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The map label for this gene is dnaA [H]

Identifier: 120608715

GI number: 120608715

Start: 71

End: 1498

Strand: Direct

Name: dnaA [H]

Synonym: Aave_0001

Alternate gene names: 120608715

Gene position: 71-1498 (Clockwise)

Preceding gene: NA

Following gene: 120608716

Centisome position: 0.0

GC content: 66.18

Gene sequence:

>1428_bases
ATGACCGAGGAACCCTCCCGCAGCCCCGACTTCGACACCGACACCGACGCCGATCCCGGCCAGGGGCTGTGGCAAGCCTG
TGTCGAGCAGCTCGCGCAGGACCTGCCCGAACAGCAGTTCAACACCTGGATCAAGCCGCTCGTCGCCCAGGTCGCTCCCG
ACTTCTCCAAGGTCACCCTGCTGGTGGCCAACCGCTTCAAGCTCGACTGGATCCGCGCCCAGTACGCGGGCCGCATCACC
GCATTGCTCGAGGGCCTGTACGGCCAGCCGGTCACGCTGGAGTTAGCGCTCGCTCAGCGGGAAAGCGTTACCCGTACGGT
GGTTCGCCCCGTGGTGCAGCAGCCCGCGGCCCCGGCGGAGACGCCCATCGGCTCCGCCCCGTCGGACGAGCCAGCGGCCG
CGCCGTTCCGCTCGCGCCTCAACCCGGCACTCACCTTCGAGACCCTGGTGGAAGGCACGGCCAACCGCATGGCGCGTTCC
GCCGCCATGCACGTCGCGGGCTCGCCGGGGCACCTGTACAACCCGCTCTTCATCTACGGCGGCGTGGGCCTGGGCAAGAC
CCACCTGGTGCATGCCGTGGGCAACCGCCTGCTGCAGGACAAGCCCGACGCCAAAGTTCTCTACATCCATGCCGAGCAGT
TCGTCTCGGATGTGGTTAAGGCCTACCAGCGCCGCACCTTCGACGAGTTCAAGGCCCACTACCACTCGCTCGACCTGCTG
CTGATCGACGACGTGCAGTTCTTCGCCAACAAGGACCGCACGCAGGAGGAGTTCTTCAACGCCTTCGAGGCGCTGCTGGC
CAAGAAGAGCCACATCGTGATGACCTCGGACACCTATCCGAAGGGCCTCGCGAACATCCACGAGCGGCTCGTCTCGCGCT
TCGACTCCGGCCTCACCGTCACCATCGAGCCGCCCGAGCTCGAGATGCGCGTGGCCATCCTGATCAACAAGGCCCGGGCC
GAGAGCGCCGAGATGCCCGAGGAAGTCGCCTTCTTCGTCGCCAAGAACGTGCGCTCCAACGTGCGCGAACTCGAAGGCGC
GCTGCGCAAGATCCTGGCCTATTCGCGCTTCAACCAGAAGGAAGTCTCCATCCAGCTCGCCCGCGAGGCGCTGCGCGACC
TGCTGTCCATCCAGAACCGGCAGATCAGCGTGGAGAACATCCAGAAGACCGTCGCCGACTACTACAAGATCAAGGTGGCG
GACATGTACAGCAAGAAGCGCCCCGCCTCCATCGCCCGGCCGCGCCAGATCGCCATGTACCTCGCCAAGGAGCTCACGCA
GAAGAGCCTGCCGGAGATCGGCGAGCTGTTCGGGGGGCGCGACCACACGACGGTGCTGCACGCGGTGCGCAAGATCGCGG
GCGAACGCCAGCAACTGACCGAGCTGAACCAGCAGCTGCACGTGCTGGAGCAGACGCTCAAGGGCTGA

Upstream 100 bases:

>100_bases
AGGCCCGCGGCCACCCCGCCCAGCTTGTGGATAACCCCTTGAAAAGCTACAATCCCAGGCCCTGATCCGTTCCTCCTATC
CACAAAAAGAACCCGCCTTC

Downstream 100 bases:

>100_bases
AAGCGGCCCGCAAGACCACGGTGAAGCCCGCCCGCGTCCAGGAAATGCCCCGGTTCCCGGGCAAAATGCCAGGTTGGCCG
AGGGGTGCCGGCAAAGGCAT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MTEEPSRSPDFDTDTDADPGQGLWQACVEQLAQDLPEQQFNTWIKPLVAQVAPDFSKVTLLVANRFKLDWIRAQYAGRIT
ALLEGLYGQPVTLELALAQRESVTRTVVRPVVQQPAAPAETPIGSAPSDEPAAAPFRSRLNPALTFETLVEGTANRMARS
AAMHVAGSPGHLYNPLFIYGGVGLGKTHLVHAVGNRLLQDKPDAKVLYIHAEQFVSDVVKAYQRRTFDEFKAHYHSLDLL
LIDDVQFFANKDRTQEEFFNAFEALLAKKSHIVMTSDTYPKGLANIHERLVSRFDSGLTVTIEPPELEMRVAILINKARA
ESAEMPEEVAFFVAKNVRSNVRELEGALRKILAYSRFNQKEVSIQLAREALRDLLSIQNRQISVENIQKTVADYYKIKVA
DMYSKKRPASIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIAGERQQLTELNQQLHVLEQTLKG

Sequences:

>Translated_475_residues
MTEEPSRSPDFDTDTDADPGQGLWQACVEQLAQDLPEQQFNTWIKPLVAQVAPDFSKVTLLVANRFKLDWIRAQYAGRIT
ALLEGLYGQPVTLELALAQRESVTRTVVRPVVQQPAAPAETPIGSAPSDEPAAAPFRSRLNPALTFETLVEGTANRMARS
AAMHVAGSPGHLYNPLFIYGGVGLGKTHLVHAVGNRLLQDKPDAKVLYIHAEQFVSDVVKAYQRRTFDEFKAHYHSLDLL
LIDDVQFFANKDRTQEEFFNAFEALLAKKSHIVMTSDTYPKGLANIHERLVSRFDSGLTVTIEPPELEMRVAILINKARA
ESAEMPEEVAFFVAKNVRSNVRELEGALRKILAYSRFNQKEVSIQLAREALRDLLSIQNRQISVENIQKTVADYYKIKVA
DMYSKKRPASIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIAGERQQLTELNQQLHVLEQTLKG
>Mature_474_residues
TEEPSRSPDFDTDTDADPGQGLWQACVEQLAQDLPEQQFNTWIKPLVAQVAPDFSKVTLLVANRFKLDWIRAQYAGRITA
LLEGLYGQPVTLELALAQRESVTRTVVRPVVQQPAAPAETPIGSAPSDEPAAAPFRSRLNPALTFETLVEGTANRMARSA
AMHVAGSPGHLYNPLFIYGGVGLGKTHLVHAVGNRLLQDKPDAKVLYIHAEQFVSDVVKAYQRRTFDEFKAHYHSLDLLL
IDDVQFFANKDRTQEEFFNAFEALLAKKSHIVMTSDTYPKGLANIHERLVSRFDSGLTVTIEPPELEMRVAILINKARAE
SAEMPEEVAFFVAKNVRSNVRELEGALRKILAYSRFNQKEVSIQLAREALRDLLSIQNRQISVENIQKTVADYYKIKVAD
MYSKKRPASIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIAGERQQLTELNQQLHVLEQTLKG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=463, Percent_Identity=51.1879049676026, Blast_Score=470, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 53278; Mature: 53146

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEEPSRSPDFDTDTDADPGQGLWQACVEQLAQDLPEQQFNTWIKPLVAQVAPDFSKVTL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHH
LVANRFKLDWIRAQYAGRITALLEGLYGQPVTLELALAQRESVTRTVVRPVVQQPAAPAE
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCC
TPIGSAPSDEPAAAPFRSRLNPALTFETLVEGTANRMARSAAMHVAGSPGHLYNPLFIYG
CCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
GVGLGKTHLVHAVGNRLLQDKPDAKVLYIHAEQFVSDVVKAYQRRTFDEFKAHYHSLDLL
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCEE
LIDDVQFFANKDRTQEEFFNAFEALLAKKSHIVMTSDTYPKGLANIHERLVSRFDSGLTV
EECCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEE
TIEPPELEMRVAILINKARAESAEMPEEVAFFVAKNVRSNVRELEGALRKILAYSRFNQK
EECCCCHHEEEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
EVSIQLAREALRDLLSIQNRQISVENIQKTVADYYKIKVADMYSKKRPASIARPRQIAMY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LAKELTQKSLPEIGELFGGRDHTTVLHAVRKIAGERQQLTELNQQLHVLEQTLKG
HHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEEPSRSPDFDTDTDADPGQGLWQACVEQLAQDLPEQQFNTWIKPLVAQVAPDFSKVTL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHH
LVANRFKLDWIRAQYAGRITALLEGLYGQPVTLELALAQRESVTRTVVRPVVQQPAAPAE
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCC
TPIGSAPSDEPAAAPFRSRLNPALTFETLVEGTANRMARSAAMHVAGSPGHLYNPLFIYG
CCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
GVGLGKTHLVHAVGNRLLQDKPDAKVLYIHAEQFVSDVVKAYQRRTFDEFKAHYHSLDLL
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCEE
LIDDVQFFANKDRTQEEFFNAFEALLAKKSHIVMTSDTYPKGLANIHERLVSRFDSGLTV
EECCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEE
TIEPPELEMRVAILINKARAESAEMPEEVAFFVAKNVRSNVRELEGALRKILAYSRFNQK
EECCCCHHEEEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
EVSIQLAREALRDLLSIQNRQISVENIQKTVADYYKIKVADMYSKKRPASIARPRQIAMY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LAKELTQKSLPEIGELFGGRDHTTVLHAVRKIAGERQQLTELNQQLHVLEQTLKG
HHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA