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The map label for this gene is fabH

Identifier: 119944845

GI number: 119944845

Start: 1357937

End: 1358896

Strand: Direct

Name: fabH

Synonym: Ping_1087

Alternate gene names: 119944845

Gene position: 1357937-1358896 (Clockwise)

Preceding gene: 119944844

Following gene: 119944846

Centisome position: 29.78

GC content: 41.56

Gene sequence:

>960_bases
ATGAATAGCAAAATTATAGGTACTGGTGGCTATTTACCAGTAACAGTGCGTAGCAACGACGACTTAGAAAAAATGGTTGA
TACCAGTGACGAATGGATCACAACCCGCACAGGTATTAAAGAGCGTCGTATTGCCAATCAACAAGAGACAATTGCCTTTA
TGGGTAAAGAAGCAGCTTTGCAAGCGTTAGAGGCTGCCAATTTAACCGCTGAAGATTTGGATCTGATTATTGTAGGGACG
ACAAGTAACCATAATGCATTCCCGTCTGCCGCCTGTGAAATACAAAATTTATTAGGTATATATGATATACCTGCCTTTGA
TATTTCAGCAGCTTGTGCCGGTTTTACCTATGCATTAAGTGCTGCTGATAACTTTATTAAAGCCGGTAGTGCAAAAAAAG
TATTAGTCATAGGGGCTGATACCTTAGCTGCAACTTGTGATTCAACGGATCGTTCGACTATCATTTTATTTGGTGATGGT
GCAGGTGCGGTTGTTATTAGTGCCACTGAAGATGAAGGTATTTTATCAACACATATCAATGCCGATGGCCGTTTTGGTGA
ATTGTTAAAATTACCCAATCCACAGCGTGGTAATGCCCAAACAGTTCATGAAGCTTACCTATCAATGTCGGGTAACGATG
TTTTTAAAGTTGCCGTTAAAAAGTTAAGCCAAGTCGTTGTTGATACACTGGCTGCTAATAATATCGAAAAAGAGCAACTG
GACTGGTTAGTGCCGCATCAGGCTAATAAGCGTATTATTACTGCTACCGCAAAAAAATTGGGTATGTCCATGGATCAAGT
TATTTTAACGCTTGAAAATCAGGGTAATACCTCTGCTGCATCTGTGCCTCTCGCCTTAGATGAGGGAGTACGTTCAGGGA
AAATAAAACCCGGCCAGTTAATCTTATTAGAAGCATTTGGCGGCGGATTTACCTGGGGCTCAGCGCTAGTGCGCATGTGA

Upstream 100 bases:

>100_bases
TGCGCTATTGAGCATGCCATACAAGAGACTCAATGGCAGATTCCTGCAAGTATTTCAAAAAAGTTAGAAACTGTATTATC
AGAGCGAGATGATTTATCAC

Downstream 100 bases:

>100_bases
ATAAATAAAAATCAATCAATATCTGGAAATATAAAAAATGACAAACTTTACATTTGCTTTCCCCGGTCAAGGCTCTCAAC
ATGTTGGCATGTTGGCCGAG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MNSKIIGTGGYLPVTVRSNDDLEKMVDTSDEWITTRTGIKERRIANQQETIAFMGKEAALQALEAANLTAEDLDLIIVGT
TSNHNAFPSAACEIQNLLGIYDIPAFDISAACAGFTYALSAADNFIKAGSAKKVLVIGADTLAATCDSTDRSTIILFGDG
AGAVVISATEDEGILSTHINADGRFGELLKLPNPQRGNAQTVHEAYLSMSGNDVFKVAVKKLSQVVVDTLAANNIEKEQL
DWLVPHQANKRIITATAKKLGMSMDQVILTLENQGNTSAASVPLALDEGVRSGKIKPGQLILLEAFGGGFTWGSALVRM

Sequences:

>Translated_319_residues
MNSKIIGTGGYLPVTVRSNDDLEKMVDTSDEWITTRTGIKERRIANQQETIAFMGKEAALQALEAANLTAEDLDLIIVGT
TSNHNAFPSAACEIQNLLGIYDIPAFDISAACAGFTYALSAADNFIKAGSAKKVLVIGADTLAATCDSTDRSTIILFGDG
AGAVVISATEDEGILSTHINADGRFGELLKLPNPQRGNAQTVHEAYLSMSGNDVFKVAVKKLSQVVVDTLAANNIEKEQL
DWLVPHQANKRIITATAKKLGMSMDQVILTLENQGNTSAASVPLALDEGVRSGKIKPGQLILLEAFGGGFTWGSALVRM
>Mature_319_residues
MNSKIIGTGGYLPVTVRSNDDLEKMVDTSDEWITTRTGIKERRIANQQETIAFMGKEAALQALEAANLTAEDLDLIIVGT
TSNHNAFPSAACEIQNLLGIYDIPAFDISAACAGFTYALSAADNFIKAGSAKKVLVIGADTLAATCDSTDRSTIILFGDG
AGAVVISATEDEGILSTHINADGRFGELLKLPNPQRGNAQTVHEAYLSMSGNDVFKVAVKKLSQVVVDTLAANNIEKEQL
DWLVPHQANKRIITATAKKLGMSMDQVILTLENQGNTSAASVPLALDEGVRSGKIKPGQLILLEAFGGGFTWGSALVRM

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=319, Percent_Identity=65.8307210031348, Blast_Score=444, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_PSYIN (A1STW1)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942525.1
- ProteinModelPortal:   A1STW1
- SMR:   A1STW1
- STRING:   A1STW1
- GeneID:   4625381
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1087
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   YLPAQVR
- PhylomeDB:   A1STW1
- BioCyc:   PING357804:PING_1087-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 33841; Mature: 33841

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 246-246 ACT_SITE 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKIIGTGGYLPVTVRSNDDLEKMVDTSDEWITTRTGIKERRIANQQETIAFMGKEAAL
CCCCEEECCCEEEEEEECCCCHHHHHCCCCCEEEECCCCHHHHHCCHHHHHHHHCHHHHH
QALEAANLTAEDLDLIIVGTTSNHNAFPSAACEIQNLLGIYDIPAFDISAACAGFTYALS
HHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCEECCCCCCHHHHHHHHHEEEH
AADNFIKAGSAKKVLVIGADTLAATCDSTDRSTIILFGDGAGAVVISATEDEGILSTHIN
HHHHHHHCCCCCEEEEEECCHHEEECCCCCCEEEEEEECCCCEEEEEECCCCCEEEEEEC
ADGRFGELLKLPNPQRGNAQTVHEAYLSMSGNDVFKVAVKKLSQVVVDTLAANNIEKEQL
CCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DWLVPHQANKRIITATAKKLGMSMDQVILTLENQGNTSAASVPLALDEGVRSGKIKPGQL
CEECCCCCCCEEEEEEHHHHCCCCCCEEEEEECCCCCCCEEECEEHHCCCCCCCCCCCCE
ILLEAFGGGFTWGSALVRM
EEEEECCCCCCHHHHHHCC
>Mature Secondary Structure
MNSKIIGTGGYLPVTVRSNDDLEKMVDTSDEWITTRTGIKERRIANQQETIAFMGKEAAL
CCCCEEECCCEEEEEEECCCCHHHHHCCCCCEEEECCCCHHHHHCCHHHHHHHHCHHHHH
QALEAANLTAEDLDLIIVGTTSNHNAFPSAACEIQNLLGIYDIPAFDISAACAGFTYALS
HHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCEECCCCCCHHHHHHHHHEEEH
AADNFIKAGSAKKVLVIGADTLAATCDSTDRSTIILFGDGAGAVVISATEDEGILSTHIN
HHHHHHHCCCCCEEEEEECCHHEEECCCCCCEEEEEEECCCCEEEEEECCCCCEEEEEEC
ADGRFGELLKLPNPQRGNAQTVHEAYLSMSGNDVFKVAVKKLSQVVVDTLAANNIEKEQL
CCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DWLVPHQANKRIITATAKKLGMSMDQVILTLENQGNTSAASVPLALDEGVRSGKIKPGQL
CEECCCCCCCEEEEEEHHHHCCCCCCEEEEEECCCCCCCEEECEEHHCCCCCCCCCCCCE
ILLEAFGGGFTWGSALVRM
EEEEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA