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The map label for this gene is hemE

Identifier: 119946828

GI number: 119946828

Start: 3977474

End: 3978538

Strand: Reverse

Name: hemE

Synonym: Ping_3222

Alternate gene names: 119946828

Gene position: 3978538-3977474 (Counterclockwise)

Preceding gene: 119946829

Following gene: 119946827

Centisome position: 87.26

GC content: 43.0

Gene sequence:

>1065_bases
ATGACAGAATTAAAAAATGATCGTTATCTTCGCGCTTTATTAAAGCAAGACGTTGATAAAACACCAGTATGGATGATGCG
TCAAGCGGGTAGATATTTACCTGAATATAAAAAGGTACGCGCGCAAGCCGGAGATTTTATGTCTTTGTGCCGCAATGCAG
ATTTGGCCTGTGAAGTAACCTTACAACCTTTACGCAGATTTGACCTTGATGCCGCTATCTTATTTTCAGATATTCTTACT
ATCCCAGATGCAATGGGACTGGGTCTTTATTTTGCAGAAGGGGAAGGGCCTAAGCTTAAACGCCCGATAACATGTAAAAA
AGACGTTGATAATTTAATCATGCCGGATCCCGAAGGCGAACTGCAATATGTTATGAATGCGGTACGCACGATACGCCGCG
AGTTAAAAGGCTCCGTTCCATTAATTGGGTTCGCCGGTAGCCCATGGACATTAGCGACTTATATGGTTGAAGGGGGGAGT
TCAAAGGCTTTCACCAAGATCAAAAAAATGGCCTTTTGTGAGCCTCAACTATTACATACTTTATTAGATAAACTTGCTGA
TTCTGTGATTGATTATTTAAATGCACAGATAGCTGCAGGCGCGCAATCGGTAATGGTCTTCGATACTTGGGGTGGCGTGT
TATCTCCTCGAGACTACAAAGATTTTTCATTACAGTATATGACCAAAATTGTTGCCGGATTACAGCGCTCCTATGAAGGT
CAAAAAATTCCAGTCACATTGTTTACTAAAAATGGCGGACAGTGGTTAGAAGCGATTGCCGATACGGGTTGTGATGCGAT
TGGACTCGATTGGACGATTGATATGGCAAGCGCAAAAGCGCGTGTTGGAGATCGTGTGGTGTTACAGGGTAATATGGATC
CTTCTATGTTATATGCAACGCCAGAGCGAATCCGTCAAGAGGTTGCGACCATATTAGCGAGTTTTGGTAAAGGAAACGGA
CATGTCTTTAACCTAGGCCACGGCATTCATCTAGATGTACCGCCTGAGAATGGCAAAGTATTTGTTGATGCAGTACACGA
GTTGAGTATGCCGTATCACGTTTAA

Upstream 100 bases:

>100_bases
TGCAAAGTCGCAATATGACAGAGTAAAAAACATTTAAAAATGGTAGCATATTTACCTATGTAAATGATTAAATGTTTAAA
AAGACAGGATAGAGATAAGC

Downstream 100 bases:

>100_bases
GTACTTCGCTTATTTTTGATAAAAACCATGCACTTGCATGGTTTTTTACTATTTTGAGTAATCTATAAGTAATTTGCTGT
TGATTTTTTGTACGATTTTA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTELKNDRYLRALLKQDVDKTPVWMMRQAGRYLPEYKKVRAQAGDFMSLCRNADLACEVTLQPLRRFDLDAAILFSDILT
IPDAMGLGLYFAEGEGPKLKRPITCKKDVDNLIMPDPEGELQYVMNAVRTIRRELKGSVPLIGFAGSPWTLATYMVEGGS
SKAFTKIKKMAFCEPQLLHTLLDKLADSVIDYLNAQIAAGAQSVMVFDTWGGVLSPRDYKDFSLQYMTKIVAGLQRSYEG
QKIPVTLFTKNGGQWLEAIADTGCDAIGLDWTIDMASAKARVGDRVVLQGNMDPSMLYATPERIRQEVATILASFGKGNG
HVFNLGHGIHLDVPPENGKVFVDAVHELSMPYHV

Sequences:

>Translated_354_residues
MTELKNDRYLRALLKQDVDKTPVWMMRQAGRYLPEYKKVRAQAGDFMSLCRNADLACEVTLQPLRRFDLDAAILFSDILT
IPDAMGLGLYFAEGEGPKLKRPITCKKDVDNLIMPDPEGELQYVMNAVRTIRRELKGSVPLIGFAGSPWTLATYMVEGGS
SKAFTKIKKMAFCEPQLLHTLLDKLADSVIDYLNAQIAAGAQSVMVFDTWGGVLSPRDYKDFSLQYMTKIVAGLQRSYEG
QKIPVTLFTKNGGQWLEAIADTGCDAIGLDWTIDMASAKARVGDRVVLQGNMDPSMLYATPERIRQEVATILASFGKGNG
HVFNLGHGIHLDVPPENGKVFVDAVHELSMPYHV
>Mature_353_residues
TELKNDRYLRALLKQDVDKTPVWMMRQAGRYLPEYKKVRAQAGDFMSLCRNADLACEVTLQPLRRFDLDAAILFSDILTI
PDAMGLGLYFAEGEGPKLKRPITCKKDVDNLIMPDPEGELQYVMNAVRTIRRELKGSVPLIGFAGSPWTLATYMVEGGSS
KAFTKIKKMAFCEPQLLHTLLDKLADSVIDYLNAQIAAGAQSVMVFDTWGGVLSPRDYKDFSLQYMTKIVAGLQRSYEGQ
KIPVTLFTKNGGQWLEAIADTGCDAIGLDWTIDMASAKARVGDRVVLQGNMDPSMLYATPERIRQEVATILASFGKGNGH
VFNLGHGIHLDVPPENGKVFVDAVHELSMPYHV

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=46.4589235127479, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=77.6203966005666, Blast_Score=577, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=39.6600566572238, Blast_Score=273, Evalue=3e-74,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=44.0922190201729, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=44.0922190201729, Blast_Score=294, Evalue=5e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_PSYIN (A1SZJ4)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944508.1
- ProteinModelPortal:   A1SZJ4
- SMR:   A1SZJ4
- STRING:   A1SZJ4
- GeneID:   4624655
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_3222
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   A1SZJ4
- BioCyc:   PING357804:PING_3222-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39299; Mature: 39168

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 154-154 BINDING 209-209 BINDING 327-327

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELKNDRYLRALLKQDVDKTPVWMMRQAGRYLPEYKKVRAQAGDFMSLCRNADLACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCCCEEEEE
LQPLRRFDLDAAILFSDILTIPDAMGLGLYFAEGEGPKLKRPITCKKDVDNLIMPDPEGE
HHHHHHHCCHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCCCCHHCCCCCCCCCCCHH
LQYVMNAVRTIRRELKGSVPLIGFAGSPWTLATYMVEGGSSKAFTKIKKMAFCEPQLLHT
HHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHH
LLDKLADSVIDYLNAQIAAGAQSVMVFDTWGGVLSPRDYKDFSLQYMTKIVAGLQRSYEG
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
QKIPVTLFTKNGGQWLEAIADTGCDAIGLDWTIDMASAKARVGDRVVLQGNMDPSMLYAT
CEEEEEEEECCCHHHHHHHHHCCCCEECCCEEEEHHHHHHCCCCEEEEECCCCCCEEEEC
PERIRQEVATILASFGKGNGHVFNLGHGIHLDVPPENGKVFVDAVHELSMPYHV
HHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCEEEEEHHHCCCCCCC
>Mature Secondary Structure 
TELKNDRYLRALLKQDVDKTPVWMMRQAGRYLPEYKKVRAQAGDFMSLCRNADLACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCCCEEEEE
LQPLRRFDLDAAILFSDILTIPDAMGLGLYFAEGEGPKLKRPITCKKDVDNLIMPDPEGE
HHHHHHHCCHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCCCCHHCCCCCCCCCCCHH
LQYVMNAVRTIRRELKGSVPLIGFAGSPWTLATYMVEGGSSKAFTKIKKMAFCEPQLLHT
HHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHH
LLDKLADSVIDYLNAQIAAGAQSVMVFDTWGGVLSPRDYKDFSLQYMTKIVAGLQRSYEG
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
QKIPVTLFTKNGGQWLEAIADTGCDAIGLDWTIDMASAKARVGDRVVLQGNMDPSMLYAT
CEEEEEEEECCCHHHHHHHHHCCCCEECCCEEEEHHHHHHCCCCEEEEECCCCCCEEEEC
PERIRQEVATILASFGKGNGHVFNLGHGIHLDVPPENGKVFVDAVHELSMPYHV
HHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCEEEEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA