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The map label for this gene is hisI [H]

Identifier: 119945358

GI number: 119945358

Start: 2003503

End: 2004132

Strand: Reverse

Name: hisI [H]

Synonym: Ping_1646

Alternate gene names: 119945358

Gene position: 2004132-2003503 (Counterclockwise)

Preceding gene: 119945359

Following gene: 119945357

Centisome position: 43.95

GC content: 39.68

Gene sequence:

>630_bases
ATGAACAAAGCGTTAATGAATGAACAACAGCTTACAGCATTAGATTGGGAAAAAGTTGATAACTTGATGCCGGTTATTGT
GCAAAATCGCACCTCAGGCAAAGTATTAATGCTGGGTTATGTAAACCAAGAGGCATTAACTGCAACCCTTACAAGTGGCA
AAATGACTTTTTTTAGCCGTACCAAGCAGCGTTTATGGTGTAAAGGGGAAGAGTCAGGTAACTTTTTAAATGTGCTGGAG
ATAAGCACCGACTGTGATAATGACACGCTGTTGGCAATAGTTGATCCCATTGGTCCTACCTGCCATCTGGGAACAGAAAG
CTGCTTTAAGGGTGAATTACAACCTGCGCTCACTTTTATCGCCGATTTAGAAAAAGTAATAGCGGGTCGTAAGAATGCTG
ATCCAAAAAGTAGCTATACTGCAAGTCTATATGCACGAGGAACAAAACGCATAGCCCAAAAAGTGGGAGAAGAAGGTGTT
GAAGTTGCACTTGCTGCGATGGCCAAAGATATGGATGAATTAACTTGTGAAAGTGCTGATTTGTTATATCATCTAACCGT
TTTATTACAAAATGAAGGTTTACAACTTTCTGATATTGCAGATAAATTACAGGAACGTCATACTGATTAA

Upstream 100 bases:

>100_bases
ATGTTGATGGTGCTCTGGCTGCGAGTGTATTCCACAAGCAGATAATTAATATTGGTGAGTTGAAAGCTTACCTTAAAACA
CAGCAGGTAGAGATAAGATT

Downstream 100 bases:

>100_bases
TTTGTAAATTTTCAGAGAAAGGTTAATGATAATAATCTCTTCATTAGCCTTTTTTACCACCACAATTTATTCCAATTGGT
TATATACATTTCGACAAAAT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MNKALMNEQQLTALDWEKVDNLMPVIVQNRTSGKVLMLGYVNQEALTATLTSGKMTFFSRTKQRLWCKGEESGNFLNVLE
ISTDCDNDTLLAIVDPIGPTCHLGTESCFKGELQPALTFIADLEKVIAGRKNADPKSSYTASLYARGTKRIAQKVGEEGV
EVALAAMAKDMDELTCESADLLYHLTVLLQNEGLQLSDIADKLQERHTD

Sequences:

>Translated_209_residues
MNKALMNEQQLTALDWEKVDNLMPVIVQNRTSGKVLMLGYVNQEALTATLTSGKMTFFSRTKQRLWCKGEESGNFLNVLE
ISTDCDNDTLLAIVDPIGPTCHLGTESCFKGELQPALTFIADLEKVIAGRKNADPKSSYTASLYARGTKRIAQKVGEEGV
EVALAAMAKDMDELTCESADLLYHLTVLLQNEGLQLSDIADKLQERHTD
>Mature_209_residues
MNKALMNEQQLTALDWEKVDNLMPVIVQNRTSGKVLMLGYVNQEALTATLTSGKMTFFSRTKQRLWCKGEESGNFLNVLE
ISTDCDNDTLLAIVDPIGPTCHLGTESCFKGELQPALTFIADLEKVIAGRKNADPKSSYTASLYARGTKRIAQKVGEEGV
EVALAAMAKDMDELTCESADLLYHLTVLLQNEGLQLSDIADKLQERHTD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=203, Percent_Identity=64.5320197044335, Blast_Score=272, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6319819, Length=209, Percent_Identity=31.5789473684211, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23059; Mature: 23059

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKALMNEQQLTALDWEKVDNLMPVIVQNRTSGKVLMLGYVNQEALTATLTSGKMTFFSR
CCCCCCCCCHHHHCCHHHHHCCCEEEEECCCCCCEEEEEECCCHHEEEEECCCCCHHHHH
TKQRLWCKGEESGNFLNVLEISTDCDNDTLLAIVDPIGPTCHLGTESCFKGELQPALTFI
HHHHEEECCCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEECCCHHHHCCCHHHHHHHH
ADLEKVIAGRKNADPKSSYTASLYARGTKRIAQKVGEEGVEVALAAMAKDMDELTCESAD
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHH
LLYHLTVLLQNEGLQLSDIADKLQERHTD
HHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKALMNEQQLTALDWEKVDNLMPVIVQNRTSGKVLMLGYVNQEALTATLTSGKMTFFSR
CCCCCCCCCHHHHCCHHHHHCCCEEEEECCCCCCEEEEEECCCHHEEEEECCCCCHHHHH
TKQRLWCKGEESGNFLNVLEISTDCDNDTLLAIVDPIGPTCHLGTESCFKGELQPALTFI
HHHHEEECCCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEECCCHHHHCCCHHHHHHHH
ADLEKVIAGRKNADPKSSYTASLYARGTKRIAQKVGEEGVEVALAAMAKDMDELTCESAD
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHH
LLYHLTVLLQNEGLQLSDIADKLQERHTD
HHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA