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The map label for this gene is grxC [C]

Identifier: 119947074

GI number: 119947074

Start: 4292564

End: 4293295

Strand: Reverse

Name: grxC [C]

Synonym: Ping_3472

Alternate gene names: 119947074

Gene position: 4293295-4292564 (Counterclockwise)

Preceding gene: 119947075

Following gene: 119947073

Centisome position: 94.16

GC content: 40.3

Gene sequence:

>732_bases
ATGTTAGATAATATCGAAGGTCAAAAAATACCGAATGTTACTTTCCCAACTCGTCAAGGCGATCAATGGGTAAATGTTTC
TACTGACGAATTATTCGCTGGTAAAACAGTCGTTGTATTTGCTTTACCAGGTGCGTTTACGCCAACCTGTTCTTCAATGC
ATCTGCCGCGCTACAACGAATTAGCTGGCGTATTTAAAGAAAATGGCGTTGATGAAATTATATGTTCAAGCGTTAATGAT
ACTTTTGTAATGAATTCTTGGATTGCTGATCAGGAAGCTGAAAATATTACTGTTGTACCAGATGGTAACGGTACATTTGC
TGAAGGTATGGGTATGCTGGTAGATAAAAGCGACCTAGGTTTTGGTAAACGCAGCTGGCGTTACAGTATGCTTGTAAAAG
ATGGCGTGATTGAAAAAATGTTTATCGAACCTAATCAGCCTGGCGACCCATTTGAAGTTTCTGATGCGGATACTATGCTT
AATTACATCAATCCTAAAGCAAAAGCACCTGCTGCGGTAACCTTATTTACTAAACCAGGTTGTCCTTTCTGTGCAACAGC
AAAAGCTGCACTAAAAGATAACAATATCGCTTTTGAAGAGATCGTTTTAGGTAAAGATGCAACCAGTGTCAGCCTTCGAG
CGGTAAGCGGAGAATCAACTTTCCCGCAGCTATTCGTTGATGGTAAACACATTGGTGATAGCGAAGCGGTAATCGCTTAC
GTTAAAGGTTAA

Upstream 100 bases:

>100_bases
CAAACTTTGCTAACTTGTTTGAAATTTCTTCAAACTATGTAATATTAATAAACGCAAACTATGTAATATTAATAAACGAA
TATAAAAAAAGGAGTTACAC

Downstream 100 bases:

>100_bases
TACCTCTTTAAAGAGCCGCATTTAAGCTCATATAAAAAGCGCACTTTCAACAGGAAGCTGCGCTTTTTTTTTACCAAAAT
TTCACCAGATTGTGTAATCA

Product: glutaredoxin family protein

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLDNIEGQKIPNVTFPTRQGDQWVNVSTDELFAGKTVVVFALPGAFTPTCSSMHLPRYNELAGVFKENGVDEIICSSVND
TFVMNSWIADQEAENITVVPDGNGTFAEGMGMLVDKSDLGFGKRSWRYSMLVKDGVIEKMFIEPNQPGDPFEVSDADTML
NYINPKAKAPAAVTLFTKPGCPFCATAKAALKDNNIAFEEIVLGKDATSVSLRAVSGESTFPQLFVDGKHIGDSEAVIAY
VKG

Sequences:

>Translated_243_residues
MLDNIEGQKIPNVTFPTRQGDQWVNVSTDELFAGKTVVVFALPGAFTPTCSSMHLPRYNELAGVFKENGVDEIICSSVND
TFVMNSWIADQEAENITVVPDGNGTFAEGMGMLVDKSDLGFGKRSWRYSMLVKDGVIEKMFIEPNQPGDPFEVSDADTML
NYINPKAKAPAAVTLFTKPGCPFCATAKAALKDNNIAFEEIVLGKDATSVSLRAVSGESTFPQLFVDGKHIGDSEAVIAY
VKG
>Mature_243_residues
MLDNIEGQKIPNVTFPTRQGDQWVNVSTDELFAGKTVVVFALPGAFTPTCSSMHLPRYNELAGVFKENGVDEIICSSVND
TFVMNSWIADQEAENITVVPDGNGTFAEGMGMLVDKSDLGFGKRSWRYSMLVKDGVIEKMFIEPNQPGDPFEVSDADTML
NYINPKAKAPAAVTLFTKPGCPFCATAKAALKDNNIAFEEIVLGKDATSVSLRAVSGESTFPQLFVDGKHIGDSEAVIAY
VKG

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=145, Percent_Identity=39.3103448275862, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI78706776, Length=125, Percent_Identity=41.6, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI78709078, Length=125, Percent_Identity=41.6, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26288; Mature: 26288

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00195 GLUTAREDOXIN ; PS00305 11S_SEED_STORAGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNIEGQKIPNVTFPTRQGDQWVNVSTDELFAGKTVVVFALPGAFTPTCSSMHLPRYNE
CCCCCCCCCCCCCCCCCCCCCEEEECCHHHEECCCEEEEEEECCCCCCCCCCCCCCCHHH
LAGVFKENGVDEIICSSVNDTFVMNSWIADQEAENITVVPDGNGTFAEGMGMLVDKSDLG
HHHHHHHCCCCHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCCCHHHCCEEEEECCCCC
FGKRSWRYSMLVKDGVIEKMFIEPNQPGDPFEVSDADTMLNYINPKAKAPAAVTLFTKPG
CCCCCEEEEEEECCCCEEEEEECCCCCCCCEECCCHHHHHHHCCCCCCCCEEEEEEECCC
CPFCATAKAALKDNNIAFEEIVLGKDATSVSLRAVSGESTFPQLFVDGKHIGDSEAVIAY
CCHHHCCHHHHCCCCCEEEHEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCEEEEE
VKG
ECC
>Mature Secondary Structure
MLDNIEGQKIPNVTFPTRQGDQWVNVSTDELFAGKTVVVFALPGAFTPTCSSMHLPRYNE
CCCCCCCCCCCCCCCCCCCCCEEEECCHHHEECCCEEEEEEECCCCCCCCCCCCCCCHHH
LAGVFKENGVDEIICSSVNDTFVMNSWIADQEAENITVVPDGNGTFAEGMGMLVDKSDLG
HHHHHHHCCCCHHHHCCCCCCEEEECCCCCCCCCEEEEEECCCCCHHHCCEEEEECCCCC
FGKRSWRYSMLVKDGVIEKMFIEPNQPGDPFEVSDADTMLNYINPKAKAPAAVTLFTKPG
CCCCCEEEEEEECCCCEEEEEECCCCCCCCEECCCHHHHHHHCCCCCCCCEEEEEEECCC
CPFCATAKAALKDNNIAFEEIVLGKDATSVSLRAVSGESTFPQLFVDGKHIGDSEAVIAY
CCHHHCCHHHHCCCCCEEEHEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCEEEEE
VKG
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]