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The map label for this gene is folC [H]

Identifier: 119945655

GI number: 119945655

Start: 2393603

End: 2394889

Strand: Reverse

Name: folC [H]

Synonym: Ping_1968

Alternate gene names: 119945655

Gene position: 2394889-2393603 (Counterclockwise)

Preceding gene: 119945656

Following gene: 119945654

Centisome position: 52.52

GC content: 39.24

Gene sequence:

>1287_bases
ATGCATAATGTTATTCCTCAAAAACTTCCTCAAACACTGCCACAATGGTTGGCCTATATTGAAATATTACACCCAAGCGC
TATCGATTTAGGGCTGTCGCGTATTGCCAAGGTCGCTTCGGCTCTGCAAGTGATCAATTTTGATGCGCAAGTGATCACTG
TTGCGGGGACAAATGGCAAGGGCACAACTTGTGCTTTTCTAGAAGAAATTTTGCTGCAAGCGGGTTTTAAAGTGGGGGTT
TACAGTTCACCGCATATCCAAAGATACACCGAGCGCTTACGTATCAATAAACAGGAATTATCCGATCAAGCGCATTGTGA
CGCTTTTTCGGCAATAGAAAAAATACGGAAAGAGACTTCATTAAGTTATTTTGAGTATGCCACATTGGGTTGTTTATCTT
TATTAAAACAAGCCCACTGTGATTATATCTTACTGGAAGTTGGGTTGGGAGGGCGTTTAGATGCCACCAATGTTGTTGAA
TCCGATGCCAGCGTGATAACCACAATAGATATAGACCATATTGATTGGCTAGGCAGCGATCGTGAAAAAATCGGTTTTGA
AAAAGCAGGTGTTTTTCGTGCGAATAAGCCGGTCATTTGCGGTGAATTTGATCCACCATTATCTTTACAAGCTCATGCGC
AAAATCTTAATTGCCAAATCAAATACGCAGGTAAAGATTTTTCCTATCAAGTAACCGGGAAGCAATGGAATTGGTCAGGA
AAACAAACGCTCAAGGATATTCGTTTACCGTTATTACCCGTTCAAAATGCGTCAACTGCACTGGCGGTTATTGAAGCGCT
GCAAGTCAAAGTAAATCCTGCTGTGCTTAAAAATGCCATTGAAAATGCAAGTTTAGCCGGTCGTTTGCAAAAAATCAGCA
CAACATCTGTTTGTGATGTGTATTTAGATGTTGCTCATAACCCGCAATCTGCAGGCTATCTTGCGAGTCAGTTACGCCTA
ATAAAGGCGGAAAAACCGGAAAAATGTAAAGTACATGCCATTGTCGGTATGTTAGCCGATAAAGATATTACCGGTACTTT
TGATCAAATAAACACAGAAATTGATTTTTGTAATCTTGTCTCTTTAGATTGTTATCGAGGTCTTAGCGCTGACTCACTGT
TAGAAAACCATCAAAAATCAAAAAATGCGCTAACGACCCCTATTTGTTTCGAAAATGTTAATCTGGCTTATGAAACAGTA
CGTAATAAAGTCGATTCATCTGATATAATTATTATCTTTGGTTCATTCCATACTGTTTCTGATTTTTTAAATTTTTCACA
AGGATAA

Upstream 100 bases:

>100_bases
GGCGGGTTATATTTAGTTGAAGTTGACTATCCCTCGCAGTATGATTTACCCCGCCCCCCCTGCGGTCCGCTATTTTTAGA
ACTATAAATCAGAGCAAAAT

Downstream 100 bases:

>100_bases
CCTGTGGCTTCTCAGTTTAAAAATCGTTTAGTAGGGGTAACTATTTTAGTTGCCTCTGTTGTTATTTTTTTGCCAACCAT
TATTGATGGTGAAAAAATAT

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MHNVIPQKLPQTLPQWLAYIEILHPSAIDLGLSRIAKVASALQVINFDAQVITVAGTNGKGTTCAFLEEILLQAGFKVGV
YSSPHIQRYTERLRINKQELSDQAHCDAFSAIEKIRKETSLSYFEYATLGCLSLLKQAHCDYILLEVGLGGRLDATNVVE
SDASVITTIDIDHIDWLGSDREKIGFEKAGVFRANKPVICGEFDPPLSLQAHAQNLNCQIKYAGKDFSYQVTGKQWNWSG
KQTLKDIRLPLLPVQNASTALAVIEALQVKVNPAVLKNAIENASLAGRLQKISTTSVCDVYLDVAHNPQSAGYLASQLRL
IKAEKPEKCKVHAIVGMLADKDITGTFDQINTEIDFCNLVSLDCYRGLSADSLLENHQKSKNALTTPICFENVNLAYETV
RNKVDSSDIIIIFGSFHTVSDFLNFSQG

Sequences:

>Translated_428_residues
MHNVIPQKLPQTLPQWLAYIEILHPSAIDLGLSRIAKVASALQVINFDAQVITVAGTNGKGTTCAFLEEILLQAGFKVGV
YSSPHIQRYTERLRINKQELSDQAHCDAFSAIEKIRKETSLSYFEYATLGCLSLLKQAHCDYILLEVGLGGRLDATNVVE
SDASVITTIDIDHIDWLGSDREKIGFEKAGVFRANKPVICGEFDPPLSLQAHAQNLNCQIKYAGKDFSYQVTGKQWNWSG
KQTLKDIRLPLLPVQNASTALAVIEALQVKVNPAVLKNAIENASLAGRLQKISTTSVCDVYLDVAHNPQSAGYLASQLRL
IKAEKPEKCKVHAIVGMLADKDITGTFDQINTEIDFCNLVSLDCYRGLSADSLLENHQKSKNALTTPICFENVNLAYETV
RNKVDSSDIIIIFGSFHTVSDFLNFSQG
>Mature_428_residues
MHNVIPQKLPQTLPQWLAYIEILHPSAIDLGLSRIAKVASALQVINFDAQVITVAGTNGKGTTCAFLEEILLQAGFKVGV
YSSPHIQRYTERLRINKQELSDQAHCDAFSAIEKIRKETSLSYFEYATLGCLSLLKQAHCDYILLEVGLGGRLDATNVVE
SDASVITTIDIDHIDWLGSDREKIGFEKAGVFRANKPVICGEFDPPLSLQAHAQNLNCQIKYAGKDFSYQVTGKQWNWSG
KQTLKDIRLPLLPVQNASTALAVIEALQVKVNPAVLKNAIENASLAGRLQKISTTSVCDVYLDVAHNPQSAGYLASQLRL
IKAEKPEKCKVHAIVGMLADKDITGTFDQINTEIDFCNLVSLDCYRGLSADSLLENHQKSKNALTTPICFENVNLAYETV
RNKVDSSDIIIIFGSFHTVSDFLNFSQG

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=205, Percent_Identity=35.1219512195122, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI66932990, Length=205, Percent_Identity=35.1219512195122, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1788654, Length=425, Percent_Identity=44.2352941176471, Blast_Score=345, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17553148, Length=468, Percent_Identity=27.5641025641026, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17553150, Length=468, Percent_Identity=27.5641025641026, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71984923, Length=468, Percent_Identity=27.5641025641026, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323760, Length=325, Percent_Identity=29.5384615384615, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324815, Length=447, Percent_Identity=24.6085011185682, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24641571, Length=161, Percent_Identity=34.7826086956522, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24581568, Length=146, Percent_Identity=35.6164383561644, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17; =6.3.2.12 [H]

Molecular weight: Translated: 47142; Mature: 47142

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS01012 FOLYLPOLYGLU_SYNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNVIPQKLPQTLPQWLAYIEILHPSAIDLGLSRIAKVASALQVINFDAQVITVAGTNGK
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCC
GTTCAFLEEILLQAGFKVGVYSSPHIQRYTERLRINKQELSDQAHCDAFSAIEKIRKETS
CCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHC
LSYFEYATLGCLSLLKQAHCDYILLEVGLGGRLDATNVVESDASVITTIDIDHIDWLGSD
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCCEEEEEECCHHHCCCCC
REKIGFEKAGVFRANKPVICGEFDPPLSLQAHAQNLNCQIKYAGKDFSYQVTGKQWNWSG
HHHCCCHHCCCEECCCCEEECCCCCCCCCEECCCCCCEEEEECCCCEEEEECCCEECCCH
KQTLKDIRLPLLPVQNASTALAVIEALQVKVNPAVLKNAIENASLAGRLQKISTTSVCDV
HHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHCCCHHHEEE
YLDVAHNPQSAGYLASQLRLIKAEKPEKCKVHAIVGMLADKDITGTFDQINTEIDFCNLV
EEECCCCCCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCCCHHHHCCCCCEEEEE
SLDCYRGLSADSLLENHQKSKNALTTPICFENVNLAYETVRNKVDSSDIIIIFGSFHTVS
EHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHCCCCCCEEEEEECHHHHH
DFLNFSQG
HHHHCCCC
>Mature Secondary Structure
MHNVIPQKLPQTLPQWLAYIEILHPSAIDLGLSRIAKVASALQVINFDAQVITVAGTNGK
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCC
GTTCAFLEEILLQAGFKVGVYSSPHIQRYTERLRINKQELSDQAHCDAFSAIEKIRKETS
CCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHC
LSYFEYATLGCLSLLKQAHCDYILLEVGLGGRLDATNVVESDASVITTIDIDHIDWLGSD
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCCEEEEEECCHHHCCCCC
REKIGFEKAGVFRANKPVICGEFDPPLSLQAHAQNLNCQIKYAGKDFSYQVTGKQWNWSG
HHHCCCHHCCCEECCCCEEECCCCCCCCCEECCCCCCEEEEECCCCEEEEECCCEECCCH
KQTLKDIRLPLLPVQNASTALAVIEALQVKVNPAVLKNAIENASLAGRLQKISTTSVCDV
HHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHCCCHHHEEE
YLDVAHNPQSAGYLASQLRLIKAEKPEKCKVHAIVGMLADKDITGTFDQINTEIDFCNLV
EEECCCCCCCHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCCCHHHHCCCCCEEEEE
SLDCYRGLSADSLLENHQKSKNALTTPICFENVNLAYETVRNKVDSSDIIIIFGSFHTVS
EHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHCCCCCCEEEEEECHHHHH
DFLNFSQG
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]