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The map label for this gene is metC [H]

Identifier: 119944455

GI number: 119944455

Start: 869224

End: 870447

Strand: Direct

Name: metC [H]

Synonym: Ping_0683

Alternate gene names: 119944455

Gene position: 869224-870447 (Clockwise)

Preceding gene: 119944453

Following gene: 119944458

Centisome position: 19.06

GC content: 41.58

Gene sequence:

>1224_bases
ATGCTAATATGGTATTACTTGCGATATTTACCGATGGAAATAAATATGAAAAAAGAAACACAAATTGTATGTCTAGGACG
TAATAAAAAATGGACAAAAGGGGTGGTTAATCCTCCGGTGGTGCGTGCTTCAACTATGTTGTTTGATACGATGGAAGATA
TGCGTTTTGCCGGCAAAAATAAAAACAATGGCGAAATGTATTATGGACGCCGTGGCGGACCGACTCACTTTGCTTTTCAA
GAGGCTATTGCTGAACTTGAAGGTGGTGCTGGTACCGCCTTATATCCTTCCGGTACCGCTGCGATTAGCAGTGCATTAAT
GTCCTTTTTAAAAGCGGGCGATCATTTATTGATGCTTGATAACGCTTACGAACCTACCCGTGCTTTATGTGATACTTTAC
TGGCCGGATTTGGTATCGAAACGACTTATTATGACCCGTTAATTGGTGCGGGGATCAGTGAGCTAATACAGCCTAATACC
AAAGTGTTATTTCTTGAATCACCAGGTTCCATCACCATGGAAATTCAAGATGTACCCACATTAAGCCGTATTGCCCATGA
AAATAATCTGATAGTGATGTTAGATAATACTTGGGCTTCTCCTATCAATTCACGTCCCTTCGAAATGGGTGTTGATATCT
CCATTCAAGCGGCGACTAAATATATCGTTGGGCATTCCGATGTTATGATGGGCACTGCCACGGCGAATACCAAGTATTGG
CCAACGCTGCGAGAACACAGTTATTTATTGGGTCAATGTACTTCGCCTGACGATGTTTATTTAGCCAGTCGTGGATTACG
TACGTTAGGTGTACGTATGGCGCAACATGAAAAAAATGCGCTTGCCGTCGCTAATTGGTTAGCAACTCGCCCTGAAGTTG
ATCACCTGCGTCATCCCGCTTTCGAAACCTGTCCGGGTCATGAGTTCTTTAAACGCGATTTTAGTGGTAGTAATGGTTTA
TTTTCATTTGTTTTAAAAGAGGGAAATTTAAAATCGGTGACTGCTTTAGTTGAGAATATGGATTATTTTAAAATGGGCTT
TTCATGGGGCGGTTTTGAAAGTCTTATTCTGGGCGTCTTTGGTATTGATAAAATACGCACGGTAACACAGTGGGATAAAA
GCAAGCCGCTGATCCGCCTGCATGTTGGTCTGGAAAATGTAGATGATCTGATTGCTGATTTAGAAGCCGGATTTGAACGA
ATGAATAAAGCCTTAAGTAAATAA

Upstream 100 bases:

>100_bases
TACTGATTGGATTATTCTGAGCTGTTTTGCGAAATTAACCCGTAAAGCAATTTTTTCTTCTAAGCTATGGCTTTATTCTC
ACTGTTCATCACTCTGTGAA

Downstream 100 bases:

>100_bases
CGTTAAGGTAAATAAAAGTTTAATATTAGCTGCCGGCAGCAGAAAGATATGCGCAGTTTAACCCAGTGCGCATATCTTAT
TAATGATACTAAATCTCTTT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLIWYYLRYLPMEINMKKETQIVCLGRNKKWTKGVVNPPVVRASTMLFDTMEDMRFAGKNKNNGEMYYGRRGGPTHFAFQ
EAIAELEGGAGTALYPSGTAAISSALMSFLKAGDHLLMLDNAYEPTRALCDTLLAGFGIETTYYDPLIGAGISELIQPNT
KVLFLESPGSITMEIQDVPTLSRIAHENNLIVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANTKYW
PTLREHSYLLGQCTSPDDVYLASRGLRTLGVRMAQHEKNALAVANWLATRPEVDHLRHPAFETCPGHEFFKRDFSGSNGL
FSFVLKEGNLKSVTALVENMDYFKMGFSWGGFESLILGVFGIDKIRTVTQWDKSKPLIRLHVGLENVDDLIADLEAGFER
MNKALSK

Sequences:

>Translated_407_residues
MLIWYYLRYLPMEINMKKETQIVCLGRNKKWTKGVVNPPVVRASTMLFDTMEDMRFAGKNKNNGEMYYGRRGGPTHFAFQ
EAIAELEGGAGTALYPSGTAAISSALMSFLKAGDHLLMLDNAYEPTRALCDTLLAGFGIETTYYDPLIGAGISELIQPNT
KVLFLESPGSITMEIQDVPTLSRIAHENNLIVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANTKYW
PTLREHSYLLGQCTSPDDVYLASRGLRTLGVRMAQHEKNALAVANWLATRPEVDHLRHPAFETCPGHEFFKRDFSGSNGL
FSFVLKEGNLKSVTALVENMDYFKMGFSWGGFESLILGVFGIDKIRTVTQWDKSKPLIRLHVGLENVDDLIADLEAGFER
MNKALSK
>Mature_407_residues
MLIWYYLRYLPMEINMKKETQIVCLGRNKKWTKGVVNPPVVRASTMLFDTMEDMRFAGKNKNNGEMYYGRRGGPTHFAFQ
EAIAELEGGAGTALYPSGTAAISSALMSFLKAGDHLLMLDNAYEPTRALCDTLLAGFGIETTYYDPLIGAGISELIQPNT
KVLFLESPGSITMEIQDVPTLSRIAHENNLIVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANTKYW
PTLREHSYLLGQCTSPDDVYLASRGLRTLGVRMAQHEKNALAVANWLATRPEVDHLRHPAFETCPGHEFFKRDFSGSNGL
FSFVLKEGNLKSVTALVENMDYFKMGFSWGGFESLILGVFGIDKIRTVTQWDKSKPLIRLHVGLENVDDLIADLEAGFER
MNKALSK

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=372, Percent_Identity=33.6021505376344, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI299473759, Length=372, Percent_Identity=30.9139784946237, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI25453487, Length=371, Percent_Identity=30.9973045822102, Blast_Score=155, Evalue=7e-38,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=51.2755102040816, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1790375, Length=392, Percent_Identity=32.1428571428571, Blast_Score=177, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI71980708, Length=372, Percent_Identity=31.989247311828, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17538055, Length=334, Percent_Identity=33.8323353293413, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17560056, Length=378, Percent_Identity=32.2751322751323, Blast_Score=180, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321170, Length=333, Percent_Identity=47.4474474474475, Blast_Score=322, Evalue=6e-89,
Organism=Saccharomyces cerevisiae, GI6319307, Length=353, Percent_Identity=30.5949008498584, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=384, Percent_Identity=25.5208333333333, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321254, Length=396, Percent_Identity=26.5151515151515, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323333, Length=384, Percent_Identity=26.3020833333333, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19922554, Length=383, Percent_Identity=33.1592689295039, Blast_Score=208, Evalue=5e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45363; Mature: 45363

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIWYYLRYLPMEINMKKETQIVCLGRNKKWTKGVVNPPVVRASTMLFDTMEDMRFAGKN
CEEEEEEHHCCEEECCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
KNNGEMYYGRRGGPTHFAFQEAIAELEGGAGTALYPSGTAAISSALMSFLKAGDHLLMLD
CCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHCCCEEEEEC
NAYEPTRALCDTLLAGFGIETTYYDPLIGAGISELIQPNTKVLFLESPGSITMEIQDVPT
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHCCCCEEEEEECCCCEEEEEECCCH
LSRIAHENNLIVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANTKYW
HHHHHCCCCEEEEECCCCCCCCCCCCCEECCCEEEEEHEEEEECCCCEEEEEECCCCCCC
PTLREHSYLLGQCTSPDDVYLASRGLRTLGVRMAQHEKNALAVANWLATRPEVDHLRHPA
CCHHHCCEEEECCCCCCCEEHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCC
FETCPGHEFFKRDFSGSNGLFSFVLKEGNLKSVTALVENMDYFKMGFSWGGFESLILGVF
CCCCCCHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHCCCHHEECCCCCCHHHHHHHHH
GIDKIRTVTQWDKSKPLIRLHVGLENVDDLIADLEAGFERMNKALSK
CHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLIWYYLRYLPMEINMKKETQIVCLGRNKKWTKGVVNPPVVRASTMLFDTMEDMRFAGKN
CEEEEEEHHCCEEECCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
KNNGEMYYGRRGGPTHFAFQEAIAELEGGAGTALYPSGTAAISSALMSFLKAGDHLLMLD
CCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHCCCEEEEEC
NAYEPTRALCDTLLAGFGIETTYYDPLIGAGISELIQPNTKVLFLESPGSITMEIQDVPT
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHCCCCEEEEEECCCCEEEEEECCCH
LSRIAHENNLIVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANTKYW
HHHHHCCCCEEEEECCCCCCCCCCCCCEECCCEEEEEHEEEEECCCCEEEEEECCCCCCC
PTLREHSYLLGQCTSPDDVYLASRGLRTLGVRMAQHEKNALAVANWLATRPEVDHLRHPA
CCHHHCCEEEECCCCCCCEEHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCC
FETCPGHEFFKRDFSGSNGLFSFVLKEGNLKSVTALVENMDYFKMGFSWGGFESLILGVF
CCCCCCHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHCCCHHEECCCCCCHHHHHHHHH
GIDKIRTVTQWDKSKPLIRLHVGLENVDDLIADLEAGFERMNKALSK
CHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]