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The map label for this gene is msrA2 [H]

Identifier: 119944786

GI number: 119944786

Start: 1297140

End: 1297730

Strand: Direct

Name: msrA2 [H]

Synonym: Ping_1028

Alternate gene names: 119944786

Gene position: 1297140-1297730 (Clockwise)

Preceding gene: 119944785

Following gene: 119944792

Centisome position: 28.45

GC content: 43.49

Gene sequence:

>591_bases
ATGAAATCTAAATTGATACTCTTTATTTTAAGCAGTTGTCTGTTGTACAGTGCCAATGCACTGGCAGATAAAGCTGTCCT
GGCCGGAGGATGTTTTTGGTGCATGGAAGCAGACTTTGAAAAACTTGAAGGGGTGAATGATGTCGTCTCAGGTTTTACCG
GCGGGAAATTAAAAAACCCAACCTATAACGGTAATCACCAGGGGCACTATGAAGCAGTGGAAATCACCTATGATGCGGAT
AAAATAAGTTACCAGGCACTGCTGGATCATTATTGGGTCAATATCGACCCCTTTGACGAGCGAGGGCAGTTTTGCGATAA
AGGGCCAAGTTACCTCAGTGCTATTTTTGTTGCCAATGAACAGCAAAGGAAAACAGCAGAACAATCTAAAGCGTTGATAG
CAGAGCAGTTTCTCGATCAAACCATTGTTACGCCCATTTTACCGGCAGCGGTTTTTTATCCGATTAAAGGTAACGAGAGT
TATCATCAGAACTATGCTGAAAACAACCCGATTCGTTATAAGGCTTATCGTTGGAATTGCGGGCGGGATAAACGTCTCAA
GGAAATTTGGGGCGAGAAGGTGACTCACTGA

Upstream 100 bases:

>100_bases
GAGCAAGGCTGATCATCTATTTGATGCGTTTCGTATTATCATTAAGCTAAGCAACTGCTTGGCTTTTTTAAACGCAATTT
TTTACCAAGGAATAAGCTTA

Downstream 100 bases:

>100_bases
TTAGTGCGTGACTGACAGCTAGCTGACTAATATAAAAAACGCTGATAATTCAGCGTTTTTTTATGCATTATATTCGCAAG
TTTTACTGATTTCTGTTTTT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MKSKLILFILSSCLLYSANALADKAVLAGGCFWCMEADFEKLEGVNDVVSGFTGGKLKNPTYNGNHQGHYEAVEITYDAD
KISYQALLDHYWVNIDPFDERGQFCDKGPSYLSAIFVANEQQRKTAEQSKALIAEQFLDQTIVTPILPAAVFYPIKGNES
YHQNYAENNPIRYKAYRWNCGRDKRLKEIWGEKVTH

Sequences:

>Translated_196_residues
MKSKLILFILSSCLLYSANALADKAVLAGGCFWCMEADFEKLEGVNDVVSGFTGGKLKNPTYNGNHQGHYEAVEITYDAD
KISYQALLDHYWVNIDPFDERGQFCDKGPSYLSAIFVANEQQRKTAEQSKALIAEQFLDQTIVTPILPAAVFYPIKGNES
YHQNYAENNPIRYKAYRWNCGRDKRLKEIWGEKVTH
>Mature_196_residues
MKSKLILFILSSCLLYSANALADKAVLAGGCFWCMEADFEKLEGVNDVVSGFTGGKLKNPTYNGNHQGHYEAVEITYDAD
KISYQALLDHYWVNIDPFDERGQFCDKGPSYLSAIFVANEQQRKTAEQSKALIAEQFLDQTIVTPILPAAVFYPIKGNES
YHQNYAENNPIRYKAYRWNCGRDKRLKEIWGEKVTH

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=35.8974358974359, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=35.8974358974359, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=39.2156862745098, Blast_Score=91, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=35.6164383561644, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24664627, Length=151, Percent_Identity=33.112582781457, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=35.2941176470588, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24664631, Length=151, Percent_Identity=32.4503311258278, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 22275; Mature: 22275

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKLILFILSSCLLYSANALADKAVLAGGCFWCMEADFEKLEGVNDVVSGFTGGKLKNP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHCCHHHHHCCCCCCCCCCC
TYNGNHQGHYEAVEITYDADKISYQALLDHYWVNIDPFDERGQFCDKGPSYLSAIFVANE
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHHHCCCC
QQRKTAEQSKALIAEQFLDQTIVTPILPAAVFYPIKGNESYHQNYAENNPIRYKAYRWNC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHCCCCCCEEEEEEEECC
GRDKRLKEIWGEKVTH
CCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKSKLILFILSSCLLYSANALADKAVLAGGCFWCMEADFEKLEGVNDVVSGFTGGKLKNP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHCCHHHHHCCCCCCCCCCC
TYNGNHQGHYEAVEITYDADKISYQALLDHYWVNIDPFDERGQFCDKGPSYLSAIFVANE
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHHHCCCC
QQRKTAEQSKALIAEQFLDQTIVTPILPAAVFYPIKGNESYHQNYAENNPIRYKAYRWNC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHCCCCCCEEEEEEEECC
GRDKRLKEIWGEKVTH
CCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]