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The map label for this gene is lysS

Identifier: 119947031

GI number: 119947031

Start: 4237748

End: 4239277

Strand: Reverse

Name: lysS

Synonym: Ping_3428

Alternate gene names: 119947031

Gene position: 4239277-4237748 (Counterclockwise)

Preceding gene: 119947032

Following gene: 119947030

Centisome position: 92.97

GC content: 42.94

Gene sequence:

>1530_bases
ATGTCAGAGCAGAATCCAACACAAGCAGCAAAGCAAGCACCACAACAAGAGTTAAATGACATTATGGCACAACGCTTGGC
CAAATTAGATGCCATGCGTGAAAAGGGACAAGCATTTCCGAATGACTTCCGCCGTGAAAATATCTCTGATGATTTACATG
CACGTTATGATGATAAAACCAAAGAAGAGCTTGAAGAGCTCGCGGTTGAAGTCAGTATTGCCGGTCGTATGATGATGCGC
CGTATTATGGGCAAAGCAAGTTTTGCGACTATTCAGGATATGGGCGGTCGTATTCAACTTTATGTGACCCGTGATAAGCT
CCCTGAAAGTTTCTACAACACTGAATTTAAAAAATGGGATTTAGGCGATATCATTGGTGCAAAAGGGGTTTTGTTTAAAA
CCCAAACTAATGAATTAAGCATTAAAGTCTCTGAAATCCGTATTCTAACTAAAGCACTGCGTCCGTTACCCGATAAATTC
CATGGACTTTCTGATACAGAAGCCTGTTACCGTCAGCGCTATCTGGACTTGATTGCCAATGACAACTCGCGCAAGACATT
CCTGTTACGTAATAAAATCGTTAATGCTATCCGTCAGTATTTAAATGATCGCGACTTTATGGAAGTAGAAACACCCATGC
TGCAATCTATTCCCGGCGGCGCAGCGGCAAAACCCTTTGAAACTTACCATAATGCACTTTCTTTACCCATGTACCTGCGT
ATTGCCCCTGAATTAAACCTAAAACGTTTAGTAGTAGGTGGTTTTGAACGTGTATTTGAAATTAACCGCAGTTTCCGTAA
CGAGGGCGTTTCAACCCGCCATAACCCTGAATTTACCATGATCGAATTTTATCAGGCCTATGCAGATTATATCGATCTGA
TGAATCTGACGGAAGAGATGTTACGCAGTATTGCAGAAAATGTATTAGGTTCAAGCATTGTCAACTACGGCGATCAAGTG
TTTGACTTTGGCGCTGCTTTTATCCGCATGACCATGAAAGAATCCGTGCTGCAATACAATGAAGGCATTGAAGCTTCTGA
ACTTGAAAGCATGGCAAGCCTTAAAGCCTTAGCCGCACGTTTCAATGTGAATATTAAAGAGAACTGGGGTGAAGGCAAAG
TCTTAACCGAGATTTTTGAGGAAACAACGGAACATAAACTGCTTCAACCAACCTTTATAACAGCTTATCCGGCTGAGGTT
TCACCTCTTGCCCGCCGTAATGATCAAGATCCGAGTGTGACCGATCGTTTTGAGTTTTTTGTGGGCGGACGTGAACTTGC
TAATGGTTTCTCTGAACTTAATGATTCTCAAGATCAAGCTGAGCGTTTCATGGATCAGGTTGCTCAGAAAGAATCCGGTG
ATGATGAGGCGATGTTCTACGATGCGGATTATATTACCGCACTTGAGCACGGTTTGCCGCCAACAGCGGGTGAAGGTATT
GGTATTGATCGTCTGGTGATGTTATTTACGGACAGCCATACAATCCGTGACGTATTGTTGTTCCCGCATATGCGTCCACA
AGCAAAATAA

Upstream 100 bases:

>100_bases
GCTCATAGTTCGAAGCTCGTAGCCTTCCAGCTTTTTATGCCGTGGGGTCGAGAATCAGGTCAACAAACCAAATTAACAGT
GAAAGATAATAGGAAATATC

Downstream 100 bases:

>100_bases
CTGTGAAGATAGCTTTCAGTCATTAGCTGTCCGCTATCAGTTAAATTCAAAATAAGAGCCTCGTTTTTATGGGGCTTTTT
TTTGTCTTTTTTCCTTACGC

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSEQNPTQAAKQAPQQELNDIMAQRLAKLDAMREKGQAFPNDFRRENISDDLHARYDDKTKEELEELAVEVSIAGRMMMR
RIMGKASFATIQDMGGRIQLYVTRDKLPESFYNTEFKKWDLGDIIGAKGVLFKTQTNELSIKVSEIRILTKALRPLPDKF
HGLSDTEACYRQRYLDLIANDNSRKTFLLRNKIVNAIRQYLNDRDFMEVETPMLQSIPGGAAAKPFETYHNALSLPMYLR
IAPELNLKRLVVGGFERVFEINRSFRNEGVSTRHNPEFTMIEFYQAYADYIDLMNLTEEMLRSIAENVLGSSIVNYGDQV
FDFGAAFIRMTMKESVLQYNEGIEASELESMASLKALAARFNVNIKENWGEGKVLTEIFEETTEHKLLQPTFITAYPAEV
SPLARRNDQDPSVTDRFEFFVGGRELANGFSELNDSQDQAERFMDQVAQKESGDDEAMFYDADYITALEHGLPPTAGEGI
GIDRLVMLFTDSHTIRDVLLFPHMRPQAK

Sequences:

>Translated_509_residues
MSEQNPTQAAKQAPQQELNDIMAQRLAKLDAMREKGQAFPNDFRRENISDDLHARYDDKTKEELEELAVEVSIAGRMMMR
RIMGKASFATIQDMGGRIQLYVTRDKLPESFYNTEFKKWDLGDIIGAKGVLFKTQTNELSIKVSEIRILTKALRPLPDKF
HGLSDTEACYRQRYLDLIANDNSRKTFLLRNKIVNAIRQYLNDRDFMEVETPMLQSIPGGAAAKPFETYHNALSLPMYLR
IAPELNLKRLVVGGFERVFEINRSFRNEGVSTRHNPEFTMIEFYQAYADYIDLMNLTEEMLRSIAENVLGSSIVNYGDQV
FDFGAAFIRMTMKESVLQYNEGIEASELESMASLKALAARFNVNIKENWGEGKVLTEIFEETTEHKLLQPTFITAYPAEV
SPLARRNDQDPSVTDRFEFFVGGRELANGFSELNDSQDQAERFMDQVAQKESGDDEAMFYDADYITALEHGLPPTAGEGI
GIDRLVMLFTDSHTIRDVLLFPHMRPQAK
>Mature_508_residues
SEQNPTQAAKQAPQQELNDIMAQRLAKLDAMREKGQAFPNDFRRENISDDLHARYDDKTKEELEELAVEVSIAGRMMMRR
IMGKASFATIQDMGGRIQLYVTRDKLPESFYNTEFKKWDLGDIIGAKGVLFKTQTNELSIKVSEIRILTKALRPLPDKFH
GLSDTEACYRQRYLDLIANDNSRKTFLLRNKIVNAIRQYLNDRDFMEVETPMLQSIPGGAAAKPFETYHNALSLPMYLRI
APELNLKRLVVGGFERVFEINRSFRNEGVSTRHNPEFTMIEFYQAYADYIDLMNLTEEMLRSIAENVLGSSIVNYGDQVF
DFGAAFIRMTMKESVLQYNEGIEASELESMASLKALAARFNVNIKENWGEGKVLTEIFEETTEHKLLQPTFITAYPAEVS
PLARRNDQDPSVTDRFEFFVGGRELANGFSELNDSQDQAERFMDQVAQKESGDDEAMFYDADYITALEHGLPPTAGEGIG
IDRLVMLFTDSHTIRDVLLFPHMRPQAK

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=456, Percent_Identity=43.421052631579, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI194272210, Length=456, Percent_Identity=43.421052631579, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI45439306, Length=339, Percent_Identity=25.3687315634218, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI40789249, Length=275, Percent_Identity=27.6363636363636, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1790571, Length=507, Percent_Identity=66.2721893491124, Blast_Score=716, Evalue=0.0,
Organism=Escherichia coli, GI1789256, Length=506, Percent_Identity=66.0079051383399, Blast_Score=714, Evalue=0.0,
Organism=Escherichia coli, GI87082379, Length=329, Percent_Identity=32.5227963525836, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1788173, Length=287, Percent_Identity=25.0871080139373, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17535927, Length=528, Percent_Identity=38.4469696969697, Blast_Score=338, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI17535925, Length=528, Percent_Identity=38.4469696969697, Blast_Score=337, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI71994340, Length=501, Percent_Identity=39.3213572854291, Blast_Score=335, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17551876, Length=342, Percent_Identity=26.6081871345029, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32566633, Length=248, Percent_Identity=27.0161290322581, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320242, Length=489, Percent_Identity=41.1042944785276, Blast_Score=354, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6324256, Length=433, Percent_Identity=31.8706697459584, Blast_Score=180, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6323011, Length=482, Percent_Identity=25.3112033195021, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321807, Length=362, Percent_Identity=24.3093922651934, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24640851, Length=483, Percent_Identity=40.9937888198758, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24640849, Length=483, Percent_Identity=40.9937888198758, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI17136276, Length=464, Percent_Identity=21.3362068965517, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24584738, Length=250, Percent_Identity=26.8, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_PSYIN (A1T047)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944711.1
- ProteinModelPortal:   A1T047
- SMR:   A1T047
- STRING:   A1T047
- GeneID:   4625619
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_3428
- eggNOG:   COG1190
- HOGENOM:   HBG631383
- OMA:   GHPQMMS
- PhylomeDB:   A1T047
- BioCyc:   PING357804:PING_3428-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 58145; Mature: 58013

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQNPTQAAKQAPQQELNDIMAQRLAKLDAMREKGQAFPNDFRRENISDDLHARYDDKT
CCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHCCCCHH
KEELEELAVEVSIAGRMMMRRIMGKASFATIQDMGGRIQLYVTRDKLPESFYNTEFKKWD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCCHHHHCCCCCCCC
LGDIIGAKGVLFKTQTNELSIKVSEIRILTKALRPLPDKFHGLSDTEACYRQRYLDLIAN
CHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCC
DNSRKTFLLRNKIVNAIRQYLNDRDFMEVETPMLQSIPGGAAAKPFETYHNALSLPMYLR
CCCCEEHHHHHHHHHHHHHHHCCCCCCHHCCHHHHCCCCCCCCCCHHHHHHHHCCCEEEE
IAPELNLKRLVVGGFERVFEINRSFRNEGVSTRHNPEFTMIEFYQAYADYIDLMNLTEEM
ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRSIAENVLGSSIVNYGDQVFDFGAAFIRMTMKESVLQYNEGIEASELESMASLKALAAR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
FNVNIKENWGEGKVLTEIFEETTEHKLLQPTFITAYPAEVSPLARRNDQDPSVTDRFEFF
HCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCCCCHHHHHHHH
VGGRELANGFSELNDSQDQAERFMDQVAQKESGDDEAMFYDADYITALEHGLPPTAGEGI
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHCCCCCCCCCC
GIDRLVMLFTDSHTIRDVLLFPHMRPQAK
CHHHEEEEEECCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SEQNPTQAAKQAPQQELNDIMAQRLAKLDAMREKGQAFPNDFRRENISDDLHARYDDKT
CCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHCCCCHH
KEELEELAVEVSIAGRMMMRRIMGKASFATIQDMGGRIQLYVTRDKLPESFYNTEFKKWD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCCHHHHCCCCCCCC
LGDIIGAKGVLFKTQTNELSIKVSEIRILTKALRPLPDKFHGLSDTEACYRQRYLDLIAN
CHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCC
DNSRKTFLLRNKIVNAIRQYLNDRDFMEVETPMLQSIPGGAAAKPFETYHNALSLPMYLR
CCCCEEHHHHHHHHHHHHHHHCCCCCCHHCCHHHHCCCCCCCCCCHHHHHHHHCCCEEEE
IAPELNLKRLVVGGFERVFEINRSFRNEGVSTRHNPEFTMIEFYQAYADYIDLMNLTEEM
ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRSIAENVLGSSIVNYGDQVFDFGAAFIRMTMKESVLQYNEGIEASELESMASLKALAAR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
FNVNIKENWGEGKVLTEIFEETTEHKLLQPTFITAYPAEVSPLARRNDQDPSVTDRFEFF
HCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCCCCHHHHHHHH
VGGRELANGFSELNDSQDQAERFMDQVAQKESGDDEAMFYDADYITALEHGLPPTAGEGI
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHCCCCCCCCCC
GIDRLVMLFTDSHTIRDVLLFPHMRPQAK
CHHHEEEEEECCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA