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The map label for this gene is msrAB [H]

Identifier: 119946746

GI number: 119946746

Start: 3860277

End: 3860780

Strand: Reverse

Name: msrAB [H]

Synonym: Ping_3135

Alternate gene names: 119946746

Gene position: 3860780-3860277 (Counterclockwise)

Preceding gene: 119946750

Following gene: 119946744

Centisome position: 84.67

GC content: 34.72

Gene sequence:

>504_bases
ATGGAAACAATCTATTTTTCTGGAGGCTGTCTCTGGGGGGTGCAAGAATTTATGAAGTACTTACCTGGAGTGGAGAGAAC
TCAGGTAGGAAGAGTAAATGGTGCGACTCATTCAACCAAAACCGCTTATGATGGTTATGGTGAATGCGTGAAAATGGAAT
TTAATCCAGCTATTGTTTCACTTGAAACCTTGATTGACTATCTTTTCGAAATTATTGACCCCTATAGTATAAACAAACAA
GGGAACGATGTAGGTGAGAAATATAGAACAGGTATTTACAGTAAAGAGACTAATCACTTACTAAAAGCAAAATGCCATAT
TGAACGGTTAGAAAATGCATTAAATGATAAAAATAAAACAAGAAAAAAAGTGGTAGTTGAAGTATTACCCCTCACCAATT
ACATTCCGAGTGATAATGAGCATCAAGACAGACTAACGTTATTTCCTGATGATTATTGTCATATTCCTTTAAGGCTACTT
CATAAGTATAAAAAGAAAACCTAA

Upstream 100 bases:

>100_bases
TTATAGTGGCTTATATTAAAATCGACTATCACTTCGAAATATCCTTCGCGTTAAAGTCAAAAATAAAATTTTTAATAATG
TATCGAGGTTAATTTAAATT

Downstream 100 bases:

>100_bases
AAATAAAAGATTTTCTTTTTATACAGGTAAATGAATCCATAACTTATTGTGGGCTAGCAATATGATTTTTTTTGTTGATG
TATTCATTAAATGCAAGCGA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
METIYFSGGCLWGVQEFMKYLPGVERTQVGRVNGATHSTKTAYDGYGECVKMEFNPAIVSLETLIDYLFEIIDPYSINKQ
GNDVGEKYRTGIYSKETNHLLKAKCHIERLENALNDKNKTRKKVVVEVLPLTNYIPSDNEHQDRLTLFPDDYCHIPLRLL
HKYKKKT

Sequences:

>Translated_167_residues
METIYFSGGCLWGVQEFMKYLPGVERTQVGRVNGATHSTKTAYDGYGECVKMEFNPAIVSLETLIDYLFEIIDPYSINKQ
GNDVGEKYRTGIYSKETNHLLKAKCHIERLENALNDKNKTRKKVVVEVLPLTNYIPSDNEHQDRLTLFPDDYCHIPLRLL
HKYKKKT
>Mature_167_residues
METIYFSGGCLWGVQEFMKYLPGVERTQVGRVNGATHSTKTAYDGYGECVKMEFNPAIVSLETLIDYLFEIIDPYSINKQ
GNDVGEKYRTGIYSKETNHLLKAKCHIERLENALNDKNKTRKKVVVEVLPLTNYIPSDNEHQDRLTLFPDDYCHIPLRLL
HKYKKKT

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=27.0967741935484, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=27.0967741935484, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=30, Blast_Score=84, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=27.1604938271605, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 19307; Mature: 19307

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIYFSGGCLWGVQEFMKYLPGVERTQVGRVNGATHSTKTAYDGYGECVKMEFNPAIVS
CCEEEECCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHH
LETLIDYLFEIIDPYSINKQGNDVGEKYRTGIYSKETNHLLKAKCHIERLENALNDKNKT
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
RKKVVVEVLPLTNYIPSDNEHQDRLTLFPDDYCHIPLRLLHKYKKKT
HHHHHHHEECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
METIYFSGGCLWGVQEFMKYLPGVERTQVGRVNGATHSTKTAYDGYGECVKMEFNPAIVS
CCEEEECCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHH
LETLIDYLFEIIDPYSINKQGNDVGEKYRTGIYSKETNHLLKAKCHIERLENALNDKNKT
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
RKKVVVEVLPLTNYIPSDNEHQDRLTLFPDDYCHIPLRLLHKYKKKT
HHHHHHHEECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA