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The map label for this gene is uvrB

Identifier: 119944840

GI number: 119944840

Start: 1353219

End: 1355231

Strand: Direct

Name: uvrB

Synonym: Ping_1082

Alternate gene names: 119944840

Gene position: 1353219-1355231 (Clockwise)

Preceding gene: 119944837

Following gene: 119944842

Centisome position: 29.68

GC content: 41.58

Gene sequence:

>2013_bases
ATGGATAAACGCTTTCAACTTGTTTCTCAATTCTCACCTGCCGGTGACCAACCCCAAGCCATTGAACAATTAATTAATGG
TCTTAAGTCTGGTCTCGCTTTTCAGACATTGCTGGGTGTGACGGGATCGGGTAAAACATTTACCTTAGCGAATGCGATTG
CAAAGCTTAACCGTCCGACCTTAATTCTTGCGCCCAATAAAACACTTGCTGCACAGTTATACGGTGAAATGAAAGAATTT
TTTCCCAATAACGCCGTCGAATATTTTGTTTCCTATTATGATTATTATCAGCCTGAAGCCTATGTACCCAGTTCAGATTC
TTTTATCGAAAAAGATGCGGCTATTAACGCGCATATTGAACAGATGCGCCTTTCTGCGACCAAAGCGCTCTTAGAACGTA
AAGATGTCGTCTTAGTGGCTTCCGTCTCAGCAATCTATGGTTTGGGTGATCCAACCGCTTATTTGCAAATGATGCTGCAC
CTCACTGTCGGGGAGATAATATCAAGCCGTGAGATACTGCAGCGTTTAGTCGATTTACAATATAACCGTAATGAAACCGA
GCTAAGTCGCGGTACCTTTCGCGTACGTGGTGAAGTGATTGATATCTTTCCTGCAGATTCGGAAAAAGAAGCCTTACGAA
TTGAGTTGTTTGATGATGAGGTCGAGCAAATTTCAGTGTTTGATCCGCTTACCGGCCAAGGAATAGATAAGCTTGCGCGT
GTGACCGTTTACCCTAAGACCCATTATGTTACTCCGCGAGAGCAAATCCTTAAAGCCGTCGACGCGATTAAAGTAGAGCT
TAATGAGCGTAAAAAAGAGTTTCTTGAGCAGAATAAACTGCTTGAAGAGCAGCGCATCTCGCAGCGTACTCTGTACGATA
TTGAGATGATGAATGAACTTGGGTATTGCTCTGGTATAGAAAACTACTCAAGGTACCTCTCGGGGCGCAGCGAGGGCCAA
GCACCTCCTACTTTGTTTGATTATCTGCCTAAAGATGCTTTATTAATTATCGATGAAAGCCATGTCACCGTGCCGCAAAT
TGGTGCCATGTATAAAGGAGACCGTTCTCGTAAAGAAAACCTGGTTAATTATGGCTTTAGGTTACCTTCTGCCCTGGACA
ACCGGCCCTTGAAATTTGCAGAGTTTGAAAAAATAGCACCACAAACTATTTATGTTTCAGCCACCCCCAGCGATTATGAA
ATTAATAAATCTCAAGGTGAGATCATACGTCAGGTTATACGTCCTACCGGTTTACTGGATCCTGTTATAGAAGTTCGCCC
GGTGACAACGCAGGTTGATGATCTGCTCTCAGAGATTAATATCCGTTTACCCTTAAAAGAACGTGTCTTAGTGACGACGT
TAACCAAGCGAATGGCGGAGGATTTGACTGATTATTTGCACGAGCACGGTATTAAAGCCCGTTATCTTCACTCCGATGTT
AATACGGTTGAACGTGTTGAGATAATCAGAGATTTACGCTTAGGTATTTTTGACGTGTTAATTGGCATTAACTTGTTACG
CGAAGGCCTGGATATTCCAGAAGTTTCTTTGGTGGCTATTTTAGATGCCGATAAAGAGGGCTTTCTGCGATCCGAACGTT
CACTTATTCAAACCATGGGACGTGCCGCCCGTAATTTAAATGGTAAAGCCATTTTATATGCCGCTCGTATTACAGGCTCT
ATGCAAAAAGCGATCAAAGTAACCGAAGATCGGCGTGAATTACAAAATAAATTTAATATTGAAAATGGCATTATTCCGCA
AGGTTTGTCGAAACAAGTTAACGATGTAATGCAGTTGGGGCAAAAAAACCTTAAAAAAGGTAATTTAAAACAGGGTAAGG
TTGCTGAATATAAAGCAAATTACCAGATACATAGCGAACAAGATATTCTTAAACAGATAGCATTATCAGAAAAACAGATG
TTTGCCTGTGCTAAAAATTTAGAGTTTGAAAAAGCGGCTTTATTTCGAGATGAGGTGACTAAGTTACACGAGCAGTTAGT
AAGTATAGGATAA

Upstream 100 bases:

>100_bases
GGCATTGATACAGACTGAATTTTTAAACTGTTATTAACTATTTTGCTGTGGTCTATTATGGGGTAATATTAAGATATTTA
GGTTAAGTAAGAGGTGATAG

Downstream 100 bases:

>100_bases
TATCCTAAACGTTTAAGGATTAAAAATAGTTAAACGTTTAGGGTAAAAAGGACTTAACCTAGCACGGGAAAATTCTCTTT
TTCCAACATGTTAATTAATG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MDKRFQLVSQFSPAGDQPQAIEQLINGLKSGLAFQTLLGVTGSGKTFTLANAIAKLNRPTLILAPNKTLAAQLYGEMKEF
FPNNAVEYFVSYYDYYQPEAYVPSSDSFIEKDAAINAHIEQMRLSATKALLERKDVVLVASVSAIYGLGDPTAYLQMMLH
LTVGEIISSREILQRLVDLQYNRNETELSRGTFRVRGEVIDIFPADSEKEALRIELFDDEVEQISVFDPLTGQGIDKLAR
VTVYPKTHYVTPREQILKAVDAIKVELNERKKEFLEQNKLLEEQRISQRTLYDIEMMNELGYCSGIENYSRYLSGRSEGQ
APPTLFDYLPKDALLIIDESHVTVPQIGAMYKGDRSRKENLVNYGFRLPSALDNRPLKFAEFEKIAPQTIYVSATPSDYE
INKSQGEIIRQVIRPTGLLDPVIEVRPVTTQVDDLLSEINIRLPLKERVLVTTLTKRMAEDLTDYLHEHGIKARYLHSDV
NTVERVEIIRDLRLGIFDVLIGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTMGRAARNLNGKAILYAARITGS
MQKAIKVTEDRRELQNKFNIENGIIPQGLSKQVNDVMQLGQKNLKKGNLKQGKVAEYKANYQIHSEQDILKQIALSEKQM
FACAKNLEFEKAALFRDEVTKLHEQLVSIG

Sequences:

>Translated_670_residues
MDKRFQLVSQFSPAGDQPQAIEQLINGLKSGLAFQTLLGVTGSGKTFTLANAIAKLNRPTLILAPNKTLAAQLYGEMKEF
FPNNAVEYFVSYYDYYQPEAYVPSSDSFIEKDAAINAHIEQMRLSATKALLERKDVVLVASVSAIYGLGDPTAYLQMMLH
LTVGEIISSREILQRLVDLQYNRNETELSRGTFRVRGEVIDIFPADSEKEALRIELFDDEVEQISVFDPLTGQGIDKLAR
VTVYPKTHYVTPREQILKAVDAIKVELNERKKEFLEQNKLLEEQRISQRTLYDIEMMNELGYCSGIENYSRYLSGRSEGQ
APPTLFDYLPKDALLIIDESHVTVPQIGAMYKGDRSRKENLVNYGFRLPSALDNRPLKFAEFEKIAPQTIYVSATPSDYE
INKSQGEIIRQVIRPTGLLDPVIEVRPVTTQVDDLLSEINIRLPLKERVLVTTLTKRMAEDLTDYLHEHGIKARYLHSDV
NTVERVEIIRDLRLGIFDVLIGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTMGRAARNLNGKAILYAARITGS
MQKAIKVTEDRRELQNKFNIENGIIPQGLSKQVNDVMQLGQKNLKKGNLKQGKVAEYKANYQIHSEQDILKQIALSEKQM
FACAKNLEFEKAALFRDEVTKLHEQLVSIG
>Mature_670_residues
MDKRFQLVSQFSPAGDQPQAIEQLINGLKSGLAFQTLLGVTGSGKTFTLANAIAKLNRPTLILAPNKTLAAQLYGEMKEF
FPNNAVEYFVSYYDYYQPEAYVPSSDSFIEKDAAINAHIEQMRLSATKALLERKDVVLVASVSAIYGLGDPTAYLQMMLH
LTVGEIISSREILQRLVDLQYNRNETELSRGTFRVRGEVIDIFPADSEKEALRIELFDDEVEQISVFDPLTGQGIDKLAR
VTVYPKTHYVTPREQILKAVDAIKVELNERKKEFLEQNKLLEEQRISQRTLYDIEMMNELGYCSGIENYSRYLSGRSEGQ
APPTLFDYLPKDALLIIDESHVTVPQIGAMYKGDRSRKENLVNYGFRLPSALDNRPLKFAEFEKIAPQTIYVSATPSDYE
INKSQGEIIRQVIRPTGLLDPVIEVRPVTTQVDDLLSEINIRLPLKERVLVTTLTKRMAEDLTDYLHEHGIKARYLHSDV
NTVERVEIIRDLRLGIFDVLIGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTMGRAARNLNGKAILYAARITGS
MQKAIKVTEDRRELQNKFNIENGIIPQGLSKQVNDVMQLGQKNLKKGNLKQGKVAEYKANYQIHSEQDILKQIALSEKQM
FACAKNLEFEKAALFRDEVTKLHEQLVSIG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=70.4918032786885, Blast_Score=951, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=310, Percent_Identity=22.9032258064516, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_PSYIN (A1STV6)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942520.1
- ProteinModelPortal:   A1STV6
- STRING:   A1STV6
- GeneID:   4625376
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1082
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   EKDLAIN
- PhylomeDB:   A1STV6
- ProtClustDB:   PRK05298
- BioCyc:   PING357804:PING_1082-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 75839; Mature: 75839

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRFQLVSQFSPAGDQPQAIEQLINGLKSGLAFQTLLGVTGSGKTFTLANAIAKLNRPT
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCE
LILAPNKTLAAQLYGEMKEFFPNNAVEYFVSYYDYYQPEAYVPSSDSFIEKDAAINAHIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
QMRLSATKALLERKDVVLVASVSAIYGLGDPTAYLQMMLHLTVGEIISSREILQRLVDLQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNRNETELSRGTFRVRGEVIDIFPADSEKEALRIELFDDEVEQISVFDPLTGQGIDKLAR
CCCCHHHHHCCEEEEECEEEEEECCCCCCCEEEEEEECCCHHHEEECCCCCCCCHHHHHH
VTVYPKTHYVTPREQILKAVDAIKVELNERKKEFLEQNKLLEEQRISQRTLYDIEMMNEL
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYCSGIENYSRYLSGRSEGQAPPTLFDYLPKDALLIIDESHVTVPQIGAMYKGDRSRKEN
HHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHH
LVNYGFRLPSALDNRPLKFAEFEKIAPQTIYVSATPSDYEINKSQGEIIRQVIRPTGLLD
HHHHCCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCC
PVIEVRPVTTQVDDLLSEINIRLPLKERVLVTTLTKRMAEDLTDYLHEHGIKARYLHSDV
CCHHEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHH
NTVERVEIIRDLRLGIFDVLIGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNLNGKAILYAARITGSMQKAIKVTEDRRELQNKFNIENGIIPQGLSKQVNDVMQLG
HHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
QKNLKKGNLKQGKVAEYKANYQIHSEQDILKQIALSEKQMFACAKNLEFEKAALFRDEVT
HHHHCCCCCCCCCEEHEECCCEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KLHEQLVSIG
HHHHHHHCCC
>Mature Secondary Structure
MDKRFQLVSQFSPAGDQPQAIEQLINGLKSGLAFQTLLGVTGSGKTFTLANAIAKLNRPT
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCE
LILAPNKTLAAQLYGEMKEFFPNNAVEYFVSYYDYYQPEAYVPSSDSFIEKDAAINAHIE
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
QMRLSATKALLERKDVVLVASVSAIYGLGDPTAYLQMMLHLTVGEIISSREILQRLVDLQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNRNETELSRGTFRVRGEVIDIFPADSEKEALRIELFDDEVEQISVFDPLTGQGIDKLAR
CCCCHHHHHCCEEEEECEEEEEECCCCCCCEEEEEEECCCHHHEEECCCCCCCCHHHHHH
VTVYPKTHYVTPREQILKAVDAIKVELNERKKEFLEQNKLLEEQRISQRTLYDIEMMNEL
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYCSGIENYSRYLSGRSEGQAPPTLFDYLPKDALLIIDESHVTVPQIGAMYKGDRSRKEN
HHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHH
LVNYGFRLPSALDNRPLKFAEFEKIAPQTIYVSATPSDYEINKSQGEIIRQVIRPTGLLD
HHHHCCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCC
PVIEVRPVTTQVDDLLSEINIRLPLKERVLVTTLTKRMAEDLTDYLHEHGIKARYLHSDV
CCHHEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHH
NTVERVEIIRDLRLGIFDVLIGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNLNGKAILYAARITGSMQKAIKVTEDRRELQNKFNIENGIIPQGLSKQVNDVMQLG
HHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
QKNLKKGNLKQGKVAEYKANYQIHSEQDILKQIALSEKQMFACAKNLEFEKAALFRDEVT
HHHHCCCCCCCCCEEHEECCCEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KLHEQLVSIG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA