Click here to switch to the map view.

The map label for this gene is cynR [H]

Identifier: 119946427

GI number: 119946427

Start: 3446823

End: 3447707

Strand: Direct

Name: cynR [H]

Synonym: Ping_2801

Alternate gene names: 119946427

Gene position: 3446823-3447707 (Clockwise)

Preceding gene: 119946422

Following gene: 119946437

Centisome position: 75.59

GC content: 40.45

Gene sequence:

>885_bases
ATGCTAAATTCTAAAATATTGTATTATTTTGTGACCATCGTTGAACATGGCAGTTATACCAAGGCAGCTCAAGCGCTGGG
TATTGCGCAATCCGCTTTAAGTATTGCAATCCGCAAGTTAGAAAAAAAAATTGGGGTGACAATATTACACCGCAGCAGTA
AAGGCGTCACGGTGACTAAAGAAGGTGAGGTTCTGTTAACCCATGCTAAAGCTATCTTAACGAAAATAAACGATGCGCAA
ATTGCCATTGATGAATTACGCGGTTTTGAGAAGGGAGAAGTAAAAATTGGCATTCCAAGCATGATGGGATCCTATTTTTT
CCCTGAAATATTAATGGCTTTTAACTTTAAGTACCCTGATATTAAACTGTCAATCGTGGAATCCGGCACACAAACCATCA
GAGCACAACTGTTAAGCGGCGAGTTGGATCTGGGAGTGATTGTCAATGACCATTTACCCAATGAACTGCAGGCCAGACAC
TTGGTAACGTCACAAATGGTTGCTGCGGTGGGTACAAATCATCCCTTAGCAGGCTTTAAAAAACTCGATTACAGTACTTT
TTTCGGACAGGAACTGGTGATGTTTAAAGTGGGTTACTTTCACCGCGAAGTGATTGATAAACTTTGCGAGCAATATCAGT
ACACGGCAAAATATTCTTTTGAAACAAATTTACTGGCGATGATGTTAAACATTGTTAAAAACGAATTTGCGATAACCGCC
CTGCTGGAATTGGTAACAGACCGCGAATCTGAAGTACTGGGTATTCCTTTTGAAGAGCCTGTCTATCTCGACCTTGCATT
TGCGTGGCGAAAAGACGGTTATTTATCAATAGCCAACAGGCGTTTTATCGACTTCACATTAAACGAGGTCAATAAAAAAG
GATAA

Upstream 100 bases:

>100_bases
TTATCACTTTATCTACTCGGTAATTTATTTTTACCTAGATTAGCCATTAAATGCTAATATTAAAAATATATTAAACTCAT
AGTTGCCATATATTAAAGTT

Downstream 100 bases:

>100_bases
TCATCTTATGCTTTTACTTACATTTTCAGAAAAACTATACCCTATGCCCCGTTCTGTGCGTATGTATCTGGGACTTCTTG
AATTGATTTCCAACTTCTGG

Product: transcriptional regulator, substrate-binding, LysR family protein

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MLNSKILYYFVTIVEHGSYTKAAQALGIAQSALSIAIRKLEKKIGVTILHRSSKGVTVTKEGEVLLTHAKAILTKINDAQ
IAIDELRGFEKGEVKIGIPSMMGSYFFPEILMAFNFKYPDIKLSIVESGTQTIRAQLLSGELDLGVIVNDHLPNELQARH
LVTSQMVAAVGTNHPLAGFKKLDYSTFFGQELVMFKVGYFHREVIDKLCEQYQYTAKYSFETNLLAMMLNIVKNEFAITA
LLELVTDRESEVLGIPFEEPVYLDLAFAWRKDGYLSIANRRFIDFTLNEVNKKG

Sequences:

>Translated_294_residues
MLNSKILYYFVTIVEHGSYTKAAQALGIAQSALSIAIRKLEKKIGVTILHRSSKGVTVTKEGEVLLTHAKAILTKINDAQ
IAIDELRGFEKGEVKIGIPSMMGSYFFPEILMAFNFKYPDIKLSIVESGTQTIRAQLLSGELDLGVIVNDHLPNELQARH
LVTSQMVAAVGTNHPLAGFKKLDYSTFFGQELVMFKVGYFHREVIDKLCEQYQYTAKYSFETNLLAMMLNIVKNEFAITA
LLELVTDRESEVLGIPFEEPVYLDLAFAWRKDGYLSIANRRFIDFTLNEVNKKG
>Mature_294_residues
MLNSKILYYFVTIVEHGSYTKAAQALGIAQSALSIAIRKLEKKIGVTILHRSSKGVTVTKEGEVLLTHAKAILTKINDAQ
IAIDELRGFEKGEVKIGIPSMMGSYFFPEILMAFNFKYPDIKLSIVESGTQTIRAQLLSGELDLGVIVNDHLPNELQARH
LVTSQMVAAVGTNHPLAGFKKLDYSTFFGQELVMFKVGYFHREVIDKLCEQYQYTAKYSFETNLLAMMLNIVKNEFAITA
LLELVTDRESEVLGIPFEEPVYLDLAFAWRKDGYLSIANRRFIDFTLNEVNKKG

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=292, Percent_Identity=28.0821917808219, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI145693105, Length=282, Percent_Identity=29.0780141843972, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1787879, Length=289, Percent_Identity=28.3737024221453, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790399, Length=257, Percent_Identity=26.8482490272374, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786401, Length=162, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788297, Length=153, Percent_Identity=36.6013071895425, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787601, Length=182, Percent_Identity=30.2197802197802, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789204, Length=238, Percent_Identity=25.2100840336134, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788887, Length=187, Percent_Identity=28.8770053475936, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788481, Length=285, Percent_Identity=23.5087719298246, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788748, Length=296, Percent_Identity=21.2837837837838, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367136, Length=237, Percent_Identity=23.6286919831224, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082132, Length=171, Percent_Identity=30.9941520467836, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87081904, Length=172, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787530, Length=217, Percent_Identity=24.8847926267281, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788296, Length=190, Percent_Identity=27.3684210526316, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1789506, Length=275, Percent_Identity=24.3636363636364, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787589, Length=148, Percent_Identity=29.7297297297297, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789440, Length=167, Percent_Identity=28.7425149700599, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786713, Length=184, Percent_Identity=25.5434782608696, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787128, Length=120, Percent_Identity=27.5, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33072; Mature: 33072

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNSKILYYFVTIVEHGSYTKAAQALGIAQSALSIAIRKLEKKIGVTILHRSSKGVTVTK
CCCCEEEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEE
EGEVLLTHAKAILTKINDAQIAIDELRGFEKGEVKIGIPSMMGSYFFPEILMAFNFKYPD
CCCEEEEHHHHHHHHCCCCEEEHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCC
IKLSIVESGTQTIRAQLLSGELDLGVIVNDHLPNELQARHLVTSQMVAAVGTNHPLAGFK
EEEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHH
KLDYSTFFGQELVMFKVGYFHREVIDKLCEQYQYTAKYSFETNLLAMMLNIVKNEFAITA
HCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHH
LLELVTDRESEVLGIPFEEPVYLDLAFAWRKDGYLSIANRRFIDFTLNEVNKKG
HHHHHHCCCCCEEECCCCCCEEEEEEEEECCCCEEEECCCEEEEEEHHHCCCCC
>Mature Secondary Structure
MLNSKILYYFVTIVEHGSYTKAAQALGIAQSALSIAIRKLEKKIGVTILHRSSKGVTVTK
CCCCEEEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEE
EGEVLLTHAKAILTKINDAQIAIDELRGFEKGEVKIGIPSMMGSYFFPEILMAFNFKYPD
CCCEEEEHHHHHHHHCCCCEEEHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCC
IKLSIVESGTQTIRAQLLSGELDLGVIVNDHLPNELQARHLVTSQMVAAVGTNHPLAGFK
EEEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHH
KLDYSTFFGQELVMFKVGYFHREVIDKLCEQYQYTAKYSFETNLLAMMLNIVKNEFAITA
HCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHH
LLELVTDRESEVLGIPFEEPVYLDLAFAWRKDGYLSIANRRFIDFTLNEVNKKG
HHHHHHCCCCCEEECCCCCCEEEEEEEEECCCCEEEECCCEEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]