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The map label for this gene is hisA

Identifier: 119945364

GI number: 119945364

Start: 2009483

End: 2010220

Strand: Reverse

Name: hisA

Synonym: Ping_1652

Alternate gene names: 119945364

Gene position: 2010220-2009483 (Counterclockwise)

Preceding gene: 119945365

Following gene: 119945363

Centisome position: 44.09

GC content: 48.37

Gene sequence:

>738_bases
ATGATTATTCCAGCACTCGATCTTATCGATGGCAAAGTCGTGCGTTTATATCAAGGTGATTACGCACAAAAAACAGTTTA
CAGTGACTCCCCGCAAAGCCAGTTTACTATTTATAACCAGCAGGGAGCCGATTGGTTACATCTGGTTGATTTAGACGGCG
CGAAAGATGTGACTAAACGCCAGCTAAAAGTGATCGCCAGCCTGATAGCTAACACCCCCGCTAAAATTCAGATTGGCGGC
GGTGTACGCACCGAGCAGGACGTACAAGATCTGTTAGATGCTGGCGCTCAGCGGGTGGTTATTGGTTCAACAGCTGTTAA
AGAACCAGCAATGGTAGCCGGTTGGATGAAAAAATACGGTGCGGAACATATCGTACTGGCACTGGATATCAACATCGACG
CACAAGGTAACAAAATTGTGGCGGTTTCCGGCTGGCAGGAAGCAAGTGGTCAAACAATTGAATCTCTGCTAGAGACTTAC
TTAGCAGTCGGCTTAAAACATGTGCTTTGTACTGACATTTCCAAAGACGGTACCTTAAGCGGCTCAAATGTCTCTCTTTA
TAAAGAAATGGCCGCAGCCTACCCGCAAGTAGCCTGGCAGGCATCGGGTGGCATCGGCTCATTAGATGATATCGCAGCGG
TTGCCCGCTCCGGCGCATCGGGCATGATTGTCGGTCGCGCGCTGCTGGAAGGTAAATTTACCGTTAAAGAGGCCATTTTC
TGTTGGGAAAACGCATAA

Upstream 100 bases:

>100_bases
GCGGCCGTTAATAAAGATAATTTTTACGGGGTACAGTTTCACCCCGAACGCTCCGGTAAAGCTGGCGCCCAACTGATTAA
AAACTTCCTGGAGCTTTAAA

Downstream 100 bases:

>100_bases
TTTTTTGCCTTTTACGTAAATAACTATCAGCACACAAATAAAAAGCTGTAATCCCTTTAAAATAAAAGAATTACAGCTTT
ATTACAGGATTGGAACTCCG

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MIIPALDLIDGKVVRLYQGDYAQKTVYSDSPQSQFTIYNQQGADWLHLVDLDGAKDVTKRQLKVIASLIANTPAKIQIGG
GVRTEQDVQDLLDAGAQRVVIGSTAVKEPAMVAGWMKKYGAEHIVLALDINIDAQGNKIVAVSGWQEASGQTIESLLETY
LAVGLKHVLCTDISKDGTLSGSNVSLYKEMAAAYPQVAWQASGGIGSLDDIAAVARSGASGMIVGRALLEGKFTVKEAIF
CWENA

Sequences:

>Translated_245_residues
MIIPALDLIDGKVVRLYQGDYAQKTVYSDSPQSQFTIYNQQGADWLHLVDLDGAKDVTKRQLKVIASLIANTPAKIQIGG
GVRTEQDVQDLLDAGAQRVVIGSTAVKEPAMVAGWMKKYGAEHIVLALDINIDAQGNKIVAVSGWQEASGQTIESLLETY
LAVGLKHVLCTDISKDGTLSGSNVSLYKEMAAAYPQVAWQASGGIGSLDDIAAVARSGASGMIVGRALLEGKFTVKEAIF
CWENA
>Mature_245_residues
MIIPALDLIDGKVVRLYQGDYAQKTVYSDSPQSQFTIYNQQGADWLHLVDLDGAKDVTKRQLKVIASLIANTPAKIQIGG
GVRTEQDVQDLLDAGAQRVVIGSTAVKEPAMVAGWMKKYGAEHIVLALDINIDAQGNKIVAVSGWQEASGQTIESLLETY
LAVGLKHVLCTDISKDGTLSGSNVSLYKEMAAAYPQVAWQASGGIGSLDDIAAVARSGASGMIVGRALLEGKFTVKEAIF
CWENA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=245, Percent_Identity=64.8979591836735, Blast_Score=328, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_PSYIN (A1SVD0)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943044.1
- ProteinModelPortal:   A1SVD0
- SMR:   A1SVD0
- STRING:   A1SVD0
- GeneID:   4626931
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1652
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   A1SVD0
- BioCyc:   PING357804:PING_1652-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26125; Mature: 26125

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: ACT_SITE 7-7 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPALDLIDGKVVRLYQGDYAQKTVYSDSPQSQFTIYNQQGADWLHLVDLDGAKDVTKR
CCCCCCCCCCCCEEEEECCCCHHHCEECCCCCCEEEEEECCCCCEEEEEECCCCHHHHHH
QLKVIASLIANTPAKIQIGGGVRTEQDVQDLLDAGAQRVVIGSTAVKEPAMVAGWMKKYG
HHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCC
AEHIVLALDINIDAQGNKIVAVSGWQEASGQTIESLLETYLAVGLKHVLCTDISKDGTLS
CCEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GSNVSLYKEMAAAYPQVAWQASGGIGSLDDIAAVARSGASGMIVGRALLEGKFTVKEAIF
CCCHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEHHHHHCCCHHHHHHEE
CWENA
EECCC
>Mature Secondary Structure
MIIPALDLIDGKVVRLYQGDYAQKTVYSDSPQSQFTIYNQQGADWLHLVDLDGAKDVTKR
CCCCCCCCCCCCEEEEECCCCHHHCEECCCCCCEEEEEECCCCCEEEEEECCCCHHHHHH
QLKVIASLIANTPAKIQIGGGVRTEQDVQDLLDAGAQRVVIGSTAVKEPAMVAGWMKKYG
HHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCC
AEHIVLALDINIDAQGNKIVAVSGWQEASGQTIESLLETYLAVGLKHVLCTDISKDGTLS
CCEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GSNVSLYKEMAAAYPQVAWQASGGIGSLDDIAAVARSGASGMIVGRALLEGKFTVKEAIF
CCCHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEHHHHHCCCHHHHHHEE
CWENA
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA