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The map label for this gene is fkpA [H]

Identifier: 119946863

GI number: 119946863

Start: 4020431

End: 4020901

Strand: Reverse

Name: fkpA [H]

Synonym: Ping_3257

Alternate gene names: 119946863

Gene position: 4020901-4020431 (Counterclockwise)

Preceding gene: 119946864

Following gene: 119946861

Centisome position: 88.19

GC content: 41.4

Gene sequence:

>471_bases
GTGTCAAAAATCATTCTTCTTATCGTATTTTTAGTGGCTGCATTTTTTGTTTTTCAGCGTATGAATGCCGGAAATAATGC
ACCAAAAAATATTCAAATAGGCTCCGCCTTTCTGGCTGCTAACGAAGCTGAAGATGGCATTTTCAGCACAGCCTCTGGTC
TGCAATATAAGGTATTAGAAAAAGGCGCTGGTCAAGTGCATCCAACGGCTAATAGCGAGGTAAAAGTGCATTACCACGGC
AGTTTAATAAACGGCACTGTTTTTGATAGTTCGGTGGAGCGCGGTACGCCAATTTCATTTGGTTTGAATCAAGTTATTCC
CGGTTGGACTGAGGGAGTACAGTTGATGGTGGAAGGTGATAAATTCCGTTTTTATATTCCCAGTCGTTTAGCCTATGGTA
ACCGTGCTACAGGGAAAATCCCAGCGGGCTCATTATTGATTTTTGATGTTGAGTTAATTGCGATTAACTAA

Upstream 100 bases:

>100_bases
AATTAATTAAAATCCAATAGGGCAAATAAAATCAGTAAATATTTCGTTTTGCCGACAAATTTAGTAAAGTTAATTTTTTA
TTATTTAAAAGGGTTTTATT

Downstream 100 bases:

>100_bases
TTTTAAATATAACTTCGACAATCTAAAACGGCCACCATTAACTTATCAAGGTGACCGTTTTATTAATGCAGAAAACTATT
TAAAACTATTTAAAACTATT

Product: peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MSKIILLIVFLVAAFFVFQRMNAGNNAPKNIQIGSAFLAANEAEDGIFSTASGLQYKVLEKGAGQVHPTANSEVKVHYHG
SLINGTVFDSSVERGTPISFGLNQVIPGWTEGVQLMVEGDKFRFYIPSRLAYGNRATGKIPAGSLLIFDVELIAIN

Sequences:

>Translated_156_residues
MSKIILLIVFLVAAFFVFQRMNAGNNAPKNIQIGSAFLAANEAEDGIFSTASGLQYKVLEKGAGQVHPTANSEVKVHYHG
SLINGTVFDSSVERGTPISFGLNQVIPGWTEGVQLMVEGDKFRFYIPSRLAYGNRATGKIPAGSLLIFDVELIAIN
>Mature_155_residues
SKIILLIVFLVAAFFVFQRMNAGNNAPKNIQIGSAFLAANEAEDGIFSTASGLQYKVLEKGAGQVHPTANSEVKVHYHGS
LINGTVFDSSVERGTPISFGLNQVIPGWTEGVQLMVEGDKFRFYIPSRLAYGNRATGKIPAGSLLIFDVELIAIN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=84, Percent_Identity=48.8095238095238, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI17149844, Length=84, Percent_Identity=48.8095238095238, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI17149842, Length=84, Percent_Identity=48.8095238095238, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI17149836, Length=109, Percent_Identity=39.4495412844037, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI4503725, Length=109, Percent_Identity=39.4495412844037, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI192448443, Length=105, Percent_Identity=40, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI4503727, Length=139, Percent_Identity=30.9352517985612, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI7706131, Length=123, Percent_Identity=38.2113821138211, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI33469985, Length=82, Percent_Identity=39.0243902439024, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI4758380, Length=108, Percent_Identity=37.962962962963, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI224809329, Length=132, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI224809327, Length=132, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI4758384, Length=132, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI224809331, Length=128, Percent_Identity=34.375, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI87082390, Length=123, Percent_Identity=49.5934959349593, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1789745, Length=132, Percent_Identity=40.9090909090909, Blast_Score=99, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17561782, Length=98, Percent_Identity=47.9591836734694, Blast_Score=83, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=39.2523364485981, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540882, Length=88, Percent_Identity=44.3181818181818, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320727, Length=89, Percent_Identity=52.8089887640449, Blast_Score=88, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=44.5544554455446, Blast_Score=84, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323482, Length=92, Percent_Identity=42.3913043478261, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323566, Length=87, Percent_Identity=42.5287356321839, Blast_Score=61, Evalue=9e-11,
Organism=Drosophila melanogaster, GI21356629, Length=131, Percent_Identity=40.4580152671756, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=40.5660377358491, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281363946, Length=84, Percent_Identity=45.2380952380952, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17352457, Length=84, Percent_Identity=45.2380952380952, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16833; Mature: 16701

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIILLIVFLVAAFFVFQRMNAGNNAPKNIQIGSAFLAANEAEDGIFSTASGLQYKVLE
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECEEEEECCCCCCCEEECCCCCEEEEEC
KGAGQVHPTANSEVKVHYHGSLINGTVFDSSVERGTPISFGLNQVIPGWTEGVQLMVEGD
CCCCEECCCCCCEEEEEECCEEEECEEECCCCCCCCCCEECHHHCCCCCCCCEEEEEECC
KFRFYIPSRLAYGNRATGKIPAGSLLIFDVELIAIN
EEEEEECCEECCCCCCCCCCCCCEEEEEEEEEEEEC
>Mature Secondary Structure 
SKIILLIVFLVAAFFVFQRMNAGNNAPKNIQIGSAFLAANEAEDGIFSTASGLQYKVLE
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECEEEEECCCCCCCEEECCCCCEEEEEC
KGAGQVHPTANSEVKVHYHGSLINGTVFDSSVERGTPISFGLNQVIPGWTEGVQLMVEGD
CCCCEECCCCCCEEEEEECCEEEECEEECCCCCCCCCCEECHHHCCCCCCCCEEEEEECC
KFRFYIPSRLAYGNRATGKIPAGSLLIFDVELIAIN
EEEEEECCEECCCCCCCCCCCCCEEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]