]

Synonym: Aave_0132

Alternate gene names: 120608840

Gene position: 142960-143877 (Clockwise)

Preceding gene: 120608837

Following gene: 120608841

Centisome position: 2.67

GC content: 70.81

Gene sequence:

>918_bases
ATGAGCACCTTCGATCCCGCCGCCCTGGAATGCCTGGCCGCCATCGTGGAAGAGGGGGGCTTCGAACGCGCGGCGCAGCG
CCTGAACGTCACCCAGTCGGCCGTCTCGCAGCGCCTGCGGGCGCTGGAGGCGCAGGTGGGCTCCGTGCTGATCGTGCGCA
GCCGGCCCCTCAAGCCCACCAGCGCGGGCCAGCTGCTGCTCAAGCACACCAAGCAGTTGCGCCTGCTGCGCGCCGACCTG
GAGCGCGACCTGCAGGAGCTCGCGCCCAGCGCACCCGGTGGCGCCCGCGAGGACGAGCGCATCGCCATCGCCATCAATGC
CGACAGCATCGCCACCTGGGCGCTGGATGCGCTGCACGACCTGGCCCGCCAGCGCCTGCCCATCGAAATCATCGTGGACG
ACCAGGACTTCACCCAGGAATGGCTGCGCTCGGGCCAGGTGCTGGGCTGCGTGACGACGCTCAGGCAGGCGCTGAGGGGC
TGCAAGGTCGTGCCGCTGGGCGCCATGCGCTACGTGGCCGTGGCCTCCCCGGGCCTGGCGGCGCACCACCTGCCCCAGGG
CCTGACGCCGCACAACTTCCGCGATGTGCCCTTCCTGTCGTTCAACCGCAAGGACGACATGCAGTCGGAATTCATCATGC
GTGCGTTCGGCCTCAAGCGCGTGGCGTTGCACCACCTTTTCGTGCCCAGTTCCGAAGGGCAGGTGCGCGCGGCGATTGCC
GGCTGGGGGGCCGGCGTGGTCCCCGAACTGCTCGCGCGTCCCGCCCTGGCGAGCGGCGCGCTGGTAGATCTCGCGCCCGG
CCACGCCCTCCCGATCCAGCTCTACTGGCATTGCTGGAATCTGGAGTCCGAGGTACTGGACTCCCTCACCGAGGCGCTGA
CGGCCACTGCGGCCCGCACGCTCGCCGCCGCCCCGTGA

Upstream 100 bases:

>100_bases
ATGGTTTTCATGGCTCCGCAGTGTGCTGCGGTGTCCGTTTTTTTTGAAGAGGAATTAAACTTCCTCCAAATTCATCAGTT
CATCTAATGAGCCGGCCGCC

Downstream 100 bases:

>100_bases
CCATCAGCTCGACCGTGAGCGACGGCGTTCTGGGCGCAGGCCCTAAGATGGCTGCATGAATACGCCTTCCCCGCTACCCC
GCCGCTCCTTCAGGGCACAG

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: OriC replication inhibitor [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSTFDPAALECLAAIVEEGGFERAAQRLNVTQSAVSQRLRALEAQVGSVLIVRSRPLKPTSAGQLLLKHTKQLRLLRADL
ERDLQELAPSAPGGAREDERIAIAINADSIATWALDALHDLARQRLPIEIIVDDQDFTQEWLRSGQVLGCVTTLRQALRG
CKVVPLGAMRYVAVASPGLAAHHLPQGLTPHNFRDVPFLSFNRKDDMQSEFIMRAFGLKRVALHHLFVPSSEGQVRAAIA
GWGAGVVPELLARPALASGALVDLAPGHALPIQLYWHCWNLESEVLDSLTEALTATAARTLAAAP

Sequences:

>Translated_305_residues
MSTFDPAALECLAAIVEEGGFERAAQRLNVTQSAVSQRLRALEAQVGSVLIVRSRPLKPTSAGQLLLKHTKQLRLLRADL
ERDLQELAPSAPGGAREDERIAIAINADSIATWALDALHDLARQRLPIEIIVDDQDFTQEWLRSGQVLGCVTTLRQALRG
CKVVPLGAMRYVAVASPGLAAHHLPQGLTPHNFRDVPFLSFNRKDDMQSEFIMRAFGLKRVALHHLFVPSSEGQVRAAIA
GWGAGVVPELLARPALASGALVDLAPGHALPIQLYWHCWNLESEVLDSLTEALTATAARTLAAAP
>Mature_304_residues
STFDPAALECLAAIVEEGGFERAAQRLNVTQSAVSQRLRALEAQVGSVLIVRSRPLKPTSAGQLLLKHTKQLRLLRADLE
RDLQELAPSAPGGAREDERIAIAINADSIATWALDALHDLARQRLPIEIIVDDQDFTQEWLRSGQVLGCVTTLRQALRGC
KVVPLGAMRYVAVASPGLAAHHLPQGLTPHNFRDVPFLSFNRKDDMQSEFIMRAFGLKRVALHHLFVPSSEGQVRAAIAG
WGAGVVPELLARPALASGALVDLAPGHALPIQLYWHCWNLESEVLDSLTEALTATAARTLAAAP

Specific function: Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=302, Percent_Identity=38.7417218543046, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI1786713, Length=266, Percent_Identity=24.4360902255639, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33049; Mature: 32918

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFDPAALECLAAIVEEGGFERAAQRLNVTQSAVSQRLRALEAQVGSVLIVRSRPLKPT
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC
SAGQLLLKHTKQLRLLRADLERDLQELAPSAPGGAREDERIAIAINADSIATWALDALHD
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHH
LARQRLPIEIIVDDQDFTQEWLRSGQVLGCVTTLRQALRGCKVVPLGAMRYVAVASPGLA
HHHHCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCH
AHHLPQGLTPHNFRDVPFLSFNRKDDMQSEFIMRAFGLKRVALHHLFVPSSEGQVRAAIA
HHHCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
GWGAGVVPELLARPALASGALVDLAPGHALPIQLYWHCWNLESEVLDSLTEALTATAART
CCCCCHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
LAAAP
HHCCC
>Mature Secondary Structure 
STFDPAALECLAAIVEEGGFERAAQRLNVTQSAVSQRLRALEAQVGSVLIVRSRPLKPT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC
SAGQLLLKHTKQLRLLRADLERDLQELAPSAPGGAREDERIAIAINADSIATWALDALHD
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHH
LARQRLPIEIIVDDQDFTQEWLRSGQVLGCVTTLRQALRGCKVVPLGAMRYVAVASPGLA
HHHHCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCH
AHHLPQGLTPHNFRDVPFLSFNRKDDMQSEFIMRAFGLKRVALHHLFVPSSEGQVRAAIA
HHHCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
GWGAGVVPELLARPALASGALVDLAPGHALPIQLYWHCWNLESEVLDSLTEALTATAART
CCCCCHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
LAAAP
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA