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The map label for this gene is adk

Identifier: 119944717

GI number: 119944717

Start: 1202742

End: 1203386

Strand: Direct

Name: adk

Synonym: Ping_0957

Alternate gene names: 119944717

Gene position: 1202742-1203386 (Clockwise)

Preceding gene: 119944716

Following gene: 119944718

Centisome position: 26.38

GC content: 43.26

Gene sequence:

>645_bases
ATGCGCATTATCTTGTTAGGTGCTCCAGGTGCCGGAAAAGGTACACAGGCTCAATTTATGATGGACAAATATGGCATTCC
GCAAATCTCTACGGGTGACATGTTACGTGCAGCAGCAAAAGCAGGCACAGAACTTGGTTTAAAAGCAAAAGAGCTAATGG
ACGCAGGGCAACTTGTTTCTGATGAATTAATTATTGATTTAGTAAAAGAGCGTATTAGCGCAGAAGACTGTGCTAAAGGT
TTCCTACTTGATGGATTCCCTCGTACTATCCCACAGGCTGATGCAATGAAAACAGCTGGTGTTGCGGTTGATTTCGTACT
TGAATTTGATGTGCCAGATGAAGAGATAGTTAAACGTATGGCGGGTCGTCGTGTCCATGCGGGTTCTGGTCGTACTTACC
ACATTGTTTACAACCCGCCAAAAGTAGCGGATAAAGATGATGTAACTGGTGATGACCTGTCGATTCGTCCTGATGATGAA
GAGTCAACCGTGCGTAAACGTCTTGATATTTACCATACTCAGACGGAGCCGCTTGTTGCTTATTATAAAAATGAAGCTGG
GCAGGGTAATGGCGAATATCATAAATTTGATGGCACTAAAACTGTTGACGTTATCAGTGCTGAGTTAGCAACTGTTCTTG
GTTAA

Upstream 100 bases:

>100_bases
ATTCTTTGTATCGCCCTGCAAGTTTGGGCATATCACCTTGAGAAATTTACCTAAAAAGTGTAAATTTCGCTTTCAATTTA
TTTATTACAAAGGATGTAAG

Downstream 100 bases:

>100_bases
TGGATTTTATGACATAAAATAAGGGGCATTTAGCCCCTTTTTTATTGTGCCGTAAGAAATAGACAAAAAATGGGTAAAAA
AACCGCCGTTCTACTGGTTA

Product: adenylate kinases

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQAQFMMDKYGIPQISTGDMLRAAAKAGTELGLKAKELMDAGQLVSDELIIDLVKERISAEDCAKG
FLLDGFPRTIPQADAMKTAGVAVDFVLEFDVPDEEIVKRMAGRRVHAGSGRTYHIVYNPPKVADKDDVTGDDLSIRPDDE
ESTVRKRLDIYHTQTEPLVAYYKNEAGQGNGEYHKFDGTKTVDVISAELATVLG

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQAQFMMDKYGIPQISTGDMLRAAAKAGTELGLKAKELMDAGQLVSDELIIDLVKERISAEDCAKG
FLLDGFPRTIPQADAMKTAGVAVDFVLEFDVPDEEIVKRMAGRRVHAGSGRTYHIVYNPPKVADKDDVTGDDLSIRPDDE
ESTVRKRLDIYHTQTEPLVAYYKNEAGQGNGEYHKFDGTKTVDVISAELATVLG
>Mature_214_residues
MRIILLGAPGAGKGTQAQFMMDKYGIPQISTGDMLRAAAKAGTELGLKAKELMDAGQLVSDELIIDLVKERISAEDCAKG
FLLDGFPRTIPQADAMKTAGVAVDFVLEFDVPDEEIVKRMAGRRVHAGSGRTYHIVYNPPKVADKDDVTGDDLSIRPDDE
ESTVRKRLDIYHTQTEPLVAYYKNEAGQGNGEYHKFDGTKTVDVISAELATVLG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=45.5399061032864, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=45.5399061032864, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI19923437, Length=201, Percent_Identity=40.2985074626866, Blast_Score=154, Evalue=4e-38,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=37.3134328358209, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=37.3134328358209, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=37.3134328358209, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=37.3134328358209, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI4502011, Length=212, Percent_Identity=30.6603773584906, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI22749187, Length=182, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI28144899, Length=212, Percent_Identity=25.9433962264151, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI28144897, Length=212, Percent_Identity=25.9433962264151, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=26.9406392694064, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=26.6187050359712, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=26.8115942028986, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=70.5607476635514, Blast_Score=313, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI17552384, Length=218, Percent_Identity=42.6605504587156, Blast_Score=181, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17567503, Length=207, Percent_Identity=32.8502415458937, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=31.7972350230415, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=26.9767441860465, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=28.6486486486486, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=219, Percent_Identity=42.9223744292237, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321018, Length=187, Percent_Identity=43.8502673796791, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=187, Percent_Identity=30.4812834224599, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=48.0874316939891, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17737899, Length=204, Percent_Identity=40.1960784313725, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24645822, Length=204, Percent_Identity=40.1960784313725, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI17647141, Length=191, Percent_Identity=28.7958115183246, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24663208, Length=191, Percent_Identity=28.7958115183246, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=26.9767441860465, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=26.9767441860465, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PSYIN (A1STI3)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942397.1
- ProteinModelPortal:   A1STI3
- SMR:   A1STI3
- STRING:   A1STI3
- GeneID:   4626669
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0957
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   A1STI3
- BioCyc:   PING357804:PING_0957-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23259; Mature: 23259

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFMMDKYGIPQISTGDMLRAAAKAGTELGLKAKELMDAGQLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DELIIDLVKERISAEDCAKGFLLDGFPRTIPQADAMKTAGVAVDFVLEFDVPDEEIVKRM
HHHHHHHHHHHHCHHHHHCCCEECCCCCCCCCHHHHHHCCEEEEEEEEECCCHHHHHHHH
AGRRVHAGSGRTYHIVYNPPKVADKDDVTGDDLSIRPDDEESTVRKRLDIYHTQTEPLVA
HCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCEEE
YYKNEAGQGNGEYHKFDGTKTVDVISAELATVLG
EEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFMMDKYGIPQISTGDMLRAAAKAGTELGLKAKELMDAGQLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DELIIDLVKERISAEDCAKGFLLDGFPRTIPQADAMKTAGVAVDFVLEFDVPDEEIVKRM
HHHHHHHHHHHHCHHHHHCCCEECCCCCCCCCHHHHHHCCEEEEEEEEECCCHHHHHHHH
AGRRVHAGSGRTYHIVYNPPKVADKDDVTGDDLSIRPDDEESTVRKRLDIYHTQTEPLVA
HCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCEEE
YYKNEAGQGNGEYHKFDGTKTVDVISAELATVLG
EEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA