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The map label for this gene is manC [H]

Identifier: 119944533

GI number: 119944533

Start: 964172

End: 965623

Strand: Direct

Name: manC [H]

Synonym: Ping_0766

Alternate gene names: 119944533

Gene position: 964172-965623 (Clockwise)

Preceding gene: 119944532

Following gene: 119944534

Centisome position: 21.15

GC content: 42.15

Gene sequence:

>1452_bases
ATGATCTCTCCTGTTATTCTGGCCGGTGGTACTGGTAGTCGATTATGGCCACTTTCTCGTGAGCTTTACCCAAAACAGTT
TTTAACCGTAACAGGTGAGCAATCAATGTTGCAGCAGACCGTTGCGCGTTTATCTGGTATGGAGCATGCCGCACCTGTAT
TAATTTGTAATGAAGATCACCGTTTTATTGCTGCTGAGCAAATGCGTTTAGGCGGTTATGATCATAGCGGTATTATCTTG
GAGCCTGTTGGCAGAAATACAGCGCCTGCTATTGCATTGGCTGCGCTACGAGCGGTTAACAATGCAGTTGATGGCGAAGA
GCCTGTTTTATTAATACTTGCTGCTGATCATATCATTGAAAATGAAGAGGCTTTTAAAACTTCAGTAGCAAAAGCATTAC
TTCTTGCAGAAAATGGCCAACTGGTTACTTTTGGTATCGTTCCTACTGCGCCTGAAACGGGTTATGGTTATATAAAAAGA
GGGACGAACTGCGAGGGGCTAGATACGAATGGCAGTCATGATGCTTTCTCTGTTAGTGAATTTGTAGAAAAACCAGACTT
GGCTACTGCAGAAGAGTATTTGGCAAGTGGGAACTACTACTGGAACTCAGGTATGTTCCTGTTCAAAGCAAGTCGTTACC
TTGAAGAATTAGCCAAATTTTCACCCATTATATTGGACGTGTGCAAGCGTGCTATTGCTGCACCATCACAAGACTTAGAT
TTTATTCGTGTTGACAAAGCTATCTTTGCAACCTGTCCAAATGACTCTATCGATTATTCGGTGATGGAGCCTCTTTGTGC
ACAGGGAAGCAATTCGGTGATGGTTGTGCCTATGGATGCTGGTTGGAGCGATGTGGGCTCTTTTTCTGCGTTATGGGAAG
TCTCAGCTAAAGATGATAACCAAAATGCCATAAAAGGTGATGTAATGGTCGTTGATTCAACCAACAATTATATCTATGCA
GAACATAAATTGGTCTCTACGGTCGGTGTTGATAACTTAGTGATTATTGAAACTAAAGATGCCATTTTAGTGGCAAGCAA
AGATAAAGTGCAAGATGTTAAAACGATTGTTAACCAGCTAAAAGAAGCAGGCCGAACTGAACATAAACTACACCGTGAAG
TATATCGTCCCTGGGGTAAATACGACTCTATCGATTTTGGTAAAAGGGATCATGTAAAACGAATTACCGTTAAACCGGGT
GAAAAACTTTCAATTCAAAAACATCACCACCGCTCGGAGCATTGGATTGTGGTATCTGGCACCGCAAGCGTGTTAAATGG
TGATAAAACTATTTTAGTCACTGAAAATGAATCAACCTACATCCCGTTAGGTACCATTCATGCGTTGGAAAATCCCGGCA
AAATCCTGTTAGAGATGATTGAAGTGCAGACAGGCAGTTATCTTGGTGAAGATGATATAGTGCGCTTCGAAGATCGCTAC
GGCCGAGTCTAA

Upstream 100 bases:

>100_bases
GATAAACAAGCAGATTTACTATTTAAATAATTAATGAGTTCTTAATGCTTTGAGCTTCATTATTGACTCGGAACTTGAAA
CTGAAACTGGAAAATAATTT

Downstream 100 bases:

>100_bases
TAAGTAAAAGCTTAACTATAGAGAAAATGGTTAAAGATAAAGTTCAGGGCAAGATTACGAATATAGACTTTTATTTTGAT
TATTAATTGCTTTTTATTTT

Product: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MISPVILAGGTGSRLWPLSRELYPKQFLTVTGEQSMLQQTVARLSGMEHAAPVLICNEDHRFIAAEQMRLGGYDHSGIIL
EPVGRNTAPAIALAALRAVNNAVDGEEPVLLILAADHIIENEEAFKTSVAKALLLAENGQLVTFGIVPTAPETGYGYIKR
GTNCEGLDTNGSHDAFSVSEFVEKPDLATAEEYLASGNYYWNSGMFLFKASRYLEELAKFSPIILDVCKRAIAAPSQDLD
FIRVDKAIFATCPNDSIDYSVMEPLCAQGSNSVMVVPMDAGWSDVGSFSALWEVSAKDDNQNAIKGDVMVVDSTNNYIYA
EHKLVSTVGVDNLVIIETKDAILVASKDKVQDVKTIVNQLKEAGRTEHKLHREVYRPWGKYDSIDFGKRDHVKRITVKPG
EKLSIQKHHHRSEHWIVVSGTASVLNGDKTILVTENESTYIPLGTIHALENPGKILLEMIEVQTGSYLGEDDIVRFEDRY
GRV

Sequences:

>Translated_483_residues
MISPVILAGGTGSRLWPLSRELYPKQFLTVTGEQSMLQQTVARLSGMEHAAPVLICNEDHRFIAAEQMRLGGYDHSGIIL
EPVGRNTAPAIALAALRAVNNAVDGEEPVLLILAADHIIENEEAFKTSVAKALLLAENGQLVTFGIVPTAPETGYGYIKR
GTNCEGLDTNGSHDAFSVSEFVEKPDLATAEEYLASGNYYWNSGMFLFKASRYLEELAKFSPIILDVCKRAIAAPSQDLD
FIRVDKAIFATCPNDSIDYSVMEPLCAQGSNSVMVVPMDAGWSDVGSFSALWEVSAKDDNQNAIKGDVMVVDSTNNYIYA
EHKLVSTVGVDNLVIIETKDAILVASKDKVQDVKTIVNQLKEAGRTEHKLHREVYRPWGKYDSIDFGKRDHVKRITVKPG
EKLSIQKHHHRSEHWIVVSGTASVLNGDKTILVTENESTYIPLGTIHALENPGKILLEMIEVQTGSYLGEDDIVRFEDRY
GRV
>Mature_483_residues
MISPVILAGGTGSRLWPLSRELYPKQFLTVTGEQSMLQQTVARLSGMEHAAPVLICNEDHRFIAAEQMRLGGYDHSGIIL
EPVGRNTAPAIALAALRAVNNAVDGEEPVLLILAADHIIENEEAFKTSVAKALLLAENGQLVTFGIVPTAPETGYGYIKR
GTNCEGLDTNGSHDAFSVSEFVEKPDLATAEEYLASGNYYWNSGMFLFKASRYLEELAKFSPIILDVCKRAIAAPSQDLD
FIRVDKAIFATCPNDSIDYSVMEPLCAQGSNSVMVVPMDAGWSDVGSFSALWEVSAKDDNQNAIKGDVMVVDSTNNYIYA
EHKLVSTVGVDNLVIIETKDAILVASKDKVQDVKTIVNQLKEAGRTEHKLHREVYRPWGKYDSIDFGKRDHVKRITVKPG
EKLSIQKHHHRSEHWIVVSGTASVLNGDKTILVTENESTYIPLGTIHALENPGKILLEMIEVQTGSYLGEDDIVRFEDRY
GRV

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=485, Percent_Identity=60.2061855670103, Blast_Score=580, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 53166; Mature: 53166

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPVILAGGTGSRLWPLSRELYPKQFLTVTGEQSMLQQTVARLSGMEHAAPVLICNEDH
CCCCEEEECCCCCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEECCCC
RFIAAEQMRLGGYDHSGIILEPVGRNTAPAIALAALRAVNNAVDGEEPVLLILAADHIIE
CEEEEEHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHC
NEEAFKTSVAKALLLAENGQLVTFGIVPTAPETGYGYIKRGTNCEGLDTNGSHDAFSVSE
CHHHHHHHHHHHHEEECCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCEEHHH
FVEKPDLATAEEYLASGNYYWNSGMFLFKASRYLEELAKFSPIILDVCKRAIAAPSQDLD
HHCCCCCCCHHHHHHCCCEEECCCEEEEHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC
FIRVDKAIFATCPNDSIDYSVMEPLCAQGSNSVMVVPMDAGWSDVGSFSALWEVSAKDDN
EEEECCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCC
QNAIKGDVMVVDSTNNYIYAEHKLVSTVGVDNLVIIETKDAILVASKDKVQDVKTIVNQL
CCCEECCEEEEECCCCEEEEEEEEEEECCCCCEEEEEECCEEEEECCHHHHHHHHHHHHH
KEAGRTEHKLHREVYRPWGKYDSIDFGKRDHVKRITVKPGEKLSIQKHHHRSEHWIVVSG
HHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEHHHCCCCCCEEEEEC
TASVLNGDKTILVTENESTYIPLGTIHALENPGKILLEMIEVQTGSYLGEDDIVRFEDRY
CHHHCCCCEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHC
GRV
CCC
>Mature Secondary Structure
MISPVILAGGTGSRLWPLSRELYPKQFLTVTGEQSMLQQTVARLSGMEHAAPVLICNEDH
CCCCEEEECCCCCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEECCCC
RFIAAEQMRLGGYDHSGIILEPVGRNTAPAIALAALRAVNNAVDGEEPVLLILAADHIIE
CEEEEEHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHC
NEEAFKTSVAKALLLAENGQLVTFGIVPTAPETGYGYIKRGTNCEGLDTNGSHDAFSVSE
CHHHHHHHHHHHHEEECCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCEEHHH
FVEKPDLATAEEYLASGNYYWNSGMFLFKASRYLEELAKFSPIILDVCKRAIAAPSQDLD
HHCCCCCCCHHHHHHCCCEEECCCEEEEHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC
FIRVDKAIFATCPNDSIDYSVMEPLCAQGSNSVMVVPMDAGWSDVGSFSALWEVSAKDDN
EEEECCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCC
QNAIKGDVMVVDSTNNYIYAEHKLVSTVGVDNLVIIETKDAILVASKDKVQDVKTIVNQL
CCCEECCEEEEECCCCEEEEEEEEEEECCCCCEEEEEECCEEEEECCHHHHHHHHHHHHH
KEAGRTEHKLHREVYRPWGKYDSIDFGKRDHVKRITVKPGEKLSIQKHHHRSEHWIVVSG
HHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEHHHCCCCCCEEEEEC
TASVLNGDKTILVTENESTYIPLGTIHALENPGKILLEMIEVQTGSYLGEDDIVRFEDRY
CHHHCCCCEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHC
GRV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]