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The map label for this gene is appC [H]

Identifier: 119946765

GI number: 119946765

Start: 3887977

End: 3889224

Strand: Reverse

Name: appC [H]

Synonym: Ping_3158

Alternate gene names: 119946765

Gene position: 3889224-3887977 (Counterclockwise)

Preceding gene: 119946766

Following gene: 119946764

Centisome position: 85.3

GC content: 47.28

Gene sequence:

>1248_bases
ATGATAAGCAGTGTATTAGCCCGTTTCGGGCCAAAAGTTAAAAAATCGCAGGATGAATCTTACTATACAGCAGGCCAGCT
GGCATTAATTAAAGCCCGCTTTATGCGTAAAACCAGCGGCGTGGTTGCGGGTTGGGTGCTTGCCTCAATCATTATGGTGA
GTTTCTTTGCGCCGTTCTTTGCGCCAATAGATCCGACCATTCGTGGTGCTGATACTAACTATCAACGCGGTGCACCGCAA
GCTTTTTACTTCTGGGATGAACAGGGTATTTCCTTACGTCCCTTTACTTACACCTACAGTAAAGATAAACCTAAGATTGA
TTTTATGGCGCTGGCGGGTAGTGGTGGATTGGCGGCATTGGATGCGCTGACTTCCAGTGGTGCTTTGAGTTCTTCCGCGC
AGAACAAATATAACATAGATGAGCAGCAGCGCCGTTATGTGCAGTTCTTTGTTAAAGGCTGGGAATATAGTCTGATTGAT
TTCAGTATTGCAGGCCTTAATCTGGATCTTCGTTGGGATAGGCACTTGTTCGGCGTTGAGCAGGGAGAAATTCACCTGAT
GGGCACCGATCAGGACGGTAAAGATGTCTTTAGCCGTACCCTGCATGCCGTATGGATTACGGTGAGTATTGCCGTGGTGG
CTTTGATTGTTAAGCTGTTTACTTCCTTGCTGGTGGGCGGTATCAGTGGTTACTTTGGCGGGCGTGTTGATGCGGTATTA
ATGAGCTTTACTGAGGCGGTACGCGTTATCCCCTCAATCCCTGTTTATTTGGCCTGTGCTGTTGCATTATCAAGCATGGA
TCTTACCGCAGTGCAGCGTTACTTTGCGATTGCTGTGGTTATCGGTGCACTGGACTTTGCGACATTAGGGCGGCGTTTGC
GCACCCATATTCTGACCGAGCGTAATCAGGACTATGTATTGGCTGCACAGCTCTGCGGCTCAAGCAGCTGGCGGATTATC
TGGCGTCATCTGATACCCAGTTTTAGCAGTTATATTATCGTCGATACCTTAATCAATTTTCCTTACGTTATTCTGGCCGA
AACCAGCCTTAGTTTTCTGGGACTCGGCTTAACTGAACCGGTTAACAGTCTGGGTGTATTACTGCAAAAAGCACAGGATC
CGGACATCCAGCAAAATATGATCTGGCAGTTCTTTCCAGTACTGGTTTTTGTGGTGTTAATTATGGCTTTTGTGTTTGTG
GGGGACGCCTTGCGTGATGCCGCAGATCCTTATTCGGAGAAAAAATAA

Upstream 100 bases:

>100_bases
ATTTCTGGTAGCCCTGGTGGTTATATCGATGAATTTCATTACTGATATTGTTCTGGCAGCGGTCGATCCGCGTGTCCGTA
ATAGTGTACTTGGGTAAATT

Downstream 100 bases:

>100_bases
TGATAATGAATAATAAAAGCATGAACAGTAACTTACTTGAAATTCGCAATCTTGGTATCGATTTCAATACCGATGAGGGT
TTAATGCGCGCGGTTGACGG

Product: peptide ABC transporter, protein inner membrane binding component

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MISSVLARFGPKVKKSQDESYYTAGQLALIKARFMRKTSGVVAGWVLASIIMVSFFAPFFAPIDPTIRGADTNYQRGAPQ
AFYFWDEQGISLRPFTYTYSKDKPKIDFMALAGSGGLAALDALTSSGALSSSAQNKYNIDEQQRRYVQFFVKGWEYSLID
FSIAGLNLDLRWDRHLFGVEQGEIHLMGTDQDGKDVFSRTLHAVWITVSIAVVALIVKLFTSLLVGGISGYFGGRVDAVL
MSFTEAVRVIPSIPVYLACAVALSSMDLTAVQRYFAIAVVIGALDFATLGRRLRTHILTERNQDYVLAAQLCGSSSWRII
WRHLIPSFSSYIIVDTLINFPYVILAETSLSFLGLGLTEPVNSLGVLLQKAQDPDIQQNMIWQFFPVLVFVVLIMAFVFV
GDALRDAADPYSEKK

Sequences:

>Translated_415_residues
MISSVLARFGPKVKKSQDESYYTAGQLALIKARFMRKTSGVVAGWVLASIIMVSFFAPFFAPIDPTIRGADTNYQRGAPQ
AFYFWDEQGISLRPFTYTYSKDKPKIDFMALAGSGGLAALDALTSSGALSSSAQNKYNIDEQQRRYVQFFVKGWEYSLID
FSIAGLNLDLRWDRHLFGVEQGEIHLMGTDQDGKDVFSRTLHAVWITVSIAVVALIVKLFTSLLVGGISGYFGGRVDAVL
MSFTEAVRVIPSIPVYLACAVALSSMDLTAVQRYFAIAVVIGALDFATLGRRLRTHILTERNQDYVLAAQLCGSSSWRII
WRHLIPSFSSYIIVDTLINFPYVILAETSLSFLGLGLTEPVNSLGVLLQKAQDPDIQQNMIWQFFPVLVFVVLIMAFVFV
GDALRDAADPYSEKK
>Mature_415_residues
MISSVLARFGPKVKKSQDESYYTAGQLALIKARFMRKTSGVVAGWVLASIIMVSFFAPFFAPIDPTIRGADTNYQRGAPQ
AFYFWDEQGISLRPFTYTYSKDKPKIDFMALAGSGGLAALDALTSSGALSSSAQNKYNIDEQQRRYVQFFVKGWEYSLID
FSIAGLNLDLRWDRHLFGVEQGEIHLMGTDQDGKDVFSRTLHAVWITVSIAVVALIVKLFTSLLVGGISGYFGGRVDAVL
MSFTEAVRVIPSIPVYLACAVALSSMDLTAVQRYFAIAVVIGALDFATLGRRLRTHILTERNQDYVLAAQLCGSSSWRII
WRHLIPSFSSYIIVDTLINFPYVILAETSLSFLGLGLTEPVNSLGVLLQKAQDPDIQQNMIWQFFPVLVFVVLIMAFVFV
GDALRDAADPYSEKK

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787498, Length=226, Percent_Identity=32.7433628318584, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789889, Length=228, Percent_Identity=29.8245614035088, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787054, Length=226, Percent_Identity=29.646017699115, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788505, Length=230, Percent_Identity=31.7391304347826, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787760, Length=233, Percent_Identity=30.0429184549356, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789964, Length=230, Percent_Identity=30, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787549, Length=203, Percent_Identity=27.0935960591133, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 46024; Mature: 46024

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSVLARFGPKVKKSQDESYYTAGQLALIKARFMRKTSGVVAGWVLASIIMVSFFAPFF
CHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
APIDPTIRGADTNYQRGAPQAFYFWDEQGISLRPFTYTYSKDKPKIDFMALAGSGGLAAL
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCEECCEEEECCCCCCCEEEEEEECCCCHHHH
DALTSSGALSSSAQNKYNIDEQQRRYVQFFVKGWEYSLIDFSIAGLNLDLRWDRHLFGVE
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEEEEEEECCCCCCCC
QGEIHLMGTDQDGKDVFSRTLHAVWITVSIAVVALIVKLFTSLLVGGISGYFGGRVDAVL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
MSFTEAVRVIPSIPVYLACAVALSSMDLTAVQRYFAIAVVIGALDFATLGRRLRTHILTE
HHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNQDYVLAAQLCGSSSWRIIWRHLIPSFSSYIIVDTLINFPYVILAETSLSFLGLGLTEP
CCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHCCCCCCH
VNSLGVLLQKAQDPDIQQNMIWQFFPVLVFVVLIMAFVFVGDALRDAADPYSEKK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MISSVLARFGPKVKKSQDESYYTAGQLALIKARFMRKTSGVVAGWVLASIIMVSFFAPFF
CHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
APIDPTIRGADTNYQRGAPQAFYFWDEQGISLRPFTYTYSKDKPKIDFMALAGSGGLAAL
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCEECCEEEECCCCCCCEEEEEEECCCCHHHH
DALTSSGALSSSAQNKYNIDEQQRRYVQFFVKGWEYSLIDFSIAGLNLDLRWDRHLFGVE
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEEEEEEECCCCCCCC
QGEIHLMGTDQDGKDVFSRTLHAVWITVSIAVVALIVKLFTSLLVGGISGYFGGRVDAVL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
MSFTEAVRVIPSIPVYLACAVALSSMDLTAVQRYFAIAVVIGALDFATLGRRLRTHILTE
HHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNQDYVLAAQLCGSSSWRIIWRHLIPSFSSYIIVDTLINFPYVILAETSLSFLGLGLTEP
CCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHCCCCCCH
VNSLGVLLQKAQDPDIQQNMIWQFFPVLVFVVLIMAFVFVGDALRDAADPYSEKK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]