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The map label for this gene is mazG [H]

Identifier: 119944437

GI number: 119944437

Start: 853285

End: 854103

Strand: Direct

Name: mazG [H]

Synonym: Ping_0665

Alternate gene names: 119944437

Gene position: 853285-854103 (Clockwise)

Preceding gene: 119944434

Following gene: 119944438

Centisome position: 18.71

GC content: 42.37

Gene sequence:

>819_bases
ATGCCAACGGCTAATTTACAACCTCTGTTAAAGATTATGGAACAACTGCGCGATCCTGAAAATGGCTGTCCCTGGGACAA
CAAACAAACCTTTGATTCCATTGTGTCTCATACTATAGAAGAAGCTTACGAGGTTGCTGACGCTATAAAGCTGAAAGACT
TCGATGAGTTAAAAGGGGAGCTGGGGGATTTATTATTTCAAGTGGTCTTTTATGCGCAGATGGCAAAAGAGCAGGGGCTG
TTTGAGTTTAATGATATTATTGAGGCGATCAGCGAAAAGCTGATTCGTCGCCATCCGCACGTATTTGCCAAGGCCGAGTT
TGCCAGTGAAGACGCCATTCATGCCAACTGGGAAGCTGAAAAAGACAAGGAGCGTGCCGCAAAAGCGTTGTCAGAAAATA
AAAGCGACAGTCTATTAGATAATATTCCCTTAAGCTTACCGGCATTAAACCGTGCTTATAAAATTCAAAAACGCTGTGCG
AGTGTGGGCTTTGATTGGGATAGTTTGCCGCCTGTTGTTGATAAAATTTATGAAGAGATAGACGAAGTGTTAGTGGAAGT
AAAACGTGATGATCTCAGCGAGCAGCAACAACAGGCGCGTATTGAAGAAGAGTTAGGGGATCTGTTATTTGCAAATGTGA
ATTTAGTGCGTCATTTAAAATGCAATCCTGAACAAGTATTACGTCAGGCGAACAGTAAATTCGAAAAACGTTTTCGTCTG
GTTGAGTTAGCTGTATTAAAACAGGGGAAAAAAATGCAGGACTGCACCATCGATGAGTTGGATGCAGTTTGGGAACAAGT
CAAAAAGCAGCAGGGTTAA

Upstream 100 bases:

>100_bases
TGCGTCTGTATATCCCGTGATCATTCATATCCTGTTTATAATCTTCGACAATTCATTTATTCTTAGCAGTTTATTTATTA
ATGTTATTAAGGATCTCTTT

Downstream 100 bases:

>100_bases
AGTGCTGTCGGCTGATAGCTGATAACTGCTAACCCCCTTAAAAAGCAAGGGTTATTTAAATAGAAACGATAAAAAAGTAC
CTTTGCAATATTCGAGTTCG

Product: MazG family protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPTANLQPLLKIMEQLRDPENGCPWDNKQTFDSIVSHTIEEAYEVADAIKLKDFDELKGELGDLLFQVVFYAQMAKEQGL
FEFNDIIEAISEKLIRRHPHVFAKAEFASEDAIHANWEAEKDKERAAKALSENKSDSLLDNIPLSLPALNRAYKIQKRCA
SVGFDWDSLPPVVDKIYEEIDEVLVEVKRDDLSEQQQQARIEEELGDLLFANVNLVRHLKCNPEQVLRQANSKFEKRFRL
VELAVLKQGKKMQDCTIDELDAVWEQVKKQQG

Sequences:

>Translated_272_residues
MPTANLQPLLKIMEQLRDPENGCPWDNKQTFDSIVSHTIEEAYEVADAIKLKDFDELKGELGDLLFQVVFYAQMAKEQGL
FEFNDIIEAISEKLIRRHPHVFAKAEFASEDAIHANWEAEKDKERAAKALSENKSDSLLDNIPLSLPALNRAYKIQKRCA
SVGFDWDSLPPVVDKIYEEIDEVLVEVKRDDLSEQQQQARIEEELGDLLFANVNLVRHLKCNPEQVLRQANSKFEKRFRL
VELAVLKQGKKMQDCTIDELDAVWEQVKKQQG
>Mature_271_residues
PTANLQPLLKIMEQLRDPENGCPWDNKQTFDSIVSHTIEEAYEVADAIKLKDFDELKGELGDLLFQVVFYAQMAKEQGLF
EFNDIIEAISEKLIRRHPHVFAKAEFASEDAIHANWEAEKDKERAAKALSENKSDSLLDNIPLSLPALNRAYKIQKRCAS
VGFDWDSLPPVVDKIYEEIDEVLVEVKRDDLSEQQQQARIEEELGDLLFANVNLVRHLKCNPEQVLRQANSKFEKRFRLV
ELAVLKQGKKMQDCTIDELDAVWEQVKKQQG

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=263, Percent_Identity=58.5551330798479, Blast_Score=308, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31296; Mature: 31165

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTANLQPLLKIMEQLRDPENGCPWDNKQTFDSIVSHTIEEAYEVADAIKLKDFDELKGE
CCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LGDLLFQVVFYAQMAKEQGLFEFNDIIEAISEKLIRRHPHVFAKAEFASEDAIHANWEAE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCH
KDKERAAKALSENKSDSLLDNIPLSLPALNRAYKIQKRCASVGFDWDSLPPVVDKIYEEI
HHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
DEVLVEVKRDDLSEQQQQARIEEELGDLLFANVNLVRHLKCNPEQVLRQANSKFEKRFRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VELAVLKQGKKMQDCTIDELDAVWEQVKKQQG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTANLQPLLKIMEQLRDPENGCPWDNKQTFDSIVSHTIEEAYEVADAIKLKDFDELKGE
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LGDLLFQVVFYAQMAKEQGLFEFNDIIEAISEKLIRRHPHVFAKAEFASEDAIHANWEAE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCH
KDKERAAKALSENKSDSLLDNIPLSLPALNRAYKIQKRCASVGFDWDSLPPVVDKIYEEI
HHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
DEVLVEVKRDDLSEQQQQARIEEELGDLLFANVNLVRHLKCNPEQVLRQANSKFEKRFRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VELAVLKQGKKMQDCTIDELDAVWEQVKKQQG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]