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The map label for this gene is pth

Identifier: 119944670

GI number: 119944670

Start: 1139177

End: 1139770

Strand: Reverse

Name: pth

Synonym: Ping_0909

Alternate gene names: 119944670

Gene position: 1139770-1139177 (Counterclockwise)

Preceding gene: 119944671

Following gene: 119944669

Centisome position: 25.0

GC content: 41.25

Gene sequence:

>594_bases
GTGTCAATTACTATTAAATTGCTTGTGGGCCTGGCTAATCCAGGCCCAGAATATGCGCAAACTAGACACAATGCCGGACA
GTGGTATGTAAGCCAACTCGCCTCTCAAGAAAATATCCAACTTAAAGCTGAACCAAAATTTTATGGTCTAACGGGAAGAA
TTCAATTTGCCGGTAATGACCTGCGTCTTCTTGTTCCAACTACCTTTATGAACCTCAGTGGAAAAGCAGTTGCTGCGATG
GCAAATTTTTATCGCATTAAACCTGAAGAAATCCTCATTGCACACGATGAGCTGGATCTGCTTCCTGGTATAGCGAAGTT
TAAATTGGGTGGTGGTCATGGTGGACATAACGGTTTAAAAGATATTATCCAAAAACTGGGTAATGATAAAAATTTTTATC
GTCTGCGTATTGGCATAGGTCACCCCGGTGATAAAAACAGAGTCAGTGGTTATGTGCTCGGTAAAGCGCCGAGTAGTGAA
CAAAACTTGATTGACCAAAGTATTGATGAAGCAGCACGTTGTACCCATATTTTAGGGCAGGACGGACTGGAAAAAGCGAT
GAATCGCTTACATAGTTTTAAAGCAGAAAAATAA

Upstream 100 bases:

>100_bases
AACTAAATAAAGGTGAAGAACATGACCTTCCTATGGTTTCAATTGCACTTTCTAAAAAAGCACCTGCTGAAGAAATAGAA
GCTGAAACTGCTGAATAATA

Downstream 100 bases:

>100_bases
TCCGCTTAACACCCCGCAATTAACACACAACTAACAAAATAGGATATAAATCATGGGTTTCAAATGTGGCATAGTAGGCT
TACCCAATGTTGGTAAATCA

Product: aminoacyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MSITIKLLVGLANPGPEYAQTRHNAGQWYVSQLASQENIQLKAEPKFYGLTGRIQFAGNDLRLLVPTTFMNLSGKAVAAM
ANFYRIKPEEILIAHDELDLLPGIAKFKLGGGHGGHNGLKDIIQKLGNDKNFYRLRIGIGHPGDKNRVSGYVLGKAPSSE
QNLIDQSIDEAARCTHILGQDGLEKAMNRLHSFKAEK

Sequences:

>Translated_197_residues
MSITIKLLVGLANPGPEYAQTRHNAGQWYVSQLASQENIQLKAEPKFYGLTGRIQFAGNDLRLLVPTTFMNLSGKAVAAM
ANFYRIKPEEILIAHDELDLLPGIAKFKLGGGHGGHNGLKDIIQKLGNDKNFYRLRIGIGHPGDKNRVSGYVLGKAPSSE
QNLIDQSIDEAARCTHILGQDGLEKAMNRLHSFKAEK
>Mature_196_residues
SITIKLLVGLANPGPEYAQTRHNAGQWYVSQLASQENIQLKAEPKFYGLTGRIQFAGNDLRLLVPTTFMNLSGKAVAAMA
NFYRIKPEEILIAHDELDLLPGIAKFKLGGGHGGHNGLKDIIQKLGNDKNFYRLRIGIGHPGDKNRVSGYVLGKAPSSEQ
NLIDQSIDEAARCTHILGQDGLEKAMNRLHSFKAEK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=34.5238095238095, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1787455, Length=194, Percent_Identity=72.1649484536082, Blast_Score=275, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321983, Length=176, Percent_Identity=30.6818181818182, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PSYIN (A1STD6)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942350.1
- ProteinModelPortal:   A1STD6
- SMR:   A1STD6
- STRING:   A1STD6
- GeneID:   4624397
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0909
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- PhylomeDB:   A1STD6
- BioCyc:   PING357804:PING_0909-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21633; Mature: 21502

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITIKLLVGLANPGPEYAQTRHNAGQWYVSQLASQENIQLKAEPKFYGLTGRIQFAGND
CEEEEEEEEECCCCCHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCEEEEEEEEEECCCC
LRLLVPTTFMNLSGKAVAAMANFYRIKPEEILIAHDELDLLPGIAKFKLGGGHGGHNGLK
EEEEEEEEEECCCCHHHHHHHHHHEECCHHEEEECCCHHHCCCCEEEEECCCCCCCHHHH
DIIQKLGNDKNFYRLRIGIGHPGDKNRVSGYVLGKAPSSEQNLIDQSIDEAARCTHILGQ
HHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
DGLEKAMNRLHSFKAEK
CHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SITIKLLVGLANPGPEYAQTRHNAGQWYVSQLASQENIQLKAEPKFYGLTGRIQFAGND
EEEEEEEEECCCCCHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCEEEEEEEEEECCCC
LRLLVPTTFMNLSGKAVAAMANFYRIKPEEILIAHDELDLLPGIAKFKLGGGHGGHNGLK
EEEEEEEEEECCCCHHHHHHHHHHEECCHHEEEECCCHHHCCCCEEEEECCCCCCCHHHH
DIIQKLGNDKNFYRLRIGIGHPGDKNRVSGYVLGKAPSSEQNLIDQSIDEAARCTHILGQ
HHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
DGLEKAMNRLHSFKAEK
CHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA