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The map label for this gene is gyrA [H]

Identifier: 119944871

GI number: 119944871

Start: 1395500

End: 1398196

Strand: Direct

Name: gyrA [H]

Synonym: Ping_1114

Alternate gene names: 119944871

Gene position: 1395500-1398196 (Clockwise)

Preceding gene: 119944868

Following gene: 119944872

Centisome position: 30.61

GC content: 42.2

Gene sequence:

>2697_bases
ATGAGCGAATTTGTATCAGACGTTTCTCCGATCAACATTGAAGATGAATTAAAGACTTCTTATCTTGAATATGCAATGAG
CGTCATTGTTGGGCGAGCTTTACCCGATGTACGCGATGGTCTTAAACCGGTTCACCGCCGTGTTTTATTTGCCATGAATG
TATTGCGTAATGACTGGAATAAACCTTACAAAAAATCAGCCCGTATTGTTGGTGATGTGATAGGTAAATATCATCCGCAC
GGTGATACTGCGGTATACGATACTATTGTTCGTATGGCGCAAGATTTCTCTCTTCGTTATATGCTTGTTGATGGCCAGGG
TAACTTTGGTTCAGTCGATGGAGATAGTGCTGCTGCAATGCGTTATACGGAAATTCGTATGCAGAAATTGGCGCATGAAT
TACTCGCTGATTTAGAGAAAGAAACTGTTGATTTTGTGCCTAACTACGACGGTACAGAATTTATTCCTGAAGTAATGCCA
ACAAAAATTCCTAATCTATTAATTAACGGATCATCAGGTATTGCGGTCGGTATGGCAACCAATATTCCACCCCATAATTT
AGGTGAAGTGATCGATGGTTGTTTAGCTCTGATTGAAGATGCAGACATTACTATTGATCAATTAATCGAATTTATTCCCG
GACCTGATTTCCCTACTTCAGGTATTATTAATGGCCGCAAGGGTATTATTGATGCTTACCACACTGGCCGAGGAAAAATA
AAAGTTCGCGCAAAAGCGGATATTGAAGTTAATGACAAAACCGGTCGTGAAACGATTGTGGTGCATGAACTTCCTTATCA
GGTTAATAAAGCGCGTTTAATTGAAAAAATTGCTGAATTCGTAAAAGATAAAAAAATAGAAGGTATTAGCGCGTTACGTG
ATGAGTCTGATAAAGACGGCATGCGGATGGTGGTTGAAGTTAAACGTGGCGAAGTGGGTGAGGTGGTTTTAAATAACCTT
TACGCACAAACACAGATGCAAGTGACCTTCGGTATTAATGCTGTGGCGCTTGACCATGGTCAACCAAAGTTATTTAACCT
CAAAGAGATGTTGGAAGCCTTTATTTTACACCGACGTGAAGTGGTCACGCGTCGTACTGTCTTTGAGCTGAAAAAAGCGC
GAGAACGTGCACATATACTGGAAGGTTTAGCTATTTCTCTTGCGAATATAGAACCTATCATTGCATTGATTCGCCATTCA
GCAACGCCAGGCGAAGCTAAAATCGCGTTACAAGCGCAGGGTTGGAATTTAGGTCATGTGTCTGCAATGCTTGAGGCCTC
AGGTGTTGATGCGGCACGTCCTGATGGTTTGGCCATTGAATTTGGTGTTCGTGACAACCAATACTTTATGACTGAAGTAC
AAGCGCAGGCTATTCTCGATTTACGTTTACAAAAACTAACCGGTCTTGAACACGAAAAAATATTAACTGAATACAAAGAA
CTGCTTGAAATTATTGCGGCATTATTATTTATCCTAGAGAACCCTGAACGTTTGATGGAAGTTATCCGTGAAGAGTTAGA
AGAGATTAAAGCCAACTTTGCTGATCCTCGTCGTACTGAAATCACCGCCAGTGAAACCGATTTAAGCATAGAAGATTTGA
TCACTGAAGAAGATGTGGTGGTCACTCTTTCCCACGAAGGTTATGTTAAATACCAAGTATTAAGCGATTACGAATCACAA
CGTCGTGGTGGTAAAGGCAAAGCGGCAACTAAGATGAAAGATGAAGATTTCATCGAAAAACTATTAGTTGCAAGCACCCA
TGATACGATTTTATGTTTCTCTACACGTGGCCGTTTATATTGGTTGAAGGTATTTCAGTTACCGTTAGCATCACGTCAGG
CACGTGGTCGTCCTATTGTTAATATTCTGCCGCTTGAAGAAGGCGAACGTATTACGGCTATTTTACCTGTTCGTGATTAT
GCCGATGATAAATTTGTCTTTATGGCGACAGCAAACGGCACGGTCAAGAAAACCGCATTAAGCGCTTATAGTCGCCCACG
TAACAGTGGCCTGATTGCAATTAATCTTAATGAGGATAATGAGTTGATTGGCGTTGGTATCACCGACGGCAGCAATGAAA
TTATGATTTTCTCCGATGCAGGTAAGGTGGTGCGCTTTAAAGAAGCAGAAGAAAGTGCAGTACTTGATGAAAATGGTGCG
CCGGTACTAGATGAAGAGGGTAATCCTGAAATCAAAGTTAAAGGTGTTCGTGCAATGGGGCGTACCGCAACTGGCGTTCG
TGGTATTAAATTAAAAGAGGGCGAAAAAGTTGTGTCCTTGATTATTCCAAACGAAACCGGCCATATCTTAACCACCACTG
AAAATGGTTACGGTAAACGTACACCCCTTGAAGATTACTCGTCTAAGAGCCGCGCAACTCAAGGTGTTATCTCAATTAAA
GTCAGCGAGCGTAACGGTAAAGTAGTGGGGGCAGTTCAAGTTGATACAAACGACGAGATCATGCTGATCACCAACAGAGG
GACGTTAGTACGTACCCGCGTTAGTGAAGTGTCAGTGGTTGGGCGTAATACTCAGGGGGTGACGCTGATTCGCACCGCTG
AAGGTGAGAAAATCGTTGCTCTACAACGTATTGAGGAAATTGAGGATCTGCCCGTTTATGAAGAAGACGAGGTAACCGGC
AGTGAAACGACTGAATTAAACGCTGAAGCTTCTGCTGATCAGACAGAAGAAGTATAA

Upstream 100 bases:

>100_bases
AAATGCCGCTCAATTCATCTCTTCATCAATAATATGTGTTAGAATGCGCAACTCACAAAAATTCAATCGATATATTAATA
AAATAAGGATCTTGGCCTCT

Downstream 100 bases:

>100_bases
CCGTAAGTCATCCCCCAATTACTTGAATCTGCCTGTTCAAGTAGTTTGGGTTTATAGGTTTAAAAAAACGGCTTTTGCCG
TTTTTTGTTTTTGCAGACGA

Product: DNA gyrase, A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 898; Mature: 897

Protein sequence:

>898_residues
MSEFVSDVSPINIEDELKTSYLEYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLRNDWNKPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDSAAAMRYTEIRMQKLAHELLADLEKETVDFVPNYDGTEFIPEVMP
TKIPNLLINGSSGIAVGMATNIPPHNLGEVIDGCLALIEDADITIDQLIEFIPGPDFPTSGIINGRKGIIDAYHTGRGKI
KVRAKADIEVNDKTGRETIVVHELPYQVNKARLIEKIAEFVKDKKIEGISALRDESDKDGMRMVVEVKRGEVGEVVLNNL
YAQTQMQVTFGINAVALDHGQPKLFNLKEMLEAFILHRREVVTRRTVFELKKARERAHILEGLAISLANIEPIIALIRHS
ATPGEAKIALQAQGWNLGHVSAMLEASGVDAARPDGLAIEFGVRDNQYFMTEVQAQAILDLRLQKLTGLEHEKILTEYKE
LLEIIAALLFILENPERLMEVIREELEEIKANFADPRRTEITASETDLSIEDLITEEDVVVTLSHEGYVKYQVLSDYESQ
RRGGKGKAATKMKDEDFIEKLLVASTHDTILCFSTRGRLYWLKVFQLPLASRQARGRPIVNILPLEEGERITAILPVRDY
ADDKFVFMATANGTVKKTALSAYSRPRNSGLIAINLNEDNELIGVGITDGSNEIMIFSDAGKVVRFKEAEESAVLDENGA
PVLDEEGNPEIKVKGVRAMGRTATGVRGIKLKEGEKVVSLIIPNETGHILTTTENGYGKRTPLEDYSSKSRATQGVISIK
VSERNGKVVGAVQVDTNDEIMLITNRGTLVRTRVSEVSVVGRNTQGVTLIRTAEGEKIVALQRIEEIEDLPVYEEDEVTG
SETTELNAEASADQTEEV

Sequences:

>Translated_898_residues
MSEFVSDVSPINIEDELKTSYLEYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLRNDWNKPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDSAAAMRYTEIRMQKLAHELLADLEKETVDFVPNYDGTEFIPEVMP
TKIPNLLINGSSGIAVGMATNIPPHNLGEVIDGCLALIEDADITIDQLIEFIPGPDFPTSGIINGRKGIIDAYHTGRGKI
KVRAKADIEVNDKTGRETIVVHELPYQVNKARLIEKIAEFVKDKKIEGISALRDESDKDGMRMVVEVKRGEVGEVVLNNL
YAQTQMQVTFGINAVALDHGQPKLFNLKEMLEAFILHRREVVTRRTVFELKKARERAHILEGLAISLANIEPIIALIRHS
ATPGEAKIALQAQGWNLGHVSAMLEASGVDAARPDGLAIEFGVRDNQYFMTEVQAQAILDLRLQKLTGLEHEKILTEYKE
LLEIIAALLFILENPERLMEVIREELEEIKANFADPRRTEITASETDLSIEDLITEEDVVVTLSHEGYVKYQVLSDYESQ
RRGGKGKAATKMKDEDFIEKLLVASTHDTILCFSTRGRLYWLKVFQLPLASRQARGRPIVNILPLEEGERITAILPVRDY
ADDKFVFMATANGTVKKTALSAYSRPRNSGLIAINLNEDNELIGVGITDGSNEIMIFSDAGKVVRFKEAEESAVLDENGA
PVLDEEGNPEIKVKGVRAMGRTATGVRGIKLKEGEKVVSLIIPNETGHILTTTENGYGKRTPLEDYSSKSRATQGVISIK
VSERNGKVVGAVQVDTNDEIMLITNRGTLVRTRVSEVSVVGRNTQGVTLIRTAEGEKIVALQRIEEIEDLPVYEEDEVTG
SETTELNAEASADQTEEV
>Mature_897_residues
SEFVSDVSPINIEDELKTSYLEYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLRNDWNKPYKKSARIVGDVIGKYHPHG
DTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDSAAAMRYTEIRMQKLAHELLADLEKETVDFVPNYDGTEFIPEVMPT
KIPNLLINGSSGIAVGMATNIPPHNLGEVIDGCLALIEDADITIDQLIEFIPGPDFPTSGIINGRKGIIDAYHTGRGKIK
VRAKADIEVNDKTGRETIVVHELPYQVNKARLIEKIAEFVKDKKIEGISALRDESDKDGMRMVVEVKRGEVGEVVLNNLY
AQTQMQVTFGINAVALDHGQPKLFNLKEMLEAFILHRREVVTRRTVFELKKARERAHILEGLAISLANIEPIIALIRHSA
TPGEAKIALQAQGWNLGHVSAMLEASGVDAARPDGLAIEFGVRDNQYFMTEVQAQAILDLRLQKLTGLEHEKILTEYKEL
LEIIAALLFILENPERLMEVIREELEEIKANFADPRRTEITASETDLSIEDLITEEDVVVTLSHEGYVKYQVLSDYESQR
RGGKGKAATKMKDEDFIEKLLVASTHDTILCFSTRGRLYWLKVFQLPLASRQARGRPIVNILPLEEGERITAILPVRDYA
DDKFVFMATANGTVKKTALSAYSRPRNSGLIAINLNEDNELIGVGITDGSNEIMIFSDAGKVVRFKEAEESAVLDENGAP
VLDEEGNPEIKVKGVRAMGRTATGVRGIKLKEGEKVVSLIIPNETGHILTTTENGYGKRTPLEDYSSKSRATQGVISIKV
SERNGKVVGAVQVDTNDEIMLITNRGTLVRTRVSEVSVVGRNTQGVTLIRTAEGEKIVALQRIEEIEDLPVYEEDEVTGS
ETTELNAEASADQTEEV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=320, Percent_Identity=28.75, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI19913406, Length=319, Percent_Identity=26.9592476489028, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1788562, Length=876, Percent_Identity=71.2328767123288, Blast_Score=1278, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=702, Percent_Identity=36.039886039886, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=34.4827586206897, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=279, Percent_Identity=28.3154121863799, Blast_Score=73, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=353, Percent_Identity=25.2124645892351, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17136538, Length=352, Percent_Identity=25.8522727272727, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 99540; Mature: 99409

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFVSDVSPINIEDELKTSYLEYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLRNDWN
CCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
KPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHH
RYTEIRMQKLAHELLADLEKETVDFVPNYDGTEFIPEVMPTKIPNLLINGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCEEEEEEC
NIPPHNLGEVIDGCLALIEDADITIDQLIEFIPGPDFPTSGIINGRKGIIDAYHTGRGKI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEE
KVRAKADIEVNDKTGRETIVVHELPYQVNKARLIEKIAEFVKDKKIEGISALRDESDKDG
EEEEEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCC
MRMVVEVKRGEVGEVVLNNLYAQTQMQVTFGINAVALDHGQPKLFNLKEMLEAFILHRRE
CEEEEEECCCCHHHHHHHHHHHHEEEEEEECCEEEEEECCCCCEECHHHHHHHHHHHHHH
VVTRRTVFELKKARERAHILEGLAISLANIEPIIALIRHSATPGEAKIALQAQGWNLGHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEECCCCCHHH
SAMLEASGVDAARPDGLAIEFGVRDNQYFMTEVQAQAILDLRLQKLTGLEHEKILTEYKE
HHHHHHCCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLEIIAALLFILENPERLMEVIREELEEIKANFADPRRTEITASETDLSIEDLITEEDVV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHCCCCCEE
VTLSHEGYVKYQVLSDYESQRRGGKGKAATKMKDEDFIEKLLVASTHDTILCFSTRGRLY
EEEECCCEEEEEEECCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEE
WLKVFQLPLASRQARGRPIVNILPLEEGERITAILPVRDYADDKFVFMATANGTVKKTAL
EEEEECCCCHHHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHH
SAYSRPRNSGLIAINLNEDNELIGVGITDGSNEIMIFSDAGKVVRFKEAEESAVLDENGA
HHHCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCEECCCCC
PVLDEEGNPEIKVKGVRAMGRTATGVRGIKLKEGEKVVSLIIPNETGHILTTTENGYGKR
CCCCCCCCCCEEEEEEEECCCCCCCCCCEEECCCCEEEEEEECCCCCCEEEECCCCCCCC
TPLEDYSSKSRATQGVISIKVSERNGKVVGAVQVDTNDEIMLITNRGTLVRTRVSEVSVV
CCCHHHCCHHHCCCCEEEEEEECCCCEEEEEEEECCCCCEEEEECCCCEEEEEHHEEEEE
GRNTQGVTLIRTAEGEKIVALQRIEEIEDLPVYEEDEVTGSETTELNAEASADQTEEV
ECCCCCEEEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEFVSDVSPINIEDELKTSYLEYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLRNDWN
CCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
KPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHH
RYTEIRMQKLAHELLADLEKETVDFVPNYDGTEFIPEVMPTKIPNLLINGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCEEEEEEC
NIPPHNLGEVIDGCLALIEDADITIDQLIEFIPGPDFPTSGIINGRKGIIDAYHTGRGKI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEE
KVRAKADIEVNDKTGRETIVVHELPYQVNKARLIEKIAEFVKDKKIEGISALRDESDKDG
EEEEEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCC
MRMVVEVKRGEVGEVVLNNLYAQTQMQVTFGINAVALDHGQPKLFNLKEMLEAFILHRRE
CEEEEEECCCCHHHHHHHHHHHHEEEEEEECCEEEEEECCCCCEECHHHHHHHHHHHHHH
VVTRRTVFELKKARERAHILEGLAISLANIEPIIALIRHSATPGEAKIALQAQGWNLGHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEECCCCCHHH
SAMLEASGVDAARPDGLAIEFGVRDNQYFMTEVQAQAILDLRLQKLTGLEHEKILTEYKE
HHHHHHCCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLEIIAALLFILENPERLMEVIREELEEIKANFADPRRTEITASETDLSIEDLITEEDVV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHCCCCCEE
VTLSHEGYVKYQVLSDYESQRRGGKGKAATKMKDEDFIEKLLVASTHDTILCFSTRGRLY
EEEECCCEEEEEEECCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEE
WLKVFQLPLASRQARGRPIVNILPLEEGERITAILPVRDYADDKFVFMATANGTVKKTAL
EEEEECCCCHHHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHH
SAYSRPRNSGLIAINLNEDNELIGVGITDGSNEIMIFSDAGKVVRFKEAEESAVLDENGA
HHHCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCEECCCCC
PVLDEEGNPEIKVKGVRAMGRTATGVRGIKLKEGEKVVSLIIPNETGHILTTTENGYGKR
CCCCCCCCCCEEEEEEEECCCCCCCCCCEEECCCCEEEEEEECCCCCCEEEECCCCCCCC
TPLEDYSSKSRATQGVISIKVSERNGKVVGAVQVDTNDEIMLITNRGTLVRTRVSEVSVV
CCCHHHCCHHHCCCCEEEEEEECCCCEEEEEEEECCCCCEEEEECCCCEEEEEHHEEEEE
GRNTQGVTLIRTAEGEKIVALQRIEEIEDLPVYEEDEVTGSETTELNAEASADQTEEV
ECCCCCEEEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]